Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,196 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03872102Recruiting
Brain imaging study to track Parkinson-related disease changes
This study uses brain scans and clinical check-ins to better diagnose and predict how Parkinson-related conditions may progress over time. It may help researchers find markers that explain why symptoms change, and could improve future care.
Dallas, TexasAges Any age - NCT03881345Recruiting
Registry for blood clots in legs or lungs
This registry collects information from people who have a blood clot in a leg or a clot in the lung. It helps researchers understand how these conditions are treated in real life.
Moscow, MoscowAges 18 years+ - NCT03883711Recruiting
Study of treatment and outlook after heart attack
This trial studies how people do after a heart attack (or related heart injury) and may test treatments that could improve outcomes. If you’re an adult and recently had this heart event, you may be able to join after discussing consent.
Bologna, BolognaAges 18 years+ - NCT03888924RecruitingPhase 2
BCG vaccine for people with radiologically isolated syndrome
This trial tests whether a BCG vaccine can help people who have radiologically isolated syndrome (RIS), a condition where MRI scans show signs of possible multiple sclerosis before symptoms develop. The study aims to see if vaccination is safe and can change disease behavior over time.
RomeAges 18 years+ - NCT03906435Recruiting
Cognitive therapy to prevent problems for very premature NICU babies
This study offers a counseling approach to help prevent “Vulnerable Child Syndrome” in babies born very early and cared for in the NICU. It focuses on support during the early months after birth and compares outcomes for families getting the therapy versus usual support.
Dallas, TexasAges Any age - NCT03908463Recruiting
Heart procedure registry for people who get coronary angioplasty
This trial is a registry that collects health information from adults who undergo a heart procedure called coronary angioplasty. It may help researchers understand outcomes and improve care for future patients undergoing similar treatments.
SeoulAges 19 years+ - NCT03920774Recruiting
Study of Familial Dysautonomia in People With IKBKAP Changes
This study looks at how familial dysautonomia (FD) progresses over time in people who have a confirmed IKBKAP genetic change. It may help doctors better understand the condition and plan future treatments.
New York, New YorkAges 4 years+ - NCT03949855RecruitingPhase 2
Belimumab plus rituximab for primary membranous nephropathy
This study tests whether adding belimumab to rituximab helps people with primary membranous nephropathy (a kidney disease) that has the right blood test marker and specific protein levels. The goal is to improve kidney outcomes and reduce disease activity while keeping treatment safe.
Birmingham, AlabamaAges 18–75 - NCT03949972Recruiting
FSGS and MCD patient registry for kidney disease
This study is a registry that collects medical information from people with nephrotic syndrome caused by FSGS or minimal change disease (MCD). It may help doctors better understand these conditions and improve future care, especially by tracking patients over time.
Cologne, North Rhine-WestphaliaAges Any age - NCT03963622Recruiting
Test of careful breathing support for severe lung distress
This study compares a more careful ventilation approach for people with severe lung breathing failure (ARDS). It aims to improve outcomes by using a specific strategy for how the ventilator controls breathing.
New York, New YorkAges 18 years+ - NCT03964506RecruitingEarly Phase 1
Hyperbaric oxygen plus donor stem cell transplant for blood cancers
This early-phase trial studies whether breathing pure oxygen in a pressurized chamber, along with a donor stem cell transplant, can improve outcomes for certain blood cancers. It may help by supporting the body during transplant and recovery, but it is still being tested for safety and effectiveness.
Rochester, New YorkAges 18–75 - NCT03989778RecruitingPhase 2
Vitamin D for PCOS with low vitamin D
This Phase 2 study tests whether vitamin D can improve hormone balance and infertility-related problems in people with PCOS who have low vitamin D. You may be able to join if you’re between 18 and 36, have primary infertility, and meet specific PCOS and vitamin D blood test levels.
