Clinical trials
Epilepsy clinical trials
Below are recruiting epilepsy clinical trials, each written for real people, not researchers. We’re tracking 339 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07353918Enrolling by invitation
Focused ultrasound for epilepsy treatment
This study tests if low-intensity focused ultrasound can calm overactive brain areas in people with epilepsy. It may offer a new way to reduce seizures without surgery or strong medications.
Roanoke, VirginiaAges 18–85 - NCT06108102Enrolling by invitation
Post-stroke epilepsy research database study
This trial is creating a global research database to learn more about seizures that happen after a stroke. By joining, you help doctors better understand who gets these seizures and how to treat them.
New Haven, ConnecticutAges 18 years+ - NCT07563881RecruitingPhase 3
Testing RAP-219 for Focal Seizure Control in Adults
This study tests whether a new medication called RAP-219 can help adults with focal seizures (seizures that start in one area of the brain) control their seizures better. You would take this medication alongside your current seizure drugs for about 12 weeks.
Palmdale, CaliforniaAges 18–75 - NCT07656857Recruiting
Flexible brain sensor study for epilepsy surgery
This trial tests a new flexible brain sensor to help guide surgery for people with drug-resistant focal epilepsy. It aims to find exactly where seizures start so surgeons can remove that area safely.
Beijing, Beijing MunicipalityAges 3–60 - NCT07600736RecruitingPhase 2
Safety study of ABS-1230 for children with KCNT1 epilepsy
This trial tests a new drug called ABS-1230 in children and young adults with KCNT1-related epilepsy, a rare genetic form of epilepsy. The study will check if the drug is safe and if it helps reduce seizures.
Hackensack, New JerseyAges 1 month–21 years - NCT07640191Recruiting
New Nerve Stimulation Device for Hard-to-Treat Epilepsy
This study tests a new implanted device that stimulates the vagus nerve (a major nerve in your neck) to help reduce seizures in people whose epilepsy doesn't respond well to medications. The device is surgically placed under the skin and may help lower how often you have seizures.
South Brisbane, QueenslandAges 4–75 - NCT05885646Recruiting
Sulthiame study using sleep EEG in children with epilepsy
This trial tests whether sulthiame changes sleep-related brain wave activity (EEG) in children with certain epilepsy syndromes. It may help doctors understand how sulthiame affects the brain’s electrical patterns between seizures.
AngersAges 6–15 - NCT04253379Recruiting
Study of social understanding in children with epilepsy
This study looks at how children with epilepsy understand social cues, compared with other children the same age. You may be asked to complete simple thinking and social tasks to see what differences exist and what they might mean.
ReimsAges 6–12 - NCT06022055Recruiting
studying brain tissue from epilepsy surgery
This study collects brain tissue from people with epilepsy that is not controlled by medication, during their planned surgery. Researchers will study the tissue to better understand epilepsy and improve treatments.
ParisAges 18 years+ - NCT06521437Enrolling by invitation
How the brain's memory center works in epilepsy
This study looks at how the hippocampus (a part of the brain important for memory) works in people with epilepsy. If you have a hard-to-treat type of epilepsy called MTLE, this research may help doctors understand memory and brain function better.
Chicago, IllinoisAges 18 years+ - NCT05608408Recruiting
Preserving Memory in People With Epilepsy Using Brain Stimulation
This study tests a type of brain stimulation in people with epilepsy to see if it can help preserve memory. Researchers will compare memory and brain effects over time to understand whether stimulation changes memory outcomes.
Rochester, MinnesotaAges 18–65 - NCT06271785Recruiting
Predicting success of epilepsy surgery in children
This study uses a special, detailed brain-mapping technique (called high-resolution electrical source imaging) to see how well it can predict success after epilepsy surgery in children. It aims to help doctors decide which children might benefit most from surgery.
AngersAges 2–17 - NCT07594119RecruitingPhase 3
Testing RAP-219 to reduce seizures in focal epilepsy
This study tests a new medication called RAP-219 to see if it can reduce seizure frequency in adults with focal epilepsy (seizures starting in one area of the brain). You'll take the medication alongside your current seizure drugs and track your seizures daily using an app.
