Clinical trials
Efficacy and Safety clinical trials
Below are recruiting efficacy and safety clinical trials, each written for real people, not researchers. We’re tracking 2,733 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05997602RecruitingPhase 2
Testing FCN-159 for children with LCH that returned
This trial tests a study drug, FCN-159, for children with a rare blood/immune disease called Langerhans cell histiocytosis (LCH) that has not responded to standard treatment or has come back. The goal is to see if this drug can shrink the LCH lesions and help the child feel better.
Beijing, Beijing MunicipalityAges 2–16 - NCT07470073RecruitingEarly Phase 1
Universal CAR-T cell therapy for B-cell leukemia (ages 12-75)
This trial tests a new type of CAR-T cell therapy (called universal CAR-T) that targets CD19 and CD20 markers on cancer cells. It is for people aged 12 to 75 with B-cell acute lymphoblastic leukemia that has not responded to standard treatments or has come back after treatment.
Wuhan, HubeiAges 12–75 - NCT07453862RecruitingPhase 1
New drug for restless legs syndrome: efficacy and safety study
This trial tests a new drug (a calcium channel modulator) to see how well it works and how safe it is for people with moderate to severe restless legs syndrome (RLS). It may offer a new treatment option for those with typical or variant RLS.
Beijing, Beijing MunicipalityAges 18–75 - NCT07459309Recruiting
Combination treatment for liver cancer for people who can't have surgery
This trial tests a new combination treatment that uses heat (ablation) and other therapies to destroy liver tumors. It's for people who cannot have surgery or choose not to, and whose tumor is a specific size.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07448038RecruitingPhase 2
Study of an anti-inflammatory pill for heart artery health
This trial tests a pill that may reduce inflammation in blood vessels, which could lower the risk of heart attacks or strokes in people with atherosclerosis. It could help if you have plaque in your arteries and are at risk for major heart events.
Beverly Hills, CaliforniaAges 18 years+ - NCT07432867RecruitingPhase 1/Phase 2
Gene therapy for severe sickle cell disease in teens and adults
This trial tests a new gene therapy for sickle cell disease. It uses your own blood stem cells (collected from bone marrow) that are modified in a lab to help produce healthy red blood cells, then given back to you after a short chemotherapy. The goal is to reduce or stop severe complications like pain crises and lung problems.
Paris, Île-de-France RegionAges 12–35 - NCT04975178RecruitingPhase 3
Test of a TB vaccine for newborns in sub-Saharan Africa
This Phase 3 study tests whether MTBVAC can safely protect newborn babies from tuberculosis and whether it helps the baby’s immune system learn to fight TB. If you enroll, the goal is to see safety and immune response in real newborn settings in sub-Saharan Africa.
Worcester, Western CapeAges 5 minutes–1 week - NCT07420985RecruitingPhase 2
Ingavirin forte for flu and other viral infections
This trial tests different doses of Ingavirin Forte capsules for treating influenza and other respiratory viruses. It may help people with fever, cough, sore throat, and body aches who have been sick less than 48 hours.
IvanovoAges 18–65 - NCT07421297RecruitingPhase 3
Study of SYH2053 for high cholesterol in Chinese adults
This trial tests a new medication called SYH2053 for people with high cholesterol or mixed high cholesterol and triglycerides. If you have high LDL cholesterol and are not taking strong cholesterol medicines, you may be able to join. The study will see if this drug is safe and works well.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07412132RecruitingPhase 3
Testing lacosamide for hard-to-treat bipolar depression
This study tests if a medication called lacosamide can help people with bipolar depression that has not improved with at least two other treatments. It's for those with moderate to severe depression in bipolar I or II.
São Paulo, São PauloAges 18–65 - NCT07388498RecruitingPhase 3
Study of pegloticase with methotrexate for uncontrolled gout
This trial tests a new way of giving pegloticase (a drug that breaks down uric acid) by injection under the skin, combined with methotrexate, to see if it works better for people with uncontrolled gout. It might help if you have painful flares that don't go away with usual treatments.
Birmingham, AlabamaAges 18 years+ - NCT07382167RecruitingPhase 3
Study of Tenapanor for Chronic Constipation in Adults
This study tests an investigational drug called tenapanor for people with chronic idiopathic constipation (constipation with no clear cause). It aims to see if the drug can safely improve bowel movements in adults.
