Clinical trials
Endometrial clinical trials
Below are recruiting endometrial clinical trials, each written for real people, not researchers. We’re tracking 363 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06096688Recruiting
Finding new ways to lower colorectal and endometrial cancer risk
This study looks for new ways to lower the risk of colorectal and endometrial cancers. It collects tissue and information from people who are getting certain procedures or treatments at Weill Cornell Medicine.
New York, New YorkAges 18 years+ - NCT07044336RecruitingPhase 3
Comparing a new drug to chemo for advanced endometrial cancer
This trial tests a new investigational drug called Puxitatug Samrotecan (AZD8205) against standard chemotherapy in people whose endometrial cancer has come back or spread after prior treatment with platinum chemo and an immunotherapy. The goal is to see if the new drug works better.
Tucson, ArizonaAges 18 years+ - NCT07022483RecruitingPhase 3
New drug vs standard chemo for HER2-positive endometrial cancer
This trial compares a new targeted medicine (trastuzumab deruxtecan) against standard chemotherapy for women with a certain type of advanced endometrial cancer that has high levels of HER2 protein. It's for people whose cancer is newly diagnosed and has spread to nearby tissues but not to distant organs.
Fort Lauderdale, FloridaAges 18 years+ - NCT04469764RecruitingPhase 2
Abemaciclib for certain recurrent ovarian or endometrial cancers
This Phase 2 study tests abemaciclib, a targeted pill treatment, for recurrent ovarian or endometrial cancer that shows specific tumor genetic patterns. It may help slow or control cancer growth in people whose tumor matches the required test results.
Los Angeles, CaliforniaAges Any age - NCT07702799Recruiting
Low-fiber diet vs enema before laparoscopic endometrial cancer surgery
This trial compares two colon preparation methods — a low-residue diet versus a rectal enema — before laparoscopic surgery for endometrial cancer. The goal is to find which approach is easier and works better for bowel preparation.
IstanbulAges 18–90 - NCT07209449RecruitingPhase 2
Elacestrant with or without abemaciclib for endometrial cancer
This trial tests a new hormone therapy (elacestrant) alone or combined with a targeted pill (abemaciclib) for people with advanced or recurrent endometrial cancer that is hormone-receptor-positive. The goal is to see if these treatments can shrink tumors or slow the cancer's growth.
Basking Ridge, New JerseyAges 18 years+ - NCT07286331RecruitingPhase 3
New drug vs chemo for advanced endometrial cancer
This trial tests a new drug (mocertatug rezetecan) compared to standard chemotherapy for people with endometrial cancer that has progressed after platinum-based chemo and immunotherapy. It may help if your tumor has a protein called B7-H4.
Buenos AiresAges 18 years+ - NCT03366051Recruiting
Check mapping of the first lymph node in high-risk uterine cancer
This trial studies how to find the “sentinel” (first) lymph node during surgery for high-risk endometrial (uterine) cancer. It may help surgeons better tell whether cancer has spread to nearby lymph nodes and guide the extent of lymph node removal.
Curitiba, ParanáAges 18–75 - NCT03438474Recruiting
Lymph node surgery study for certain early endometrial cancers
This trial studies whether adding lymph node removal (lymphadenectomy) during surgery helps people with certain early-stage endometrial cancer. It focuses on patients who do not have visibly enlarged lymph nodes and who can safely have the operation.
AalenAges 18–75 - NCT03463252RecruitingPhase 2/Phase 3
Hormone IUD to preserve fertility in early uterine cancer
This study looks at whether a hormone-releasing IUD (LNG-IUS) can treat early-stage endometrial cancer or very early abnormal cell growth while helping you keep the option for future pregnancy. It aims to see how well the treatment works and how it affects fertility-related outcomes.
Chengdu, SichuanAges Up to 40 years - NCT03564340RecruitingPhase 1/Phase 2
Testing ubamatamab alone or with cemiplimab for ovarian and MUC16+ cancers
This early-phase study tests ubamatamab, a cancer-targeting antibody, given by itself or with cemiplimab. It is meant to treat adults whose cancer has come back and who may not have other good standard options left.
Birmingham, AlabamaAges 18 years+ - NCT03624244RecruitingPhase 2
Stopping or continuing hormone pill for low-grade uterine cancer
This Phase 2 trial tests whether it is better to stop a hormone tablet (an aromatase inhibitor) versus keep taking it in people with low-grade endometrial stromal sarcoma whose cancer is currently controlled. It may help find the safest way to maintain disease control while avoiding unnecessary treatment if stopping is possible.
