Clinical trials
Drug Use Disorders clinical trials
Below are recruiting drug use disorders clinical trials, each written for real people, not researchers. We’re tracking 287 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06712602RecruitingPhase 1
Testing PT150 for Alcohol Use Disorder
This study tests whether a drug called PT150 can help people with moderate to severe alcohol use disorder who are not currently seeking treatment. You will be asked to stay abstinent from alcohol for short periods and attend sessions to see how PT150 affects your body and alcohol cravings.
Lexington, KentuckyAges 21–55 - NCT06803706Recruiting
Gut bacteria changes during smoking quit attempt
This study looks at how quitting smoking changes your body's gut bacteria and metabolism. It is for people with a substance use disorder who want to stop smoking.
FehringAges 18 years+ - NCT06856161Recruiting
Blood test to help diagnose mental health conditions
This study is testing a new blood test that might help doctors better understand and diagnose conditions like depression, psychosis, or schizophrenia. If you are 19 or older and have one of these conditions, you may be able to join.
New Westminster, British ColumbiaAges 19 years+ - NCT06939088RecruitingPhase 2
Tirzepatide for alcohol reduction in schizophrenia
This trial tests if tirzepatide, a once-weekly injection, can help reduce heavy drinking in people who have both schizophrenia and alcohol use disorder. If you struggle with alcohol and have stable schizophrenia, this study may offer a new treatment option.
Aalborg, DenmarkAges 18–70 - NCT06959342Recruiting
Brain stimulation to reduce cravings in alcohol use disorder
This trial tests if a gentle brain stimulation technique (tDCS) can help people with alcohol use disorder control their cravings and drinking habits. It is an add-on to your regular treatment.
MannheimAges 18–65 - NCT06981195RecruitingPhase 2
Testing lemborexant for insomnia in people on buprenorphine
This study tests if the sleep medication lemborexant can help people with opioid use disorder who also have chronic insomnia. Participants must already be taking buprenorphine (Suboxone) for at least 4 weeks. The goal is to see if better sleep improves mood and reduces opioid use.
Richmond, VirginiaAges 18 years+ - NCT07071779Recruiting
Online training to help young people resist alcohol or cocaine
This study tests a web-based training program to help teens and young adults (ages 14–35) improve their ability to say no to alcohol or cocaine. The training could make it easier to resist cravings during treatment.
BernAges 14–35 - NCT07118839RecruitingPhase 2/Phase 3
MDMA therapy for veterans with PTSD and alcohol use
This study tests whether MDMA-assisted therapy can help veterans who have both PTSD and alcohol use disorder. If you have tried a standard therapy before and want to reduce or stop drinking, this treatment may offer a new option.
West Haven, ConnecticutAges 18 years+ - NCT07171359Recruiting
TMS therapy for opioid and alcohol use recovery
This trial tests whether TMS (a non-invasive brain stimulation) can improve recovery for people with both opioid and alcohol use disorders. You must be in a specific outpatient program in Portland, Oregon.
Portland, OregonAges 18 years+ - NCT07199335RecruitingPhase 4
Injectable HIV prevention drug for people who inject drugs
This study tests a long-acting injectable medication called cabotegravir to prevent HIV in people who inject drugs. If you have injected street drugs recently, you may be able to get this shot every few months instead of taking daily pills.
Boston, MassachusettsAges 18 years+ - NCT07214467Recruiting
Adaptive brain stimulation for opioid use disorder
This study tests a new type of brain stimulation that adapts to your brain activity, aiming to reduce cravings and help you control opioid use. It is for people with long-standing opioid use disorder who have not gotten lasting relief from at least 3 treatment attempts, including medication.
San Francisco, CaliforniaAges 22–75 - NCT07318480Recruiting
tDCS for Cocaine Use Disorder
This study tests whether a non-invasive brain stimulation method called tDCS can help reduce cocaine use. You would receive several sessions of mild electrical current applied to your scalp, which may help control cravings and improve your ability to stay abstinent.
