Clinical trials
Glioma clinical trials
Below are recruiting glioma clinical trials, each written for real people, not researchers. We’re tracking 339 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06221553RecruitingPhase 1
New CAR T-cell treatment for DIPG brain tumor
This trial tests a new type of immunotherapy called B7H3 IL-7Ra CAR T-cells for children with DIPG, a tough-to-treat brain tumor. The treatment is given directly into the fluid around the brain using a special catheter, and the goal is to see if it's safe and if it can help fight the tumor.
Bangkok, PathumwanAges 1–18 - NCT06264388RecruitingPhase 2
Gene therapy plus oral drug for recurrent brain tumors
This trial tests a two-part treatment: an injected virus (DB107-RRV) plus an oral medication (DB107-FC) for people whose high-grade glioma (a type of brain tumor) has come back. The virus is designed to deliver a gene that makes the tumor sensitive to the oral drug, which then helps kill the cancer cells.
Miami, FloridaAges 18–75 - NCT06271421Recruiting
Nanoparticle heat therapy for recurrent glioblastoma
This trial tests a new treatment for recurrent glioblastoma using tiny magnetic particles (nanoparticles) that are heated to kill cancer cells. The particles are injected into the tumor, and then a magnetic field device heats them up. It's for people who have already tried standard therapy and whose tumor has come back.
PoznanAges 18 years+ - NCT06326411RecruitingPhase 1
Testing NST-628 pills for advanced solid tumors with RAS/MAPK changes
This trial tests an experimental pill called NST-628 for people with advanced solid tumors that have specific genetic changes in the RAS/MAPK pathway. The goal is to see if it is safe and effective when other treatments are no longer working.
San Francisco, CaliforniaAges 18 years+ - NCT06329570RecruitingPhase 1/Phase 2
Bevacizumab with focused ultrasound for recurrent glioblastoma
This trial tests whether adding a focused ultrasound system (NaviFUS) to the drug bevacizumab can help people whose glioblastoma has come back. The treatment aims to deliver the drug more precisely to the brain tumor and potentially improve outcomes.
Charlottesville, VirginiaAges 18 years+ - NCT06344130RecruitingPhase 1
Shorter radiation for recurrent glioblastoma
This trial tests a new, shorter course of radiation therapy (called hypofractionation) for people with glioblastoma that has come back. It is for patients who have already had radiation and are doing well enough to consider another round.
Bethesda, MarylandAges 18–120 - NCT06470711Recruiting
Mapping brain electrical properties with MRI
This study uses MRI scans to map the brain's electrical properties in healthy volunteers and in people who have had surgery for a brain tumor (glioma). It aims to better understand brain function and tumor effects.
Scottsdale, ArizonaAges 18 years+ - NCT06496971RecruitingPhase 3
Testing focused ultrasound plus Avastin for recurrent glioblastoma
This study tests whether adding focused ultrasound to the standard drug Avastin (bevacizumab) can help treat recurrent glioblastoma. The ultrasound may help more of the drug reach the tumor.
TaipeiAges 18–80 - NCT06528691RecruitingPhase 2
Entrectinib for young children with NTRK/ROS1 brain tumors
This trial tests a targeted drug (entrectinib) in very young children (under 3) with a newly diagnosed brain tumor that has a specific genetic change (NTRK or ROS1 fusion). The drug works by blocking signals that help the tumor grow, and is given as the first treatment, before any chemotherapy or radiation.
Memphis, TennesseeAges Up to 3 years - NCT06572475Recruiting
New MRI contrast for brain tumors
This trial uses a new type of MRI contrast dye (USPIO) to get clearer images of certain slow-growing brain tumors (vestibular schwannomas and low-grade gliomas). The goal is to see if this dye helps doctors better understand and treat these tumors.
Salford, Greater ManchesterAges 16–100 - NCT06607692RecruitingPhase 1/Phase 2
LuPARPed: Targeted radiation plus olaparib for certain childhood cancers
This trial tests a combination of a radioactive drug (Lutathera) and a targeted pill (olaparib) for children and teens whose solid tumors have come back or not responded to treatment and show high levels of a specific receptor (SSTR) on scans. The goal is to see if this two-drug approach can shrink tumors or stop them from growing.
Boadilla del Monte, MadridAges 3 years+ - NCT06650163RecruitingPhase 1
New imaging test for brain tumor surgery planning
This trial tests a new kind of PET scan that uses a special tracer (Zr-89 crefmirlimab berdoxam) to help doctors see brain tumors more clearly before surgery. If you are scheduled to have your brain tumor removed, this scan may give your surgeon extra information to guide the operation.