BesançonAges 18 years+ - NCT03675893RecruitingPhase 2
Test abemaciclib plus letrozole with or without extra drugs
This Phase 2 study tests whether adding medicines to standard hormone therapy (letrozole) can control endometrial cancer that has come back, spread, or stopped responding to usual treatments. It also explores whether extra drugs (metformin or gedatolisib) improve results for certain patient groups.
Boston, MassachusettsAges 18 years+ - NCT03832361RecruitingPhase 2
Mirvetuximab for folate-receptor–positive endometrial cancer
This Phase 2 study tests mirvetuximab (a targeted antibody drug) in women whose endometrial cancer is positive for folate receptor-alpha. It aims to shrink tumors and improve outcomes, especially in cancer that has returned or kept growing after previous treatment.
New Haven, ConnecticutAges 18–100 - NCT07622901Recruiting
Fasting and Exercise for Early-Stage Endometrial Cancer
This study tests whether fasting (not eating for extended periods) and exercise before surgery might help improve outcomes for women with early-stage endometrial cancer. Participants will be randomly assigned to either practice fasting and exercise or receive standard care.
Miami, FloridaAges 18 years+ - NCT04453904Recruiting
Testing best added chemo and radiation after stage III uterine cancer
This study compares different ways of giving radiation and chemotherapy after surgery for stage III endometrial (uterine) cancer. It aims to find which approach works best to reduce cancer risk and improve outcomes.
Beijing, Beijing MunicipalityAges Any age - NCT04486352RecruitingPhase 1/Phase 2
Targeted therapy trial for recurrent or persistent endometrial cancer
This Phase 1/2 study tests targeted drug(s) for endometrial cancer that has come back or never fully went away after prior treatments. You may be eligible if your tumor can be tested for specific biomarkers and your health allows treatment safely.
Duarte, CaliforniaAges 18 years+ - NCT04504006Recruiting
Tracking surgery choices for lymph node spread in endometrial cancer
This is an observational study that follows people with endometrial cancer who have had surgery to check and remove pelvic (and sometimes paraaortic) lymph nodes. It looks at how different surgical approaches and any added treatment affect local control (keeping cancer from coming back in the pelvis/nearby areas).
Essen, North Rhine-WestphaliaAges 18 years+ - NCT04512144Recruiting
Mindfulness coaching for endometrial or cervical cancer patients
This study tests a mindfulness program (using an app) for people newly diagnosed with endometrial cancer surgery or cervical cancer treated with chemo-sensitizing radiation. It may help improve how you cope during treatment.
St Louis, MissouriAges 18–90 - NCT04570553Recruiting
Testing a tool during surgery for early endometrial cancer
This study looks at how well a surgical tool is used during standard surgery for early endometrial cancer, and whether it relates to test results from fluid taken in the abdomen. It may help surgeons improve how samples are collected and interpreted during routine care.
York, PennsylvaniaAges 18 years+ - NCT04586959Recruiting
Uterine movement study during minimally invasive cancer surgery
This study looks at how moving the uterus during minimally invasive surgery may affect women with early-stage endometrial cancer. It may help doctors choose the safest, most effective surgical approach.
Cleveland, OhioAges 18–90 - NCT04683653RecruitingPhase 1/Phase 2
Pelvic radiation test for uterine or cervical cancer
This trial studies a specific radiation schedule aimed at the pelvis (lower belly area) for uterine or cervical cancer. It looks at whether this “hypofractionated” approach can control cancer while limiting side effects, especially in patients whose disease has not spread to distant organs.
Atlanta, GeorgiaAges 18 years+ - NCT04716686RecruitingPhase 2
Niraparib alone to help prevent cancer coming back
This Phase 2 study tests niraparib by itself to keep endometrial serous cancer from returning or to control it after chemotherapy helps. It may help some people by targeting tumor DNA repair weaknesses, especially in cancers with certain gene changes.
Jinan, ShandongAges 18 years+ - NCT04774419RecruitingPhase 2
Radiation plus dostarlimab for post-surgery endometrial cancer
This Phase 2 study tests whether adding dostarlimab (an immunotherapy medicine) to radiation after surgery can lower cancer returning and improve outcomes. It’s for people with certain endometrial cancers found to have specific genetic/molecular changes and who have stage III/IVA disease after surgery.
Basking Ridge, New JerseyAges 18 years+
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Common questions
- Are there clinical trials for endometrial?
- Yes. Clin2 currently lists 363 recruiting endometrial studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a endometrial trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a endometrial trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.