Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,060 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04165109Recruiting
Down syndrome study to test memory and thinking changes
This study enrolls adults with Down syndrome to better understand how thinking and memory develop and change over time. It may help by building a “trial-ready” group and by measuring thinking in a careful, consistent way.
Phoenix, ArizonaAges 25–55 - NCT04187703RecruitingEarly Phase 1
Testing azacitidine and decitabine for bone marrow cancers
This early-phase study tests whether combining two “epigenetic” medicines—azacitidine and decitabine—can improve outcomes for certain bone marrow cancers. It may help if you have a type of myelodysplastic syndrome (MDS) or MDS/MPN overlap that is expected to be sensitive to these medicines.
Cleveland, OhioAges 18 years+ - NCT04189822Enrolling by invitation
Heart rhythm genetic registry and blood sample bio bank
This study is building a Canadian database and tissue/blood bank for people and families with inherited heart rhythm conditions (and some inherited heart muscle diseases). It collects consented health and genetic information to help researchers better understand who is at risk and how these conditions work.
Vancouver, British ColumbiaAges Any age - NCT04206215Recruiting
Noninvasive brain stimulation for carpal tunnel pain relief
This study tests whether a noninvasive brain stimulation treatment can reduce chronic carpal tunnel (CTS) pain, especially when pain spreads beyond the usual nerve area. If you have long-lasting CTS pain that hasn’t improved with standard treatments, you may be able to try this therapy while being closely monitored for safety.
Charlestown, MassachusettsAges 18–80 - NCT04203979Recruiting
Sepsis care tailored to patients
This study looks at how to better recognize and manage sepsis (a serious body-wide reaction to infection) and tailor care to the individual. You may be eligible if you are newly admitted to the emergency department and your care is handled by a rapid response team for sepsis.
OsloAges 18 years+ - NCT04061421RecruitingPhase 1/Phase 2
Testing new medicine combos for bone marrow disease overlap syndromes
This early-phase trial studies a new treatment plan (decitabine-related medicine with other targeted drugs, depending on the arm) for adults with MDS/MPN overlap syndromes. It aims to improve control of the disease by targeting the abnormal bone marrow cells. Because it’s Phase 1/2, the main goal is to find safe dosing and see whether it helps responses.
Tampa, FloridaAges 18 years+ - NCT04041713RecruitingPhase 2
Antioxidant drink trial for children with Rett syndrome
This Phase 2 trial studies whether an antioxidant “cocktail” helps children and teens with Rett syndrome compared with a placebo (inactive drink). If you join, you’ll get study assessments and blood tests to see if the treatment is safe and helpful.
Toronto, OntarioAges 2–21 - NCT04018118Recruiting
Study of the course of high eosinophil blood disease
This study follows people with long-term high eosinophils (a type of white blood cell) and related conditions to learn how the illness changes over time. It helps doctors understand patterns of organ involvement and outcomes, which may improve future care.
LilleAges Any age - NCT04008173Enrolling by invitation
Survey study of acute heart attack symptoms
This study collects information about symptoms and experiences during acute coronary syndromes, which are sudden, serious heart events like heart attacks or unstable angina. It may help researchers understand patterns of care and symptoms to improve future treatment and support.
Bologna, BolognaAges 18 years+ - NCT03914664Enrolling by invitation
Brain and sensation study in adults with Tourette syndrome
This study looks at brain activity and how sensory experiences feel in adults with Tourette syndrome. It compares you to carefully matched adults without neurologic or psychiatric conditions to understand what is different in the brain.
Nashville, TennesseeAges 18 years+ - NCT03994367Recruiting
Study of diet protein types and how they affect blood sugar
This study looks at how eating more or different types of proteins (animal vs plant) may change your blood sugar handling. It mainly targets adults who eat relatively little protein and have no diabetes.
Columbia, MissouriAges 21–70 - NCT03836482Recruiting
SCD test for people with heart and kidney failure awaiting LVAD
This study looks at whether a treatment called SCD is safe and workable in people who have worsening heart failure along with kidney problems, and who are waiting to get an LVAD (a mechanical heart pump). It is mainly a feasibility study, meaning the researchers want to see if this approach can be used in real hospital care and monitor effects on key health measures.
