Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,196 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05776914RecruitingPhase 2
Fecal transplant to treat moderate to severe IBS symptoms
This trial tests whether putting stool (fecal microbiota) from a donor into your bowel can improve symptoms in people with IBS who are not IBS-C. It may help by changing the gut bacteria that can influence IBS symptoms.
Rochester, MinnesotaAges 18–70 - NCT05780099Recruiting
Study of patients treated in internal medicine clinics
This observational study follows people receiving care in Internal Medicine at San Raffaele Hospital to better understand what kinds of conditions they have. It does not test a new treatment, but your information may help improve future care.
MilanAges 18 years+ - NCT05782582Recruiting
Testing care for long-term heart artery symptoms in primary care
This study looks at people who come to primary care with symptoms that may be caused by long-term narrowing of heart arteries. The goal is to test an approach for identifying and managing this condition earlier or more accurately in everyday care.
LinköpingAges 18 years+ - NCT05782556Recruiting
Freiburg TIPS Registry for portal hypertension patients
This is a registry study that collects information from people who need a procedure called TIPS for portal hypertension. It may help doctors better understand outcomes and care for both cirrhotic and non-cirrhotic causes of portal hypertension.
Freiburg im BreisgauAges 18–100 - NCT05783245Recruiting
Cooling therapy to reduce pain after open carpal tunnel surgery
This trial studies whether cooling (cold therapy) can lessen pain after open carpal tunnel release surgery. If you’re having this surgery, your answers to questionnaires and your current pain-medication status will determine whether you can join.
Chicago, IllinoisAges 18 years+ - NCT05787379Recruiting
Care program for Veterans with long-lasting COVID symptoms
This trial tests a care approach for Veterans who have long-COVID—aiming to improve symptoms and follow-up care through participating VA clinicians. You may be included if you are a Veteran with long-COVID and can be seen by a participating clinician soon, unless you had severe COVID requiring ICU care.
East Orange, New JerseyAges Any age - NCT05788679RecruitingPhase 2
Use a patient’s genetic test to guide treatment after transplant
This study looks at a personalized lab test to detect small amounts of disease after a stem cell transplant and then decide what treatment comes next. It may help some people with certain bone-marrow diseases stay in remission while avoiding unnecessary treatment.
StockholmAges 18 years+ - NCT05795140RecruitingPhase 3
Long-term safety study of iptacopan for aHUS
This study follows people with aHUS who are already taking iptacopan to check how well it continues to work and how safe it is over the long term. You may be asked to keep taking the study medicine and follow extra safety rules, including infection and pregnancy precautions.
São Paulo, São PauloAges 18–100 - NCT05797272Recruiting
In-utero stem cell treatment for Bart’s hydrops
This trial studies whether giving hematopoietic (blood-forming) stem cells while the baby is still in the womb can treat fetuses with Bart’s hydrops fetalis syndrome. It aims to improve outcomes after prenatal intervention in carefully selected pregnancies.
ShatinAges 18 years+ - NCT05800210RecruitingPhase 2
T cell and B cell immune “wipeout” after stem cell transplant
This Phase 2 trial studies whether removing certain immune cells (alpha/beta T cells and CD19+ B cells) around the time of a stem cell transplant can improve outcomes for people with high-risk blood cancers. It may help by reducing the immune responses that can interfere with the transplant working, while keeping the process safe.
Gainesville, FloridaAges 6 months–39 years - NCT05802121RecruitingEarly Phase 1
Testing a gut bacteria supplement side effects during prostate hormone therapy
This early-phase study looks at how changing gut bacteria (especially Akkermansia) affects metabolic side effects in men starting prostate hormone therapy (ADT). It may help researchers understand how to reduce or manage side effects for people on ADT.
London, OntarioAges 18 years+ - NCT05805202Recruiting
Study rare gene changes in atypical HUS for tailored care
This study looks at how rare gene mutations may explain atypical HUS (aHUS) and how that could guide more personalized treatment. It mainly involves people who have had aHUS affecting blood counts and kidneys.
