Clinical trials
High Risk clinical trials
Below are recruiting high risk clinical trials, each written for real people, not researchers. We’re tracking 921 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05406999RecruitingPhase 2
Intense hormone treatment before prostate surgery for high-risk cancer
This Phase 2 trial studies giving strong hormone-based treatment before prostate surgery to shrink and control high-risk, locally advanced prostate cancer. It may help improve surgical success and reduce cancer spread risk, but it requires careful health checks and prior-treatment limits.
Nanjing, JiangsuAges 18–80 - NCT07572396RecruitingPhase 2
HPV treatment with vaginal suppositories for mild cervical changes
This study tests a new vaginal medication (Dysplasix) to treat mild cervical cell changes caused by high-risk HPV. The goal is to see if this treatment can help your body clear the virus and prevent these changes from getting worse.
Shatin, New TerritoriesAges 18–65 - NCT07481669RecruitingPhase 2
Stem cell transplant for lymphoma at high risk of brain relapse
This trial tests a stem cell transplant with a special chemo combination (TEAM) to see if it can prevent lymphoma from coming back in the brain or spinal cord for people with high-risk non-Hodgkin lymphoma.
Hangzhou, ZhejiangAges 18–70 - NCT07296744Recruiting
Study of a heart pump for high-risk angioplasty
This trial tests a new device called the Supira system to support the heart during a high-risk procedure to open blocked arteries. It is for people who are stable enough to wait for the procedure (not in emergency or shock).
Loma Linda, CaliforniaAges 18–90 - NCT07239245RecruitingPhase 2
TACE plus immunotherapy for high-risk liver cancer before surgery
This trial tests whether a combination of two therapies—targeted chemotherapy delivered directly to the liver (TACE) plus immunotherapy (atezolizumab) and a targeted drug (bevacizumab)—can keep liver cancer from coming back after surgery. It is for people whose tumors can be surgically removed but are at high risk of recurrence.
Beijing, Beijing MunicipalityAges 18–75 - NCT06869265RecruitingPhase 2
Thiotepa added to standard chemo before a stem cell transplant for older adults with high-risk AML
This trial tests whether adding a drug called thiotepa to the usual chemotherapy (busulfan and fludarabine) before a half-matched stem cell transplant can safely and effectively treat older adults (55–70) with high-risk AML.
Beijing, Beijing MunicipalityAges 55–70 - NCT05593497RecruitingPhase 2
Combination therapy before prostate surgery for high-risk prostate cancer
This study tests a combination of hormone therapy and a targeted drug before prostate surgery for men with high-risk prostate cancer that has not spread. The goal is to see if this approach can improve outcomes.
West Los Angeles, CaliforniaAges 18 years+ - NCT06736964Enrolling by invitation
Testing new fillings for gum-line cavities in high-risk adults
This study tests how well two newer, tooth-friendly filling materials work for cavities at the gum line in people who are prone to tooth decay. If you need a couple of these fillings, this trial could help restore your teeth and protect them from future cavities.
CairoAges 25–45 - NCT07074951Recruiting
Tonsillectomy and immune therapy for high-risk IgA kidney disease
This trial tests whether removing the tonsils (tonsillectomy) plus immune-suppressing therapy can help people with a high-risk form of IgA nephropathy, a kidney disease. It aims to slow down kidney damage and delay the need for dialysis.
Saint PetersburgAges 18–75 - NCT06140524RecruitingPhase 2
Study of Linvoseltamab for high-risk MGUS or smoldering myeloma
This trial tests if linvoseltamab can remove abnormal plasma cells that might turn into multiple myeloma. It is for patients with high-risk MGUS (a precancerous condition) or non-high-risk smoldering myeloma who have not yet developed active myeloma.
Baltimore, MarylandAges 18 years+ - NCT06907095Recruiting
Early cancer detection study for high-risk individuals
This study tests if a simple blood or fluid test can find cancer early in people with a higher-than-average risk. If you have certain genetic mutations, a strong family history of cancer, or other high-risk conditions, you may be able to join.
VillejuifAges 18 years+ - NCT03222635Recruiting
Follow-up for certain early esophageal cancer found by endoscopy
This study follows people whose early esophageal adenocarcinoma was found during an endoscopy (ER) sample. The goal is to better understand what follow-up tests are needed based on higher-risk features and to watch for spread or incomplete removal.
