Clinical trials
HFpEF clinical trials
Below are recruiting hfpef clinical trials, each written for real people, not researchers. We’re tracking 84 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07643818Enrolling by invitationPhase 2
Iron Infusions for Heart Failure and Iron Deficiency
This trial tests whether intravenous iron infusions can help people with heart failure (preserved ejection fraction) who also have low iron levels. The goal is to improve symptoms, quality of life, and how far you can walk.
Saint HelierAges 18 years+ - NCT07539766Recruiting
Obesity Surgery Study to Prevent Heart Problems
This study follows people with obesity who are having weight-loss surgery to see if the surgery can help prevent a specific type of heart problem (HFpEF) that sometimes develops in people carrying excess weight. Researchers will track your heart health and metabolism before and after surgery.
Heerlen, LimburgAges 35 years+ - NCT07077811Enrolling by invitation
Pulsed field ablation for heart failure with preserved pumping strength
This trial tests a new procedure called pulsed field ablation for people who have both persistent atrial fibrillation and a type of heart failure (HFpEF). It aims to see if this ablation safely helps control the heart rhythm.
Nantong, JiangsuAges 18–80 - NCT06937320Enrolling by invitationPhase 2
Testing ketone supplements for heart failure with preserved ejection fraction (HFpEF)
This study tests whether a special dietary supplement (ketone esters) can improve exercise ability and heart function in people with a type of heart failure where the heart pumps well but is stiff (HFpEF). You might join if you have stable symptoms, an ejection fraction of 50% or higher, and signs of fluid buildup in the heart.
Durham, North CarolinaAges 18 years+ - NCT06930495Enrolling by invitation
Weight loss and heart failure with normal pumping strength
This study tests whether weight loss treatments can improve muscle and blood vessel function in people with a specific type of heart failure (HFpEF) who also have obesity. It may help if you have heart failure with a normal ejection fraction and a high BMI.
Dallas, TexasAges 18 years+ - NCT06337812Recruiting
Fiber supplement study for heart failure and diabetes
This study tests whether adding a daily fiber supplement can improve health in people with heart failure and type 2 diabetes. Participants take the supplement for several weeks to see if it helps manage symptoms and blood sugar.
Ann Arbor, MichiganAges 18 years+ - NCT06514820Recruiting
Exercise MRI study for obesity-related heart failure
This study uses an exercise test with MRI to understand how obesity affects the heart in people with heart failure. It aims to find better ways to diagnose and help patients.
GroningenAges 18 years+ - NCT06312748RecruitingPhase 1
Improving blood vessels in veterans with heart failure
This test is looking at whether certain medications (like statins) can help improve blood vessel health in veterans who have heart failure with preserved pumping function. It may help reduce symptoms and keep you out of the hospital.
Salt Lake City, UtahAges 18 years+ - NCT04913805RecruitingPhase 2
Study for HFpEF using heart pressure and energy signals
This Phase 2 study tests how matching heart “filling pressure” and heart muscle “energy use” may improve understanding or treatment of HFpEF, a type of heart failure with preserved pumping strength. You may be asked to have heart scans/tests and follow a study plan if your symptoms and test results fit.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04822649Recruiting
Assessing exercise capacity in people with heart microvascular problems
This study looks at how well you can exercise and how your body composition relates to tiny blood-vessel problems in the heart. It may help doctors better understand symptoms and function in people who don’t have major blockages in the large heart arteries.
SeoulAges 20–80 - NCT04600115RecruitingEarly Phase 1
New MRI methods for heart failure with preserved pumping function
This study tests advanced MRI techniques to better understand heart failure with preserved ejection fraction (HFpEF), a condition where the heart pumps normally but still doesn't work well. It may help improve diagnosis and treatment for patients with this type of heart failure.
Salt Lake City, UtahAges 18 years+ - NCT05441839Recruiting
Heart failure with preserved pumping function study in the UK
This trial studies people who have heart failure symptoms but whose heart pumping strength is largely preserved. It aims to better understand this specific type of heart failure and how best to treat or evaluate it.