Bentonville, ArkansasAges 18–75 - NCT07287163Enrolling by invitationPhase 3
Long-term study of vormatrigine for epilepsy
This trial is for adults with epilepsy who have already taken vormatrigine in a previous study or through a special access program. It aims to collect ongoing safety and effectiveness information.
Miami, FloridaAges 18–85 - NCT07271966Recruiting
Vitamin B6 for Keppra side effects in brain tumor patients
This trial tests whether vitamin B6 can help reduce mood and behavior side effects of levetiracetam (Keppra) in people with brain tumors and seizures. If you're taking Keppra and feeling down or distressed, this study might offer a way to feel better.
Durham, North CarolinaAges 18 years+ - NCT07147309Recruiting
PET scans for epilepsy surgery planning
This trial tests three types of PET scans to help doctors exactly locate the part of the brain causing seizures before surgery. It's for people with epilepsy that isn't controlled by medication and who are already planning surgery or an SEEG.
Fuzhou, FujianAges 18–50 - NCT03268824Recruiting
Brain imaging study in drug-resistant focal epilepsy
This study uses MRI brain scans to see how “epileptic discharges” may affect brain connections in the developing brain. It also scans comparison participants without drug-resistant focal epilepsy to help researchers understand what is different.
ParisAges 1.5 years–16 years - NCT03400371Recruiting
Study of brain signals in juvenile myoclonic epilepsy
This study looks at EEG brain recordings in people with juvenile myoclonic epilepsy, especially those whose seizures started between ages 10 and 25. It may help researchers better understand how this epilepsy works and improve future care.
New York, New YorkAges 10–40 - NCT03644732Recruiting
Study of brain activity during epilepsy testing using SEEG
This study maps how thinking and memory work by recording brain signals during a presurgical epilepsy workup. It may help doctors better understand drug-resistant focal epilepsy and improve how they plan treatment.
GrenobleAges 18–65 - NCT03738072Recruiting
Test of brain electrical stimulation to plan epilepsy surgery
This study looks at how using a mild electrical stimulation in the brain may help doctors plan surgery for people with drug-resistant focal (partial) epilepsy. It happens during a hospital procedure to map the seizure areas (SEEG), so it may help improve where surgery targets.
ToulouseAges 12–65 - NCT03868293Recruiting
Low-intensity ultrasound for drug-resistant temporal lobe seizures
This pilot study tests whether low-intensity focused ultrasound can reduce seizures in adults whose temporal lobe epilepsy hasn’t improved with at least two anti-seizure medicines. You may be asked to track seizure timing and undergo brain imaging before and during the study.
Boston, MassachusettsAges 18 years+ - NCT04076449Recruiting
MRI measurements for epilepsy from a single brain blood vessel lump
This study uses special MRI scans to measure brain changes in people whose seizures are related to one cerebral cavernous malformation (a type of abnormal blood vessel in the brain). It aims to find a measurable “biomarker” from MRI that may help understand the epilepsy and the brain structure around it.
Beijing, Beijing MunicipalityAges 18–70 - NCT04126369Recruiting
Mindfulness program to improve quality of life in drug-resistant epilepsy
This trial tests whether a mindfulness training program can improve quality of life for people with drug-resistant epilepsy. It looks at whether learning mindfulness skills helps you cope day-to-day alongside your usual treatment.
GrenobleAges 18 years+ - NCT04144439RecruitingPhase 4
GABA treatment for ADHD and seizures in children with epilepsy
This trial studies whether adding GABA (a substance that affects brain signaling) can help children who have both epilepsy (seizures) and ADHD. If it works, it may reduce symptoms related to either seizures, ADHD, or both.
TantaAges 4–18
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Common questions
- Are there clinical trials for epilepsy?
- Yes. Clin2 currently lists 339 recruiting epilepsy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a epilepsy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a epilepsy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.