Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,196 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03569826Recruiting
Study for primary biliary cholangitis and autoimmune hepatitis
This study is for people diagnosed with primary biliary cholangitis or autoimmune hepatitis. It aims to learn more about these autoimmune liver conditions and may help guide better care in the future.
Calgary, AlbertaAges 18 years+ - NCT03579875RecruitingPhase 2
Testing an inherited bone marrow transplant approach for rare blood disorders
This Phase 2 study tests a special “T-cell depleted” transplant plan for people with inherited bone marrow failure disorders (Fanconi anemia or T-Beta-thalassemia—or “TBD”). It may help restore healthy blood production while lowering the chance of certain transplant complications.
Minneapolis, MinnesotaAges Up to 65 years - NCT03589729RecruitingPhase 2
Dexrazoxane to help protect the heart during blood-cancer chemo
This Phase 2 study tests dexrazoxane, a heart-protecting medicine, to reduce heart side effects from chemotherapy in people with certain blood cancers. If you qualify, you would receive dexrazoxane along with chemotherapy, and the team will monitor your heart function closely.
Houston, TexasAges 12 years+ - NCT03592563Recruiting
Brain health follow-up study for adults
This study follows adults over time to better understand brain health and brain-related conditions. You may join if you already have certain neurological or psychiatric diagnoses, are at higher risk, or simply want to help research on maintaining brain health.
Hong KongAges 18 years+ - NCT03604835Recruiting
MPS VII monitoring program for patients and caregivers
This trial enrolls people with mucopolysaccharidosis type VII (MPS VII) to track their health over time. It may help your care team better understand how the condition behaves and how monitoring should be done.
Orange, CaliforniaAges Any age - NCT03606200Recruiting
Join a registry for primary ciliary dyskinesia
This study is a registry that collects information from people diagnosed with primary ciliary dyskinesia. It may help researchers better understand the condition over time and improve future care.
BernAges Any age - NCT03642002Recruiting
Music therapy for adults on breathing machines in the ICU
This trial tests whether music therapy can improve comfort and recovery for adults who need a breathing machine (mechanical ventilation) in the ICU for at least 48 hours. It may help with stress, mood, and other ICU-related symptoms while you are in critical care.
New York, New YorkAges 18 years+ - NCT03683433RecruitingPhase 2
Enasidenib plus azacitidine for IDH2-mutated AML
This trial studies the combination of enasidenib and azacitidine in people with acute myeloid leukemia (AML) that has an IDH2 gene mutation. It may help control the leukemia when prior treatments didn’t work or the disease came back.
Houston, TexasAges 18 years+ - NCT03718923Recruiting
Study for people with FOXP1 gene changes
This study looks at how people with FOXP1-related neurodevelopmental conditions work and how they’re affected, using genetic, medical, and thinking/learning tests. It may help researchers better understand the condition and improve future care.
New York, New YorkAges 2 years+ - NCT03723564RecruitingPhase 1
Serial amnioinfusions for severe fetal kidney underdevelopment
This Phase 1 study tests whether repeatedly adding fluid into the amniotic sac (amnioinfusion) can help babies with very severe kidney problems before birth. The goal is to see if this “regenerative therapy” is safe and potentially beneficial, while closely tracking pregnancy and baby outcomes.
Rochester, MinnesotaAges Any age - NCT03735563RecruitingPhase 4
Less invasive surfactant timing with different pre-medications
This study tests whether giving a pre-medication before a less invasive lung treatment (surfactant) improves breathing in premature babies. It may help some babies avoid more invasive ventilation while still getting the lung medication they need.
OuluAges Any age - NCT03742011Recruiting
Study of babies born to mothers with PCOS in Guangzhou
This study looks at children born to mothers who have polycystic ovary syndrome (PCOS). It aims to learn about their health by following families in Guangzhou over time.
