Clinical trials
Effectiveness clinical trials
Below are recruiting effectiveness clinical trials, each written for real people, not researchers. We’re tracking 6,374 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03866382RecruitingPhase 2
Immunotherapy plus a targeted drug for rare genitourinary tumors
This Phase 2 study tests whether nivolumab and ipilimumab (immunotherapy drugs) plus cabozantinib (a targeted anti-cancer drug) can shrink or control rare cancers of the urinary/reproductive system that have spread. It may help by boosting the immune system and blocking cancer growth signals at the same time.
Birmingham, AlabamaAges 18 years+ - NCT03753555RecruitingPhase 4
High-intensity statin treatment for certain stroke artery plaque cases
This trial tests whether a higher-dose statin can help after an ischemic stroke in people who have specific plaque patterns in brain blood vessels. It may help lower the risk of another stroke by targeting the artery plaque process.
ShenyangAges 18–80 - NCT03865290RecruitingPhase 2
Ondansetron for stomach nerve and motion problems in diabetes
This trial tests whether ondansetron can improve stomach “sensorimotor” problems—how the gut senses food and moves it—especially in people with diabetes and troubling indigestion. It may help reduce symptoms like early fullness, nausea, and discomfort after eating.
Rochester, MinnesotaAges 18–75 - NCT03845036Recruiting
Diet and exercise study for leg circulation problems
This study looks at how diet changes and an exercise program may improve walking and leg symptoms in people with peripheral artery disease (PAD). You may be eligible if you have a history of claudication (leg pain with walking) and tests or treatment history show PAD.
Oklahoma City, OklahomaAges 40 years+ - NCT03808337RecruitingPhase 2
SBRT radiation plus standard treatment for spread cancer
This trial looks at adding a focused radiation treatment called SBRT to standard care for cancers that have spread to a limited number of spots. It aims to control those spread-out tumors while still using the usual cancer treatment plan.
San Carlos, CaliforniaAges 18 years+ - NCT03857945Recruiting
Training to prevent falls after foot or ankle surgery
This trial studies whether teaching people to use mobility devices before surgery can lower the chance of falling afterward. It’s for adults having planned (elective) one-sided foot or ankle surgery and who will need limited walking after surgery.
Birmingham, AlabamaAges 18 years+ - NCT03811964Recruiting
Test how light affects your sleep, mood, nerves, and vision
This study uses a light-based test (the “photomotor reflex”) to see how non-visual effects of light may affect sleep-wake timing, brain function, mental health, and eyesight. You may be assigned to a group based on your condition, or you may be in the healthy control group.
StrasbourgAges 18 years+ - NCT03734900RecruitingPhase 4
Comparing two knee injection treatments for osteoarthritis
This study compares two knee injection treatments for knee osteoarthritis. It aims to see which one works better for reducing pain and improving function, so you might experience less knee pain and better mobility.
TaipeiAges 50–80 - NCT03667196Recruiting
Test opening blocked heart arteries using two different procedures
This trial studies whether two ways of threading a device to open a long-term blocked coronary artery are both safe and effective. You may qualify if you have a chronic total blockage and heart-related symptoms, and you can follow the study follow-up plan.
AnyangAges 19 years+ - NCT03533985Recruiting
Music therapy for newborns in the NICU with withdrawal symptoms
This study looks at whether music therapy can help infants who are born with neonatal abstinence syndrome (withdrawal symptoms after birth). It may support comfort, bonding, or overall newborn well-being while they’re in the NICU.
New Orleans, LouisianaAges 6 months+ - NCT03587701RecruitingPhase 2
Anakinra for steroid-resistant inner ear inflammation
This trial tests an anti-inflammatory drug (anakinra) in people whose inner-ear hearing problems have not improved with steroid treatment. It aims to reduce worsening hearing caused by autoimmune inner ear disease or difficult-to-control Meniere’s disease.
New Hyde Park, New YorkAges 18–75 - NCT03544489Recruiting
Exercise program after ICD implant
This trial studies whether adding a structured exercise program after an ICD implant is safe and helpful for people with certain heart rhythm problems. You may qualify if you can comfortably walk daily and can follow the study schedule for several months.
