Clinical trials
Head and Neck Cancer clinical trials
Below are recruiting head and neck cancer clinical trials, each written for real people, not researchers. We’re tracking 618 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05777824RecruitingPhase 2
Testing treatment after head and neck cancer response to chemo-immunotherapy
This Phase 2 study looks at what treatment is best after you first receive chemotherapy plus immunotherapy, then have surgery for head and neck squamous cell cancer. It tries to use how your tumor responds (shown in lab tissue after treatment) to guide the next steps, which may improve outcomes.
Beijin, Beijing MunicipalityAges 18–75 - NCT06940505Recruiting
Follow-up from home for early larynx cancer
This trial tests if follow-up appointments from home, using video calls, work just as well as in-person visits for people treated for early-stage larynx cancer. It may save you time and travel.
Groningen, Provincie GroningenAges 18 years+ - NCT04671940Recruiting
Study tumor DNA changes during robot surgery after radiation
This study looks at how a cancer’s DNA changes over time in people who had head and neck cancer treated with radiation and then need robot-assisted surgery. It may help doctors understand why some cancers come back or persist and how to better plan treatment.
LondonAges 19 years+ - NCT07278557RecruitingPhase 2
MRI-guided radiation to reduce dry mouth from head and neck cancer treatment
This trial tests if using an MRI to map saliva glands before radiation can help spare them, reducing dry mouth. It is for people with oropharynx cancer who will receive radiation with or without chemotherapy.
Chapel Hill, North CarolinaAges 18 years+ - NCT06345287RecruitingPhase 2
Adaptive radiotherapy after immunotherapy for head and neck cancer
This trial tests a personalized radiotherapy approach after a few rounds of chemo-immunotherapy for people with HPV-negative head and neck cancer. It aims to adjust the radiation dose based on how the tumor responds, possibly reducing side effects while still controlling the cancer.
BeijingAges 18–75 - NCT06819228RecruitingPhase 1
Lighted antibody imaging in head and neck cancer surgery
This trial tests a special fluorescent dye attached to panitumumab, a cancer-targeting antibody, to help surgeons see tumor tissue more clearly during head and neck cancer surgery. The goal is to improve removal of all cancer cells while sparing healthy tissue.
Nashville, TennesseeAges 18 years+ - NCT06821243Recruiting
Finding markers in HPV-related throat cancer to guide treatment
This study looks for certain markers in people with HPV-related throat cancer that could help doctors choose the best treatment. If you are planning to have surgery for your throat cancer, you may be able to join.
Rome, RomeAges 18 years+ - NCT04003051RecruitingPhase 2
Online program to help throat cancer patients swallow and cope
This trial tests a web-based program meant to help people with throat (head and neck) cancer follow swallowing exercises and use coping strategies during curative radiation treatment. It may help improve comfort and how well you can keep up with exercises while you’re getting treatment.
Fort Worth, TexasAges 18 years+ - NCT03238378Recruiting
Radiation boost plus warming for recurrent head and neck tumors
This trial tests a “salvage” treatment that combines targeted radiation (brachytherapy) with controlled body warming (hyperthermia) for head and neck cancer that has come back. It may help by better shrinking tumors while fitting the treatment to the tumor’s exact location.
ErlangenAges 18 years+ - NCT02661139Recruiting
Registry of jaw reconstruction for cancer patients who need implants
This study is a “real-world” registry that follows people with jaw problems related to cancer or cancer treatment. It looks at how well jaw reconstruction with dental implants and fixed teeth works when removable dentures are not suitable.
BrugesAges Any age - NCT05319483Recruiting
Study of new head and neck cancer patients
This study enrolls adults with a first-time head and neck cancer diagnosis and collects health and treatment information to better understand the disease. It may help clinicians improve care by learning which treatments and patient features matter most.
Pécs, BaranyaAges Any age - NCT06161779Recruiting
Reconstructing the hypopharynx after cancer removal
This trial tests a surgical technique using a flap from under your chin to rebuild the hypopharynx after removing cancer. It may help people with hypopharyngeal cancer that has not spread far and who have not had radiation before.
Guangzhou, GuangdongAges 18–80 - NCT06307314Recruiting
Can SAA1 predict mouth sores from radiation therapy?
