Clinical trials
HFpEF clinical trials
Below are recruiting hfpef clinical trials, each written for real people, not researchers. We’re tracking 88 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07436689Enrolling by invitationPhase 3
Long-term study of oral levosimendan for heart failure
This long-term study gives continued access to the oral levosimendan medication for people who finished the earlier TNX-103 study. The goal is to see if ongoing treatment remains safe and helpful.
Chicago, IllinoisAges Any age - NCT07416279Recruiting
Can tiny bubbles replace catheters for heart pressure checks?
This trial tests if tiny ultrasound contrast bubbles can measure heart pressure, possibly replacing the need for catheter tubes. If you're already getting a heart catheterization, you may be able to join.
LondonAges 21–81 - NCT07385417Recruiting
Early AF treatment for heart failure with preserved pumping function
This study tests using a new electrical pulse treatment for atrial fibrillation (AF) early on, in people who also have a type of heart failure where the heart pumps normally but is stiff. The goal is to see if this treatment helps manage both conditions better.
Frankfurt am MainAges 18–80 - NCT07375433Recruiting
Heart failure and COPD study for patients aged 50 to 70
This trial looks at how heart failure with preserved pumping function affects people who also have COPD. It aims to understand the course of the disease and long-term outlook.
Kazan'Ages 50–70 - NCT06774014Recruiting
Heart failure and diabetes: cell study
This study looks at how cells talk to each other in people who have both diabetes and heart failure. It may help doctors understand these conditions better.
Leeds, West YorkshireAges 18 years+ - NCT06685237Recruiting
Copenhagen heart failure with preserved pumping study
This study is for people in the Capital Region of Denmark who are at least 50 years old and have certain health conditions that put them at risk for a type of heart failure where the heart pumps normally but doesn't relax properly. The study aims to find and help people before heart failure develops.
HellerupAges 50–89 - NCT07336316Enrolling by invitation
Heart MRI study for early heart failure with preserved pump function
This trial uses advanced MRI scans to study early signs of heart failure in people whose heart pumps normally but who have risk factors like diabetes, high blood pressure, or obesity. It aims to improve detection and understanding of this condition.
Ages Any age - NCT07326605Enrolling by invitation
Heart MRI study for heart failure with preserved pumping function
This trial uses a special heart MRI to create pressure-volume loops in people with heart failure who have a normal pumping strength (ejection fraction of 50% or higher). It aims to better understand heart function and could help guide future treatments. You may qualify if you have heart failure symptoms and specific heart structure or function changes.
Ages 18 years+ - NCT06826963Recruiting
Eccentric exercise for older adults with heart failure and muscle loss
This study tests whether a special type of exercise (eccentric, or lengthening, exercises) can help older adults with heart failure who also have muscle loss. It aims to see if the exercise is safe and improves strength and function.
Verona, VeronaAges 65–85 - NCT07270536Recruiting
Pacing and heart pressure in HFpEF exercise
This study tests whether a special pacing setting during exercise can help improve heart filling pressures in people with heart failure with preserved ejection fraction (HFpEF) who already have a DDD pacemaker. If you have HFpEF and a pacemaker, you may help researchers find better ways to manage your condition during activity.
HasseltAges 18 years+ - NCT07272902Recruiting
Atrial fibrillation treatment: Ablation vs. medication
This trial compares two ways to treat atrial fibrillation in people with heart failure where the heart's pumping strength is still normal. You'll either get a procedure called ablation to restore normal rhythm or medication to control your heart rate. The goal is to see which approach works better for people like you.
Halifax, Nova ScotiaAges 18 years+ - NCT07237451Recruiting
Heart and kidney study of SGLT2 inhibitors
This study looks at whether a type of diabetes medicine called SGLT2 inhibitors (also known as flozins) can help protect the heart and kidneys in people with both heart failure with preserved pumping function and moderate chronic kidney disease, with or without diabetes.