Foley, AlabamaAges 18–80 - NCT07371338RecruitingPhase 1
Testing a new drug for advanced Parkinson's
This trial tests an investigational drug called IPS101A in people with advanced Parkinson's disease. It aims to see if the drug is safe and how well it works when standard treatments are no longer enough.
SeoulAges 50–80 - NCT07365462RecruitingPhase 2
Study of NBI-1065890 for tardive dyskinesia in adults
This trial tests whether an oral medication, NBI-1065890, can reduce the involuntary muscle movements caused by long-term use of antipsychotic drugs. It is for adults with moderate to severe tardive dyskinesia who also have a stable mental health condition like schizophrenia or bipolar disorder.
Bryant, ArkansasAges 18–75 - NCT07355972RecruitingEarly Phase 1
CT1195E cell therapy for progressive scleroderma
This trial tests a new cell therapy called CT1195E for people with refractory or progressive systemic sclerosis (scleroderma) that also affects the lungs. It aims to see if the treatment is safe and can help slow or stop the disease.
Wuhan, HubeiAges 18–60 - NCT06852079RecruitingPhase 3
Testing a herbal pill for mild to moderate high blood pressure
This study tests if a traditional herbal pill called Qurs e Fishar can safely lower blood pressure in adults with mild to moderate hypertension. It may be an option for people looking for natural treatments.
Karachi, SindhAges 30–60 - NCT06857292RecruitingPhase 2
A study of a new medicine to prevent fever in children on chemotherapy
This study tests a new medicine called Telpegfilgrastim to help prevent fever from low white blood cell counts in children (14–17) with certain cancers who are getting strong chemotherapy. It aims to see if the medicine is safe and works well.
Guangzhou, GuangdongAges 14–18 - NCT07347951RecruitingPhase 2
New drug combo for rectal cancer patients who want to save their anus
This trial tests a combination of short-course radiation, chemotherapy, and two targeted drugs (Serplulimab and Bevacizumab) for people with a specific type of rectal cancer. It aims to see if this treatment can help shrink the tumor enough to avoid surgery and keep the anus.
Wenzhou, ZhejiangAges 18–75 - NCT07342803RecruitingPhase 2
LP-003 injection for allergic asthma
This trial tests an injection called LP-003 for people with allergic asthma that is not well controlled by current inhalers and other medications. It aims to see if the drug can improve asthma control and reduce flare-ups.
ShanghaiAges 18–75 - NCT07339332RecruitingEarly Phase 1
CAR-T cell therapy for moderate to severe lupus
This study tests whether a new CAR-T cell treatment (called CT1195E) can help people with lupus that hasn't improved with standard medicines. CAR-T cells are specially trained immune cells that seek out and destroy certain faulty immune cells, which may reduce lupus symptoms. The trial is for people with moderate to severe active lupus affecting organs like the kidneys, heart, or blood system.
Wuhan, HubeiAges 18–65 - NCT07326709RecruitingPhase 3
Votoplam for Huntington's disease: a Phase 3 study
This study tests an investigational drug called Votoplam for people with Huntington's disease. It aims to see if the drug can slow progression of symptoms like movement and thinking problems.
Birmingham, AlabamaAges 21–70 - NCT06871995Recruiting
Spinal block safety for infants under 3 months
This study is testing how well and how safely a spinal block (numbing medicine injected into the lower back) works for babies under 3 months old who need certain belly or groin surgeries. It may help avoid general anesthesia for these infants.
CairoAges 1 day–3 months - NCT06873100RecruitingPhase 1/Phase 2
Upadacitinib for relapsing polychondritis
This trial tests whether upadacitinib, an oral medication, is safe and effective for people with relapsing polychondritis that hasn't improved enough with standard treatments. It aims to reduce inflammation and control symptoms.
Beijing, Beijing MunicipalityAges 18–70 - NCT07308548RecruitingPhase 2
Testing HP515 for fatty liver disease (NASH/MASH)
This trial tests a new drug called HP515 for people with non-alcoholic fatty liver disease, including NASH or MASH. It aims to see if the drug can help reduce liver fat and improve liver health.
Beijing, Beijing MunicipalityAges 18–65
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Common questions
- Are there clinical trials for efficacy and safety?
- Yes. Clin2 currently lists 2,733 recruiting efficacy and safety studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a efficacy and safety trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a efficacy and safety trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.