Clinical trials
High Grade Glioma (III or IV) clinical trials
Below are recruiting high grade glioma (iii or iv) clinical trials, each written for real people, not researchers. We’re tracking 1,292 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06170177Recruiting
Life after bladder removal surgery study
This study looks at how people feel and their health after having their bladder removed. It aims to understand quality of life after this surgery.
Milan, MIAges 18 years+ - NCT06183489RecruitingPhase 2
Elranatamab for high-risk smoldering multiple myeloma
This trial tests a new drug called Elranatamab for people with a high-risk form of smoldering multiple myeloma (SMM). The goal is to see if the drug can prevent or delay the progression to active multiple myeloma.
HelsinkiAges 18 years+ - NCT06183645Recruiting
Predicting CIDP decline during IVIg treatment changes
This study looks at people with CIDP who are stable on IVIg treatment to see if we can predict when they might get worse if their treatment is adjusted. It aims to make treatment management easier and more personalized.
Liège, LiègeAges 18–99 - NCT06207799RecruitingPhase 2
Drug combo before and after transplant for high-risk myeloma
This trial tests a two-step approach for people with newly diagnosed, high-risk multiple myeloma who are eligible for a stem cell transplant. You'll get a drug called elranatamab before transplant to 'purge' the cancer, and then after transplant, you'll get maintenance therapy guided by how well your cancer is controlled. The goal is to see if this reduces the chance of the cancer coming back.
Houston, TexasAges 18–75 - NCT06225427RecruitingPhase 1
Gilteritinib for advanced ALK-positive lung cancer
This trial tests a drug called gilteritinib for people with a specific genetic type of lung cancer (ALK-positive) that has spread and has been treated before. You may be eligible if you have already tried at least one targeted therapy, and your cancer is still growing.
Los Angeles, CaliforniaAges 18 years+ - NCT06234579Recruiting
Genetic changes in ALK-positive lung cancer over time
This study looks at the genetic changes in ALK-positive lung cancer over time. It is for people who have already started one of three targeted treatments (alectinib, brigatinib, or lorlatinib) and are willing to provide extra tissue or blood samples for testing.
RomeAges 18 years+ - NCT06236269RecruitingPhase 2
Sacituzumab Govitecan for HR+/HER2- advanced breast cancer
This trial tests a drug called Sacituzumab Govitecan for people with HR+/HER2- advanced or metastatic breast cancer that has stopped responding to a CDK4/6 inhibitor. It looks at whether the drug can slow down the cancer and requires you to have a tumor biopsy.
Badalona, BarcelonaAges 18 years+ - NCT06236438RecruitingPhase 2/Phase 3
Livmoniplimab plus budigalimab and chemo for untreated lung cancer
This trial tests a new combination of two immune system drugs (livmoniplimab and budigalimab) plus standard chemotherapy compared to the current standard treatment (pembrolizumab plus chemo) for people with advanced non-small cell lung cancer that has not been treated yet. The goal is to see if the new combination works better at controlling the cancer.
La Jolla, CaliforniaAges 18 years+ - NCT06246968RecruitingPhase 1
Pembrolizumab and Cryoablation for Breast Cancer
This trial is testing a combination of a freezing procedure (cryoablation) and an immunotherapy drug called pembrolizumab (Keytruda) for people with triple-negative breast cancer that has spread. The goal is to see if freezing the tumor helps the immune system fight the cancer better.
Basking Ridge, New JerseyAges 18 years+ - NCT06247449Recruiting
MRI screening for brain metastases in aggressive breast cancer
This trial uses an MRI scan to look for early signs of breast cancer spreading to the brain in people with certain aggressive breast cancer types (triple-negative or HER2-positive) that are stage IIb or III. The goal is to find and treat brain metastases earlier, before they cause symptoms.
Toronto, OntarioAges 18 years+ - NCT06251752Recruiting
Long-term study of kneecap after knee realignment surgery
This study looks at how well the kneecap joint holds up many years after a knee realignment surgery (high tibial osteotomy) for inner knee arthritis. If you had this surgery more than 5 years ago, you may be able to join a long-term checkup that uses X-rays and medical records to see how your knee is doing.
BolognaAges 18–65 - NCT06260033RecruitingPhase 2
Radiation Therapy for Oligoprogressive ER+ Breast Cancer
This trial tests whether a precise radiation treatment (SBRT) can target a few growing spots of estrogen receptor-positive breast cancer that has spread to other parts of the body. It also uses a special PET scan (FES PET/CT) to see how well the cancer responds. The goal is to slow down the cancer and delay the need for stronger treatments.