New York, New YorkAges 18–60 - NCT07340554Recruiting
Brain imaging study for teens who use cannabis
This study looks at the brains of teenagers who use cannabis using an MRI scanner. It aims to understand how cannabis affects the developing brain, which might help improve treatment options.
Indianapolis, IndianaAges 14–17 - NCT07466784Recruiting
Opioid use registry for emergency patients
This study is for people who come to the emergency department because of an opioid overdose, withdrawal, or related problem. It will collect information about patients' experiences to help improve care and support for opioid use.
Vancouver, British ColumbiaAges Any age - NCT06790576RecruitingPhase 1
Optimizing TMS for stimulant use disorder
This test uses a safe, non-invasive brain stimulation method called TMS (transcranial magnetic stimulation) to see if it can help people with stimulant use disorder reduce their cravings and stay sober. You would need to be in an addiction treatment program and have been clean for at least 2 weeks to join.
Minneapolis, MinnesotaAges 18 years+ - NCT07490600Recruiting
Testing brain stimulation and rewards for quitting cocaine
This trial combines deep transcranial magnetic stimulation (TMS) with a reward program (contingency management) to help people stop using cocaine. It may help if you are struggling with moderate to severe cocaine use and want a non-drug treatment.
Houston, TexasAges 18–65 - NCT06320366Recruiting
Faster TMS for methamphetamine use disorder
This study tests a faster brain stimulation technique (TMS) to help people reduce methamphetamine use. It may be a good option if you have moderate to severe methamphetamine use disorder and are looking for new treatment approaches.
Aurora, ColoradoAges 21–65 - NCT06457243Recruiting
Brain stimulation for methamphetamine use disorder
This trial tests a type of brain stimulation (called cTBS) to see if it can reduce methamphetamine cravings and improve thinking. If you are in recovery or still using, you may be able to join.
Shanghai, Shanghai MunicipalityAges 18–60 - NCT05472818RecruitingEarly Phase 1
Imaging study for treating cannabis use disorder with a test dose
This early-phase study uses brain scans to study cannabis use disorder and looks at whether a treatment approach is suitable for people who use cannabis every day. It may help researchers understand brain changes related to quitting and recovery.
New Haven, ConnecticutAges 18–75 - NCT07313371RecruitingPhase 4
Clonidine for reducing cravings in cocaine and crack users
This trial tests whether the medication clonidine can help reduce cravings for people hospitalized with cocaine or crack use disorder. You must be staying in a specific hospital ward and be able to take pills by mouth.
São Paulo, São PauloAges 18–65 - NCT07226596Recruiting
Methamphetamine use: can you reduce without quitting?
This study tests whether people who use methamphetamine can reduce use even if they are not completely abstinent. It offers a 12-week program and checks how you're doing for another 12 weeks after.
Lexington, KentuckyAges 18 years+ - NCT06269627RecruitingPhase 4
Brain activity study for alcohol use treatment
This trial tests how the medication acamprosate affects brain activity in people with moderate to severe alcohol use disorder. It may help researchers understand how this treatment works.
Bethesda, MarylandAges 21–65 - NCT04066192RecruitingPhase 2
Brexpiprazole trial for alcohol use disorder in adults
This study tests whether brexpiprazole can help adults with alcohol use disorder. You must currently not be taking alcohol-focused treatment or alcohol medicines, and you’ll likely complete questionnaires and brain scans.
Aurora, ColoradoAges 21–65 - NCT05452772RecruitingPhase 2
Psilocybin plus niacin to help quit smoking
This Phase 2 study tests whether a psilocybin “session” with niacin can help people quit smoking. It’s for adults who smoke daily and want to quit but have tried and struggled before.
Birmingham, AlabamaAges 21 years+
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Common questions
- Are there clinical trials for drug use disorders?
- Yes. Clin2 currently lists 287 recruiting drug use disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a drug use disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a drug use disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.