Clinical trials
Head and Neck clinical trials
Below are recruiting head and neck clinical trials, each written for real people, not researchers. We’re tracking 691 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06469008RecruitingPhase 1
Study of BL-B16D1 for advanced head and neck cancer and other solid tumors
This study tests a new drug, BL-B16D1, for people with advanced head and neck cancer or other solid tumors that have not been helped by standard treatments. The goal is to see if the drug is safe and effective.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06437522RecruitingPhase 2
New drug combo for recurrent head and neck cancer
This trial tests a new drug combination (BL-B01D1 plus a PD-1 inhibitor) for people with advanced head and neck cancer or other solid tumors that have come back or spread. It aims to see if the treatment can help shrink tumors or slow the disease.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06006169RecruitingPhase 2
Study of new drugs for head and neck cancer and other solid tumors
This trial tests two new drugs, BL-B01D1 and SI-B003, alone or together, for people with head and neck squamous cell carcinoma that has come back or spread. It may also include other solid tumors. The goal is to see if these drugs can shrink tumors or slow their growth.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05815927RecruitingPhase 3
Pembrolizumab with targeted radiation for limited head and neck spread
This Phase 3 trial studies whether adding pembrolizumab (an immune medicine) to focused radiation (SABR) can better control head and neck cancer that has spread to only 1–5 spots. It may help some people live longer or delay cancer worsening by treating both the immune system and the specific metastases.
BrusselsAges 18 years+ - NCT05047094Recruiting
DaRT radiation plus pembrolizumab for head and neck cancer
This trial tests whether a targeted internal radiation treatment (DaRT) combined with pembrolizumab (an immune therapy) can shrink recurrent or metastatic head and neck squamous cell cancer that cannot be fully removed with surgery. It may help by making cancer more visible to the immune system while delivering localized radiation to a tumor area.
JerusalemAges 18 years+ - NCT04261192Recruiting
Grow lab models of head and neck cancer to test treatments
This study collects tissue from people with newly diagnosed head and neck squamous cell cancer and grows “mini tumor models” in the lab. The goal is to see how these models respond to new therapies, which may help guide more effective treatment choices in the future.
CaenAges 18 years+ - NCT07532928Enrolling by invitation
Personalized Post-Surgery Care Plan for Advanced Head and Neck Cancer
This study helps doctors create a personalized plan for follow-up treatment after surgery for advanced head and neck cancer. Researchers will use imaging scans and patient data to predict which patients need extra treatment and which ones can be monitored closely instead.
GuangzhouAges 18 years+ - NCT07180901Recruiting
Optimizing care for head and neck cancer surgery patients
This trial uses a computer system to send reminders and tracking alerts to doctors and patients, aiming to improve care and outcomes after surgery for head and neck cancer. It may help you stay on track with your treatment plan.
Montreal, QuebecAges 18 years+ - NCT07457281RecruitingPhase 1
A new drug combo for head and neck cancer before surgery
This trial tests two drugs, GV20-0251 and Sintilimab, given before surgery for head and neck cancer. The goal is to see if this combination can shrink tumors and make surgery more effective.
ChengduAges 18–70 - NCT07063212RecruitingPhase 2
Sacituzumab govitecan plus cetuximab for head and neck cancer
This trial tests a combination of two drugs—sacituzumab govitecan and cetuximab—for people with advanced head and neck cancer that has gotten worse after immunotherapy. The goal is to see if this new treatment can shrink or slow the cancer.
Basking Ridge, New JerseyAges 18 years+ - NCT06851988Recruiting
Can exercise boost immunity and reduce head and neck cancer relapse?
This study tests whether a supervised exercise program can boost your immune system and lower the chances of cancer coming back after chemoradiation for head and neck cancer.
New Taipei CityAges 20–80 - NCT06706401RecruitingPhase 3
Lymphocyte-sparing radio-immunotherapy for head and neck cancer
This trial tests a new approach that combines radiation and immunotherapy, while trying to protect your immune cells. It is for people with head and neck cancer that has not spread across the midline of the body and has not been treated yet.
