Clinical trials
Epilepsy clinical trials
Below are recruiting epilepsy clinical trials, each written for real people, not researchers. We’re tracking 339 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05135091RecruitingPhase 3
Cell therapy trial for hard-to-control one-sided temporal lobe epilepsy
This Phase 3 study tests a neural cell therapy (NRTX-1001) for adults whose seizures come from one side of the hippocampus and have not improved with standard seizure medicines. The goal is to reduce seizure frequency and improve seizure control where other treatments have not worked.
Birmingham, AlabamaAges 18–75 - NCT05527093Recruiting
Brain-scan study mapping social thinking changes in epilepsy
This study uses special thinking and brain-scanning tests to understand how “social thinking” may change in people with certain types of epilepsy. You might benefit by having a detailed evaluation during your planned pre-surgery workup.
Gif-sur-YvetteAges 18–65 - NCT05609084Recruiting
Speech therapy before surgery for drug-resistant temporal epilepsy
This study tests an intensive pre-surgery speech rehabilitation program for people whose seizures come from the language-related area in the temporal part of the brain. The goal is to improve speech outcomes before planned epilepsy surgery.
BordeauxAges 16 years+ - NCT05673915Recruiting
Brain stimulation study for hard-to-control epilepsy
This trial tests whether noninvasive brain stimulation (using gentle electrical current through the scalp) can reduce seizures in people with epilepsy that has not responded to at least two anti-seizure medicines. If you qualify, you’d also be asked to keep track of seizures in a diary during the study.
Rochester, MinnesotaAges 6 years+ - NCT05755919Recruiting
Brain mapping during epilepsy surgery with special brain electrodes
This study looks at how to map brain function in people having epilepsy surgery by recording brain signals using special electrodes placed on or inside the brain. It may help doctors better understand which brain areas cause seizures.
Detroit, MichiganAges 6 months–21 years - NCT05864547Recruiting
Study risk factors for seizures after a first stroke
This study looks at what factors can make seizures happen after a first stroke. It may help doctors identify who is more at risk so future care can be better targeted.
TrondheimAges 18–85 - NCT05928598Recruiting
Learning goals for epilepsy clinic visits
This study asks adults with hard-to-control epilepsy to share what goals they want from their epilepsy clinic visits. It may help the clinic improve visit planning to better support patients day to day.
Ann Arbor, MichiganAges 18 years+ - NCT05947656Recruiting
NaviFUS treatment for drug-resistant temporal lobe seizures
This trial tests the NaviFUS system to treat seizures that keep happening despite seizure medicines, specifically in people with temporal lobe epilepsy. If you qualify, you would be carefully checked before and during the study, including seizure tracking and brain scans, to see whether treatment helps reduce seizures.
Melbourne, VictoriaAges 18 years+ - NCT06052605Recruiting
Healthy aging study for older adults with epilepsy
This study looks at healthy aging in people with epilepsy. You will fill out a survey to help researchers understand your experiences and needs.
Cleveland, OhioAges 55–90 - NCT06210022Recruiting
Cognitive problems in drug-resistant vs drug-responsive epilepsy
This study compares thinking skills in people with focal epilepsy that responds well to medication versus epilepsy that doesn't. It aims to understand how different types of epilepsy affect memory, attention, and other cognitive functions.
MilanAges 18–60 - NCT06265103Recruiting
Epilepsy learning healthcare system registry
This is a registry study that collects information from people being treated for epilepsy at participating healthcare centers. The goal is to improve care by learning from real-world patient data.
Phoenix, ArizonaAges Any age - NCT07110337Recruiting
Diagnosing epilepsy to help guide treatment
This trial tests a new device to help diagnose epilepsy in people whose previous EEG brain monitoring did not give clear answers. If you have drug-resistant epilepsy with at least one seizure a month on average, this study may help find better treatment options.