Guangzhou, GuangdongAges Up to 18 years - NCT03749980Recruiting
Study following people with von Hippel-Lindau (VHL)
This study follows people who have von Hippel-Lindau (VHL) over time to better understand how the condition changes. It may help doctors plan future treatments by collecting long-term health information.
Boston, MassachusettsAges Any age - NCT03759522RecruitingPhase 1
PET brain scan for inflammation in MS, fibromyalgia, or CFS
This early-stage study tests an imaging medicine ([F-18]DPA-714) that can help researchers see inflammation in the brain and nervous system. It may help doctors better understand how “inflammation signals” differ across conditions like multiple sclerosis, fibromyalgia, and chronic fatigue syndrome.
Birmingham, AlabamaAges 18–65 - NCT03773003Recruiting
Study of fatigue caused by cancer or chronic fatigue
This study looks at why fatigue happens in people with cancer and, in some cases, in people with chronic fatigue conditions. It may help researchers better understand the causes of fatigue so future treatments can be improved.
Homburg, SaarlandAges 18–80 - NCT03794531Recruiting
Study of health, stress, and lifestyle changes in Puerto Rico
This study looks at how people’s health, day-to-day stress, and living conditions in Puerto Rico change over time. You might help researchers understand what trends are happening and what could be improved.
San JuanAges 30–75 - NCT03816345RecruitingPhase 1
Nivolumab for advanced cancer with autoimmune conditions
This Phase 1 study tests nivolumab, an immunotherapy “anti-cancer accelerator,” in people with advanced cancer who also have an autoimmune disorder. It aims to see if nivolumab can be given safely and whether it may help shrink or control cancer.
Birmingham, AlabamaAges 18 years+ - NCT03823547Recruiting
Research study for adults with ACS
This study is for adults who are being seen for ACS, to help improve future care. You may be invited to join if you can provide informed consent.
Apeldoorn, GelderlandAges 18 years+ - NCT03825835Recruiting
Different oxygen levels at birth for very preterm babies
This trial studies whether giving 30% versus 60% oxygen during early resuscitation (breathing support) affects brain and nerve development in very low birthweight, very preterm infants. If you/your baby fits the birth and care timing requirements, the goal is to find an oxygen approach that supports better long-term outcomes.
Calgary, AlbertaAges birth–10 minutes - NCT03835312Recruiting
Transplant plan for children with genetic immune problems and diabetes
This trial tests a two-step transplant approach using immune-related stem cells and islet (pancreas insulin–making) cells in children and teens who have type 1 diabetes caused by a genetic immune problem. It aims to improve insulin control and protect other organs that are being affected by their immune system.
Shanghai, Shanghai MunicipalityAges Up to 18 years - NCT03838107Recruiting
Tracking changes in pediatric CRPS using study markers
This study looks at how signs in the body change over time in children with CRPS (complex regional pain syndrome). It mainly involves being assessed alongside the usual CRPS care, and often includes MRI checks to better understand the pain course.
Cincinnati, OhioAges 10–17 - NCT03841981Recruiting
Body fat and female hormone function study
This study looks at how body fat and exercise relate to how your ovaries work and how your hormones function. It may help explain why some women have irregular ovulation or hormone problems, and how lifestyle factors affect them.
Madrid, MadridAges 18–40 - NCT03850574RecruitingPhase 1/Phase 2
Tuspetinib for relapsed or hard-to-treat AML
This early-phase study tests tuspetinib in people with AML that has come back or did not respond to treatment. The goal is to learn whether it is safe and tolerable, how the drug behaves in the body, and whether it shows signs of benefit.
Birmingham, AlabamaAges 18 years+ - NCT03867539RecruitingPhase 4
Numbing shot and education to reduce opioids after carpal tunnel surgery
This study tests whether giving a long-lasting numbing injection (Exparel) plus education about pain management can help people avoid taking opioid pain pills after carpal tunnel release surgery. It may help reduce opioid use while still supporting comfort during recovery.
Dayton, OhioAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,196 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.