Karachi, SindhAges 18–36 - NCT03994874RecruitingPhase 1/Phase 2
Testing fluid removal through the belly in heart-kidney failure
This trial studies a treatment that removes extra fluid through a catheter placed in the abdomen (peritoneal ultrafiltration) for people with “cardio-renal syndrome” (heart and kidney problems together). It may help those who stay congested despite high-dose water pills (diuretics) and have certain heart circulation and fluid signs.
ChietiAges 18 years+ - NCT04000061Recruiting
Tracking heart failure and heart attack progress in hospital
This study looks at how heart problems progress while you’re in the hospital, using your medical information (clinical data). It may help doctors better predict outcomes and improve care for people with heart attacks and heart failure.
BaselAges 18 years+ - NCT03999723RecruitingPhase 2
Test azacitidine with vitamin C to improve DNA changes
This Phase 2 study tests whether combining azacitidine (a standard blood cancer medicine) with vitamin C helps improve disease control by changing DNA activity in high-risk blood cancers. It may be an option if you have certain types of higher-risk MDS, CMML, or low-blast AML and can meet safety requirements.
AalborgAges 18 years+ - NCT07703683Recruiting
Muscle health in metabolic and hormone diseases
This trial looks at how muscle health is affected by metabolic or hormone disorders, aiming to find better markers for muscle loss called sarcopenia.
Woluwe-Saint-Pierre - Sint-Pieters-WoluweAges 18 years+ - NCT07008989Recruiting
Phone app to improve memory in Down syndrome
This study tests a smartphone app called HippoCamera to see if it can help teenagers and young adults with Down syndrome remember everyday events better. You would use the app at home with some help from a parent or guardian.
Chestnut Hill, MassachusettsAges 15–35 - NCT04024761RecruitingPhase 1
NK cell therapy for leukemia relapse after transplant
This Phase 1 study tests whether an infusion of special immune cells (NK cells) from a donor can help control leukemia or related blood cancers that come back or do not fully go away after a stem cell transplant. It also uses short chemotherapy to “make space” for the NK cells to work, and IL-2 to help them function.
Boston, MassachusettsAges 12 years+ - NCT04033224Recruiting
Blood-filter treatments for ICU patients with kidney and organ failure
This trial tests a specific type of blood-filter treatment in critically ill ICU patients who have acute kidney injury and/or failure of other organs. It aims to see whether these filters can improve care by supporting kidney function and/or calming harmful inflammation.
Empoli, FirenzeAges Any age - NCT04033614Recruiting
Device to help close an open abdomen between surgeries
This study looks at a device (“Fasciotens”) used to help manage an open abdomen and support closure during planned or necessary return surgeries. It aims to see how safely and effectively the device works in people who need a temporary open belly treatment.
Aachen, North Rhine-WestphaliaAges 18 years+ - NCT04040777Recruiting
Cardiometabolic risk registry for adults
This study is a health registry that collects information about risk factors for heart and metabolic problems in adults. It may help doctors better understand who is at higher risk and guide future prevention strategies.
Pilar, Buenos AiresAges 18 years+ - NCT04049331RecruitingPhase 2
Testosterone therapy for cancer survivors with fatigue
This trial tests whether testosterone replacement can help male cancer survivors who have ongoing fatigue and low testosterone levels. It is for men who have completed chemotherapy or radiation and are cancer-free for at least a year.
Boston, MassachusettsAges 18–54 - NCT04064060RecruitingPhase 3
Long-term safety follow-up for luspatercept study participants
This trial studies the long-term safety of luspatercept (ACE-536) in people who already took part in an earlier luspatercept study. It mainly helps doctors better understand ongoing side effects and overall safety over time.
Los Angeles, CaliforniaAges 18 years+ - NCT04068597RecruitingPhase 1/Phase 2
Testing inobrodib for blood cancers that came back
This is an early-stage study of inobrodib (CCS1477) for blood cancers like lymphoma, multiple myeloma, or acute myeloid leukemia that have returned or did not respond to standard treatment. It aims to see whether the drug is safe and can help control the cancer.
Atlanta, GeorgiaAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,196 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.