Clinical trials
Efficacy and Safety clinical trials
Below are recruiting efficacy and safety clinical trials, each written for real people, not researchers. We’re tracking 2,831 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05792722Recruiting
Testing a prostate-sparing bladder surgery for bladder cancer
This trial studies whether a “prostate-sparing” radical cystectomy is safe and effective for bladder cancer patients who are having surgery. It aims to see if this approach can treat bladder cancer while reducing prostate-related side effects.
Washington D.C., District of ColumbiaAges 18 years+ - NCT05797519Recruiting
Transcatheter valve replacement for leaking tricuspid valve
This trial studies a catheter-based procedure to replace the tricuspid valve in people with severe valve leakage. It aims to improve symptoms and heart function while tracking safety and effectiveness.
Sydney, New South WalesAges 18 years+ - NCT05799326Recruiting
Levofloxacin after sudden stroke to improve safety and recovery
This trial tests whether the antibiotic levofloxacin can be given soon after an acute ischemic stroke to improve outcomes and monitor side effects. It’s for people with a moderate stroke severity who are not having certain emergency treatments or infections.
Changchun, JilinAges 18–75 - NCT05814952Recruiting
LX103 eye treatment for X-linked retinoschisis
This trial studies whether LX103 can improve vision and is safe for people with X-linked retinoschisis (XLRS) caused by RS1 gene changes. It focuses on a specific level of vision in the study eye and checks for medical conditions that could affect eye testing or safety.
ShanghaiAges 6 years+ - NCT05824169RecruitingPhase 1/Phase 2
Gene therapy for babies with severe spinal muscular atrophy
This early-stage study tests whether a one-time gene therapy can safely improve outcomes for babies with the most severe type of spinal muscular atrophy (SMA type 1). It focuses on safety and early signs of benefit, and participation requires specific genetic and health criteria.
BeijingAges birth–6 months - NCT05829733Recruiting
Synolis injection for 6 months in hip arthritis pain
This trial studies whether a treatment injection (Synolis VA 80/160) can safely reduce hip arthritis pain and improve function over 6 months. You may be eligible if you have confirmed hip osteoarthritis, ongoing pain despite common pain medicines, and no recent steroid or “visco-supplement” injections in that hip.
BelfortAges 18 years+ - NCT05832229RecruitingPhase 2
Studying rosuvastatin to slow liver scarring in cirrhosis
This Phase 2 trial tests whether rosuvastatin (a cholesterol-lowering medicine) can improve how well the liver functions and slow worsening scarring in people with cirrhosis. It also checks for side effects and safety.
La Jolla, CaliforniaAges 18–75 - NCT05835518Recruiting
Study of Adalloce safety and effects in rheumatoid or ankylosing arthritis
This is an observational study that follows people with rheumatoid arthritis (RA) or ankylosing spondylitis (AS) who are planning to start Adalloce. It aims to understand how safe the medicine is and how well it works in real-world care.
DaeguAges 19–74 - NCT05837104RecruitingPhase 2
Magnesium and vitamin B6 for early bipolar depression
This Phase 2 trial tests whether magnesium plus vitamin B6 can reduce depressive symptoms in people who are newly diagnosed with bipolar I disorder. It also checks for safety over a short, 4-week treatment period.
Belmont, MassachusettsAges 18–50 - NCT05838066RecruitingPhase 3
KN026 plus HB1801 for HER2-positive advanced breast cancer
This Phase 3 study tests whether taking KN026 with HB1801 as first treatment works better and is safe for people with HER2-positive breast cancer that has come back or spread. It may help by improving tumor response and delaying progression compared with the study’s treatment plan.
Beijing, chaoyangAges 18 years+ - NCT05843968RecruitingPhase 2
Rituximab or mycophenolate for steroid-dependent childhood kidney syndrome
This trial tests whether rituximab works as well as mycophenolate in children whose nephrotic syndrome (kidney condition) comes back when steroid medicines are reduced. It aims to find the safest and most effective option during a relapse.
Chongqing, Chongqing MunicipalityAges 3–16 - NCT05848284Recruiting
Tricuspid valve replacement to reduce leaking in the heart
This trial tests a new catheter-based procedure that replaces the tricuspid valve to reduce severe valve leaking. It may help people who still have symptoms despite heart medicines, but only if their heart shape and other health details fit the device requirements.
