Clinical trials
Heart Failure, Diastolic clinical trials
Below are recruiting heart failure, diastolic clinical trials, each written for real people, not researchers. We’re tracking 103 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06009276Recruiting
Gut bacteria, muscle blood flow, and fitness study
This study looks at how the bacteria in your gut affect blood flow to your muscles and your overall fitness. You will provide samples and do some exercise tests to help researchers understand this link.
Charlottesville, VirginiaAges 18 years+ - NCT06015776Recruiting
Heart cell signals after menopause
This trial studies how heart cells communicate after menopause. Researchers are looking at a chemical signal called purinergic signaling during heart surgery.
Boston, MassachusettsAges 30–88 - NCT05677100Recruiting
Aortix device for acute heart failure
This trial is testing a small pump placed in the aorta to help the kidneys remove extra fluid when standard IV diuretics aren't working well enough for severe heart failure. It may help you if you're hospitalized and still very congested (swollen, fluid buildup) despite strong water pills.
Phoenix, ArizonaAges 21 years+ - NCT05585125RecruitingPhase 4
Testing an informed approach for older adults with HFpEF
This study looks at an “informed” approach to help manage HFpEF (a type of heart failure) in people age 65 and older. It checks whether a structured plan and monitoring are practical and safe for you over time.
New York, New YorkAges 65 years+ - NCT05577819Recruiting
Screening for ATTR heart amyloid in older HFpEF patients
This study looks at how often a specific heart condition (ATTR amyloid) occurs in people age 65+ who have HFpEF. It also tries to predict who might have it, using a special heart scan, and may help your care team identify it earlier.
Boston, MassachusettsAges 65 years+ - NCT05064709Recruiting
Test device for heart failure symptoms in some patients
This study tests whether a heart-related device called CCM can improve symptoms and daily function in people with heart failure and a moderately reduced pumping strength. It may help if you’ve had recent heart-failure-related hospital care or urgent treatment and your heart and overall health fit the study limits.
Birmingham, AlabamaAges 18 years+ - NCT00762008Recruiting
Test blood markers to understand progression to heart failure
This study looks at blood “markers” (substances in the blood) to help explain how some people move from early heart strain to full heart failure. You may be enrolled if you have stable or worsening heart failure symptoms, or you may qualify as a healthy control for comparison.
Farmington, ConnecticutAges 18 years+ - NCT07692256RecruitingPhase 2
Empagliflozin for heart failure in children
This trial tests if empagliflozin, a diabetes medicine that also helps the heart, can improve symptoms in children with heart failure. It may help kids with severe symptoms or high levels of a heart stress marker called BNP.
Cairo, Cairo GovernorateAges 1 month–18 years - NCT05802849RecruitingPhase 4
Oral acetazolamide for worsening heart failure
This trial tests whether taking acetazolamide by mouth can help prevent or improve worsening (decompensation) of heart failure after you needed IV water pills (diuretics). It’s mainly for adults with a recent heart-failure flare and specific heart/lab signs, while carefully excluding certain low blood pressure, kidney issues, and electrolyte or acid–base problems.
SamaraAges 18 years+ - NCT07325942Recruiting
Low vs high volume high-intensity interval training for heart failure
This study compares two different types of high-intensity interval exercise programs (one shorter, one longer) in people with chronic heart failure. It aims to see which program improves heart health and daily function more.
Cairo, Giza GovernorateAges 18 years+ - NCT07243769Recruiting
Comparing exercise types for heart rehab
This trial compares core, aerobic, and combined exercise in patients doing phase II cardiac rehab. It aims to find which type works best for heart recovery.
TaipeiAges 18 years+ - NCT06364644Recruiting
Reducing heart failure risk in low-income adults with diabetes
This study looks at how low income and diabetes together raise the risk of heart failure. It offers a program to help you manage your health and reduce that risk.
