Clinical trials
Heart Failure, Diastolic clinical trials
Below are recruiting heart failure, diastolic clinical trials, each written for real people, not researchers. We’re tracking 103 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06409585Recruiting
Heart muscle disease imaging study for scarring
This study uses advanced imaging (PET/MR or PET/CT) to look at scarring (fibrosis) in the heart muscle. It is for people with various heart muscle diseases, including heart failure with preserved pumping, thickened heart muscle, high blood pressure-related heart damage, heart inflammation, and others.
Edinburgh, ScotlandAges 30–90 - NCT05972356Recruiting
How heart relaxation affects outcomes in heart surgery
This study looks at whether a measurement of how well the heart relaxes helps predict outcomes after heart surgery. It focuses on patients treated in Amsterdam UMC and uses care data to understand who may be at higher or lower risk.
Amsterdam, North HollandAges 18 years+ - NCT07589452Recruiting
Pacemaker heart rate settings and blood pressure in older adults
This study tests whether a specific pacemaker heart-rate setting helps control blood pressure and improve heart function in adults over 65 with slow heartbeats and high blood pressure. You would receive a dual-chamber pacemaker (a standard treatment) and be monitored to see how the rate setting affects your health.
Taiyuan, ShanxiAges 65 years+ - NCT07830758RecruitingPhase 1
Resmetirom for fatty liver disease with heart failure
This trial tests a drug called resmetirom for people who have both a type of fatty liver disease (MASH) and a type of heart failure (HFpEF). It aims to see if the drug can help both conditions. You may be able to join if you have both conditions and meet certain health criteria.
Peoria, ArizonaAges 18 years+ - NCT06125925Recruiting
Ablation for AFib in patients with heart failure and preserved ejection fraction
This study tests whether a catheter ablation procedure can help people with atrial fibrillation and a kind of heart failure where the heart pumps normally but doesn't relax properly (HFpEF). It looks at whether the procedure can improve symptoms and heart function.
NanjingAges 18–80 - NCT07858799Recruiting
Study of a new device for heart failure with reduced pumping ability
This trial tests a new device that creates a small shunt (passage) in the heart to help relieve pressure and improve symptoms in people with heart failure and a weak heart pump. The goal is to see if the device is safe and helpful for patients like you.
Cologne, GermanyAges 18 years+ - NCT03523416Recruiting
Shunt device for heart failure with reduced pumping function
This trial studies a small device placed in the heart to create a passage that may help relieve pressure and improve symptoms in people with heart failure and a weak pumping function. It aims to see if the device is safe and helpful for daily life.
La Jolla, CaliforniaAges 18 years+ - NCT06459934Recruiting
Heart and cardiovascular disease study
This study looks at the health outcomes of people with common heart conditions like coronary artery disease, high blood pressure, heart failure, or cardiomyopathy. It may help researchers understand how these conditions progress and how to better manage them.
Ürümqi, XinjiangAges 18–80 - NCT07656454RecruitingPhase 1
Comparing two ways to give CDR132L in healthy volunteers
This study measures how well the drug CDR132L enters the blood when injected under the skin, compared to injection into a vein. It is done in healthy volunteers to find the best way to give the drug.
BerlinAges 18–55 - NCT07527715Recruiting
Heart MRI Study for Dilated Heart Muscle Disease
This research uses cardiac MRI scans and patient data to better predict outcomes in people with dilated cardiomyopathy—a condition where the heart's main pumping chamber becomes enlarged and weakened. Participating could help doctors improve how they care for similar patients in the future.
Jinan, ShandongAges 18 years+ - NCT07493915Recruiting
Personalized rehab for veterans with heart failure with preserved ejection fraction
This study tests a tailored exercise program for veterans who have heart failure with preserved ejection fraction (HFpEF). It aims to see if a personalized rehab plan can improve your heart function and quality of life.
Columbia, South CarolinaAges 18 years+ - NCT07489547RecruitingPhase 2/Phase 3
Can stable heart failure patients stop some medications?
