Clinical trials
Efficacy and Safety clinical trials
Below are recruiting efficacy and safety clinical trials, each written for real people, not researchers. We’re tracking 2,733 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05066217RecruitingPhase 3
Study tests clemizole for Lennox-Gastaut seizures
This Phase 3 trial studies whether clemizole helps reduce seizures in people with Lennox-Gastaut syndrome (LGS) and checks safety. If you have LGS and meet the seizure and heart-safety requirements, this could be an option to explore.
Little Rock, ArkansasAges 2–55 - NCT05008965RecruitingPhase 2
Study drug for allergic asthma in adults
This Phase 2 trial tests whether FB825 can improve symptoms and safety in adults with moderate-to-severe allergic asthma. It is mainly for people whose asthma is not well controlled despite regular inhaler treatment.
Kaohsiung CityAges 18–75 - NCT05025605RecruitingPhase 1
Study medicine for agitation in youth with bipolar or schizophrenia
This Phase 1 trial tests whether BXCL501 is safe and can help reduce agitation in children and teens who have bipolar disorder or schizophrenia. You may be considered if your agitation is significant during screening, but certain recent medication and health factors can make you ineligible.
Anaheim, CaliforniaAges 10–17 - NCT05037279RecruitingPhase 3
Testing BCG treatment for bladder cancer after full tumor removal
This trial studies a BCG-based bladder instillation in people with newly diagnosed, intermediate- or high-risk non-muscle invasive bladder cancer who have had their tumor fully removed. The goal is to see whether this treatment is safer and works better to lower the chance of the cancer coming back.
Vancouver, British ColumbiaAges 18 years+ - NCT05019716RecruitingPhase 1/Phase 2
Adding ZEN003694 to chemo for NUT cancer
This early-phase study tests whether adding ZEN003694 to standard chemotherapy (cisplatin/etoposide or carboplatin/paclitaxel) is safe and can help control NUT carcinoma. It enrolls people ages 12–17 and adults, including some patients whose cancer has spread or can’t be safely removed.
Los Angeles, CaliforniaAges 12 years+ - NCT05052541RecruitingPhase 3
Oral cannabis for long-term spine pain
This trial studies whether taking cannabis by mouth can safely reduce chronic spine pain and improve daily comfort. You may be eligible if you have long-lasting spine pain and can follow study rules about stopping or limiting other cannabis and certain other treatments.
Aurora, ColoradoAges 21–84 - NCT05024097RecruitingPhase 2
New medicines with chemotherapy after short radiation for rectal cancer
This trial tests two new immune-related medicines (an anti–PD-1 drug and an adenosine blocker) added to standard chemotherapy after a short course of radiation for rectal cancer. It aims to improve cancer control while checking safety.
New York, New YorkAges 18–90 - NCT05028829RecruitingPhase 2
Atorvastatin to lower liver cancer risk in people with liver scarring
This trial tests whether atorvastatin (a cholesterol medicine) can lower the chance of liver cancer (HCC) in people with advanced liver scarring or cirrhosis. Participants are compared to placebo (inactive pill) while researchers track safety and cancer risk.
Boston, MassachusettsAges 18 years+ - NCT04929821Recruiting
Study of a dissolvable stent for bile duct narrowing
This study is testing a new type of stent that eventually dissolves on its own. The stent is placed in a narrowed bile duct to open it up and let bile flow properly. This might help people with strictures caused by scarring, stones, past surgeries, or certain bile duct cancers.
Hong KongAges 18 years+ - NCT04929236RecruitingPhase 3
Testing different PANZYGA doses for children with CIDP
This Phase 3 study compares different dose schedules of PANZYGA (immune-globulin) in children with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). It aims to find a dosing plan that is both safe and effective for improving symptoms and function.
Birmingham, AlabamaAges 2–17 - NCT04929223RecruitingPhase 1
Targeted drug study for metastatic colon or rectal cancer
This Phase 1 study tests targeted cancer treatments in people with metastatic colorectal cancer, using genetic “biomarker” results to match you to the right treatment group. It focuses first on safety, and also looks for early signs the treatment may work in specific tumor subgroups.
Birmingham, AlabamaAges 18 years+ - NCT04984512RecruitingPhase 2/Phase 3
Testing mitizodone tablets for major depression symptoms
This trial studies whether mitizodone phosphate tablets can improve symptoms of major depressive disorder (MDD). It also checks the treatment’s safety, including mood and physical health effects.
Dongguan, GuangdongAges 18–65 - NCT04937309Recruiting
Vagus nerve stimulation for nausea from chemo
This trial tests a non-invasive device that stimulates a nerve in your ear to help prevent nausea caused by chemotherapy. It is for people with breast cancer who are about to start a specific type of chemo (anthracycline and cyclophosphamide).