Duarte, CaliforniaAges 18 years+ - NCT06264531RecruitingPhase 2/Phase 3
Bevacizumab for adults with symptomatic, untreatable brain AVMs
This trial tests a medication called bevacizumab (given as an IV infusion) to see if it can improve symptoms in people with brain arteriovenous malformations (AVMs) that cannot be treated with standard therapies. It is for those whose AVMs cause significant disability.
Paris, Île-de-France RegionAges 18 years+ - NCT06265350Recruiting
Freezing lung tumors plus immunotherapy for liver cancer with lung spread
This study tests a combination of treatments—freezing the lung tumors (cryoablation) plus two drugs (cardonilizumab and bevacizumab)—for people with liver cancer that has spread only to their lungs. It may be an option if your first treatment stopped working but your liver tumors are under control.
Guanzhou, GuangdongAges 18–75 - NCT06272461Recruiting
Comparing lidocaine vs. ketamine for colorectal surgery pain
This trial compares two pain-relief medicines (lidocaine vs. ketamine) given through an IV during open colorectal surgery. It aims to find which one works better to reduce pain after surgery.
NabeulAges 18–90 - NCT06287723Recruiting
Blood test for cancer DNA after liver surgery in colorectal cancer
This study uses a simple blood test (liquid biopsy) to look for tiny bits of cancer DNA after surgery for colorectal cancer that spread to the liver. It aims to see if this test can find cancer earlier than standard scans, which may help guide future treatment decisions.
MontpellierAges 18 years+ - NCT06287775RecruitingPhase 1/Phase 2
Testing a new drug combo for small cell lung cancer
This trial tests adding a new drug, iadademstat, to standard immunotherapy drugs (atezolizumab or durvalumab) for people with small cell lung cancer that responded to initial treatment. The goal is to see if this combination works better at preventing cancer from returning.
Duarte, CaliforniaAges 18 years+ - NCT06289582RecruitingEarly Phase 1
Brain imaging study for Parkinson's disease
This study uses a special PET scan to look at inflammation in the brain of people with Parkinson's disease or those at risk for it. The goal is to better understand the disease and possibly find new ways to track its progression.
Birmingham, AlabamaAges 18–99 - NCT06296264Recruiting
Comparing two ultrasound methods for placing a peripheral IV in patients with difficult veins
This trial tests whether a small, portable ultrasound device works as well as a standard ultrasound machine to help nurses insert a peripheral IV line in patients whose veins are hard to find or access. It could lead to fewer needle sticks and less discomfort.
Lyon, Auvergne-Rhône-AlpesAges 18 years+ - NCT06313567RecruitingPhase 3
Metronomic capecitabine for stage III stomach cancer
This trial tests a low-dose, frequent regimen of the chemotherapy drug capecitabine (taken as a pill) to see if it can help prevent stage III stomach cancer from coming back after surgery. It's for people who have had their stomach cancer completely removed with a specific type of lymph node dissection.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06313541RecruitingPhase 2
Adaptive radiation with immunotherapy for advanced lung cancer
This trial is testing a combination of immunotherapy and targeted radiation for people with advanced lung cancer that has no targetable gene changes. The goal is to see if adjusting radiation based on how well the tumor responds can improve outcomes.
ShanghaiAges 18 years+ - NCT06319846RecruitingPhase 3
Tirofiban for recent mild stroke or TIA with narrowed brain artery
This trial tests the drug tirofiban (a blood thinner) to prevent another stroke in people who have had a mild stroke or high-risk TIA and have a narrowed artery in the brain. It must be started within 24 hours of symptoms.
Harbin, HeilongjiangAges 40 years+ - NCT06558604RecruitingPhase 2
Study of glofitamab with venetoclax for high-risk mantle cell lymphoma
This trial tests a new combination of drugs (glofitamab plus venetoclax, with or without zanubrutinib) for people with mantle cell lymphoma that is either newly diagnosed with high risk features, or has come back or not responded to earlier treatments. The goal is to see if these targeted therapies can improve outcomes.
BrugesAges 18–79 - NCT06780098RecruitingPhase 2
Study of new treatments for advanced squamous lung cancer
This trial tests new drugs for people with advanced squamous non-small cell lung cancer that has gotten worse after standard treatments like immunotherapy and chemotherapy. The goal is to find better options for those who need them.
Lexington, KentuckyAges 18 years+
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Common questions
- Are there clinical trials for high grade glioma (iii or iv)?
- Yes. Clin2 currently lists 1,292 recruiting high grade glioma (iii or iv) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high grade glioma (iii or iv) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high grade glioma (iii or iv) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.