Clinical trials
Epilepsy clinical trials
Below are recruiting epilepsy clinical trials, each written for real people, not researchers. We’re tracking 339 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04419272RecruitingPhase 4
Methylphenidate for thinking problems in adults with focal seizures
This trial studies whether methylphenidate (a stimulant medicine) can improve thinking and memory problems related to epilepsy. You may be kept on your usual seizure medicines, and your thinking will be tested over about 16 weeks.
Miami, FloridaAges 18 years+ - NCT04451278Recruiting
Brain scan study to predict outcomes after epilepsy surgery in kids
This trial uses resting-state brain MRI (a scan while you’re not doing a task) to help predict how well children with hard-to-treat epilepsy may do after surgery. If you qualify, you would help researchers see whether the scan can forecast prognosis.
Paris, PARISAges 6–18 - NCT06202196Recruiting
Epilepsy education program for uncontrolled seizures
This study tests a program that teaches people with hard-to-control epilepsy how to better manage their condition. If you have seizures that continue despite treatment, or have been seizure-free for over a year but could use more support, this program may help you learn skills to improve your daily life.
MontpellierAges 18–60 - NCT04945213RecruitingPhase 3
Biperiden to prevent seizures after traumatic brain injury
This trial tests whether biperiden can lower the chance of developing epilepsy after an acute traumatic brain injury (with bleeding or bruising seen on CT). If you qualify, you would get the medicine or a placebo soon after the injury, and researchers will compare outcomes.
Fortaleza, CearáAges 18–75 - NCT04986683Recruiting
MRI study to reduce brain deficits after pediatric epilepsy surgery
This study uses special MRI pictures to better plan epilepsy surgery and help lower the chance of new brain problems after surgery. It includes children and teens with drug-resistant focal epilepsy who are having a two-stage surgery with brain surface electrodes.
Detroit, MichiganAges 3–19 - NCT05082181Recruiting
Phone group support for adults with epilepsy and depression
This study tests whether telephone-based group support helps adults with epilepsy who also have elevated depressive symptoms. Sessions are recorded, and you’ll join by phone in English or Spanish.
New York, New YorkAges 18–99 - NCT05100771Recruiting
MRI study for kids with focal epilepsy
This trial studies how to make MRI images better for children with epilepsy that starts in one area of the brain. It may help doctors use brain MRI more effectively when evaluating where seizures begin.
AngersAges 1–18 - NCT05104983RecruitingPhase 2
Sirolimus to prevent first seizures in babies with TSC
This Phase 2 study tests whether sirolimus (a targeted medicine) can stop or slow the start of seizures in very young babies diagnosed with tuberous sclerosis complex (TSC). If seizures are prevented early, it may also help protect early brain development.
Birmingham, AlabamaAges 1 day–6 months - NCT05290610Recruiting
Brain stimulation mapping during epilepsy surgery planning
This study uses a special kind of brain recording with stimulation to better map seizure activity while you are already having monitoring for epilepsy surgery. It may help doctors understand how to plan safer, more effective treatment.
Minneapolis, MinnesotaAges 18 years+ - NCT05307146Recruiting
Brain activity study during treatment for epilepsy
This study measures brain activity in people with epilepsy while doctors place temporary electrodes inside the brain. It may help researchers better understand seizures and how to improve treatment.
LeuvenAges 18–90 - NCT05335187Recruiting
Electrode test during epilepsy surgery planning
This study tests a new “hybrid” type of electrodes placed inside the brain to better map where seizures start in people with difficult (drug-resistant) focal epilepsy. It may help doctors plan safer and more effective surgery, though it involves an invasive brain monitoring procedure.
Bern, Canton of BernAges 18 years+ - NCT05450822Recruiting
Personalized testing to guide treatment for epilepsy
This trial uses detailed brain tests to better match people with epilepsy to the right treatment. It may help by using “precision medicine” methods to understand what in the brain is driving seizures.
