Clinical trials
Epilepsy clinical trials
Below are recruiting epilepsy clinical trials, each written for real people, not researchers. We’re tracking 328 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05845255Recruiting
Test wearable monitoring for epilepsy quality of life and safety
This study tests a wearable device that records seizure-related information to understand how epilepsy affects daily life and safety. It may help your care team better track seizures in real-world settings and understand quality-of-life changes.
KorkAges 12–65 - NCT06053671Recruiting
Understanding genetics in focal epilepsy brain tissue
This study is looking at brain tissue from people with a specific type of epilepsy (Focal Cortical Dysplasia Type II). The goal is to understand what causes the seizures and how they develop, which may help improve future treatments.
LondonAges Any age - NCT07663240Enrolling by invitation
Program to help women with epilepsy reduce ER visits
This study is for Black or Hispanic women with epilepsy who often go to the emergency room for seizures. It aims to help reduce ER visits by connecting you with better follow-up care and support.
Atlanta, GeorgiaAges 18 years+ - NCT07656857Recruiting
Flexible brain sensor study for epilepsy surgery
This trial tests a new flexible brain sensor to help guide surgery for people with drug-resistant focal epilepsy. It aims to find exactly where seizures start so surgeons can remove that area safely.
Beijing, Beijing MunicipalityAges 3–60 - NCT07651709Recruiting
Bone Health During Pregnancy in Women With Epilepsy
This study looks at how epilepsy and epilepsy medications affect bone health during pregnancy and after delivery. Researchers want to understand how to keep bones strong while you're pregnant and taking seizure medications, which can sometimes weaken bones.
ZhejiangAges 18 years+ - NCT07640191Recruiting
New Nerve Stimulation Device for Hard-to-Treat Epilepsy
This study tests a new implanted device that stimulates the vagus nerve (a major nerve in your neck) to help reduce seizures in people whose epilepsy doesn't respond well to medications. The device is surgically placed under the skin and may help lower how often you have seizures.
Herston, QueenslandAges 4–75 - NCT05670847RecruitingPhase 2/Phase 3
Ketone drinks for drug-resistant epilepsy
This trial tests whether taking “ketone ester” supplements can reduce seizures in people with drug-resistant epilepsy. It may help by changing how the brain uses energy, but you must meet several safety and diet-related conditions.
SohagAges 1–16 - NCT07599150Recruiting
Brain mapping study for epilepsy and breathing patterns
This research studies how the brain controls breathing in people with drug-resistant epilepsy. Researchers use special electrodes placed in your brain during surgery to map these connections and better understand seizures.
Bron, RhoneAges 18–55 - NCT07592676Recruiting
Moving from pediatric to adult epilepsy care
This study looks at how young people with epilepsy transition from pediatric (children's) specialists to adult neurologists. Researchers want to understand what helps or challenges this transition to improve the care experience.
RomaAges 15 years+ - NCT07588971Recruiting
Understanding childhood epilepsy outcomes and long-term patterns
This study tracks children with epilepsy to understand how different types progress over time and what factors affect their outcomes. By learning more about your child's epilepsy journey, researchers hope to improve how doctors predict and manage the condition.
RomeAges Up to 18 years - NCT02846272Recruiting
Brain scans in children with hard-to-treat epilepsy
This study uses special brain imaging to look at how brain cells and networks work in children with intractable, or hard-to-treat, epilepsy. The goal is to connect the scan findings with what’s found in clinical evaluation to better understand the condition.
Houston, TexasAges birth–18 years - NCT07563881RecruitingPhase 3
Testing RAP-219 for Focal Seizure Control in Adults
This study tests whether a new medication called RAP-219 can help adults with focal seizures (seizures that start in one area of the brain) control their seizures better. You would take this medication alongside your current seizure drugs for about 12 weeks.
Palmdale, CaliforniaAges 18–75 - NCT06719791RecruitingEarly Phase 1
Sirolimus for hard-to-treat focal epilepsy
This trial tests if the drug sirolimus can help people with focal seizures (starting in one part of the brain) that don't improve with at least two other medications. It aims to reduce seizure frequency in adults aged 18 to 60.
BeijingAges 18–60 - NCT07509190Recruiting
Helping patients learn about epilepsy surgery
This study aims to improve access to epilepsy surgery by educating patients about social factors that affect health. It includes surveys and focus groups for people with epilepsy who have undergone surgery evaluation at Cleveland Clinic.
Cleveland, OhioAges 18 years+ - NCT07509177Recruiting
Infrared light therapy for stress in epilepsy
This trial tests if infrared light therapy can help reduce stress in people with epilepsy. You would wear a ring to track your sleep and activity, and attend 45 light therapy sessions over several months.
North Miami, FloridaAges 18 years+ - NCT06695767Recruiting
Behavioral therapy for epilepsy and depression in veterans
This trial tests a special therapy program for veterans who have both epilepsy and major depression. It uses talk therapy and text message support to help improve mood and seizure control.
Houston, TexasAges 18 years+ - NCT07490769RecruitingPhase 3
Taking levetiracetam three times daily for epilepsy
This trial is for adults with uncontrolled epilepsy who have been taking a high dose of Levetiracetam alone for at least a year. It tests whether taking Levetiracetam three times a day works better than the usual schedule.
Riyadh, Riyadh RegionAges 18 years+ - NCT07474285Enrolling by invitation
Cenobamate for autoimmune epilepsy
This trial tests whether a new seizure medicine (cenobamate) helps people whose seizures are caused by an overactive immune system. You would stay on your current treatments and add cenobamate to see if it reduces seizures.
Rome, LazioAges 18 years+ - NCT06782074Recruiting
Epilepsy's impact on thinking and emotions in teens
This study looks at how idiopathic generalized epilepsy affects thinking skills and emotions in adolescents aged 11 to 18. It aims to better understand these effects to improve care.
PaviaAges 11–17 - NCT05632978Recruiting
Study of epilepsy using real-world patient data
This is an observational study that looks at how epilepsy is diagnosed and how people do over time, using information from routine care. It may help doctors better understand epilepsy biology and outcomes using real-world data.
CardiffAges 16 years+ - NCT06262594RecruitingPhase 3
Testing a sleep medicine for epilepsy-related insomnia
This study tests a new sleep medicine called lemborexant for people with epilepsy whose seizures happen during sleep and who also have trouble sleeping. The goal is to see if the medicine can help you sleep better without making your seizures worse.
Durham, North CarolinaAges 18 years+ - NCT07363603RecruitingPhase 1/Phase 2
Tianasen for GNAO1-related epilepsy and movement disorders
This trial tests a new drug called Tianasen for children with a specific GNAO1 gene change who have seizures and movement problems that haven't improved with standard treatments. The drug is given via a lumbar puncture (spinal tap) and aims to reduce symptoms.
MoscowAges 1–14 - NCT07350551Recruiting
Brain activity study for epilepsy surgery planning
This study looks at how the brain works during epilepsy monitoring to help doctors better plan surgery. If you join, you'll do simple tasks on a computer while doctors record your brain activity.
Dallas, TexasAges 3–25 - NCT06863350Recruiting
Closing a heart hole to treat drug-resistant epilepsy
This trial tests if closing a small hole in the heart (called a PFO) can reduce seizures in people whose epilepsy isn't controlled by medication. It might offer a new treatment option for those who have both drug-resistant epilepsy and this heart condition.
Chengdu, SichuanAges 18–60
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Common questions
- Are there clinical trials for epilepsy?
- Yes. Clin2 currently lists 328 recruiting epilepsy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a epilepsy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a epilepsy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.