SydneyAges 18 years+ - NCT07778212Recruiting
New drug combo for aggressive lymphoma
This trial tests a new combination of drugs for people newly diagnosed with an aggressive type of lymphoma called diffuse large B-cell lymphoma (DLBCL). The combo includes orelabrutinib plus standard chemo-immunotherapy, and may help improve outcomes for those at intermediate or high risk.
Xiamen, FujianAges 18 years+ - NCT07601074RecruitingPhase 2
Testing DARE-HPV to Clear Persistent HPV Infection
This study tests whether DARE-HPV, a new treatment, can help your body clear a persistent human papillomavirus (HPV) infection that hasn't gone away on its own. HPV is a common virus; persistent infection with certain high-risk types can lead to cervical cancer, so clearing it early may prevent future problems.
Phoenix, ArizonaAges 22–50 - NCT05557487Recruiting
Real-world low-dose CT screening for people at high lung risk
This study looks at how people at high risk for lung cancer use low-dose CT scans in real life, and what outcomes happen over time. It may help confirm which groups benefit most from regular screening and support safer screening decisions.
Taichung, TaiwanAges 20–80 - NCT06184009RecruitingPhase 2
Treatment for high-risk childhood leukemia
This trial tests a new treatment approach for children and teens with high-risk acute lymphoblastic leukemia (ALL). It aims to improve outcomes for those with certain genetic changes or cancer that has spread.
Seoul, SeoulAges 1–19 - NCT06050707RecruitingPhase 2
MRI-guided radiation therapy for anal cancer
This trial tests a new, more precise type of radiation therapy for anal cancer. It uses daily MRI scans to adjust the radiation dose based on how the tumor shrinks, aiming to give stronger treatment to the cancer while protecting healthy tissue.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07300449RecruitingPhase 2
Predicting chemo response in children with hepatoblastoma
This trial tests a new way to see if chemotherapy will work for children with hepatoblastoma, a type of liver cancer. It uses a blood test (ctDNA 5hmc) to help predict treatment success and monitor if the cancer comes back.
Guangzhou, GuangdongAges Up to 18 years - NCT05763069Enrolling by invitation
Home monitoring for high-risk pregnancies
This study tests whether checking certain pregnancy warning signs at home (with monitoring technology) can help manage high-risk pregnancies. It may allow closer follow-up while you stay at home, aiming to improve safety and decision-making.
OsloAges 18–50 - NCT06845592Recruiting
Stronger radiation and cell therapy before stem cell transplant for high-risk leukemia
This trial tests a special transplant approach for people with high-risk acute leukemia. It uses a stronger dose of radiation before transplant, followed by an infusion of immune cells (regulatory and conventional T cells) to help the transplant work better and fight the leukemia.
Perugia, PGAges 18–65 - NCT06108492RecruitingPhase 1
A new bladder cancer drug given directly into the bladder
This study tests a new drug, SHR-2005, given directly into the bladder through a catheter. It is for people with intermediate- or high-risk bladder cancer that hasn't spread into the muscle, and aims to see if it is safe and how well it works.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07540585Recruiting
Mental health support for pregnant patients with pregnancy complications
This study tests whether providing mental health care while you're in the hospital for pregnancy-related complications can help you feel better and have better outcomes. It's designed for patients who've had difficulties with past pregnancies.
Indianapolis, IndianaAges 18–100 - NCT07333547Recruiting
WILLEM AI ECG study for high-risk heart patients
This study is collecting information from people who have had an ECG (a heart test) to see if a special AI program called WILLEM can help doctors find high-risk heart patients. The study looks at your ECG data and health records to improve heart care.
Nashville, TennesseeAges 18 years+ - NCT04221035RecruitingPhase 3
Trial for children with high-risk neuroblastoma testing next steps
This Phase 3 study tests treatment strategies for children with high-risk neuroblastoma, aiming to improve how well the cancer responds and how long patients can stay in control. It compares different intensities and add-ons at key treatment steps depending on your child’s response and health.
Sydney, RandwickAges Up to 21 years
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Common questions
- Are there clinical trials for high risk?
- Yes. Clin2 currently lists 921 recruiting high risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.