Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,196 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03364803Recruiting
Sharing treatment results for people with Cushing’s syndrome
This is a study that collects and reviews information about how people with Cushing’s syndrome (including some mild forms and certain “silent” tumors) are diagnosed and treated, and what outcomes they have. It may help researchers understand which treatments work best in different types of the condition.
Basking Ridge, New JerseyAges 14 years+ - NCT03137472Recruiting
Brain stimulation to treat complex regional pain syndrome
This trial studies whether noninvasive brain stimulation (TMS) can reduce pain in people with complex regional pain syndrome (CRPS). It may help if your CRPS has lasted at least a few months and you can safely undergo the stimulation and study tasks.
Redwood City, CaliforniaAges 18–70 - NCT03275480Recruiting
Registry study for myelodysplastic syndromes patients
This study is a database that collects information from people diagnosed with myelodysplastic syndromes. It may help researchers better understand the condition and how patients do over time.
Marseille, PACAAges 18 years+ - NCT07280091Recruiting
Skin and gut bacteria in Netherton syndrome
This study looks at the bacteria on the skin and in the gut of people with Netherton syndrome, a condition that affects the skin barrier and often causes allergies. It also compares these findings to healthy volunteers to understand how the microbiome might be different.
Paris, Île-de-France RegionAges 10 years+ - NCT07675746RecruitingEarly Phase 1
RC001 for children with Dravet syndrome
This early-phase trial tests an experimental medicine called RC001 in children with Dravet syndrome caused by SCN1A gene changes. The goal is to see if RC001 is safe and how the body processes it, with the hope of reducing seizures.
Guangzhou, GuangdongAges 2–18 - NCT07675109Recruiting
Extended therapy for restless legs syndrome
This study tests a device that delivers nerve stimulation to help with restless legs syndrome (RLS). It aims to see if using the device for a longer period each night can reduce RLS symptoms and improve sleep.
Pleasanton, CaliforniaAges 21 years+ - NCT01902407Enrolling by invitation
Sleep scan study using computer models in people with Down syndrome
This study uses computer simulations to understand breathing airways and lung changes during sleep in people with Down syndrome. It may help researchers better interpret sleep MRI/CT scans and improve how sleep apnea (OSA) is studied in the future.
Cincinnati, OhioAges 1–90 - NCT01852370Enrolling by invitationPhase 1/Phase 2
Lung and bone marrow transplant plan for immune system disorders
This early-phase study tests a step-by-step transplant approach: first replacing the lungs, then doing a bone marrow (stem cell) transplant to treat certain immune deficiency diseases. It may help people whose immune problem has led to severe, end-stage lung disease.
Pittsburgh, PennsylvaniaAges 5–45 - NCT00616317Recruiting
Study for children with antiphospholipid syndrome and blood clots
This study is for children who have antiphospholipid syndrome (APS) and a history of blood vessel clots. Researchers want to learn more about APS in pediatric patients who have specific blood test signs and clot history.
Sacramento, CaliforniaAges 1 minute–18 years - NCT07400783Recruiting
Study of short bowel syndrome in children
This study looks at short bowel syndrome in children who have had intestinal surgery. It may help doctors understand how to better treat this condition.
Florence, FlorenceAges 4 months–17 years - NCT07400848Recruiting
Symptoms and recovery after COVID-19 vaccine
This study looks at people who developed new, long-lasting symptoms after a COVID-19 vaccine. It aims to understand their symptoms, do lab tests, and see how they recover over time.
BernAges 18 years+ - NCT07401888Recruiting
Milk Study for Metabolic Syndrome
This study looks at how drinking milk affects adults with metabolic syndrome — a set of conditions like high blood pressure and high blood sugar. It may help if you are at risk for heart disease or diabetes and want to see if adding milk can improve your health.
