Efficacy and Safety clinical trials

Testing Multiple Treatments for Myasthenia Gravis

This trial tests multiple treatment combinations for people with myasthenia gravis (MG), a condition that causes muscle weakness. It aims to find safer and more effective options by comparing different therapies.

Study tests clemizole for Lennox-Gastaut seizures

This Phase 3 trial studies whether clemizole helps reduce seizures in people with Lennox-Gastaut syndrome (LGS) and checks safety. If you have LGS and meet the seizure and heart-safety requirements, this could be an option to explore.

Orforglipron for peripheral artery disease with leg pain

This trial tests a new oral medication called orforglipron to see if it can improve walking distance in people with peripheral artery disease (PAD) who have leg pain when walking. It may be a good option if you have PAD and your walking is limited by leg cramping, not other health issues.

A study of empasiprubart for chronic inflammatory demyelinating polyneuropathy (CIDP)

This study tests a new medicine called Empasiprubart for adults with ongoing CIDP. It aims to see if fewer symptoms return and if it can replace current treatments.

Study of injections for forehead and frown lines

This trial tests an injectable treatment for moderate to severe forehead lines and frown lines in adults. It aims to see if the injections can safely reduce the appearance of these lines.

Safety and Efficacy of Flaus Electric Flosser on Plaque and Gingivitis Compared to a Manual Toothbrush

New vs existing treatment for diabetic macular edema

This study compares a new medication, tabirafusp tedromer, to an existing treatment, aflibercept, for people with diabetic macular edema (swelling in the back of the eye from diabetes). It may help if your DME hasn't improved or you're looking for a new option.

Ruxolitinib for steroid-resistant graft-versus-host disease

This trial tests a new pill, ruxolitinib, for people whose acute graft-versus-host disease (a complication after a stem cell transplant) is not improving with steroids. It aims to see if it can better control the disease and improve recovery.

Long-term safety and effectiveness of APG777 for eczema

This study looks at the long-term safety and how well APG777 works for people with eczema (atopic dermatitis). It is for people who have already completed treatment with APG777 in an earlier study and may benefit from continuing it.

Long-Term Safety Study of Afimkibart for Rheumatoid Arthritis

This is a follow-up study for people who already completed a previous trial testing afimkibart (an experimental drug) for rheumatoid arthritis. It checks whether the drug continues to work safely and effectively over a longer period.

Study of sapablursen for phlebotomy-dependent polycythemia vera

This trial tests an investigational drug called sapablursen for people with polycythemia vera who still need frequent phlebotomies. The goal is to see if the drug can reduce the need for blood removal and help control the disease safely.

Study of KarXT plus KarX-EC for Alzheimer's cognitive symptoms

This trial tests a new combination treatment (KarXT plus KarX-EC) to see if it can help with thinking and memory problems caused by Alzheimer's disease. It is for people with mild to moderate Alzheimer's who have a caregiver available.

Afimkibart for moderate to severe Crohn's disease

This study tests an experimental drug called afimkibart for people with moderate to severe Crohn's disease who haven't responded well to other treatments. The goal is to see if the drug can help control symptoms and reduce inflammation over time.

Study of asciminib for children with Ph+ CML

This trial tests an oral medication called asciminib in children and teens with a type of leukemia called Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). It aims to see if the drug is safe and effective for patients who are newly diagnosed or whose current treatment has stopped working or caused side effects.

A Study to Investigate Efficacy and Safety of FWY003 Compared With Placebo in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration

Stem cell therapy for acne scars

This trial tests a treatment made from your own fat cells to improve deep acne scars. It aims to see if the therapy is safe and helps reduce the appearance of scars.

Brain implant for severe mental health conditions

This trial tests a brain implant called deep brain stimulation (DBS) for people with severe mental health conditions that have not improved with usual treatments. The goal is to see if it can reduce symptoms and improve quality of life.

Study of duvakitug for moderate to severe ulcerative colitis

This study tests a new drug called duvakitug for people with moderate to severe ulcerative colitis that hasn't been helped enough by standard treatments. The goal is to see if this medicine can reduce inflammation and improve symptoms.

Probiotic lozenge study for healthy adults

This trial tests a probiotic lozenge (a dissolvable tablet) to see if it's safe and works well. It's for healthy adults who don't smoke and are between 18 and 70 years old.

A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine

Study drugs for Richter transformation in CLL

This Phase 2 study tests zanubrutinib plus tislelizumab, with or without sonrotoclax, for people whose CLL has changed into Richter transformation (an aggressive lymphoma). It aims to improve anti-cancer response while tracking side effects and safety.

An Exploratory Study on the Efficacy and Safety of Enlonstobart Combined With Concurrent Radiotherapy and Chemotherapy Following Induction Therapy With Enlonstobart Plus Chemotherapy in Patients With Locally Advanced Cervical Cancer.

Safety and Efficacy of Cryoablation for Thyroid Tumors

Belantamab for multiple myeloma

This study tests the safety and effectiveness of the drug belantamab, alone or with other treatments, for people with multiple myeloma that has come back or stopped responding to previous treatments.