BloisAges 18 years+ - NCT04970121RecruitingPhase 2
Duloxetine for chemotherapy nerve pain in solid tumor patients
This Phase 2 trial tests duloxetine to see if it safely reduces painful nerve damage caused by chemotherapy (especially taxanes) in people with solid tumors. If you have moderate-to-severe nerve pain and meet lab and heart-safety checks, this study may be an option.
Bengbu, AnhuiAges 18–75 - NCT04910685RecruitingPhase 2/Phase 3
BLU-263 for indolent mast cell disease with symptom control
This trial tests BLU-263, a study medicine, against placebo (inactive treatment) to see if it improves symptoms in people with indolent systemic mastocytosis. It also checks safety and how well the dose is tolerated before and during treatment.
Birmingham, AlabamaAges 18 years+ - NCT04872660RecruitingPhase 4
Gushen Antai pill to improve IVF ongoing pregnancy rates
This trial studies whether a traditional Chinese medicine pill (Gushen Antai) can improve the chance of an IVF pregnancy that continues (“ongoing pregnancy rate”) and assess its safety. It’s for people starting their first IVF/ICSI cycle with normal ovarian function reserve.
Jinan, ShandongAges 21–42 - NCT04902703RecruitingPhase 2
GM-CSF drug trial for mild to moderate Alzheimer’s disease
This Phase 2 study tests whether sargramostim (a GM-CSF related medicine) is safe and can slow or improve Alzheimer’s symptoms. You might be a good fit if you have mild or moderate Alzheimer’s, positive amyloid testing, and can complete frequent visits with a close caregiver who knows you well.
Aurora, ColoradoAges 60–85 - NCT04798430Enrolling by invitationPhase 3
Study drug follow-up for LDL reduction in high-risk cholesterol patients
This Phase 3 study looks at the long-term safety and benefit of OLE LIB003 for people with very high cholesterol or heart disease risk who still need lower LDL (“bad cholesterol”). It’s likely a continuation study for participants who already did earlier LIB003 Phase 3 trials.
Evanston, IllinoisAges 10 years+ - NCT04853342RecruitingPhase 3
Furmonertinib after lung tumor removal for EGFR-mutated lung cancer
This trial tests whether furmonertinib, an oral targeted medicine, can improve outcomes after your lung tumor has been completely removed. It also checks for side effects and compares results against placebo in people with specific EGFR gene mutations.
Suzhou, JiangsuAges 18–75 - NCT04836507RecruitingPhase 1/Phase 2
Study of a lab-made cell therapy for lymphoma and leukemia
This Phase 1/2 trial tests CRC01, a lab-made immune cell therapy, for adults whose lymphoma or B-cell leukemia has come back or did not respond to treatment. If you qualify, the study aims to see how safe CRC01 is and whether it can shrink tumors and improve outcomes.
SeoulAges 19 years+ - NCT04817618RecruitingPhase 3
Iptacopan for kidney inflammation in C3 glomerulopathy
This trial studies whether iptacopan can improve outcomes and safety for people with C3 glomerulopathy, a kidney disease caused by overactive parts of the immune system. Participants must already be on standard kidney-protecting medicines and meet specific kidney function and urine protein criteria.
Aurora, ColoradoAges 12–60 - NCT04802759RecruitingPhase 1/Phase 2
Testing drug combinations for recurrent or advanced ER-positive breast cancer
This early-phase trial tests several combinations of cancer medicines to slow or control ER-positive breast cancer that has returned or progressed. It also checks safety and whether tumor or blood biomarkers can help match the right treatment to the right person.
Duarte, CaliforniaAges 18 years+ - NCT04772079RecruitingPhase 3
Test drug safety and effectiveness for youth plaque psoriasis
This study checks whether deucravacitinib works well and is safe in children and teens with moderate to severe plaque psoriasis. It also looks at drug levels in the body to help understand how the treatment behaves over time.
Ciudad Autonoma de Buenos Aires, Buenos AiresAges 4–18 - NCT04844866RecruitingPhase 2
CAR T-cell treatment versus standard care for relapsed lymphoma
This trial tests a CAR T-cell therapy (MB-CART2019.1) against standard treatment in people with certain types of aggressive B-cell lymphoma that has come back or didn’t respond to the first treatment. It aims to improve how well the lymphoma responds and to check for side effects and safety.
GrazAges 18–70
Hear when a new Efficacy and Safety trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for efficacy and safety?
- Yes. Clin2 currently lists 2,733 recruiting efficacy and safety studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a efficacy and safety trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a efficacy and safety trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.