Clinical trials
GERD clinical trials
Below are recruiting gerd clinical trials, each written for real people, not researchers. We’re tracking 54 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07252115Recruiting
Comparing two surgeries for hiatal hernia and stubborn GERD
This trial compares two surgical approaches (a 'partial wrap' and a 'full wrap' of the stomach around the esophagus) to fix a hiatal hernia and treat severe, hard-to-control reflux (GERD). It may be a good option if your reflux hasn't improved with medication and you have a hiatal hernia.
BeijingAges 18–85 - NCT07227506Recruiting
Mucosal impedance testing for chronic esophagus issues
This trial uses a special device during an upper endoscopy to measure the electrical properties of the esophagus lining, which may help diagnose chronic reflux or swallowing problems.
Milwaukee, WisconsinAges 18 years+ - NCT07158008Recruiting
Weight loss surgery for people with obesity and heartburn
This study compares two weight-loss surgeries for people who have both obesity and severe heartburn or GERD. One surgery combines part of the stomach removal with an anti-reflux wrap, while the other reroutes the stomach to help with weight loss and reflux.
KrakowAges 18–65 - NCT07121803Recruiting
Special ice cream for esophagus health in diabetes
This study tests whether a special ice cream can help the esophagus (the tube that carries food to your stomach) work better in people with type 2 diabetes. Researchers want to see if the ice cream can improve how food moves down the esophagus.
MoscowAges 18–80 - NCT07125521Recruiting
Smartphone app study for GERD medication adherence
This study tests whether using a smartphone app called GERDCare helps people with GERD take their medications as prescribed. It may be a good fit if you have typical GERD symptoms like heartburn or regurgitation and are comfortable using a smartphone app.
HanoiAges 18 years+ - NCT07063576RecruitingPhase 2/Phase 3
Baclofen for persistent heartburn or regurgitation
This trial tests whether the drug baclofen can help patients who still have acid reflux symptoms (heartburn or regurgitation) despite taking standard treatments like PPIs for 8 weeks. If you've tried PPIs and still have symptoms, this may be an option.
DhakaAges 18 years+ - NCT04901429Recruiting
Check truncal nerve procedure during weight-loss surgery
This study looks at a nerve-related surgical step (“truncal vagotomy”) during revision weight-loss surgery that changes a sleeve stomach to a gastric bypass. It may help improve outcomes for people who need this type of second surgery.
Dallas, TexasAges 18 years+ - NCT06999577RecruitingPhase 4
The Mechanism Versus PPI Trial for throat reflux
This study tests how well omeprazole (a common acid-blocking medicine) works for people with laryngopharyngeal reflux (LPR), a condition where stomach acid irritates the throat. If you have had throat symptoms for more than 8 weeks and are already scheduled for an endoscopy with acid monitoring, you may qualify to see if this medicine helps more than a placebo.
San Deigo, CaliforniaAges 18–89 - NCT06984484Recruiting
Afluxin for GERD: safety and performance study
This trial tests a new treatment called Afluxin for people with gastroesophageal reflux disease (GERD), which causes heartburn and regurgitation. It aims to see if Afluxin is safe and works better than a placebo (inactive control) to relieve symptoms.
GenovaAges 18–75 - NCT04422405Recruiting
One-anastomosis stomach bypass study for reflux and stomach changes
This study looks at how a one-anastomosis gastric bypass changes how your stomach and esophagus work, especially relating to acid reflux. You may be offered the planned surgery if you fit the weight and heartburn/reflux-related conditions, and the team will measure changes before and after.
Schlieren, Canton of ZurichAges 18–65 - NCT06928350Recruiting
Normal esophagus readings in healthy Indian adults
This trial is studying normal acid and fluid movement in the esophagus of healthy people in India. It will help doctors better understand what is typical, which may improve care for people with acid reflux or other swallowing issues.
Hyderabad, TelanganaAges 18–50 - NCT06953986Recruiting
Comparing three medicines for severe acid reflux healing
This trial tests vonaprazan (two doses) against esomeprazole to see which better heals moderate-to-severe reflux esophagitis (a damaged esophagus from acid reflux) in 8 weeks. You may qualify if you have had heartburn or regurgitation for at least a month and your doctor found grade B, C, or D damage on an endoscopy.
