Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,177 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT02725060Enrolling by invitation
Study of autoimmune changes in postural tachycardia syndrome
This trial studies whether an autoimmune (immune system–related) process is involved in postural tachycardia syndrome (POTS), a condition where your heart rate rises when you stand. The study may help researchers understand what causes POTS and how it could be treated or monitored.
Oklahoma City, OklahomaAges 18–50 - NCT02413450Enrolling by invitation
Using patient DNA cells to study inherited heart rhythm risks
This study uses your blood or genetic information to make “iPS cells,” lab-grown cells that can help researchers study inherited heart rhythm problems like LQTS, Brugada syndrome, CPVT, or early repolarization syndrome. It may help improve understanding of why these rhythms happen and guide future treatments.
Baltimore, MarylandAges 18–85 - NCT07410325Recruiting
Health coach and AI app study for metabolic syndrome
This study tests if a health coach supported by an AI-powered smartphone app can help people improve their metabolic syndrome. It is designed for adults who are willing to use the app and follow a structured lifestyle program.
SingaporeAges 21–65 - NCT07473635Recruiting
Botox injections for nerve pain in CRPS — an early safety study
This study tests whether a specially targeted injection of botulinum toxin (like Botox) around nerves can help reduce pain from CRPS. It aims to see if the treatment is safe and doable for people with long-lasting CRPS.
Glostrup, Region SjællandAges 18 years+ - NCT07478172Recruiting
Electrical muscle stimulation exercise for neuromuscular disease
This study tests whether whole-body electrical muscle stimulation (using small electrodes on the skin) can help adults with certain neuromuscular diseases exercise and improve muscle strength. It may be an option if you can stand for about 15 minutes at a time and have some muscle strength left.
Columbia, MissouriAges 18 years+ - NCT07491315Recruiting
Do ME/CFS patients react differently to exercise?
This study looks at whether people with ME/CFS have a different reaction to exercise compared to people with heart conditions who also feel tired. It involves filling out online questionnaires and may help doctors better understand ME/CFS.
MarseilleAges 18 years+ - NCT07516964Recruiting
Studying autoimmune kidney disease in children and adults
This study collects medical information and samples from patients with podocytopathy—a type of autoimmune kidney disease that causes protein leakage into urine. Researchers will analyze your medical records and any blood or kidney tissue samples you've already had to better understand the disease and find better treatments.
Rochester, MinnesotaAges birth–99 years - NCT07517029Recruiting
Gut Bacteria Study in Post-Infectious IBS
This study looks at how gut bacteria may change in people who developed irritable bowel syndrome (IBS) after a stomach infection. Researchers hope to understand why some people recover completely while others develop ongoing digestive problems.
RomeAges 18 years+ - NCT07519395RecruitingPhase 2
Camlipixant for abdominal symptoms in IBS-D and IBS-M
This study tests whether a new drug called camlipixant can reduce belly pain and other uncomfortable symptoms in people with irritable bowel syndrome that causes diarrhea or mixed symptoms. The trial compares camlipixant to a placebo (inactive pill) to see if it works better.
Anniston, AlabamaAges 18–80 - NCT07563621Recruiting
Understanding Vaginal Health Changes in Breast Cancer Survivors
This study examines vaginal dryness and discomfort—common side effects of breast cancer treatment—in women who've survived the disease. Researchers want to understand how often this happens and how much it affects daily life, which may help doctors better support survivors.
Hasselt, LimburgAges 18 years+ - NCT07576114Recruiting
Gluteal and Core Exercises for Dead Butt Syndrome
This study compares two exercise approaches to help people with Dead Butt Syndrome—a condition where prolonged sitting weakens the buttock muscles, causing pain and weakness. Researchers want to see which type of exercise works better to strengthen these muscles and reduce symptoms.
IslamabadAges 18–55 - NCT07581756Recruiting
Brain Stimulation Treatment for Diarrhea-Prone Irritable Bowel Syndrome
This trial tests whether repeated magnetic stimulation applied to the scalp (a non-invasive procedure) can reduce diarrhea and belly pain in people with diarrhea-predominant IBS. The goal is to see if this brain-based treatment can improve your symptoms.