This study is looking at a blood marker called SAA1 to see if it can predict how severe mouth sores (oral mucositis) will be after radiation therapy. If you have head and neck cancer and are about to get radiation, this trial may help answer questions about side effects.
Guangzhou, GuangdongAges 18 years+ - NCT06353685RecruitingPhase 2
Less radiation after surgery for oral cancer with good response
This trial is testing whether giving less radiation after surgery is safe and effective for people with oral cancer whose surgery results were very good (no cancer cells or very few left). It aims to reduce side effects while still preventing cancer from coming back.
GuangzhouAges 18–80 - NCT06468852Recruiting
Fluid management during head and neck cancer surgery
This trial tests whether a specific way of giving fluids during surgery (called goal-directed fluid therapy) can improve recovery after head and neck cancer surgery. It involves having a small tube in your artery to closely watch your blood pressure.
Beijing, Beijing MunicipalityAges 18 years+ - NCT04593589RecruitingPhase 1
Stem cell transplant to protect salivary function after oral cancer
This Phase 1 study tests whether transplanting stem cells into the submandibular gland can help restore saliva function after surgery and radiation for oral cavity squamous cell cancer. You may be considered because you recently had tumor removal and radiation aimed at the neck area, which can damage salivary glands.
GroningenAges 18 years+ - NCT05082961Recruiting
Blood immune markers and brain radiation after head/neck surgery
This study looks at immune system signals in your blood during and after postoperative radiation therapy for certain head and neck cancers involving the brain or skull base. Researchers want to see whether these “immune markers” relate to treatment response or side effects.
CaenAges 18 years+ - NCT07546045Recruiting
Robotic Surgery and Swallowing Recovery for Head and Neck Cancer
This trial tests a specialized robotic surgical approach for head and neck cancers, combined with personalized speech and swallowing rehabilitation. The goal is to remove tumors while preserving organ function and improving your ability to swallow and speak after surgery.
LausanneAges 18 years+ - NCT07528495RecruitingPhase 2/Phase 3
Skipping neck radiation for oral cancer after surgery
This trial tests whether patients with early-stage oral cancer who have surgery and lymph-node removal can skip radiation to the neck if certain favorable conditions are met. The goal is to reduce side effects like difficulty swallowing while keeping cancer control strong.
Jhajjar, HaryanaAges 18–70 - NCT06354712RecruitingPhase 2
Can N-acetylcysteine prevent mouth sores during radiation?
This study tests whether a medicine called N-acetylcysteine (NAC) can prevent mouth sores caused by radiation therapy for head and neck cancer. If you are starting radiation, this trial may help protect your mouth from painful side effects.
Al MansurahAges 18–80 - NCT06549946RecruitingPhase 1/Phase 2
Ixovex-1 injection alone or with another drug for advanced solid tumors
This trial tests an experimental injection called Ixovex-1, either alone or with another drug (pembrolizumab), for people with advanced solid tumors that can be injected. It is for those who have run out of standard options and have tumors that are not too deep inside the body.
LondonAges 18 years+ - NCT07447570RecruitingPhase 2
Iparomlimab and Tuvonralimab plus radiation and chemo for head and neck cancer
This trial tests a combination of two immunotherapy drugs (Iparomlimab and Tuvonralimab) with low-dose radiation and chemotherapy for advanced head and neck cancer. It aims to see if this approach can help patients who have not had prior treatment for their cancer.
Hangzhou, ZhejiangAges 18–75 - NCT07339774RecruitingPhase 2
Traditional Chinese medicine for mouth sores from radiation
This trial tests whether a traditional Chinese medicine can help prevent or reduce the severity of mouth sores caused by radiation therapy for head and neck cancer. If you are scheduled to get radiation for non-spreading head or neck cancer, this treatment might help protect your mouth.
Chengdu, SichuanAges 18–65 - NCT07337161Recruiting
Radiation for skin cancer that spread to neck lymph nodes
This trial tests a focused radiation treatment after surgery for people with a common skin cancer (squamous cell carcinoma) that has spread to the lymph nodes in the neck or near the ear. The goal is to see if this approach can prevent the cancer from coming back.
London, OntarioAges 18 years+
Hear when a new Head and Neck Cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for head and neck cancer?
- Yes. Clin2 currently lists 618 recruiting head and neck cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head and neck cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head and neck cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.