Clinical trials
Head and Neck Cancer clinical trials
Below are recruiting head and neck cancer clinical trials, each written for real people, not researchers. We’re tracking 619 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06007092RecruitingPhase 1/Phase 2
HPV vaccine trial for oropharyngeal cancer patients
This trial tests a therapeutic vaccine for people with HPV16-positive oropharyngeal cancer who have finished curative treatment and are free of disease. The vaccine aims to help the immune system prevent the cancer from coming back.
VillejuifAges 18 years+ - NCT04003051RecruitingPhase 2
Online program to help throat cancer patients swallow and cope
This trial tests a web-based program meant to help people with throat (head and neck) cancer follow swallowing exercises and use coping strategies during curative radiation treatment. It may help improve comfort and how well you can keep up with exercises while you’re getting treatment.
Fort Worth, TexasAges 18 years+ - NCT06531083Recruiting
Early monitoring and physical therapy to prevent jaw stiffness after radiation
This study tests whether a program of early monitoring and physical therapy can help prevent or reduce jaw stiffness (trismus) after radiation therapy for head and neck cancer. It is for patients who are about to start radiation and want to keep their jaw working well.
Edmonton, AlbertaAges 18 years+ - NCT06666881Recruiting
Exercise training for head and neck cancer patients
This trial studies if exercise training can improve outcomes for people with head and neck squamous cell cancer who need chemotherapy and radiation. It uses body scans to see if muscle changes from exercise are linked to better prognosis.
New Taipei CityAges 20–80 - NCT07546045Recruiting
Robotic Surgery and Swallowing Recovery for Head and Neck Cancer
This trial tests a specialized robotic surgical approach for head and neck cancers, combined with personalized speech and swallowing rehabilitation. The goal is to remove tumors while preserving organ function and improving your ability to swallow and speak after surgery.
LausanneAges 18 years+ - NCT06161779Recruiting
Reconstructing the hypopharynx after cancer removal
This trial tests a surgical technique using a flap from under your chin to rebuild the hypopharynx after removing cancer. It may help people with hypopharyngeal cancer that has not spread far and who have not had radiation before.
Guangzhou, GuangdongAges 18–80 - NCT07337161Recruiting
Radiation for skin cancer that spread to neck lymph nodes
This trial tests a focused radiation treatment after surgery for people with a common skin cancer (squamous cell carcinoma) that has spread to the lymph nodes in the neck or near the ear. The goal is to see if this approach can prevent the cancer from coming back.
London, OntarioAges 18 years+ - NCT07282483RecruitingPhase 2
Chinese medicine mouthwash for radiation mouth sores
This trial tests whether a traditional Chinese medicine mouthwash and oral liquid can help prevent or reduce mouth sores caused by radiation therapy for head and neck cancer. If you are getting radiation and are at risk for these painful sores, this study might offer you extra relief.
Chengdu, SichuanAges 18–65 - NCT06005324RecruitingPhase 1
Personalized treatment for advanced head and neck cancer
This trial tests a custom treatment plan for people with advanced head and neck cancer that is not caused by HPV. It combines radiation and chemotherapy with a targeted drug called cetuximab, adjusted based on your tumor's characteristics.
Chicago, IllinoisAges 18 years+ - NCT06111430Recruiting
Long-term effects of radiation on brain and blood vessels
This study looks at long-term effects of radiation therapy on the brain and blood vessels in people who have had head and neck cancer. It aims to understand how radiation may affect your health years later.
TaipeiAges 20–100 - NCT07339774RecruitingPhase 2
Traditional Chinese medicine for mouth sores from radiation
This trial tests whether a traditional Chinese medicine can help prevent or reduce the severity of mouth sores caused by radiation therapy for head and neck cancer. If you are scheduled to get radiation for non-spreading head or neck cancer, this treatment might help protect your mouth.
Chengdu, SichuanAges 18–65 - NCT03238378Recruiting
Radiation boost plus warming for recurrent head and neck tumors
This trial tests a “salvage” treatment that combines targeted radiation (brachytherapy) with controlled body warming (hyperthermia) for head and neck cancer that has come back. It may help by better shrinking tumors while fitting the treatment to the tumor’s exact location.
