Clinical trials
Glioma clinical trials
Below are recruiting glioma clinical trials, each written for real people, not researchers. We’re tracking 333 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05293197RecruitingPhase 1
Safety study of repeated blood-brain barrier opening for pediatric brain tumors
This Phase 1 study tests whether a device can safely and repeatedly open the blood-brain barrier (a protective shield in the brain) in children with malignant brain tumors. It aims to help the tumor treatment work better while watching for safety issues.
ParisAges 5–17 - NCT05271240RecruitingPhase 3
Targeted brain-artery drug added to standard treatment for new GBM
This Phase 3 trial tests whether delivering a cancer drug directly into brain blood vessels, along with standard radiation and temozolomide, works better than standard treatment alone in newly diagnosed glioblastoma (GBM). The goal is to improve control of the tumor while comparing side effects between the two approaches.
New York, New YorkAges 18 years+ - NCT05190172Recruiting
Proton versus photon radiation for IDH-mutated brain tumors
This trial compares two types of radiation—proton therapy versus photon (standard) therapy—for adults with an IDH-mutated grade 2 or 3 brain tumor. The goal is to see which approach works better and/or causes fewer side effects while treating the tumor.
OsloAges 18–65 - NCT05139056RecruitingPhase 1
Stem cell virus therapy for recurrent brain tumors
This trial tests a new treatment that uses specially modified stem cells (taken from donors) to deliver a virus directly into the tumor during surgery. The goal is to see if it is safe and effective for brain tumors that have come back after standard therapy.
Duarte, CaliforniaAges 18 years+ - NCT05086497Recruiting
Personal TTFields device guided by imaging for brain tumor
This trial tests whether using a personalized TTFields device—placed based on imaging—can help treat adults with glioblastoma (GBM) after surgery and radiation. It’s designed for specific GBM genetic types and may help deliver therapy more precisely.
Philadelphia, PennsylvaniaAges 22 years+ - NCT05049148Recruiting
Study platelets in brain and spinal tumors
This study looks at how blood “platelets” may be involved in brain or spinal (medullary) tumors by testing tumor tissue taken during surgery or biopsy. It may help researchers understand disease biology and guide future treatments.
ParisAges 18 years+ - NCT04908709Recruiting
MRI-guided proton therapy for high-grade brain tumors in children
This study looks at how metabolism in a child’s brain tumor changes during proton therapy, using special MRI scans. It may help doctors better understand treatment response and tailor care for pediatric high-grade gliomas.
Atlanta, GeorgiaAges Up to 21 years - NCT04794972RecruitingPhase 1
Testing a targeted antibody for advanced solid tumors
This Phase 1 trial tests a new antibody drug (GNC-039) that targets a specific feature found on some cancer cells. It is for adults with solid tumors that have come back or stopped responding to standard treatment, aiming to see safety and early signs of effectiveness.
Beijing, Beijing MunicipalityAges 18 years+ - NCT04648462Recruiting
Proton therapy planning for certain brain tumors
This study builds and tests how proton therapy planning could better protect the brain compared with standard radiation (photon therapy) for adults with certain brain tumors. It may help reduce radiation to sensitive areas like the hippocampus, with the goal of better long-term brain function.
Maastricht, LimburgAges 18 years+ - NCT04274283Recruiting
Study of brain tumor samples and blood tests
This trial studies newly diagnosed or progressing brain tumors (grade 2–4 gliomas) to better understand the disease using tumor tissue and blood samples. It may help doctors learn which treatments could work best for different tumor types by matching tumor material to blood results.
BirminghamAges 16 years+ - NCT04313140Recruiting
MRI virtual biopsy to predict glioma grade
This study uses special MRI images to estimate the “grade” of a suspected brain tumor (glioma) without taking a tissue sample first. If it works well, it may help doctors better plan care based on imaging.
PoitiersAges 18 years+ - NCT04063514Enrolling by invitation
MRI-focused ultrasound study of blood-brain barrier in low-grade glioma
This study uses special imaging during routine MRI scans to check how well the blood-brain barrier lets substances pass in people with low-grade brain tumors. It may help researchers better measure and track treatment effects over time.
Santa Monica, CaliforniaAges 18 years+ - NCT04047264Recruiting
Monitoring brain chemistry during brain surgery
This study tests whether a tiny probe can safely measure brain chemistry during and after brain surgery. It may help doctors better understand and treat brain conditions like tumors or epilepsy.
Rochester, MinnesotaAges 18 years+ - NCT03922555RecruitingPhase 1
ASTX727 for IDH-mutant low-grade brain tumors
This early-stage study tests ASTX727 in adults with IDH-mutant gliomas that are coming back or progressing. It aims to see whether the medicine can slow the tumor and understand how it works in the body and tumor tissue.
Boston, MassachusettsAges 18 years+ - NCT03830151RecruitingPhase 1
C-13 pyruvate MRI to help diagnose brain gliomas
This early-phase study tests a special MRI scan using C-13 pyruvate to help identify and understand gliomas (a type of brain tumor) in people with brain tumors going to surgery or biopsy. It may help doctors see tumor signals better before or around the time of your procedure.
Houston, TexasAges 19 years+ - NCT03643549RecruitingPhase 1/Phase 2
Combination treatment for recurring brain cancer
This trial tests a combination of two drugs, bortezomib and temozolomide, for people whose brain tumor (glioblastoma) has returned after initial treatment. It's designed for tumors that don't respond well to standard treatments, and the goal is to see if this combination can help control the cancer.
BergenAges 18 years+ - NCT03340506RecruitingPhase 4
Follow-on treatment study for dabrafenib and trametinib
This study lets people who finished a prior dabrafenib/trametinib trial (sponsored by Novartis or former GSK) continue those medicines if the study doctor thinks it will help. It mainly focuses on ongoing treatment benefit rather than testing a new drug.
Scottsdale, ArizonaAges 18–100 - NCT03122197RecruitingEarly Phase 1
Letrozole for recurrent high-grade brain tumors
This early-phase study tests letrozole, a hormone-blocking medicine, in adults with recurrent high-grade gliomas. The goal is to see if it can help control the tumor and is safe enough to study further.
Cincinnati, OhioAges 18 years+ - NCT03213002RecruitingPhase 1/Phase 2
CAPTEM pills after brain radiation for newly diagnosed glioblastoma
This trial studies whether taking two chemotherapy pills (capecitabine and temozolomide) after the initial 6-week radiation-and-chemo phase can help people with newly diagnosed glioblastoma. It aims to test safety and early effectiveness right before the usual maintenance temozolomide phase.
New York, New YorkAges 18–74 - NCT02800486RecruitingPhase 2
Targeted antibody plus repeat radiation for recurrent brain tumors
This trial studies giving cetuximab (a targeted antibody) directly into an artery along with repeat radiation to treat certain recurring or treatment-resistant brain tumors. It may help by delivering the drug more directly to tumor areas and testing whether this approach can control the disease after it comes back.
New York, New YorkAges 18 years+ - NCT01772771Recruiting
Molecular testing to guide personalized cancer treatment plans
This trial uses special lab tests to look for tumor “molecular fingerprints” in your tumor or blood sample. The goal is to help your care team choose more personalized treatment options based on those results.
Houston, TexasAges Any age
Hear when a new Glioma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for glioma?
- Yes. Clin2 currently lists 333 recruiting glioma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a glioma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a glioma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.