Clinical trials
Epilepsy; Seizure clinical trials
Below are recruiting epilepsy; seizure clinical trials, each written for real people, not researchers. We’re tracking 50 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07219407RecruitingPhase 2
Long-term safety study of RAP-219 for focal seizures
This study tests the long-term safety and effectiveness of RAP-219, an investigative medication for focal epilepsy. It is for people who already completed an earlier study of RAP-219, have a type of epilepsy that doesn't respond to standard medicines, and use a surgically implanted brain device (RNS system) to help manage seizures.
Boise, IdahoAges 18–70 - NCT07012148RecruitingEarly Phase 1
Seizure forecasting device for temporal lobe epilepsy
This study tests a small device placed under the scalp that may help predict when seizures are likely to happen, using EEG (brain wave) readings. It is designed for people with temporal lobe epilepsy to improve seizure management and safety.
Scottsdale, ArizonaAges 18–75 - NCT06388707RecruitingPhase 1/Phase 2
Ultrasound therapy for drug-resistant temporal lobe epilepsy
This study tests if a new, non-invasive ultrasound treatment can safely reduce seizures in people whose seizures start in the temporal lobe and have not been controlled by at least two anti-epileptic drugs. The ultrasound is delivered through the scalp to gently stimulate the brain area where the seizures begin.
Palo Alto, CaliforniaAges 18 years+ - NCT07594119RecruitingPhase 3
Testing RAP-219 to reduce seizures in focal epilepsy
This study tests a new medication called RAP-219 to see if it can reduce seizure frequency in adults with focal epilepsy (seizures starting in one area of the brain). You'll take the medication alongside your current seizure drugs and track your seizures daily using an app.
Huntsville, AlabamaAges 18–75 - NCT03478852Recruiting
Epilepsy screening and evaluation for people 8 and older
This study checks how people with known or suspected epilepsy are evaluated and followed. It may help by improving screening and understanding care for epilepsy in children and adults.
Bethesda, MarylandAges 8–110 - NCT07563881RecruitingPhase 3
Testing RAP-219 for Focal Seizure Control in Adults
This study tests whether a new medication called RAP-219 can help adults with focal seizures (seizures that start in one area of the brain) control their seizures better. You would take this medication alongside your current seizure drugs for about 12 weeks.
Palmdale, CaliforniaAges 18–75 - NCT04559919Recruiting
Building a regional database for people with epilepsy
This study collects information about adults who have had an unprovoked seizure or who have epilepsy. The goal is to better understand epilepsy in the community and improve future care.
BoråsAges 18 years+ - NCT05864547Recruiting
Study risk factors for seizures after a first stroke
This study looks at what factors can make seizures happen after a first stroke. It may help doctors identify who is more at risk so future care can be better targeted.
TrondheimAges 18–85 - NCT06492720Recruiting
Testing focused ultrasound for drug-resistant epilepsy
This study tests a new device called NaviFUS that uses focused sound waves to gently stimulate a small area of the brain. It is for people whose seizures start in one part of the brain and are not fully controlled by seizure medicines.
TaipeiAges 18–65 - NCT05724719Recruiting
Study brain signals after a first unprovoked seizure
This study looks at people ages 18 to 65 after they have a first seizure that is not clearly triggered. It also compares them with healthy volunteers to better understand what might predict whether seizures come back.
Halifax, Nova ScotiaAges 18–65 - NCT06952764Enrolling by invitation
ECLIPSE: Tracking epilepsy cycles to predict seizures
This trial tests if tracking your brain activity with an implanted device can help predict when seizures might happen. It is for adults who have seizures despite medication and already have the RNS System implanted.
San Francisco, CaliforniaAges 18 years+ - NCT02824822Recruiting
Genetic test study for heart rhythm risk in people with seizures
This study checks whether genetic markers are linked to heart rhythm problems in people with epilepsy or seizure-related events, and in some close relatives. It may help doctors better spot who is at risk for dangerous heart rhythm issues.
