Clinical trials
Epilepsy clinical trials
Below are recruiting epilepsy clinical trials, each written for real people, not researchers. We’re tracking 325 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06813612Recruiting
Play therapy for kids with specific epilepsy types
This trial tests if a play-based cognitive behavioral therapy can help children ages 6 to 10 with certain types of epilepsy. It may offer a new way to support their emotional and behavioral well-being.
PaviaAges 6–10 - NCT05755919Recruiting
Brain mapping during epilepsy surgery with special brain electrodes
This study looks at how to map brain function in people having epilepsy surgery by recording brain signals using special electrodes placed on or inside the brain. It may help doctors better understand which brain areas cause seizures.
Detroit, MichiganAges 6 months–21 years - NCT07353918Enrolling by invitation
Focused ultrasound for epilepsy treatment
This study tests if low-intensity focused ultrasound can calm overactive brain areas in people with epilepsy. It may offer a new way to reduce seizures without surgery or strong medications.
Roanoke, VirginiaAges 18–85 - NCT06855901Recruiting
Home EEG monitoring for rare epilepsy
This study tests using a small, home-based EEG device to monitor brain activity over several weeks in people with hard-to-control seizures, rare epilepsies, or developmental and epileptic encephalopathies. The goal is to see if this method can better track seizures and improve care.
Roma, ItalyAges 12 years+ - NCT05527093Recruiting
Brain-scan study mapping social thinking changes in epilepsy
This study uses special thinking and brain-scanning tests to understand how “social thinking” may change in people with certain types of epilepsy. You might benefit by having a detailed evaluation during your planned pre-surgery workup.
Gif-sur-YvetteAges 18–65 - NCT07249034Recruiting
How epilepsy affects brain chemicals and breathing
This study looks at how epilepsy affects a chemical in the brainstem that helps control breathing and alertness. It uses a special PET scan and breathing tests to measure this in people with hard-to-control seizures.
BronAges 18–55 - NCT07219407RecruitingPhase 2
Long-term safety study of RAP-219 for focal seizures
This study tests the long-term safety and effectiveness of RAP-219, an investigative medication for focal epilepsy. It is for people who already completed an earlier study of RAP-219, have a type of epilepsy that doesn't respond to standard medicines, and use a surgically implanted brain device (RNS system) to help manage seizures.
Boise, IdahoAges 18–70 - NCT07110337Recruiting
Diagnosing epilepsy to help guide treatment
This trial tests a new device to help diagnose epilepsy in people whose previous EEG brain monitoring did not give clear answers. If you have drug-resistant epilepsy with at least one seizure a month on average, this study may help find better treatment options.
Birmingham, AlabamaAges 18–75 - NCT07012148RecruitingEarly Phase 1
Seizure forecasting device for temporal lobe epilepsy
This study tests a small device placed under the scalp that may help predict when seizures are likely to happen, using EEG (brain wave) readings. It is designed for people with temporal lobe epilepsy to improve seizure management and safety.
Scottsdale, ArizonaAges 18–75 - NCT04559919Recruiting
Building a regional database for people with epilepsy
This study collects information about adults who have had an unprovoked seizure or who have epilepsy. The goal is to better understand epilepsy in the community and improve future care.
BoråsAges 18 years+ - NCT06701084Recruiting
Genetic Causes of Infant Epilepsy at Boston Children's
This study looks at the genetic causes of epilepsy that starts in babies under 1 year old. It aims to learn how a genetic diagnosis might help guide care.
Boston, MassachusettsAges Any age - NCT06623994Recruiting
Epilepsy care access study in Kenya
This trial tests a program to help people with epilepsy in Kenya who are not taking their medication regularly get better access to care and support.
EldoretAges 12 years+ - NCT06585605Recruiting
Study of epilepsy and movement disorder genes in children
This study looks at children with epilepsy and movement disorders to better understand the genes involved. It aims to help doctors recognize and treat these conditions more effectively.
