Clinical trials
Drug Use Disorders clinical trials
Below are recruiting drug use disorders clinical trials, each written for real people, not researchers. We’re tracking 278 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07158853RecruitingPhase 1
Brain stimulation and training for opioid use disorder
This trial combines a gentle brain stimulation technique called tDCS with thinking exercises to see if it helps people with opioid use disorder who are already on medication. It aims to improve treatment outcomes
Minneapolis, MinnesotaAges 18 years+ - NCT05986578Recruiting
Brain stimulation for cocaine use disorder
This study tests whether brain stimulation can help people with cocaine use disorder. It is a research study that aims to identify brain targets for treatment with a non-invasive technique called transcranial magnetic stimulation (TMS).
Houston, TexasAges 18–65 - NCT07029529RecruitingPhase 2
Apremilast for alcohol use disorder
This study tests whether a drug called apremilast can help people who drink heavily reduce their alcohol use. You will take the medication daily for several weeks and attend study visits to track your progress.
New Haven, ConnecticutAges 21–65 - NCT06994338RecruitingPhase 2
Tirzepatide for alcohol use disorder
This study tests whether a medication called tirzepatide (a once-weekly injection) can help people reduce their alcohol consumption. It is for people who drink heavily, have a high BMI, and are actively seeking help to drink less.
Los Angeles, CaliforniaAges 21–65 - NCT06866379Recruiting
Brain study on alcohol use disorder: septal nuclei
This study uses brain scans (fMRI) to look at a small area deep in the brain called the septal nuclei, which may play a role in alcohol use disorder. It aims to understand how the brain's structure and activity relate to heavy drinking, which could lead to better treatments.
FrederiksbergAges 30–65 - NCT06790576RecruitingPhase 1
Optimizing TMS for stimulant use disorder
This test uses a safe, non-invasive brain stimulation method called TMS (transcranial magnetic stimulation) to see if it can help people with stimulant use disorder reduce their cravings and stay sober. You would need to be in an addiction treatment program and have been clean for at least 2 weeks to join.
Minneapolis, MinnesotaAges 18 years+ - NCT06643988Recruiting
Memory and thinking study for opioid use disorder
This study looks at how people with opioid use disorder remember personal events. You'll do tasks on a cellphone and at home while taking medication for opioid use disorder.
Philadelphia, PennsylvaniaAges 18–60 - NCT06620276Recruiting
Ketamine and therapy for alcohol use disorder and depression
This trial tests if combining ketamine infusions with weekly therapy can help people who have both alcohol use disorder and hard-to-treat depression. You may qualify if you drink at least moderately, have treatment-resistant depression, and are willing to attend 8 therapy sessions.
Montreal, QuebecAges 18–70 - NCT06538558RecruitingPhase 1
Study of tezampanel for opioid withdrawal
This trial tests if tezampanel can help relieve withdrawal symptoms in people with opioid use disorder who are seeking treatment. Participants must already be in an outpatient addiction program.
Indianapolis, IndianaAges 18–65 - NCT06444256RecruitingPhase 2
Testing a sleep medication for people with stimulant use
This trial tests whether a medication that blocks a brain chemical involved in wakefulness can help people with stimulant use disorder sleep better. If you use cocaine or methamphetamine and have trouble sleeping, this study may be an option.
Houston, TexasAges 18–65 - NCT06474026Recruiting
Focused Ultrasound for Stimulant Use Disorder
This trial tests a non-invasive brain treatment called focused ultrasound for people with stimulant use disorder (like methamphetamine or cocaine). It aims to help reduce cravings and improve recovery by gently stimulating a brain area involved in addiction.
Seoul, SeoulAges 19–60 - NCT06426303RecruitingPhase 4
Alcohol Use Disorder Treatment in Veterans: Brain and Inflammation
This study is for veterans with alcohol use disorder who have been sober for 5 days to 3 weeks. It looks at how trauma, inflammation, and brain function relate to alcohol problems and how well treatment works. You will be in a group that gets medication or a placebo.