Los Angeles, CaliforniaAges 18 years+ - NCT05852717RecruitingPhase 2
Epcoritamab plus GDP chemotherapy for relapsed large B-cell lymphoma
This Phase 2 study tests epcoritamab combined with GDP chemotherapy to treat adults whose large B-cell lymphoma has come back or did not respond to prior treatment. It aims to improve how safely and effectively the disease can be controlled after standard chemotherapy.
Indianapolis, IndianaAges 18 years+ - NCT05854641RecruitingPhase 4
Stem cell treatment for poor blood flow in the leg ulcers
This trial tests whether a stem cell product (Stempeucel®) can improve healing and safety for people with critical limb ischemia caused by peripheral artery disease. It is for patients who cannot have (or have already tried) procedures to reopen blocked leg arteries and who have a leg ulcer and low blood-flow measurements.
Kuala LumpurAges 18–65 - NCT05854615RecruitingPhase 4
Stem cell treatment for painful poor blood flow in limbs
This trial tests whether a stem cell product (Stempeucel®) is safe and effective for people with Buerger’s disease causing critical limb ischemia and foot ulcers. It may help improve healing and blood flow when other options may be limited.
Kuala LumpurAges 18–65 - NCT05855083RecruitingPhase 2
Narsoplimab for high-risk TMA after bone marrow transplant
This trial studies the medicine narsoplimab in children who develop a serious complication called HSCT-TMA after a bone marrow transplant. It aims to improve safety and effectiveness for high-risk cases where the condition is ongoing or causing organ problems.
San Diego, CaliforniaAges 4 weeks–17 years - NCT05854823Recruiting
Reduced radiation after surgery for advanced head and neck cancer
This trial looks at whether giving less (de-escalated) radiation after surgery is as effective and safer for people with locally advanced head and neck squamous cell carcinoma who had a strong response to treatment before surgery. If you had no remaining cancer or only very small amounts of cancer left in the surgical specimen, this approach may help reduce side effects while keeping control of the disease.
Zhuhai, GuangdongAges 18–70 - NCT05855421Recruiting
Ear acupuncture sessions for moderate depression during COVID
This trial tests whether auricular (ear) acupuncture can safely improve symptoms of moderate depression during the COVID period. You may be able to join if you’re an adult with moderate depression and can attend the study sessions.
Palhoça, Santa CatarinaAges 18–50 - NCT05860465RecruitingPhase 2/Phase 3
Tested blood cancer medicine with hormone therapy for breast cancer
This trial studies SPH4336 given together with standard hormone (endocrine) therapy for breast cancer that has spread or cannot be treated with surgery. It aims to see whether the combination is safer and more effective than hormone therapy alone.
Guangzhou, GuangdongAges 18–75 - NCT05860400Recruiting
Testing add-on treatment to calm artery inflammation after heart procedures
This study looks at whether a comprehensive add-on treatment—starting with immune medicine and then a heart procedure when needed—can improve outcomes for people whose coronary artery disease is getting worse quickly. It focuses on cases where inflammation is likely driving new artery blockages or worsening chest pain.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05862259Recruiting
Immunotherapy as first treatment for advanced stage IV cancers
This study looks at whether immune checkpoint inhibitors given as the first treatment work well and are safe for people with advanced (stage IV) solid tumors. You might qualify if you can take study treatment reliably and your cancer type and health match the study rules.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT05865002RecruitingPhase 1
Safety and drug test for AUR107 in advanced cancers
This early-phase study tests whether AUR107 is safe and may help shrink or control advanced solid tumors that have come back or progressed. You may be considered if standard treatments no longer work and you meet specific blood, organ, and health requirements.
Vijayawada, Andhra PradeshAges 18 years+ - NCT05865457Recruiting
Testing two eye treatments for dry eye symptoms
This trial compares two different dry-eye eye drops to see which works better and is safe. You may be able to join if you’ve had dry eye for at least 3 months and meet specific eye-test results.
GrazAges 18 years+ - NCT05878717RecruitingPhase 2/Phase 3
Belimumab for adults with scleroderma lung scarring
This Phase 2/3 study tests whether belimumab can improve outcomes and safety in adults with systemic sclerosis (scleroderma) that has caused lung scarring. It may help by reducing active or worsening immune-driven disease in the lungs.
Phoenix, ArizonaAges 18 years+
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Common questions
- Are there clinical trials for efficacy and safety?
- Yes. Clin2 currently lists 2,831 recruiting efficacy and safety studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a efficacy and safety trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a efficacy and safety trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.