Clinical trials
Epilepsy clinical trials
Below are recruiting epilepsy clinical trials, each written for real people, not researchers. We’re tracking 339 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05944692Recruiting
Tripolar EEG test during seizure monitoring
This study checks whether a new type of EEG recording (a brain wave test) can detect seizure activity in people with epilepsy. You may join if you are already scheduled for routine and video EEG testing (and possibly inpatient monitoring) as part of your clinical care, including a brain MRI.
Phoenix, ArizonaAges 6 years+ - NCT05992402Recruiting
Brain training program for epilepsy surgery readiness
This study tests a cognitive training program called ReBOOT for adults with epilepsy who are eligible for surgery. The program is done online and aims to improve brain function before surgery.
Cleveland, OhioAges 18–60 - NCT06053671Recruiting
Understanding genetics in focal epilepsy brain tissue
This study is looking at brain tissue from people with a specific type of epilepsy (Focal Cortical Dysplasia Type II). The goal is to understand what causes the seizures and how they develop, which may help improve future treatments.
LondonAges Any age - NCT06063850RecruitingPhase 1/Phase 2
Gene therapy for adults with hard-to-control epilepsy
This trial tests a one-time gene therapy (AMT-260) for adults whose seizures start in one area of the brain (the temporal lobe) and aren't controlled by medication. The goal is to see if it's safe and reduces seizure frequency.
Birmingham, AlabamaAges 18–75 - NCT06075485Recruiting
Ketogenic diet for drug-resistant epilepsy in children
This study looks at how well the ketogenic diet (a high-fat, low-carb diet) works for children with epilepsy that doesn't improve with standard medicines. It uses a special product called KetoCal to help maintain the diet and tracks results in real life.
LilleAges 5 months–18 years - NCT06097195Recruiting
EEG test to help diagnose epilepsy after a first seizure
This trial studies a new way of analyzing EEG results to help doctors decide if a first suspected seizure was caused by epilepsy. If you had a first seizure and your EEG did not show clear signs of epilepsy, this test might improve your diagnosis.
TruroAges 18 years+ - NCT06105645Recruiting
Brain wave study for hard-to-treat epilepsy surgery
This study looks at special brain wave patterns called "fast-ripples" to help doctors better plan surgery for epilepsy that doesn't get better with medicine. It may improve how surgeons decide where to operate.
AmiensAges 18–65 - NCT06132893RecruitingPhase 2/Phase 3
Testing BHV-7000 for hard-to-control focal seizures in adults
This study tests a new medicine called BHV-7000 for adults whose focal seizures (starting in one part of the brain) are not controlled by current treatments. The goal is to see if it can reduce seizures safely.
Phoenix, ArizonaAges 18–75 - NCT06205160Recruiting
Flexible brain electrodes for epilepsy surgery
This trial is testing new flexible brain electrodes during epilepsy surgery. These electrodes may help doctors map brain activity better than standard rigid ones. If you are having surgery for epilepsy caused by a brain lesion, you might be able to join.
UtrechtAges 18 years+ - NCT06212609Recruiting
Personalized brain stimulation for kids with hard-to-control epilepsy
This trial tests a personalized brain stimulation method (transcranial electrical stimulation) to reduce seizures in children with hard-to-control partial epilepsy. It aims to find the best stimulation spot and settings for each patient by using advanced brain scans.
AmiensAges 1–18 - NCT06241963Recruiting
Brain stimulation for hard-to-treat epilepsy
This study tests a new type of gentle brain stimulation (HD-tDCS) to see if it can reduce seizures in people with epilepsy that does not get better with standard medicines. The treatment uses a small device to send a weak electrical current to specific areas of the brain.
Hefei, AnhuiAges 18–50 - NCT06248333Recruiting
Deep brain stimulation for focal motor epilepsy
This trial tests whether deep brain stimulation of a small area in the brain can help reduce seizures that start in the motor part of the brain and do not respond to medication. It may be an option for people who cannot have surgery or whose surgery did not help enough.