CopenhagenAges 16–55 - NCT05485649Recruiting
Pregnant people with epilepsy followed at a Toronto clinic
This study follows pregnant people who have epilepsy who were seen at a specific Toronto epilepsy clinic over a set time period. It aims to learn about health outcomes during pregnancy, which may help improve care and planning for future patients.
Toronto, OntarioAges Any age - NCT05493722RecruitingEarly Phase 1
Adjusting deep brain stimulator settings for hard-to-control seizures
This early-phase study tests whether changing your deep brain stimulator settings can improve seizure control in people whose epilepsy is not helped by usual treatments. It is mainly for patients who already have the stimulator placed.
Minneapolis, MinnesotaAges 18 years+ - NCT05503290Recruiting
Music sessions for pregnant people with epilepsy
This trial tests whether a guided music program (called “The Lullaby Project”) can be helpful during pregnancy for people with epilepsy. It focuses on participating in online musical sessions while you’re pregnant.
Toronto, OntarioAges 18 years+ - NCT05518578RecruitingPhase 2
Drug trial for hard-to-control focal epilepsy with brain scar
This Phase 2 trial tests SPN-817 in adults whose seizures are still not well controlled despite trying multiple seizure medicines. It targets people with a specific type of brain finding called focal cortical dysplasia and looks at safety/tolerability and seizure outcomes over several weeks.
Jacksonville, FloridaAges 18–70 - NCT05524493Recruiting
Brain scans for migraine, visual snow, or epilepsy symptoms
This study uses a very strong MRI brain scanner to better understand conditions like migraine, visual snow, or epilepsy that don’t fully respond to treatment. You may be able to join if you meet specific diagnosis and safety requirements for the scanner.
ZurichAges 18–65 - NCT05559749Recruiting
Support program for anxiety and depression in people with epilepsy
This study tests a “collaborative care” program to help reduce anxiety and depression symptoms in adults with epilepsy. You would answer questionnaires and work with a care team, and the study is designed to see how well this approach can help over time.
Winston-Salem, North CarolinaAges 18 years+ - NCT05632978Recruiting
Study of epilepsy using real-world patient data
This is an observational study that looks at how epilepsy is diagnosed and how people do over time, using information from routine care. It may help doctors better understand epilepsy biology and outcomes using real-world data.
CardiffAges 16 years+ - NCT05637086RecruitingPhase 2
Test pentoxifylline plus celecoxib for grand mal epilepsy on phenytoin
This Phase 2 study tests whether adding two medicines—pentoxifylline and celecoxib—to current phenytoin treatment is safe and may help people with grand mal (generalized) epilepsy. It focuses mainly on safety while you stay on a single epilepsy medicine.
Al MansurahAges 18–75 - NCT05670847RecruitingPhase 2/Phase 3
Ketone drinks for drug-resistant epilepsy
This trial tests whether taking “ketone ester” supplements can reduce seizures in people with drug-resistant epilepsy. It may help by changing how the brain uses energy, but you must meet several safety and diet-related conditions.
SohagAges 1–16 - NCT05751525Recruiting
Oral sulfonylurea study for children with KCNJ11-related delay and epilepsy
This study looks at whether switching to an oral sulfonylurea medicine can improve thinking, development, and seizure-related outcomes in children with a specific KCNJ11 gene change. You may be able to join if your child already has this mutation and has been able to take the medicine by mouth.
Chicago, IllinoisAges 2–50 - NCT05794295Recruiting
Sleep study in people with focal epilepsy
This trial studies how sleep patterns relate to thinking and memory in people with focal epilepsy. It may help researchers understand what sleep changes could support brain function in epilepsy.
Sacramento, CaliforniaAges 18–40 - NCT05845255Recruiting
Test wearable monitoring for epilepsy quality of life and safety
This study tests a wearable device that records seizure-related information to understand how epilepsy affects daily life and safety. It may help your care team better track seizures in real-world settings and understand quality-of-life changes.
KorkAges 12–65
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Common questions
- Are there clinical trials for epilepsy?
- Yes. Clin2 currently lists 339 recruiting epilepsy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a epilepsy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a epilepsy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.