Clinical trials
Efficacy and Safety clinical trials
Below are recruiting efficacy and safety clinical trials, each written for real people, not researchers. We’re tracking 2,733 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05872347RecruitingPhase 2
Brain metastasis breast cancer trial with hormone therapy plus SPH4336
This trial tests whether SPH4336, added to standard hormone (endocrine) therapy, can improve outcomes for people with breast cancer that has spread to the brain. It also looks closely at safety and side effects.
Hefei, AnhuiAges 18–75 - NCT05848284Recruiting
Tricuspid valve replacement to reduce leaking in the heart
This trial tests a new catheter-based procedure that replaces the tricuspid valve to reduce severe valve leaking. It may help people who still have symptoms despite heart medicines, but only if their heart shape and other health details fit the device requirements.
Los Angeles, CaliforniaAges 18 years+ - NCT05860465RecruitingPhase 2/Phase 3
Tested blood cancer medicine with hormone therapy for breast cancer
This trial studies SPH4336 given together with standard hormone (endocrine) therapy for breast cancer that has spread or cannot be treated with surgery. It aims to see whether the combination is safer and more effective than hormone therapy alone.
Guangzhou, GuangdongAges 18–75 - NCT05852717RecruitingPhase 2
Epcoritamab plus GDP chemotherapy for relapsed large B-cell lymphoma
This Phase 2 study tests epcoritamab combined with GDP chemotherapy to treat adults whose large B-cell lymphoma has come back or did not respond to prior treatment. It aims to improve how safely and effectively the disease can be controlled after standard chemotherapy.
Indianapolis, IndianaAges 18 years+ - NCT05865028RecruitingPhase 2
Test drug APG-157 for abnormal mouth tissue
This Phase 2 trial studies whether APG-157 can safely improve abnormal cells in the mouth (dysplasia) or early cancer-like changes (carcinoma in situ). You may be eligible if you have a visible, biopsy-proven lesion and can take oral medication while meeting blood and health requirements.
Miami, FloridaAges 18 years+ - NCT05832229RecruitingPhase 2
Liver cirrhosis network rosuvastatin trial
This study tests whether the drug rosuvastatin, a cholesterol-lowering medicine, can improve liver health in people with cirrhosis. If you have compensated cirrhosis (no recent serious liver problems), you might be able to join.
La Jolla, CaliforniaAges 18–75 - NCT05829733Recruiting
Synolis injection for 6 months in hip arthritis pain
This trial studies whether a treatment injection (Synolis VA 80/160) can safely reduce hip arthritis pain and improve function over 6 months. You may be eligible if you have confirmed hip osteoarthritis, ongoing pain despite common pain medicines, and no recent steroid or “visco-supplement” injections in that hip.
BelfortAges 18 years+ - NCT05844449Enrolling by invitationPhase 3
Check long-term safety and effectiveness of CF medicines
This Phase 3 study looks at how well and how safely Vanzacaftor/Tezacaftor/Deutivacaftor works over the long term in people with cystic fibrosis who already took the study medicine before. It may help confirm the best long-term plan and spot important safety issues.
Orange, CaliforniaAges 1 year+ - NCT05835310RecruitingPhase 3
IV anifrolumab for active lupus in children
This study tests whether an intravenous medicine called anifrolumab can safely improve active systemic lupus (SLE) in children. If you qualify, you may receive the study treatment and be closely monitored for safety and lupus symptoms.
Phoenix, ArizonaAges 5–17 - NCT05814432RecruitingPhase 3
High-dose antifungal for widespread Histoplasmosis in HIV
This Phase 3 trial tests whether a high-dose form of amphotericin B made in tiny fat particles (liposomal amphotericin B) is safer and more effective for treating widespread Histoplasmosis in adults with HIV. It may help people who have a serious, whole-body infection caused by Histoplasma.
Goiânia, GoiásAges 18 years+ - NCT05837104RecruitingPhase 2
Magnesium and vitamin B6 for early bipolar depression
This Phase 2 trial tests whether magnesium plus vitamin B6 can reduce depressive symptoms in people who are newly diagnosed with bipolar I disorder. It also checks for safety over a short, 4-week treatment period.
Belmont, MassachusettsAges 18–50 - NCT05816343RecruitingPhase 2
Orlistat for high triglycerides in people with rare genetic lipid conditions
This Phase 2 trial studies how well and how safely orlistat works over the long term for people who have very high triglycerides linked to rare genetic lipid disorders. It may help lower triglycerides and assess long-term side effects, but you must meet specific genetic, lab, and health requirements.