Rochester, MinnesotaAges 18–50 - NCT05518578RecruitingPhase 2
Drug trial for hard-to-control focal epilepsy with brain scar
This Phase 2 trial tests SPN-817 in adults whose seizures are still not well controlled despite trying multiple seizure medicines. It targets people with a specific type of brain finding called focal cortical dysplasia and looks at safety/tolerability and seizure outcomes over several weeks.
Jacksonville, FloridaAges 18–70 - NCT06108102Enrolling by invitation
Post-stroke epilepsy research database study
This trial is creating a global research database to learn more about seizures that happen after a stroke. By joining, you help doctors better understand who gets these seizures and how to treat them.
New Haven, ConnecticutAges 18 years+ - NCT06967012RecruitingPhase 4
Zonisamide as add-on treatment for children with epilepsy
This trial tests adding zonisamide to the current epilepsy medication for children aged 1 to 14 who still have focal seizures. The goal is to see if the combination works better and is safe.
Nantong, JiangsuAges 1–14 - NCT04076449Recruiting
MRI measurements for epilepsy from a single brain blood vessel lump
This study uses special MRI scans to measure brain changes in people whose seizures are related to one cerebral cavernous malformation (a type of abnormal blood vessel in the brain). It aims to find a measurable “biomarker” from MRI that may help understand the epilepsy and the brain structure around it.
Beijing, Beijing MunicipalityAges 18–70 - NCT05725174Recruiting
Study seizure signals using quick, non-invasive breath tests
This study looks for “volatile” (gaseous) body signals from breath to help identify seizure events. If you were recently admitted for seizure diagnosis, you may be asked to provide breath samples in a non-invasive way.
London, BuckinghamshireAges 18 years+ - NCT06700356Recruiting
Can a brain stimulator detect seizures in the thalamus?
This study tests whether a special brain stimulator (already implanted in some people with epilepsy) can detect seizures in the thalamus. It may help improve seizure monitoring without extra surgery.
Rochester, MinnesotaAges 18 years+ - NCT06598189Recruiting
Ear-seizure detection study for epilepsy monitoring
This study tests a wearable ear device that may help detect seizures during your stay in the Epilepsy Monitoring Unit. It aims to see if the device can work alongside standard monitoring to improve seizure detection.
Worcester, MassachusettsAges 18 years+ - NCT06265103Recruiting
Epilepsy learning healthcare system registry
This is a registry study that collects information from people being treated for epilepsy at participating healthcare centers. The goal is to improve care by learning from real-world patient data.
Phoenix, ArizonaAges Any age - NCT05944692Recruiting
Tripolar EEG test during seizure monitoring
This study checks whether a new type of EEG recording (a brain wave test) can detect seizure activity in people with epilepsy. You may join if you are already scheduled for routine and video EEG testing (and possibly inpatient monitoring) as part of your clinical care, including a brain MRI.
Phoenix, ArizonaAges 6 years+ - NCT07287163Enrolling by invitationPhase 3
Long-term study of vormatrigine for epilepsy
This trial is for adults with epilepsy who have already taken vormatrigine in a previous study or through a special access program. It aims to collect ongoing safety and effectiveness information.
Miami, FloridaAges 18–85 - NCT07116330Recruiting
Seizures starting after 50: testing heart and blood vessel risk
This study looks at whether checking and treating heart and blood vessel risk factors can help people who start having seizures after age 50. It includes two parts: one that adds a risk check to your regular care, and one that uses your medical records to learn more about this condition.
BoråsAges 50 years+ - NCT06908356RecruitingPhase 2
Testing PRAX-628 for focal or tonic-clonic seizures
This study tests an experimental pill called PRAX-628 for adults whose seizures are not fully controlled by current medications. It aims to see if the drug is safe and effective at reducing seizures.
Phoenix, ArizonaAges 18–75
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Common questions
- Are there clinical trials for epilepsy; seizure?
- Yes. Clin2 currently lists 50 recruiting epilepsy; seizure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a epilepsy; seizure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a epilepsy; seizure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.