Rochester, MinnesotaAges 18–70 - NCT07406932Recruiting
JAK inhibitors vs standard therapy for lung scarring in Anti-Synthetase Syndrome
This trial tests whether a new class of drugs called JAK inhibitors (which block inflammation signals) is better than a standard treatment (calcineurin inhibitors) for people with lung scarring (interstitial lung disease) caused by Anti-Synthetase Syndrome. It is for people who have not yet taken any immune-suppressing medications for this condition.
Beijing, Beijing MunicipalityAges 18–75 - NCT07410819Recruiting
Cervicothoracic exercises for carpal tunnel syndrome
This study tests whether specific neck and upper back exercises can reduce pain and improve function in people with carpal tunnel syndrome. It may be an option if you have had symptoms for at least 12 weeks and have not had wrist surgery or injections.
Istanbul, PendikAges 18 years+ - NCT07413978RecruitingPhase 1/Phase 2
Stem cell injection for severe ARDS
This trial tests whether an injection of stem cells from umbilical cords can help people with severe ARDS (a type of lung failure) recover faster. It is for those who have not improved after standard treatment and whose ARDS is caused by an infection (not COVID-19).
Wuhan, HubeiAges 18–80 - NCT07414069Recruiting
Laser therapy for carpal tunnel syndrome
This trial tests high-intensity laser therapy as a treatment for mild to moderate carpal tunnel syndrome. It aims to see if the laser can improve symptoms and hand function without surgery or injections.
Ankara, Ankara, ÇankayaAges 18–65 - NCT07415967Recruiting
Dual-task exercise for rotator cuff shoulder pain
This study tests an exercise program that combines shoulder movements with mental tasks (like counting or naming things) to improve pain and function. It is for people with ongoing shoulder pain from common rotator cuff problems.
IstanbulAges 18–65 - NCT07421011RecruitingPhase 1
Comparing two forms of a drug for healthy volunteers
This study tests two different versions of a drug called Trimedat to see if they work the same way in the body. It is for healthy volunteers to understand how the drug is absorbed and if it is safe.
Saint PetersburgAges 18–45 - NCT07421427Recruiting
Preventing pain after mastectomy with added medication
This trial tests if adding amantadine or duloxetine to the standard drug pregabalin can better prevent chronic pain after a mastectomy. It may help you if you're undergoing a modified radical mastectomy for breast cancer.
CairoAges 18–65 - NCT07426016Recruiting
Comparing two ways to give surfactant to premature babies
This study compares two methods—video laryngoscopy and direct laryngoscopy—to give surfactant (a medicine that helps babies' lungs work better) to very premature infants. It aims to find which method is safer and easier for babies born at 28 weeks or earlier who need surfactant within the first 36 hours after birth.
Dallas, TexasAges birth–3 days - NCT07428863Recruiting
Jump rope for foot health in Down syndrome
This study tests if jumping rope can help improve foot arch alignment in children with Down syndrome who have flat feet. It may offer a simple, fun way to strengthen feet and reduce foot problems.
Lahore, Punjab ProvinceAges 4–15 - NCT07430046RecruitingPhase 2
Testing mirtazapine for breathing problems in Rett syndrome
This study tests whether the drug mirtazapine can reduce breathing issues in females with Rett syndrome. Participants must have a confirmed MECP2 mutation and specific breathing dysfunction like breath holding or hyperventilation.
GenovaAges 5–40 - NCT07430839Recruiting
Exercise and artery health in metabolic syndrome
This study looks at how exercise affects the arteries in people with metabolic syndrome (a group of conditions like high blood pressure, high blood sugar, and unhealthy cholesterol). It may help find ways to improve heart health.
Madison, WisconsinAges 18–40 - NCT07432191Recruiting
Testing a new ventilator for safe breathing support
This study tests a new breathing machine (INBENTUS VERSATILE ventilator) for people who need help breathing. It checks if the machine is safe and works well for patients who need a ventilator and then slowly come off it.
MurciaAges 18 years+
Hear when a new Down Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,196 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.