Hyderabad, TelanganaAges 18–75 - NCT06955520Recruiting
Comparing two heartburn drugs after POEM surgery
This study compares two medications—vonoprazan and esomeprazole—to see which one heals acid reflux-related damage in the esophagus better after POEM surgery for achalasia. If you have had POEM and now have heartburn and moderate to severe esophagitis, this trial may help find the best treatment for you.
Hyderabad, TelanganaAges 18–75 - NCT06939465Recruiting
Cognitive therapy for throat and chest symptoms
This trial tests if a cognitive-behavioral therapy (a type of talk therapy that helps change thoughts and habits) can improve chronic throat and chest symptoms like heartburn, reflux, lump in throat, or trouble swallowing. It is for people who have these symptoms without a known structural problem in the esophagus.
Hualien CityAges 18–75 - NCT06783751Recruiting
New surgical method to reduce acid reflux after weight loss surgery
This trial tests a modified version of sleeve gastrectomy that aims to reduce the risk of acid reflux (GERD) after surgery. It is for people aged 18–65 with a BMI between 35 and 55 who already have some degree of GERD and are planning to have weight loss surgery.
Orange, CaliforniaAges 18–65 - NCT06778824Recruiting
Brain-gut medicine trial for chronic esophagus issues
This trial tests a type of brain-gut medicine to see if it helps with ongoing esophagus problems like heartburn, acid reflux, a lump in the throat, trouble swallowing, or chest pain. It might help if other treatments haven't worked well.
Hualien CityAges 18–75 - NCT04255693Recruiting
Real-life reflux study of diet and behavior changes
This study looks at how following specific diet and behavior changes affects symptoms of acid reflux (heartburn/regurgitation) in everyday life. It may help you understand what lifestyle steps improve reflux and how symptoms change over time.
MoscowAges 18–80 - NCT06687603Recruiting
Detecting Barrett's esophagus in people without heartburn
This study aims to screen for Barrett's esophagus in people who are getting a routine colonoscopy but do not have chronic heartburn. It uses a simple, non-invasive cell collection device (EsoCheck) to see if you might have Barrett's esophagus, which can increase the risk of esophageal cancer.
Aurora, ColoradoAges 50 years+ - NCT06280664Recruiting
Closing the hiatal gap for GERD relief
This trial tests if surgically closing a small hiatal defect helps reduce acid reflux (GERD) symptoms. It is for people who are surgical candidates and have confirmed acid exposure on testing.
Chicago, IllinoisAges 18–50 - NCT06241183RecruitingPhase 4
Famotidine and antacids for stomach pain
This trial tests if a combination of famotidine (Pepcid) and antacids (like Maalox) can relieve stomach pain in people with indigestion. It aims to find a fast and effective treatment for pain in the emergency room.
Stony Brook, New YorkAges 18 years+ - NCT05974722Recruiting
Compare two ways to repair large hiatal hernias
This study compares two surgical materials (mesh vs pledgets) used to repair a large hiatal hernia, helping doctors find which approach works best over time. You may be able to join if you have a specific type and size of hiatal hernia and can attend long-term follow-up visits and surveys.
Cleveland, OhioAges 18 years+ - NCT05696184Recruiting
Studying why reflux reaches the throat and what stops it
This study looks at the “upward reflux” that can irritate the throat and sometimes worsen symptoms like cough or asthma. It aims to understand the mechanisms that prevent or allow throat reflux, which may lead to better ways to manage symptoms.
Milwaukee, WisconsinAges 18–85 - NCT05697393Recruiting
Testing a pressure band to ease GERD throat and cough symptoms
This study tests whether using an “external Shaker pressure band” can reduce GERD symptoms that affect the throat and airway, like chronic cough, choking, or food coming back up. It also checks whether these people can safely tolerate the study measurements through the nose.
Milwaukee, WisconsinAges 18–85 - NCT05570448Recruiting
Endoscopy treatment using APC for chronic reflux disease
This trial studies whether an endoscopy procedure using APC (a type of heat/energy treatment) can improve symptoms in people with chronic GERD and confirmed acid reflux. It may help reduce reflux-related discomfort for people who meet specific testing and safety requirements.
Kansas City, MissouriAges 18–80
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Common questions
- Are there clinical trials for gerd?
- Yes. Clin2 currently lists 54 recruiting gerd studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a gerd trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a gerd trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.