Seattle, WashingtonAges 18 years+ - NCT03662776Enrolling by invitation
How past eye-cancer treatment affects survivors’ well-being
This study looks at how different treatments for one affected eye retinoblastoma may affect survivors’ emotional and social functioning. It may help doctors understand which treatment approaches are linked with better day-to-day well-being over time.
New York, New YorkAges 8–17 - NCT03552705RecruitingPhase 2
Tranexamic acid to reduce knee inflammation after ACL injury
This Phase 2 study tests whether tranexamic acid can reduce swelling and protect knee cartilage after an ACL injury. It may help by limiting bleeding-related inflammation in the injured joint soon after injury.
Stanford, CaliforniaAges 18–30 - NCT03692455Enrolling by invitation
Compare two weight-loss surgeries for reflux over 8 years
This study follows people for up to 8 years to see how two different weight-loss surgeries affect ongoing heartburn and acid reflux. You would join only if you were already enrolled in an earlier related study and can complete required follow-up visits and tests.
Passo Fundo, Rio Grande do SulAges 18–78 - NCT03589729RecruitingPhase 2
Dexrazoxane to help protect the heart during blood-cancer chemo
This Phase 2 study tests dexrazoxane, a heart-protecting medicine, to reduce heart side effects from chemotherapy in people with certain blood cancers. If you qualify, you would receive dexrazoxane along with chemotherapy, and the team will monitor your heart function closely.
Houston, TexasAges 12 years+ - NCT03687710Enrolling by invitation
Alzheimer’s registry for people with memory concerns or risk
This is a research registry that helps doctors compare how different memory and Alzheimer’s risk groups change over time. It may help researchers learn which people are more likely to develop Alzheimer’s and how to better track early changes.
New York, New YorkAges 18–99 - NCT03321045RecruitingEarly Phase 1
PET scan to predict benefit from HER2-targeted breast cancer therapy
This early-phase study uses a special PET scan with a drug tagged for imaging to predict how well HER2-targeted treatments will work. It may help doctors choose the most effective therapy for HER2-positive breast cancer.
Birmingham, AlabamaAges 18 years+ - NCT03474029RecruitingPhase 2/Phase 3
Daily rifapentine treatment test for latent tuberculosis infection
This trial studies whether taking rifapentine every day is safe and helps prevent active tuberculosis (TB) in people who have latent TB infection. It aims to find the best way to stop TB from becoming a serious illness later.
Denver, ColoradoAges Any age - NCT03502590Recruiting
Test of a throat breathing device for people with neck radiation
This study tests how well a specific airway device works during general anesthesia for people who had radiation therapy to the neck. It may help improve safety and comfort during planned surgeries.
LivingstonAges 18 years+ - NCT03320304Recruiting
VNS for long-term depression that hasn’t improved with treatment
This trial studies how well and how efficiently VNS therapy works for people with long-lasting or repeated major depression that hasn’t responded to enough antidepressant treatments. It may help patients who are already receiving depression treatment but are still struggling.
ViennaAges 18 years+ - NCT03407079RecruitingPhase 2
Study of sucralose’s effects on digestion of drugs
This study tests whether the sugar substitute sucralose changes how your body absorbs and breaks down certain medicines. You’d take sucralose or a placebo for 4 weeks, visit the clinic, and complete required samples and medicine doses during visits.
Bethesda, MarylandAges 18–60 - NCT03384927Enrolling by invitation
Dairy intake study for muscle stiffness in spasticity
This trial looks at whether eating dairy can reduce spasticity, or muscle stiffness/tightness. It’s testing dairy as an add-on by comparing your muscle symptoms and treatment goals during the study.
Glostrup MunicipalityAges Any age - NCT03353584Recruiting
Virtual reality for pain relief during sickle cell pain crises
This trial tests whether a virtual reality (VR) experience can help reduce pain during a sickle cell “vaso-occlusive crisis,” which is an episode of sudden, severe pain. It’s offered alongside the care team’s usual pain management to see if VR makes pain feel better.
Memphis, TennesseeAges 6–25
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Common questions
- Are there clinical trials for effectiveness?
- Yes. Clin2 currently lists 6,374 recruiting effectiveness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a effectiveness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a effectiveness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.