Clinical trials
Efficacy and Safety clinical trials
Below are recruiting efficacy and safety clinical trials, each written for real people, not researchers. We’re tracking 2,831 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05701293Recruiting
RenZan stent check for leg artery narrowing
This trial follows how well the RenZan stent works and how safe it is for people with blocked or badly narrowed thigh-to-knee leg arteries. It may help by improving blood flow and adding careful monitoring to see how outcomes compare over time.
SienaAges 18 years+ - NCT05711758Recruiting
Endoscopic stomach muscle cut for weight loss
This trial tests whether an endoscopic procedure that cuts a stomach outlet muscle can help with weight loss and be safe. You would be screened to make sure you don’t have certain stomach, heart/lung, or pregnancy-related conditions that could make the procedure unsafe.
Boston, MassachusettsAges 18–70 - NCT05722392Recruiting
Two-step surgery for localized prostate cancer
This trial studies a “two-step” type of prostate removal surgery for men with localized prostate cancer, focusing on whether it is safe and effective. It may help if you have certain prostate size, PSA level, and tumor features that match their criteria.
Guangzhou, GuangdongAges Any age - NCT05730244RecruitingPhase 1
Test cream made from cassia alata for skin rash
This Phase 1 study tests how safe and how well a 20% cassia alata (a plant extract) cream works for tinea versicolor, a common skin condition. You may be able to join if your rash matches the study’s confirmed diagnosis and you have not used treatment recently.
Kingston, OtherAges 18–89 - NCT05737121RecruitingPhase 2
Study drug for bladder pain compared with lidocaine, heparin, or placebo
This Phase 2 trial tests VNX001 to see if it helps people with interstitial cystitis/bladder pain syndrome (IC/BPS) compared with its separate ingredients (lidocaine and heparin) or a placebo (inactive treatment). You may be eligible if you have had IC/BPS for months and recently had a moderate-to-severe bladder pain flare.
Escondido, CaliforniaAges 18 years+ - NCT05738187Recruiting
Cryotherapy for repeat head and neck cancer after prior radiation
This pilot study tests whether cooling treatment on the tumor area (cryotherapy) can control a repeat head/neck cancer that can’t be removed and has already been treated with radiation. It also checks safety, especially in areas that have received radiation before.
StrasbourgAges 18 years+ - NCT05739591Recruiting
Long-term follow-up for people treated in a breast cancer trial
This study checks how well a previous early breast cancer treatment works over the long term and monitors safety. It may help you and future patients by providing long-term results from the original trial.
InnsbruckAges 18 years+ - NCT05740319Recruiting
Test stool transplant to treat irritable bowel syndrome
This trial studies fecal microbiota transplantation, which is transferring stool bacteria from a healthy donor to help rebalance gut microbes. If you have irritable bowel syndrome (IBS) that hasn’t improved after several standard treatments, this study may see whether it reduces your symptoms and is safe.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT05741905Recruiting
Levofloxacin antibiotic with IV clot-busting for acute stroke
This trial tests whether adding the antibiotic levofloxacin to standard IV clot-busting treatment is safe and improves outcomes after an acute ischemic stroke. It may help by reducing complications related to infection or inflammation, but you must meet specific heart, liver, kidney, and medication-safety rules.
Changchun, JilinAges 18–75 - NCT05747261RecruitingPhase 1/Phase 2
Single-dose gene therapy for children with spinal muscular atrophy
This trial tests a one-time gene therapy given through a vein to add a working SMN gene in children with spinal muscular atrophy (SMA). It mainly looks at safety first, and also checks early signs that treatment helps the disease.
MinskAges Up to 8 months - NCT05750628RecruitingPhase 2
Testing malaria medicines in uncomplicated falciparum malaria
This trial studies how well and how safely different anti-malaria medicines work for people who have uncomplicated malaria caused by Plasmodium falciparum. You may be eligible if you have a confirmed infection with a certain parasite level and do not have signs of severe disease or major health conditions.
BanforaAges 2–100 - NCT05754203Recruiting
Radiation plus immunotherapy for advanced lung cancer
This trial studies whether a more intensive form of targeted radiation, combined with immunotherapy (immune checkpoint inhibitors), can work better and be safe for people with advanced non-small cell lung cancer. You may be considered if your tumor is limited in size and you’re able to receive both treatments.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT05757505Recruiting
Intracranial stent for narrowed brain arteries after symptoms
This trial studies whether an intracranial stent (a small mesh tube placed inside the brain artery) improves outcomes and safety for people with severe, symptomatic narrowing of brain arteries. It may help if symptoms continue despite antiplatelet medicine or if blood flow to the brain is poor.