Ann Arbor, MichiganAges 18 years+ - NCT03851484Recruiting
Study sensory symptoms in people with Tourette-related tics
This study looks at sensory symptoms in adults who have Tourette syndrome or similar long-term tic disorders. Your answers to questionnaires may help researchers understand these symptoms and how they relate to the condition.
Nashville, TennesseeAges 18 years+ - NCT03794466Recruiting
Study pain relief after blocking gonadal veins for pelvic congestion
This study looks at how much pelvic pain improves after a procedure called gonadal vein embolization (blocking problem veins). It mainly applies to people diagnosed with pelvic congestion syndrome caused by venous (vein) problems, treated during a specific time window.
Kansas City, KansasAges 18 years+ - NCT03708900RecruitingPhase 2
Osilodrostat study for children with Cushing’s syndrome
This Phase 2 study tests how osilodrostat works in children and teens with Cushing’s syndrome—what the drug does in the body, how it affects hormones, and how safely it’s tolerated. It may help families who cannot have immediate surgery or whose surgery has already failed or is still pending.
San Francisco, CaliforniaAges 2–17 - NCT03587844RecruitingPhase 2
Test dosing of brentuximab for skin lymphoma
This Phase 2 study tests how brentuximab vedotin should be dosed for people with mycosis fungoides or Sezary syndrome (skin T-cell lymphoma), and also for lymphomatoid papulosis. It may help improve how well the treatment works while tracking side effects.
Stanford, CaliforniaAges 18 years+ - NCT03584815Recruiting
Test of physiotherapy versus surgery for exercise leg muscle pressure
This trial compares a physiotherapy program to a surgical procedure (fasciotomy) for chronic “compartment” pressure in the lower leg triggered by exercise. If you have symptoms that reliably come on with walking/running and improve with rest, the study may offer a structured way to find the best treatment for you.
Copenhagen, CopehagenAges 18–50 - NCT03568669Recruiting
Testing thinking and learning in congenital central hypoventilation syndrome
This study looks at thinking and memory in people with congenital central hypoventilation syndrome (CCHS) to better understand how the condition affects the brain. It may help researchers measure changes over time and guide future care.
Los Angeles, CaliforniaAges 3–85 - NCT03702309Recruiting
Banking and testing blood samples to study cancer
This study collects blood samples to “test and store” (bank) information that may help doctors understand cancer in the future. You might be able to join if you’re an adult with confirmed cancer or a higher-than-usual risk for cancer.
Toronto, OntarioAges 18 years+ - NCT03113643RecruitingPhase 1
SL-401 with standard drugs for hard-to-treat blood cancers
This Phase 1 study tests SL-401, given with azacitidine and sometimes venetoclax, to treat acute myeloid leukemia (AML), high-risk myelodysplastic syndrome (MDS), or blastic plasmacytoid dendritic cell neoplasm (BPDCN). It aims to find a safe dose and see whether the combination can improve blood cancer control.
Duarte, CaliforniaAges 18 years+ - NCT03124212Recruiting
Genetic testing guidance for inherited breast, ovarian, or colon cancer risk
This study helps people in Switzerland who already have a known inherited cancer gene change understand what it means for them and their family. It focuses on people with specific known mutations related to hereditary breast/ovarian cancer and Lynch syndrome.
Fribourg, Canton of FribourgAges 18 years+ - NCT03176836Enrolling by invitation
TP53 mutation imaging study for Li-Fraumeni syndrome
This study takes special body images (MRI) in people from families with Li-Fraumeni syndrome, especially those who carry a TP53 gene mutation. The goal is to see whether MRI can help spot problems earlier in a higher-risk group.
Toronto, OntarioAges Up to 18 years - NCT03137472Recruiting
Brain stimulation to treat complex regional pain syndrome
This trial studies whether noninvasive brain stimulation (TMS) can reduce pain in people with complex regional pain syndrome (CRPS). It may help if your CRPS has lasted at least a few months and you can safely undergo the stimulation and study tasks.
Redwood City, CaliforniaAges 18–70 - NCT03088020Recruiting
CCHS patient registry for people with PHOX2B gene changes
This study is a registry, meaning it collects health information to better understand congenital central hypoventilation syndrome (CCHS). It enrolls only people whose CCHS has been confirmed by a PHOX2B gene test.
Chicago, IllinoisAges Any age
Hear when a new Down Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,060 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.