Los Angeles, CaliforniaAges 18 years+ - NCT06703255RecruitingPhase 1/Phase 2
Testing HX301 for advanced high-grade glioma
This trial tests an experimental drug called HX301 for people with high-grade gliomas (fast-growing brain tumors). It is for patients whose tumor has come back after temozolomide chemo, or for those with newly diagnosed glioblastoma that has been surgically removed. The study aims to see if HX301 can help control the tumor.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06740097Recruiting
Testing tissue monitoring during brain tumor surgery
This study looks at a new way to check brain tumor tissue during surgery. If you are having surgery for an aggressive brain tumor, the doctors want to see if this monitoring technique is practical and helpful.
Kuopio, Northern SavoniaAges 18 years+ - NCT06779487Recruiting
Predicting memory changes from brain radiation
This study looks for biomarkers in your blood that might predict how radiation treatment affects brain function. The goal is to understand and possibly reduce cognitive side effects.
Mumbai, MaharashtraAges 5–39 - NCT06797661Recruiting
Brain lesion blood flow study before surgery
This study looks at how blood flow in the brain changes when there is a mass that can be removed with surgery. You would join before any treatment, which helps doctors understand the link between the brain lesion and blood vessel function.
BrusselsAges 18–90 - NCT06831461Recruiting
Proton vs photon radiation for brain tumors
This study compares two types of radiation therapy for adults with primary brain tumors that have a good outlook (expected survival longer than 5 years). You will receive either standard photon radiation or the more targeted proton radiation, to see if one works better or causes fewer side effects.
MumbaiAges 18–70 - NCT06910306Recruiting
DaRT alpha radiation for recurrent glioblastoma
This trial tests a device called DaRT that delivers alpha radiation directly to a recurrent glioblastoma tumor. It may help patients who cannot have surgery and have a single, small tumor regrowth.
Scottsdale, ArizonaAges 18–85 - NCT06914479RecruitingPhase 1
Gene therapy and valacyclovir for recurrent brain tumors in young people
This trial tests a new gene therapy that uses two special viruses and an oral antiviral drug (valacyclovir) to treat brain tumors that have come back in children and young adults. The therapy is given right after surgery to remove the tumor, with the goal of helping your immune system fight the cancer.
Ann Arbor, MichiganAges 3–39 - NCT06917885RecruitingPhase 1
CUE-102 for Recurrent Glioblastoma: A Safety Study
This study tests an experimental drug, CUE-102, for people with recurrent glioblastoma. It aims to see if the drug is safe and how well it works. You may be eligible if your tumor has come back once, you have a specific genetic marker (HLA-A*0201), and you are not on other treatments.
Boston, MassachusettsAges 18 years+ - NCT06930846Recruiting
Brain cancer cognitive training study
This study tests a home-based program called HOBSCOTCH-CA to help with memory and thinking problems after brain cancer treatment. The program uses phone and internet sessions to teach self-management skills.
Lebanon, New HampshireAges 18 years+ - NCT06988475RecruitingPhase 2/Phase 3
Capmatinib for cancers with MET gene changes
This study tests an oral drug called capmatinib for people whose cancers have specific changes in the MET gene (except for one type of lung cancer). It aims to see if the drug can shrink tumors or slow their growth.
BelfastAges 18 years+ - NCT07003542RecruitingPhase 2
Sitagliptin for people with high-grade brain tumors
This trial tests whether sitagliptin, a medicine usually used for diabetes, can help people with a fast-growing type of brain tumor (grade 4 glioma). You will take sitagliptin before your planned surgery, and researchers will study how it affects your tumor.
Cleveland, OhioAges 18 years+ - NCT07017816RecruitingEarly Phase 1
Gene therapy, checkpoint inhibitor, and radiation for children with brain cancer
This trial tests a new combination treatment for children and young adults with brain tumors that have come back or not responded to standard therapy. The treatment includes a gene therapy (SGT-53) that delivers a normal TP53 gene, a checkpoint inhibitor drug that helps the immune system attack the cancer, and focused radiation. The goal is to see if this combination is safe and can shrink tumors.
Washington D.C., District of ColumbiaAges 3–21
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Common questions
- Are there clinical trials for glioma?
- Yes. Clin2 currently lists 339 recruiting glioma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a glioma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a glioma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.