IașiAges 18 years+ - NCT07215715Recruiting
Heart ultrasound study for older adults with heart failure
This study uses a special ultrasound to measure heart stiffness in people 60 and older who have heart failure with preserved or mildly reduced pumping function, with or without a condition called ATTR amyloidosis (a protein buildup in the heart). It also includes healthy controls.
Boston, MassachusettsAges 60 years+ - NCT07185100Recruiting
Finding early heart failure in at-risk adults across Germany
This study uses heart MRI scans to find unrecognized heart failure in people who have risk factors like diabetes, kidney disease, high blood pressure, or obesity but haven't been diagnosed with heart failure yet. If you join, you will help researchers learn how common hidden heart failure is and take an important step for your own heart health.
BerlinAges 40–69 - NCT05441839Recruiting
Heart failure with preserved pumping function study in the UK
This trial studies people who have heart failure symptoms but whose heart pumping strength is largely preserved. It aims to better understand this specific type of heart failure and how best to treat or evaluate it.
AbercynonAges 18 years+ - NCT07093528Recruiting
CS Reducer study for heart failure with preserved pumping function
This trial is testing a device called CS Reducer to see if it can help people with a certain type of heart failure (HFpEF) and a problem with small blood vessels in the heart (CMD). The device may improve blood flow and reduce symptoms.
Rochester, MinnesotaAges 18 years+ - NCT07057466Recruiting
Checking heart scans with artificial intelligence
This study uses AI to read electrocardiograms (heart rhythm tests) to see if they can detect certain heart structure problems earlier. If you are already scheduled for an echocardiogram (heart ultrasound), your data may be used to help improve detection.
BristolAges 18–90 - NCT06956560Recruiting
Heart Scar Imaging Study for Heart Attack and Failure Patients
This study uses a special imaging agent to see a protein called PDGFRß in the heart, which may help detect scarring (fibrosis) after a heart attack or in heart failure. It aims to improve how we understand and treat heart muscle damage.
UppsalaAges 40–70 - NCT06909682Recruiting
AI monitoring with wearables for chronic heart failure
This trial tests an AI system that uses wearable devices and mini-invasive tools to monitor people with chronic heart failure. The goal is to detect changes early and help manage the condition at home.
SalernoAges 19 years+ - NCT06337812Recruiting
Fiber supplement study for heart failure and diabetes
This study tests whether adding a daily fiber supplement can improve health in people with heart failure and type 2 diabetes. Participants take the supplement for several weeks to see if it helps manage symptoms and blood sugar.
Ann Arbor, MichiganAges 18 years+ - NCT06702501Recruiting
Shunt device to treat heart failure with preserved ejection fraction
This trial tests a tiny tube (shunt) placed in the heart to relieve pressure and ease severe shortness of breath. It's for people with a type of heart failure where the heart pumps well but doesn't relax enough.
Rochester, MinnesotaAges 30 years+ - NCT06763549Enrolling by invitation
AI-powered wearable patch for heart and lung monitoring
This study tests an AI-powered wearable patch (the COR ECG) to see if it can better track heart and lung health. It may help doctors find problems earlier without needing bulky equipment.
Melbourne, FloridaAges 18 years+ - NCT06762964RecruitingPhase 2
Dapagliflozin for Failing Fontan Circulation
This study tests whether a medication called dapagliflozin (a pill for heart failure) can help people with a Fontan circulation who feel short of breath. It aims to improve symptoms and quality of life.
Rochester, MinnesotaAges 18 years+ - NCT06768437Recruiting
Heart fat and preserved ejection fraction heart failure trial
This study looks at whether fat around the heart affects a type of heart failure where the heart pumps well but is stiff (HFpEF). You may be able to join if you have this condition, are 18 or older, and can understand English.
Leicester, LeicestershireAges 18 years+
Hear when a new HFpEF trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for hfpef?
- Yes. Clin2 currently lists 88 recruiting hfpef studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hfpef trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hfpef trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.