ErlangenAges 18 years+ - NCT04266223Recruiting
Head and neck mask monitoring during radiation to improve setup
This trial tests a surface-monitoring technology that checks a head-and-neck radiation “positioning mask” during treatment. It may help the radiation team make sure the mask and patient are aligned correctly for safer, more accurate therapy.
Blacktown, New South WalesAges 18 years+ - NCT04593589RecruitingPhase 1
Stem cell transplant to protect salivary function after oral cancer
This Phase 1 study tests whether transplanting stem cells into the submandibular gland can help restore saliva function after surgery and radiation for oral cavity squamous cell cancer. You may be considered because you recently had tumor removal and radiation aimed at the neck area, which can damage salivary glands.
GroningenAges 18 years+ - NCT04632654Recruiting
Video game exercise program to help head and neck cancer symptoms
This study tests a “motion-based video game” type exercise to help with moderate fatigue and/or pain in adults with head and neck cancer. It may help you feel better day to day while staying active at a low-to-moderate intensity.
Birmingham, AlabamaAges 18 years+ - NCT05082961Recruiting
Blood immune markers and brain radiation after head/neck surgery
This study looks at immune system signals in your blood during and after postoperative radiation therapy for certain head and neck cancers involving the brain or skull base. Researchers want to see whether these “immune markers” relate to treatment response or side effects.
CaenAges 18 years+ - NCT05319483Recruiting
Study of new head and neck cancer patients
This study enrolls adults with a first-time head and neck cancer diagnosis and collects health and treatment information to better understand the disease. It may help clinicians improve care by learning which treatments and patient features matter most.
Pécs, BaranyaAges Any age - NCT05505188Recruiting
Predicting long-term pain after head and neck radiotherapy
This study looks for ways to predict and improve pain you may have months after radiotherapy for first head and neck cancer. It may help doctors better anticipate pain and support patients during recovery.
CaenAges 18 years+ - NCT05539638Recruiting
Testing blood DNA for head and neck squamous cancer
This study looks at how tumor DNA found in a blood sample (a “DNA signal”) relates to head and neck cancer in the oropharynx. It may help doctors understand disease status and improve how they monitor treatment, for both HPV-positive and HPV-negative cancers.
Dundee, DD2 1SGAges 18 years+ - NCT05621889RecruitingPhase 1/Phase 2
Virtual speech therapy program for head and neck cancer patients
This trial tests a partner-guided virtual speech therapy program delivered through group sessions and questionnaires for people with head and neck cancer. If you’re starting curative chemo-radiation, the program may help with speech and swallowing-related symptoms during treatment.
Montreal, QuebecAges 18 years+ - NCT05853692Recruiting
Preventing mouth sores during head and neck radiation
This trial tests a gel called “Gel X” to help prevent painful mouth sores (oral mucositis) in people receiving radiation for head and neck cancer. It may help you stay more comfortable and maintain eating and speaking during treatment.
Roma, ItalyAges 18 years+ - NCT06127784Recruiting
Survivorship program for head and neck cancer follow-up
This trial tests a new program to help people who finished treatment for head and neck cancer stay on track with follow-up care. You may be able to join if you completed treatment 3 to 6 months ago and your cancer has not spread.
London, OntarioAges 18 years+ - NCT06307314Recruiting
Can SAA1 predict mouth sores from radiation therapy?
This study is looking at a blood marker called SAA1 to see if it can predict how severe mouth sores (oral mucositis) will be after radiation therapy. If you have head and neck cancer and are about to get radiation, this trial may help answer questions about side effects.
Guangzhou, GuangdongAges 18 years+ - NCT06307327Recruiting
Comparing new and old ways to classify mouth sores from radiation
This study compares a new way of classifying radiation-induced mouth sores (mucositis) with the traditional method. It aims to better understand and manage these painful sores in people receiving radiation for head and neck cancer.
Guangzhou, GuangdongAges 18 years+
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Common questions
- Are there clinical trials for head and neck cancer?
- Yes. Clin2 currently lists 619 recruiting head and neck cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head and neck cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head and neck cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.