Suzhou, JiangsuAges 18–70 - NCT07594821Recruiting
Two approaches to carpal tunnel surgery: comparing outcomes
This study compares two surgical approaches for carpal tunnel syndrome—one that releases pressure on the median nerve in one location versus releasing it in two locations. The goal is to find out which approach works better for relieving symptoms like numbness and tingling in the hand.
Rotterdam, South HollandAges 18 years+ - NCT07637084Recruiting
Light therapy for chronic pain and fatigue in Ehlers-Danlos Syndrome
This trial tests whether a non-invasive light therapy called photobiomodulation can reduce chronic pain and fatigue in people with hypermobile Ehlers-Danlos Syndrome (hEDS), a genetic condition affecting connective tissue. The light is applied to the skin and may help cells produce energy and reduce inflammation.
Boulogne-Billancourt, Île-de-France RegionAges 18 years+ - NCT07654114RecruitingPhase 2
Testing CTH120 for men with Fragile X syndrome
This trial tests a new medicine called CTH120 to see if it is safe and helpful for adult men with Fragile X syndrome. You may be able to join if you meet certain health and age requirements.
Barcelona, BarcelonaAges 18–45 - NCT07094776Enrolling by invitation
MG53 protein levels in women with PCOS
This study measures a protein called MG53 in the blood of women with and without PCOS to see if it could be a marker for the condition. If you have PCOS and are not taking certain medications, you may be able to join and help researchers better understand the disease.
Gaziosmanpaşa, IstanbulAges 18–45 - NCT07036952Enrolling by invitation
Omega-3 for metabolic syndrome in PCOS
This trial tests if adding omega-3 supplements to standard care helps women with PCOS who also have metabolic syndrome. It may offer a natural way to improve associated health issues.
Dhaka, BsmmuAges 18–36 - NCT06435494Enrolling by invitation
Using patient reports to improve shoulder care across clinics
This study tests whether asking patients about their shoulder symptoms using a phone or computer app can help doctors and therapists work together to improve care. It is for adults with shoulder pain that started without a sudden injury.
Gentofte Municipality, HellerupAges 18–120 - NCT07758842Recruiting
Lifestyle changes for erectile dysfunction in men with metabolic syndrome
This study tests whether a six-month lifestyle modification program (including diet and exercise) can improve erectile function in men who have both erectile dysfunction and metabolic syndrome. If you're eligible, you may get support to make healthier lifestyle changes, which could help improve your symptoms.
CairoAges 30–65 - NCT06303193RecruitingPhase 1/Phase 2
Testing a kinase inhibitor drug for MDS and MDS/MPN in adults and teens
This trial tests a drug called pacritinib in people with myelodysplastic syndromes (MDS) or MDS/myeloproliferative neoplasms (MDS/MPN). The drug targets several proteins that may help control the disease, especially for those who have not responded to other treatments.
Bethesda, MarylandAges 12–120 - NCT07450664Enrolling by invitation
Observational study of VYKAT XR for Prader-Willi syndrome
This study follows people with Prader-Willi syndrome who are already taking or starting VYKAT XR, including those switching from an earlier version of the drug (DCCR). It aims to understand how the treatment works in everyday life.
Phoenix, ArizonaAges 4 years+ - NCT04462770RecruitingPhase 3
Clemizole trial for children and adults with Dravet syndrome
This Phase 3 study tests EPX-100 (clemizole) to help reduce seizures in people with Dravet syndrome whose seizures are not fully controlled by current anti-seizure medicines. You may consider this study if your Dravet diagnosis is confirmed and your medical situation fits the specific rules about medicines and seizure causes.
Birmingham, AlabamaAges 2 years+ - NCT07211685RecruitingPhase 2
Testing a new drug for adults with Alport syndrome
This study tests a new medicine called BAY 3401016 to see if it can help adults with Alport syndrome, a genetic condition that affects the kidneys. The drug is given as an infusion or injection and the study will check how well it works and if it is safe.
Birmingham, AlabamaAges 18–45 - NCT07754149Recruiting
Progressive resistance training for PMS in teen girls
This study tests whether a 6-week progressive strength training program can reduce symptoms of premenstrual syndrome (PMS) in teenage girls. It compares different exercise intensities to see what works best and may offer a drug-free way to manage PMS.
Islamabad, FederalAges 11–19
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,177 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.