Luoyang, HenanAges 18–75 - NCT05759676Recruiting
Diabetes and a new drug-free heart stent after angioplasty
This trial tests whether a polymer-free amphilimus-eluting stent is safe and works well for people with diabetes after a recent heart blockage procedure. It may help improve how well the artery stays open, while tracking side effects over time.
SeoulAges 19 years+ - NCT05761899RecruitingPhase 1/Phase 2
Gene-corrected lung immune cells for a rare lung disease
This early-phase study tests a treatment that uses gene-corrected immune cells to treat hPAP, a rare lung condition. The goal is to check safety and see whether the treatment improves breathing and lung function.
Cincinnati, OhioAges 18 years+ - NCT05762510RecruitingEarly Phase 1
Testing a gene-based treatment for transfusion-dependent thalassemia
This early study tests the safety and potential benefit of the LentiRed gene-based drug in people with transfusion-dependent beta-thalassemia (TDT) who are planning an autologous stem cell transplant. It may help reduce the severity of anemia, but the main goal at this stage is to check safety and side effects.
Nanning, GuangxiAges 5–35 - NCT05765175Recruiting
Radioablation versus repeat ablation for hard-to-treat VT
This trial compares a heart procedure using targeted radiation (called radioablation) to a repeat catheter ablation for people with high-risk, hard-to-control ventricular tachycardia (VT). It aims to find which approach is safer and works better after standard ablation and amiodarone have not stopped the abnormal rhythm.
Los Angeles, CaliforniaAges 18 years+ - NCT05768035RecruitingPhase 1/Phase 2
Testing SMART101 after half-matched stem cell transplant
This trial studies a new immune treatment called SMART101 given after a half-matched (haploidentical) stem cell transplant that uses post-transplant cyclophosphamide to prevent complications. It mainly checks safety, and may also look at how well SMART101 helps people with blood cancers recover after transplant.
MarseilleAges 18 years+ - NCT05769660RecruitingPhase 1
Study BEY1107 plus temozolomide for recurrent glioblastoma
This Phase 1 study tests the safety and early effectiveness of BEY1107 combined with temozolomide in adults whose glioblastoma has come back or kept growing after standard treatment. If you qualify, you may be able to receive this combination while the researchers closely monitor side effects and tumor response.
SeoulAges 19 years+ - NCT05772871RecruitingPhase 4
Prednisone plus herbal granules for children with nephrotic syndrome
This trial tests whether adding Huaiqihuang granules to prednisone can improve outcomes for children with primary, hormone-sensitive nephrotic syndrome. It also closely monitors safety to see if the combination causes fewer or more side effects than usual care.
Hefei, AnhuiAges 1.5 years–18 years - NCT05774288Recruiting
Testing a device to close a heart opening called PFO
This trial studies whether a Cera™ device is safe and effective for closing a patent foramen ovale (PFO), a small hole in the heart. It is for adults whose PFO is linked to certain types of stroke or ongoing clot-related events.
Beijing, Beijing MunicipalityAges 18–60 - NCT05780359Recruiting
Testing a drug-coated stent for leg artery blockages
This study tests whether a special “drug-eluting” stent placed in a leg artery works safely and improves blood flow for people with peripheral artery disease. It may help reduce re-narrowing and improve walking, depending on your blockage details and overall health.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT05786443RecruitingPhase 2
Empagliflozin test in adults on regular dialysis
This study tests whether the medicine empagliflozin is safe and helpful for adults who are on regular hemodialysis and still make a small amount of urine. The goal is to see if it can improve health outcomes while tracking side effects closely.
Boston, MassachusettsAges 18 years+ - NCT05786768RecruitingPhase 2/Phase 3
Obinutuzumab vs rituximab for relapsing childhood kidney syndrome
This study compares two antibody medicines, obinutuzumab and rituximab, to prevent relapses of steroid-dependent or frequently relapsing nephrotic syndrome in children. It looks at whether one option works better and is safer, including infection risk.
ParisAges 3–18
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Common questions
- Are there clinical trials for efficacy and safety?
- Yes. Clin2 currently lists 2,831 recruiting efficacy and safety studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a efficacy and safety trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a efficacy and safety trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.