Portland, OregonAges 18–60 - NCT06320366Recruiting
Faster TMS for methamphetamine use disorder
This study tests a faster brain stimulation technique (TMS) to help people reduce methamphetamine use. It may be a good option if you have moderate to severe methamphetamine use disorder and are looking for new treatment approaches.
Aurora, ColoradoAges 21–65 - NCT06269627RecruitingPhase 4
Brain activity study for alcohol use treatment
This trial tests how the medication acamprosate affects brain activity in people with moderate to severe alcohol use disorder. It may help researchers understand how this treatment works.
Bethesda, MarylandAges 21–65 - NCT05988632RecruitingPhase 1/Phase 2
Insulin nasal spray for alcohol use disorder
This trial tests whether a nasal spray with insulin can help people with alcohol use disorder. It may affect how the brain responds to alcohol and reduce drinking.
Providence, Rhode IslandAges 21 years+ - NCT05859347Recruiting
Brain stimulation study for cannabis use disorder
This trial tests whether a treatment called repetitive transcranial magnetic stimulation (a non-surgical magnetic stimulation to the brain) can help people reduce or stop cannabis use. You may be eligible if you have cannabis use disorder and meet specific safety and symptom criteria.
Toronto, OntarioAges 18–65 - NCT05781009RecruitingPhase 2
Pregnenolone treatment for alcohol use disorder
This Phase 2 study tests pregnenolone to help reduce or improve alcohol use disorder symptoms. It looks for adults who drink regularly and meet diagnostic criteria for moderate to severe alcohol use disorder, while excluding people with certain other substance use, medicines, or serious mental/medical conditions.
New Haven, ConnecticutAges 18–70 - NCT05722561RecruitingPhase 2
E-cigarettes to reduce smoking in opioid use disorder
This Phase 2 study tests whether e-cigarettes can help people who use opioids (and also smoke cigarettes) cut down on combustible cigarette smoking. It looks at whether switching to e-cigarettes for “harm reduction” is safe and helps you smoke fewer cigarettes without requiring you to quit completely.
New York, New YorkAges 21–75 - NCT05472818RecruitingEarly Phase 1
Imaging study for treating cannabis use disorder with a test dose
This early-phase study uses brain scans to study cannabis use disorder and looks at whether a treatment approach is suitable for people who use cannabis every day. It may help researchers understand brain changes related to quitting and recovery.
New Haven, ConnecticutAges 18–75 - NCT05452772RecruitingPhase 2
Psilocybin plus niacin to help quit smoking
This Phase 2 study tests whether a psilocybin “session” with niacin can help people quit smoking. It’s for adults who smoke daily and want to quit but have tried and struggled before.
Birmingham, AlabamaAges 21 years+ - NCT05015881Enrolling by invitationPhase 2/Phase 3
Brain and heart scans in alcohol use disorder
This study uses special brain and heart scans to see how sugar (glucose) is used in people with alcohol use disorder compared with people without it. It may help researchers understand the brain–heart connection in alcohol use disorder.
Philadelphia, PennsylvaniaAges 21–65 - NCT04066192RecruitingPhase 2
Brexpiprazole trial for alcohol use disorder in adults
This study tests whether brexpiprazole can help adults with alcohol use disorder. You must currently not be taking alcohol-focused treatment or alcohol medicines, and you’ll likely complete questionnaires and brain scans.
Aurora, ColoradoAges 21–65 - NCT03667846RecruitingPhase 2
Biomarker-guided treatment for drinking and PTSD symptoms
This Phase 2 study tests whether blood/brain “biomarkers” can help choose a treatment plan for people who have alcohol use disorder and PTSD. The goal is to improve outcomes related to drinking and PTSD symptoms compared with a standard approach.
New York, New YorkAges 18–70 - NCT03470480Recruiting
Brain stimulation for methamphetamine cravings
This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help reduce cravings for methamphetamine in people who have stopped using it for at least 4 weeks. If you are trying to stay off methamphetamine and struggling with cravings, this treatment might help.
Portland, OregonAges 18–65
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Common questions
- Are there clinical trials for drug use disorders?
- Yes. Clin2 currently lists 278 recruiting drug use disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a drug use disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a drug use disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.