Boston, MassachusettsAges birth–18 years - NCT06388174Recruiting
Idiopathic Generalized Epilepsy Study
This study is looking at people with a specific type of epilepsy called idiopathic generalized epilepsy (IGE). The goal is to collect health information and use a 24-hour brain wave test to learn more about the condition.
Hangzhou, ZhejiangAges 4–40 - NCT06425029Recruiting
Music app therapy for hard-to-control epilepsy with RNS
This study is testing a music-based app that you can use at home to help treat seizures. It is for adults with focal epilepsy who already have an RNS device and whose seizures are not controlled by medication.
Worcester, MassachusettsAges 18 years+ - NCT06388707RecruitingPhase 1/Phase 2
Ultrasound therapy for drug-resistant temporal lobe epilepsy
This study tests if a new, non-invasive ultrasound treatment can safely reduce seizures in people whose seizures start in the temporal lobe and have not been controlled by at least two anti-epileptic drugs. The ultrasound is delivered through the scalp to gently stimulate the brain area where the seizures begin.
Palo Alto, CaliforniaAges 18 years+ - NCT06108102Enrolling by invitation
Post-stroke epilepsy research database study
This trial is creating a global research database to learn more about seizures that happen after a stroke. By joining, you help doctors better understand who gets these seizures and how to treat them.
New Haven, ConnecticutAges 18 years+ - NCT06052605Recruiting
Healthy aging study for older adults with epilepsy
This study looks at healthy aging in people with epilepsy. You will fill out a survey to help researchers understand your experiences and needs.
Cleveland, OhioAges 55–90 - NCT05947656Recruiting
NaviFUS treatment for drug-resistant temporal lobe seizures
This trial tests the NaviFUS system to treat seizures that keep happening despite seizure medicines, specifically in people with temporal lobe epilepsy. If you qualify, you would be carefully checked before and during the study, including seizure tracking and brain scans, to see whether treatment helps reduce seizures.
Melbourne, VictoriaAges 18 years+ - NCT05864547Recruiting
Study risk factors for seizures after a first stroke
This study looks at what factors can make seizures happen after a first stroke. It may help doctors identify who is more at risk so future care can be better targeted.
TrondheimAges 18–85 - NCT03865771Recruiting
Sleep study to improve memory in children with focal epilepsy
This study looks at how sleep affects memory in children with certain types of age-related focal epilepsy. It compares them to children hospitalized for non-nerve (non-neurologic) reasons to see whether sleep-related brain patterns relate to learning and memory.
NancyAges 6–13 - NCT05673915Recruiting
Brain stimulation study for hard-to-control epilepsy
This trial tests whether noninvasive brain stimulation (using gentle electrical current through the scalp) can reduce seizures in people with epilepsy that has not responded to at least two anti-seizure medicines. If you qualify, you’d also be asked to keep track of seizures in a diary during the study.
Rochester, MinnesotaAges 6 years+ - NCT05135091RecruitingPhase 3
Cell therapy trial for hard-to-control one-sided temporal lobe epilepsy
This Phase 3 study tests a neural cell therapy (NRTX-1001) for adults whose seizures come from one side of the hippocampus and have not improved with standard seizure medicines. The goal is to reduce seizure frequency and improve seizure control where other treatments have not worked.
Birmingham, AlabamaAges 18–75 - NCT04649008RecruitingEarly Phase 1
MRI and brain electrodes to map epilepsy areas
This early study looks at how MRI scans and implanted brain electrodes (intracranial EEG) can pinpoint where seizures start, especially in the temporal (side) lobe. It may help doctors better localize seizure sources for people whose seizures don’t respond well to medications.
Philadelphia, PennsylvaniaAges 18 years+
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Common questions
- Are there clinical trials for epilepsy?
- Yes. Clin2 currently lists 325 recruiting epilepsy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a epilepsy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a epilepsy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.