This trial is testing whether people whose heart failure has improved (with better pumping strength) can safely stop taking some of their heart medications. It is for stable patients who have had significant improvement in their heart function from a low point.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT07413198Recruiting
Combined home and clinic exercise coaching for heart failure
This trial tests a program that combines home-based and clinic-based exercise coaching to help people with heart failure get more active. It aims to improve health and quality of life.
Winston-Salem, North CarolinaAges 55 years+ - NCT07385417Recruiting
Early AF treatment for heart failure with preserved pumping function
This study tests using a new electrical pulse treatment for atrial fibrillation (AF) early on, in people who also have a type of heart failure where the heart pumps normally but is stiff. The goal is to see if this treatment helps manage both conditions better.
Frankfurt am MainAges 18–80 - NCT07344480Recruiting
Study on heart disease in children with RASopathy
This study looks at medical records of children with a genetic condition called RASopathy who developed thickened heart muscle and needed hospital care for heart failure in their first six months of life. The goal is to understand how the heart condition progresses over time.
MünchenAges Any age - NCT07324772Recruiting
Exercise program to improve symptoms in atrial fibrillation and heart failure
This study tests if starting a supervised exercise program can help older adults with both atrial fibrillation and a type of heart failure called HFpEF feel better and have a better quality of life. You'll be asked to join exercise sessions and have regular check-ins to see how you're doing.
Chicago, IllinoisAges 60–99 - NCT07251361Enrolling by invitation
Exercise program for heart failure with preserved ejection fraction
This study tests whether a special exercise program that combines different types of training (like aerobic, strength, and balance) can improve heart and muscle function, daily abilities, and quality of life in people with heart failure with preserved ejection fraction (HFpEF). You may benefit if your heart failure is stable and you are able to exercise safely.
Pamplona, NavarreAges 18 years+ - NCT07215715Recruiting
Heart ultrasound study for older adults with heart failure
This study uses a special ultrasound to measure heart stiffness in people 60 and older who have heart failure with preserved or mildly reduced pumping function, with or without a condition called ATTR amyloidosis (a protein buildup in the heart). It also includes healthy controls.
Boston, MassachusettsAges 60 years+ - NCT05712824Recruiting
Device to measure left-heart pressure in advanced heart failure
This trial tests a wirelessly implanted device that measures pressure in the left upper heart chamber (left atrial pressure) in people with advanced heart failure. By tracking that pressure, researchers hope to better understand disease status and guide care.
Tbilisi, GeorgiaAges 22–88 - NCT06147336Recruiting
Testing the V-Lap system for heart failure monitoring
This trial tests a new device called V-Lap that is placed in the heart to monitor pressure. It may help doctors better manage heart failure and reduce hospital stays. Researchers want to see if it works well in people with mild to moderate heart failure.
Boston, MassachusettsAges 22–88 - NCT06956560Recruiting
Heart Scar Imaging Study for Heart Attack and Failure Patients
This study uses a special imaging agent to see a protein called PDGFRß in the heart, which may help detect scarring (fibrosis) after a heart attack or in heart failure. It aims to improve how we understand and treat heart muscle damage.
UppsalaAges 40–70 - NCT03951467Recruiting
Health literacy support to help you follow medical advice
This study tests whether a communication tool matched to your health literacy level can improve how well people follow medical recommendations after an acute episode. It may help you understand your care plan and take the right next steps at home.
BronAges 18 years+ - NCT06130059RecruitingPhase 2
Low-dose colchicine for heart failure with inflammation
This trial tests whether a low-dose colchicine (LoDoCo) can help people with heart failure and inflammation feel better and exercise more. It is for adults 50 and older with HFpEF who have signs of inflammation in their blood.
Dallas, TexasAges 50 years+ - NCT05023785Recruiting
Lifestyle program for cancer survivors with early heart strain
This trial tests a structured lifestyle and exercise change program for young people who finished cancer treatment and have signs of early heart weakness. The goal is to improve heart health and lower the chance of heart failure later.
Toronto, OntarioAges 18–45
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Common questions
- Are there clinical trials for heart failure, diastolic?
- Yes. Clin2 currently lists 103 recruiting heart failure, diastolic studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure, diastolic trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure, diastolic trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.