Beijing, Beijing MunicipalityAges 14–65 - NCT06262594RecruitingPhase 3
Testing a sleep medicine for epilepsy-related insomnia
This study tests a new sleep medicine called lemborexant for people with epilepsy whose seizures happen during sleep and who also have trouble sleeping. The goal is to see if the medicine can help you sleep better without making your seizures worse.
Durham, North CarolinaAges 18 years+ - NCT06263920Recruiting
Study on late-onset epilepsy and its links
This study looks at people who had their first seizure or were diagnosed with epilepsy after age 18, and compares them to people with migraine. The goal is to understand what might be connected to epilepsy that starts later in life.
Preston, LancashireAges 18 years+ - NCT06280092RecruitingEarly Phase 1
Stem cells plus brain stimulation for epilepsy
This trial is testing if injecting stem cells from a donor during deep brain stimulation (DBS) surgery can help control seizures better than DBS alone. It is for adults with epilepsy that does not respond to medicines.
Jacksonville, FloridaAges 18–75 - NCT06304389Recruiting
Blue light therapy for epilepsy with vagus nerve stimulation
This trial tests if blue light exposure can improve the effects of vagus nerve stimulation (VNS) in people with epilepsy that is hard to control. It also includes some healthy volunteers for comparison. The goal is to find new ways to make VNS work better.
Woluwe-Saint-LambertAges 18–60 - NCT06321822Recruiting
Genetic diagnosis and personalized medicine for epilepsy patients
This study aims to find genetic causes of epilepsy and use that information to personalize your care. It involves analyzing your DNA to look for gene changes that may be linked to your seizures.
MilanAges Any age - NCT06401538RecruitingPhase 2
BMB-101 for absence epilepsy and DEE
This trial tests a new drug called BMB-101 for people with absence epilepsy (including Jeavons syndrome) or developmental epileptic encephalopathies (DEE) like Dravet or Lennox-Gastaut. It aims to see if the drug can reduce seizure frequency and is safe.
Randwick, New South WalesAges 18–65 - NCT06334029Recruiting
Observing brain connections in epilepsy
This study is observing how the brain's connections and activity work in people with epilepsy. It uses MRI scans and EEG recordings to learn more about the condition, which may help improve future treatments.
Conegliano, TrevisoAges 6–65 - NCT06334952Recruiting
Personalized brain stimulation for hard-to-treat epilepsy
This study tests a personalized, non-invasive brain stimulation method called tDCS for people with drug-resistant epilepsy that starts in one part of the brain. It aims to reduce seizures in those who cannot have surgery or have not been helped by surgery.
BordeauxAges 9 years+ - NCT06422923RecruitingPhase 1/Phase 2
Cell therapy for hard-to-treat epilepsy starting in both temporal lobes
This trial tests a new cell therapy (NRTX-1001) for people with epilepsy that starts in both sides of the brain's temporal lobes and doesn't get better with medication. It aims to reduce or stop seizures.
Little Rock, ArkansasAges 18–75 - NCT06444126Recruiting
Study of fever seizures coming back and epilepsy risk
This study follows children who had their first seizure with a fever to see how often seizures come back and if they develop epilepsy. It helps doctors understand which children need extra monitoring.
Ho Chi Minh CityAges 1 month–8 years - NCT06466681Recruiting
Attention changes after a seizure in epilepsy
This study looks at how attention and concentration change right after a seizure in people with epilepsy. It uses a short hospital stay to track these changes, which may help improve understanding and future treatment.
LilleAges 18–80 - NCT06483061RecruitingPhase 2
Enhanced MRI Study for Epilepsy and Healthy Volunteers
This study tests whether a special MRI contrast agent (Ferumoxytol) can improve brain imaging in healthy people and people with temporal lobe epilepsy. It may help doctors see more detail in the brain.
Edmonton, AlbertaAges 18–64
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Common questions
- Are there clinical trials for epilepsy?
- Yes. Clin2 currently lists 339 recruiting epilepsy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a epilepsy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a epilepsy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.