Clinical trials
High Risk clinical trials
Below are recruiting high risk clinical trials, each written for real people, not researchers. We’re tracking 921 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06949579Recruiting
Risk of Eye Bulge in Highly Myopic Europeans
This study looks at the risk of a back-of-the-eye bulge (posterior staphyloma) in people with high myopia. It uses existing eye images to understand the anatomy of highly myopic eyes.
ParisAges 18 years+ - NCT05754580Recruiting
Boost radiation for intermediate or higher-risk prostate cancer
This study tests a stronger, focused radiation plan for intermediate to higher-risk prostate cancer. It combines a high-dose internal radiation “boost” with external radiation to try to improve cancer control while keeping side effects manageable.
Omaha, NebraskaAges 19 years+ - NCT05579626Enrolling by invitationPhase 4
Low-dose statin plus ezetimibe vs high-dose statin for prediabetes
This trial compares two cholesterol-lowering approaches in people with prediabetes to see which one is less likely to lead to new-onset diabetes. It may help you choose a safer medication plan if you need strong cholesterol treatment to prevent future heart problems.
Bucheon-siAges 18–75 - NCT07499349Recruiting
Optimizing Erwinase dosing for ALL patients
This study aims to find the best dose of Erwinase for children with ALL to reduce side effects like high ammonia levels. It focuses on how the drug is processed by the body.
AarhusAges 1 month–45 years - NCT03770312RecruitingPhase 4
Testing low/moderate statin use to prevent heart problems in older adults
This study looks at whether taking a low- to moderate-dose statin can prevent first-time heart and stroke problems in people age 70 and older. It may help you lower “bad cholesterol” (LDL) and see if that leads to fewer heart events over time.
SeoulAges 70 years+ - NCT04416581RecruitingPhase 4
Compare two stomach-protecting medicines to prevent bleeding
This trial compares a potassium-competitive acid blocker to a proton pump inhibitor to help prevent stomach or intestinal bleeding in people at high risk who take blood-thinning medicines. It may help reduce dangerous GI bleeding while you stay on heart/stroke medicines.
AnyangAges 19 years+ - NCT06200974Recruiting
Genetic study of HDR brachytherapy for low-risk prostate cancer
This study looks at a type of radiation therapy called HDR brachytherapy for men with low-risk or slightly higher risk prostate cancer. It aims to understand how your genes affect treatment outcomes.
Kelowna, British ColumbiaAges 18 years+ - NCT07634159Recruiting
Health effects of ultra-processed food intake
This study compares the health effects of a diet high in ultra-processed foods (like packaged snacks and sugary drinks) with a diet of less processed foods, to see how they affect your body. If you qualify, you'll eat these diets for a period of time, and researchers will monitor your health.
GothenburgAges 20–60 - NCT07345923Recruiting
Rectal swab test to predict resistant infections in ICU
This study looks at whether a simple rectal swab test can help predict the risk of developing infections that are resistant to common antibiotics. It focuses on patients in the intensive care unit (ICU) who have already had this swab done as part of their care.
StrasbourgAges 18 years+ - NCT07772869Recruiting
Uterine washing test to detect ovarian cancer risk
This study is testing a new way to find ovarian cancer early. It uses a gentle washing of the uterus (like a Pap test) to collect cells and look for signs of cancer in women who are at high risk because of a BRCA gene mutation. The goal is to see if this method can detect cancer before it spreads, which might help save more lives.
Seattle, WashingtonAges 18 years+ - NCT07439822Enrolling by invitationPhase 4
High-flow oxygen for patients at risk of low oxygen during endoscopy
This trial tests whether high-flow oxygen therapy can prevent low oxygen levels in patients at risk during a digestive endoscopy with deep sedation. It might help if you have obesity, stable lung or heart disease, or sleep apnea.
Valladolid, ValladolidAges 18 years+ - NCT06274645Recruiting
Study of IVUS for Complex Heart Procedures
This study will look at how using a special ultrasound (IVUS) during a heart procedure (PCI) can help people with complex blockages, such as heavy calcium or multiple narrowings. It aims to see if this approach improves outcomes.