Ranica, BGAges Any age - NCT05806801Recruiting
Study how weight loss changes the body with or without exercise
This study looks at how your metabolism (how your body uses energy and controls blood sugar/fats) changes during weight loss, comparing weight loss alone versus weight loss plus exercise. It may help researchers understand what body changes happen with different approaches and why.
Ann Arbor, MichiganAges 18–40 - NCT05807932RecruitingPhase 1/Phase 2
Venetoclax added to conditioning before stem cell transplant
This trial tests adding venetoclax to a standard “conditioning” chemotherapy plan before an allogeneic stem cell transplant (using a donor) for certain bone marrow cancers. It aims to improve how well the transplant works and how safe this combination is for people with MDS, CMML, or sAML.
Aachen, North Rhine-WestphaliaAges 18 years+ - NCT05808036Recruiting
Test a diet app for IBS symptoms using the DOMINO diet
This trial studies whether a specific diet plan delivered through a phone app (the DOMINO diet) can improve symptoms in people with irritable bowel syndrome (IBS). It may help by changing what you eat to reduce gut symptoms, compared with standard care rules in the study.
LeuvenAges 18–70 - NCT05815602RecruitingPhase 3
Ebastine vs mebeverine for non-constipation IBS
This Phase 3 study compares ebastine and mebeverine to see which works better for people with IBS that is not constipation-predominant. If you have IBS symptoms without an underlying intestinal disease, you may be offered one of these medicines and monitored for symptom improvement.
Antwerp, AntwerpenAges 18–65 - NCT05816954Recruiting
Imaging test to predict lung injury risk in ARDS
This study looks at scan images to better predict the risk of a serious lung complication (barotrauma) in people with ARDS. It may help doctors choose safer treatment strategies in the ICU.
Catanzaro, CalabriaAges 18 years+ - NCT05819697Recruiting
Helping burning mouth symptoms with improved memory recall
This trial looks at ways to reduce how much people with burning mouth syndrome struggle to recall information during the study. If you qualify, you may be asked to complete study tasks and share saliva to support the research.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05822193Recruiting
Study of long COVID in Brazil
This study looks at how often “post-COVID-19 condition” (long COVID) happens, what factors are linked to it, and how much it affects people’s daily lives. It may help researchers better understand long COVID and who is most impacted.
Cachoeirinha, Rio Grande do SulAges 18 years+ - NCT05822869Recruiting
Testing early EIT monitoring in people with ARDS
This trial looks at monitoring people with ARDS (a serious lung condition) very early after breathing support starts, using a technology called EIT. The goal is to see whether this early monitoring can help guide care during the first critical hours.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05845424RecruitingPhase 4
High-intensity cholesterol pills for people with silent calcium
This trial studies whether high-intensity statin plus ezetimibe can improve heart health in people who do not have symptoms but have calcium buildup in their heart arteries. It may help lower cholesterol and reduce future heart risks for the right participants.
SeoulAges 40 years+ - NCT05847634Recruiting
Testing how deep sedation affects blood flow in ARDS
This study looks at whether giving deep sedation (and sometimes muscle-paralyzing medicines) changes blood flow and oxygen delivery in the brain during acute respiratory distress syndrome (ARDS). It is a pilot study, meaning it mainly aims to understand safety and gather early information.
Winnipeg, ManitobaAges 18 years+ - NCT05849662RecruitingPhase 1/Phase 2
Trametinib plus azacitidine for newly diagnosed JMML
This trial studies whether trametinib and azacitidine can control juvenile myelomonocytic leukemia (JMML) soon after diagnosis. It’s designed to test safety and how well the treatment works in children and young adults who meet specific leukemia and genetic criteria.
Phoenix, ArizonaAges 1 month–21 years - NCT05849779RecruitingPhase 3
Breathing sevoflurane to help prevent ARDS in ICU patients
This Phase 3 trial tests whether inhaled sevoflurane (a breathing anesthetic) can help prevent ARDS, a serious lung injury, in high-risk ICU patients who need sedation. It aims to reduce the chance of developing ARDS by using this medication during the early period on a breathing machine.
Clermont-Ferrand, Not Required For This CountryAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,196 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.