AbercynonAges 18 years+ - NCT07270536Recruiting
Pacing and heart pressure in HFpEF exercise
This study tests whether a special pacing setting during exercise can help improve heart filling pressures in people with heart failure with preserved ejection fraction (HFpEF) who already have a DDD pacemaker. If you have HFpEF and a pacemaker, you may help researchers find better ways to manage your condition during activity.
HasseltAges 18 years+ - NCT06762964RecruitingPhase 2
Dapagliflozin for Failing Fontan Circulation
This study tests whether a medication called dapagliflozin (a pill for heart failure) can help people with a Fontan circulation who feel short of breath. It aims to improve symptoms and quality of life.
Rochester, MinnesotaAges 18 years+ - NCT07634640RecruitingEarly Phase 1
Testing an Inflammation Treatment for Heart Failure
This early-stage trial tests a new approach to treat heart failure with preserved ejection fraction (HFpEF)—a type of heart failure where the heart's pumping strength is normal, but it doesn't relax properly. Researchers believe inflammation plays a role and want to see if targeting it can help patients feel better and function more easily.
Gainesville, FloridaAges 18–85 - NCT05784753Recruiting
Exercise coaching for adults with heart failure and preserved heart strength
This study tests an exercise-focused program (including coaching/support) for adults with heart failure where the pumping strength is preserved. It may help improve exercise ability and daily function while monitoring safety.
Detroit, MichiganAges 18 years+ - NCT07326605Enrolling by invitation
Heart MRI study for heart failure with preserved pumping function
This trial uses a special heart MRI to create pressure-volume loops in people with heart failure who have a normal pumping strength (ejection fraction of 50% or higher). It aims to better understand heart function and could help guide future treatments. You may qualify if you have heart failure symptoms and specific heart structure or function changes.
Ages 18 years+ - NCT07093528Recruiting
CS Reducer study for heart failure with preserved pumping function
This trial is testing a device called CS Reducer to see if it can help people with a certain type of heart failure (HFpEF) and a problem with small blood vessels in the heart (CMD). The device may improve blood flow and reduce symptoms.
Rochester, MinnesotaAges 18 years+ - NCT06702501Recruiting
Shunt device to treat heart failure with preserved ejection fraction
This trial tests a tiny tube (shunt) placed in the heart to relieve pressure and ease severe shortness of breath. It's for people with a type of heart failure where the heart pumps well but doesn't relax enough.
Rochester, MinnesotaAges 30 years+ - NCT06670001Recruiting
Increasing daily steps in heart failure with preserved ejection fraction
This study tests if simple rewards and reminders on a smartphone can help people with a certain type of heart failure (HFpEF) become more physically active. The goal is to see if increasing daily steps improves their health and well-being.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06685237Recruiting
Copenhagen heart failure with preserved pumping study
This study is for people in the Capital Region of Denmark who are at least 50 years old and have certain health conditions that put them at risk for a type of heart failure where the heart pumps normally but doesn't relax properly. The study aims to find and help people before heart failure develops.
HellerupAges 50–89 - NCT06309550Recruiting
Testing for heart failure with preserved ejection fraction
This trial uses special tests to see if you have a type of heart failure where the heart pumps well but doesn't relax properly (HFpEF). It's for people who feel short of breath but haven't been diagnosed with this condition yet.
MilanAges Any age - NCT06486649Recruiting
AI tool for diagnosing HFpEF heart failure
This trial is testing a new AI-powered tool to help doctors better diagnose a specific type of heart failure called HFpEF, where the heart pumps normally but doesn't relax properly. It may help you if you have symptoms like shortness of breath or swelling and your heart ultrasound shows normal pumping ability.
Beijing, Beijing MunicipalityAges 18–80 - NCT06208007Recruiting
Predicting heart failure with stiff arteries
This study looks at whether stiffer arteries can help predict a type of heart failure where the heart doesn't relax properly (HFpEF). It's for people who have risk factors like high blood pressure, diabetes, or being older, and who may have early signs of heart trouble.
Göttingen, Lower SaxonyAges 18 years+
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Common questions
- Are there clinical trials for hfpef?
- Yes. Clin2 currently lists 84 recruiting hfpef studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hfpef trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hfpef trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.