Lyon, FranceAges 18 years+ - NCT06125743Recruiting
Self-management program for head and neck swelling
This study tests a self-management program to help people with head and neck cancer manage swelling (lymphedema) and tightness (fibrosis) after treatment. It may be a good fit if you have finished cancer therapy, are cancer-free, and have access to internet at home.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05738187Recruiting
Cryotherapy for repeat head and neck cancer after prior radiation
This pilot study tests whether cooling treatment on the tumor area (cryotherapy) can control a repeat head/neck cancer that can’t be removed and has already been treated with radiation. It also checks safety, especially in areas that have received radiation before.
StrasbourgAges 18 years+ - NCT03429036Recruiting
Collecting head and neck tissue samples for research
This study collects tissue and fluid samples from people with head and neck disorders to help researchers learn more about these conditions. By donating leftover samples from your regular medical care, you can help advance research without extra procedures.
Washington D.C., District of ColumbiaAges 3–120 - NCT03751566Recruiting
Acupuncture to ease short-term side effects of head and neck radiation
This trial studies whether adding acupuncture to standard radiation care can reduce short-term side effects from radiation for head and neck tumors. You might qualify if you are having treatment with the goal of cure or after-surgery prevention and can reliably complete symptom/side-effect tracking.
BrnoAges 18 years+ - NCT02678884Recruiting
PET-CT scan study for head and neck cancer before radiotherapy
This study uses PET-CT scans (a type of imaging that highlights active cancer cells) in people with a specific kind of head and neck cancer. The goal is to see how well the first scan identifies tumors that should be checked again with a second scan, to better guide care with radiotherapy.
Toronto, OntarioAges 18 years+ - NCT07851857RecruitingPhase 3
Short course of antibiotics after head and neck cancer surgery
This trial tests whether giving antibiotics for one day after head and neck surgery works just as well as giving them for longer to prevent infections. It might help you have a smoother recovery with fewer side effects from antibiotics.
São Paulo, São PauloAges 18 years+ - NCT07465276RecruitingPhase 2
Two immunotherapies before surgery for head and neck cancer
This trial tests a new combination of two immunotherapy drugs (ficerafusp alfa and pembrolizumab) given before surgery for advanced head and neck cancer that can be removed. The goal is to see if this approach can shrink the tumor and improve outcomes.
Boston, MassachusettsAges 18 years+ - NCT07211139Recruiting
Head and neck cancer immunotherapy research study
This study is looking for people with advanced head and neck cancer who have already received immunotherapy plus chemotherapy as their first treatment. Researchers will study your tumor tissue and proteins to find better ways to use immunotherapy.
Seoul, SeoulAges 20 years+ - NCT06535607RecruitingPhase 2
Study of volrustomig for advanced solid tumors
This trial tests a new drug called volrustomig, alone or with other cancer treatments, for people with advanced or metastatic solid tumors. It aims to see if the drug can help shrink or control the cancer.
Los Angeles, CaliforniaAges 18 years+ - NCT06487403Recruiting
Delaying radiation for head and neck cancer: MRI and immune markers study
This study tests whether delaying radiation therapy can help doctors learn more from MRI scans and immune system changes in patients with head and neck cancer. This could lead to better treatment decisions.
Toronto, OntarioAges 18 years+ - NCT06129864RecruitingPhase 3
Study of Volrustomig for advanced head and neck cancer after chemoradiation
This trial tests a new drug called volrustomig (MEDI5752) for people with advanced head and neck cancer that was not removed by surgery and has been treated with chemoradiation. The goal is to see if the drug can help prevent the cancer from coming back.
Birmingham, AlabamaAges 18–130 - NCT06085781Recruiting
MRI and tumor study for head and neck cancer patients
This trial uses special MRI scans to look at your head, neck, and tumor environment before treatment. It aims to find better ways to understand your cancer and guide care.
Toronto, OntarioAges 18 years+
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Common questions
- Are there clinical trials for head and neck?
- Yes. Clin2 currently lists 691 recruiting head and neck studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head and neck trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head and neck trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.