Phoenix, ArizonaAges 18–75 - NCT06353620Recruiting
Brain connections study for certain epilepsies and genetic syndromes
This study uses MRI and a special EEG to understand brain connections in people with specific types of epilepsy or genetic conditions like Angelman syndrome and Dup15q. It may help find better ways to treat these conditions.
Conegliano, TrevisoAges 6–75 - NCT06388174Recruiting
Idiopathic Generalized Epilepsy Study
This study is looking at people with a specific type of epilepsy called idiopathic generalized epilepsy (IGE). The goal is to collect health information and use a 24-hour brain wave test to learn more about the condition.
Hangzhou, ZhejiangAges 4–40 - NCT06388707RecruitingPhase 1/Phase 2
Ultrasound brain stimulation for drug-resistant epilepsy
This trial tests a low-intensity focused ultrasound device that aims to calm overactive brain areas causing seizures. It's for people whose seizures are not controlled by medication.
Palo Alto, CaliforniaAges 18 years+ - NCT06425029Recruiting
Music app therapy for hard-to-control epilepsy with RNS
This study is testing a music-based app that you can use at home to help treat seizures. It is for adults with focal epilepsy who already have an RNS device and whose seizures are not controlled by medication.
Worcester, MassachusettsAges 18 years+ - NCT06585605Recruiting
Study of epilepsy and movement disorder genes in children
This study looks at children with epilepsy and movement disorders to better understand the genes involved. It aims to help doctors recognize and treat these conditions more effectively.
Boston, MassachusettsAges birth–18 years - NCT06700811RecruitingPhase 1
Ketogenic diet to prevent infant seizures in genetic epilepsy
This trial tests whether starting a special high-fat diet (ketogenic diet) early can prevent epileptic spasms in babies with genetic epilepsy. It uses a specific formula called KetoVie and is for infants under 9 months old.
Boston, MassachusettsAges birth–9 months - NCT06769659RecruitingPhase 2
Testing NPT 2042 for absence seizures in genetic epilepsy
This trial tests a new medication called NPT 2042 for people with a type of epilepsy that causes brief staring spells (absence seizures). It aims to see if the drug can reduce seizure frequency compared to a placebo (an inactive pill).
Little Rock, ArkansasAges 16–75 - NCT06778772Recruiting
Moving from child to adult epilepsy care
This study helps teens with epilepsy make a smooth switch from a children's hospital to an adult hospital. It looks at how to improve this important transition so you don't miss any care.
PaviaAges 17–18 - NCT06813612Recruiting
Play therapy for kids with specific epilepsy types
This trial tests if a play-based cognitive behavioral therapy can help children ages 6 to 10 with certain types of epilepsy. It may offer a new way to support their emotional and behavioral well-being.
PaviaAges 6–10 - NCT06855901Recruiting
Home EEG monitoring for rare epilepsy
This study tests using a small, home-based EEG device to monitor brain activity over several weeks in people with hard-to-control seizures, rare epilepsies, or developmental and epileptic encephalopathies. The goal is to see if this method can better track seizures and improve care.
Roma, ItalyAges 12 years+ - NCT07012148Recruiting
Seizure forecasting with EEG and wearables for epilepsy
This study tests a wearable device that records brain waves to help predict and track seizures in people with temporal lobe epilepsy. It may help you better understand your seizure patterns and reduce uncertainty.
Rochester, MinnesotaAges 18–75 - NCT07219407RecruitingPhase 2
Long-term safety study of RAP-219 for focal seizures
This study tests the long-term safety and effectiveness of RAP-219, an investigative medication for focal epilepsy. It is for people who already completed an earlier study of RAP-219, have a type of epilepsy that doesn't respond to standard medicines, and use a surgically implanted brain device (RNS system) to help manage seizures.
Boise, IdahoAges 18–70
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Common questions
- Are there clinical trials for epilepsy?
- Yes. Clin2 currently lists 339 recruiting epilepsy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a epilepsy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a epilepsy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.