ShanghaiAges 18 years+ - NCT07046078RecruitingPhase 2
Chemo, radiation, and donor transplant for older adults with high-risk AML
This trial tests a combination of chemotherapy (FLAG-Ida) followed by low-dose total body radiation and a stem cell transplant from a donor. It is for people age 60 and older with newly diagnosed high-risk blood cancers, aiming to improve outcomes with a less intense transplant preparative regimen.
Seattle, WashingtonAges 18 years+ - NCT07391774RecruitingPhase 3
Hormone therapy with or without chemo for early breast cancer
This trial tests whether skipping chemotherapy and using only hormone therapy with a drug called ribociclib works as well as chemotherapy followed by hormone therapy with ribociclib for certain early breast cancers that have a low risk of coming back.
Jonesboro, ArkansasAges 18 years+ - NCT07215533Recruiting
Exercise trials for teens and young adults at risk for diabetes
This study compares two types of exercise—high-intensity interval training (HIIT) and time-restricted eating (TRE)—to help lower the risk of developing type 2 diabetes in teens and young adults who are overweight or have obesity.
Syracuse, New YorkAges 14–30 - NCT06416488Recruiting
HIIT for heart health in school-age kids
This trial tests whether a high-intensity interval training (HIIT) program can improve heart health and reduce risk factors like high blood sugar, cholesterol, and blood pressure in school-age children. It's for children who have at least one of these problems and are not already doing intense exercise.
Shanghai, Shanghai MunicipalityAges 7–18 - NCT04101188Recruiting
Study how extra potassium affects blood vessels
This study looks at how eating more potassium may protect blood vessels in healthy people. You may be eligible if you have normal blood pressure and a normal heart rhythm test, and you do not have certain health conditions.
Newark, DelawareAges 18–45 - NCT06825377Recruiting
Comparing high-protein vs. standard nutrition for ICU patients
This trial tests whether a high-protein diet or standard protein diet is better for critically ill patients who are at risk for refeeding syndrome (dangerous shifts in fluids and minerals when starting nutrition after starvation). The goal is to see which type of nutrition helps recovery.
TehranAges 18–65 - NCT07655986Recruiting
Suicide prevention program for at-risk adults
This study tests a special program from a university designed to prevent suicidal behavior in adults who have been seen in the emergency room. The program provides close follow-up and support to help keep you safe.
Salamanca, SalamancaAges 18 years+ - NCT01558544Recruiting
Freezing ovarian tissue for future fertility after early menopause risk
This study looks at freezing (cryopreserving) ovarian tissue in people who are at risk of early menopause because of cancer treatment or surgery. It may help preserve natural hormone function and possible future fertility for those who cannot or do not want to freeze eggs or embryos.
New York, New YorkAges Up to 45 years - NCT07725250Recruiting
AI-guided blood pressure trial for stage I-II hypertension
This study tests whether combining artificial intelligence with personalized medicine can help lower blood pressure in people with stage I or II hypertension (140/90 or higher). If you have high blood pressure and can walk without help, this trial may be for you.
La Jolla, CaliforniaAges 18 years+ - NCT07330804Recruiting
Gene study: CORIN and high blood pressure in Afro-Caribbeans
This study looks at whether a specific gene (CORIN) is linked to high blood pressure in people of Afro-Caribbean descent in Guadeloupe. It compares people with high blood pressure to healthy volunteers to see if the gene is more common in those with hypertension.
Petit-BourgAges 18 years+ - NCT06539767Recruiting
Brain aneurysm risk study using MRI
This study looks at people with brain aneurysms to understand which ones are more likely to cause problems. It uses a special MRI to get detailed images and help predict risk.
Guangzhou, GuangdongAges 18–80 - NCT07588256Recruiting
AI Digital Health Platform for High Blood Pressure and Related Conditions
This study uses artificial intelligence and a digital health app to help manage high blood pressure, high cholesterol, diabetes, kidney disease, and heart disease. It aims to help people track their health at home and receive better care recommendations through technology.
New Taipei CityAges Any age
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Common questions
- Are there clinical trials for high risk?
- Yes. Clin2 currently lists 921 recruiting high risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.