Baltimore, MarylandAges 30–70 - NCT04405583Recruiting
Follow-up study for a heart device in heart failure patients
This study follows people with chronic heart failure to see how well an implanted device (called the Occlutech AFR) works and whether it is safe over time. It may help doctors better understand who benefits and how to manage treatment safely.
BesançonAges 18 years+ - NCT07572955Recruiting
Understanding Fluid Changes in Hospitalized Heart Failure
This study observes patients admitted to the hospital with heart failure that has suddenly worsened. Researchers will use daily ultrasound scans of your lungs to track fluid buildup and understand how the heart failure progresses during your hospital stay.
Rochester, MinnesotaAges 18 years+ - NCT07492524Recruiting
Village doctor telehealth program for heart failure with atrial fibrillation
This trial tests a program where village doctors use telehealth to support patients who have both atrial fibrillation (an irregular heartbeat) and heart failure (when the heart doesn't pump well). It aims to improve their health and quality of life.
Yancheng, DongtaiAges 65–80 - NCT07296081Recruiting
PET scan study for heart scarring in heart failure
This study uses a special PET scan to look for scarring (fibrosis) in the heart muscle of people with heart failure. It may help doctors better understand why some hearts get stiff or weak.
Coimbra, Coimbra DistrictAges 18 years+ - NCT06927440Enrolling by invitation
Registry for children with severe heart failure in China
This study is creating a registry to learn more about children with advanced heart failure. It will help doctors understand who can benefit from treatments like medicine, devices, or transplants.
Shanghai, Shanghai MunicipalityAges Up to 18 years - NCT07349797Recruiting
Transdermal GFR system to check kidney function in heart failure
This trial tests a sensor placed on the skin to measure kidney function in adults with heart failure. It may help understand how well the kidneys are working without repeated blood draws.
New York, New YorkAges 18 years+ - NCT06992089Recruiting
Pacemaker study for heart failure with low heart rate
This trial tests a special pacemaker setting to help your heart beat faster during exercise. It may improve your ability to be active if you have heart failure with preserved ejection fraction (HFpEF) and a low resting heart rate.
ValenciaAges 18 years+ - NCT06061627Recruiting
LOT-CRT vs standard CRT for heart failure with NICD
This study compares a newer pacing therapy (LOT-CRT) to standard cardiac resynchronization therapy (BiVP) for people with heart failure who have a specific type of electrical delay in the heart (NICD). The goal is to see if the newer method works better.
Nanjing, JiangsuAges 18–80 - NCT05562167RecruitingPhase 2
Inorganic nitrate plus exercise for heart failure performance
This Phase 2 study tests whether taking inorganic nitrate can improve exercise ability and heart-function symptoms in people with heart failure with reduced pumping. It also checks whether the treatment is safe when combined with an exercise program.
St Louis, MissouriAges 19–79 - NCT04602338Recruiting
Imaging tests to better diagnose heart failure with preserved function
This trial uses several types of heart imaging to diagnose heart failure where squeezing function is still fairly normal. It may help doctors sort out what’s causing your symptoms and guide better care by comparing imaging findings across many patients.
Beijing, Beijing MunicipalityAges Any age - NCT04603404Recruiting
Imaging tests to find and predict HFpEF risk
This study uses different heart imaging tests to help screen for HFpEF (heart failure with preserved pumping strength), make the diagnosis, and estimate your future risk. You may benefit by getting a clearer diagnosis and a better risk picture based on the scans.
Beijing, Beijing MunicipalityAges Any age - NCT03895541Recruiting
Heart ultrasound stiffness test for elderly diastolic heart failure
This trial tests a new heart ultrasound method to measure stiffness in the heart muscle, which could help doctors diagnose a type of heart failure where the heart is stiff but still squeezes normally. It is for elderly patients with heart failure, and the findings might lead to a simpler and safer way to identify this condition.
ParisAges 18–100
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Common questions
- Are there clinical trials for heart failure, diastolic?
- Yes. Clin2 currently lists 103 recruiting heart failure, diastolic studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure, diastolic trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure, diastolic trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.