Dallas, TexasAges 8 years+ - NCT05837806RecruitingPhase 2
Tislelizumab and disitamab as pre-surgery treatment for HER2 UTUC
This trial tests whether giving tislelizumab plus disitamab vedotin before surgery (neoadjuvant therapy) can improve outcomes for people with HER2-positive, high-risk upper tract urothelial cancer. It also looks at the treatment’s safety and helps doctors learn if certain tumor features predict response.
TianjinAges 18 years+ - NCT05786443RecruitingPhase 2
Empagliflozin test in adults on regular dialysis
This study tests whether the medicine empagliflozin is safe and helpful for adults who are on regular hemodialysis and still make a small amount of urine. The goal is to see if it can improve health outcomes while tracking side effects closely.
Boston, MassachusettsAges 18 years+ - NCT05791227Enrolling by invitation
Testing AI tool that measures heart wall thickness on ultrasound
This study tests an artificial-intelligence (AI) software tool that measures heart muscle thickness from routine heart ultrasound images. It focuses on whether the AI measurements are safe and accurate when used by the clinic’s echocardiography team.
Los Angeles, CaliforniaAges 18–100 - NCT05797519Recruiting
Transcatheter valve replacement for leaking tricuspid valve
This trial studies a catheter-based procedure to replace the tricuspid valve in people with severe valve leakage. It aims to improve symptoms and heart function while tracking safety and effectiveness.
Sydney, New South WalesAges 18 years+ - NCT05789056RecruitingPhase 2/Phase 3
Study lotion for Netherton syndrome safety and symptom improvement
This trial tests a prescription lotion (QRX003) to see if it is safe and helpful for people with Netherton syndrome. Because the study checks skin symptoms on certain body areas and closely controls other treatments, it may be best for patients who can keep their current regimen stable.
San Diego, CaliforniaAges 14 years+ - NCT05802329RecruitingPhase 1
Testing eye injections for diabetic macular swelling
This Phase 1 study tests the safety and early effectiveness of OCU200 eye injections in people with diabetic macular edema (DME) that affects the center of vision. It may help by reducing the eye swelling that blurs vision from diabetes.
Deerfield Beach, FloridaAges 18 years+ - NCT05757505Recruiting
Intracranial stent for narrowed brain arteries after symptoms
This trial studies whether an intracranial stent (a small mesh tube placed inside the brain artery) improves outcomes and safety for people with severe, symptomatic narrowing of brain arteries. It may help if symptoms continue despite antiplatelet medicine or if blood flow to the brain is poor.
Luoyang, HenanAges 18–75 - NCT05755386RecruitingPhase 3
Iptacopan for idiopathic IC-MPGN with heavy protein in urine
This trial tests iptacopan (an add-on medicine) in people with idiopathic immune-complex membranoproliferative glomerulonephritis (IC-MPGN), a kidney disease causing significant protein loss in urine. It aims to improve kidney outcomes and safety when added to standard treatments.
Los Angeles, CaliforniaAges 12–60 - NCT05754450RecruitingPhase 3
Extension study for AVTX-803 in LAD type II
This trial is a follow-up study testing whether AVTX-803 continues to be safe and effective for people with Leukocyte Adhesion Deficiency type II (LAD II). If you already took part in an earlier AVTX-803 LAD II study, this may be the next step while researchers monitor benefits and side effects.
Rochester, MinnesotaAges 6 months–75 years - NCT05765175Recruiting
Radioablation versus repeat ablation for hard-to-treat VT
This trial compares a heart procedure using targeted radiation (called radioablation) to a repeat catheter ablation for people with high-risk, hard-to-control ventricular tachycardia (VT). It aims to find which approach is safer and works better after standard ablation and amiodarone have not stopped the abnormal rhythm.
Los Angeles, CaliforniaAges 18 years+ - NCT05761899RecruitingPhase 1/Phase 2
Gene-corrected lung immune cells for a rare lung disease
This early-phase study tests a treatment that uses gene-corrected immune cells to treat hPAP, a rare lung condition. The goal is to check safety and see whether the treatment improves breathing and lung function.
Cincinnati, OhioAges 18 years+ - NCT05712200RecruitingPhase 3
Abelacimab for atrial fibrillation when blood thinners aren’t suitable
This Phase 3 study tests whether abelacimab can prevent stroke and other blood-clot problems in people with atrial fibrillation (or atrial flutter) who cannot safely take usual mouth blood thinners. It also looks at safety, especially bleeding risk.
Birmingham, AlabamaAges 65 years+
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Common questions
- Are there clinical trials for efficacy and safety?
- Yes. Clin2 currently lists 2,733 recruiting efficacy and safety studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a efficacy and safety trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a efficacy and safety trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.