Clinical trials
Hypercapnia clinical trials
Below are recruiting hypercapnia clinical trials, each written for real people, not researchers. We’re tracking 20 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05536076Recruiting
Breathing treatment to help recovery after spinal cord injury
This study tests whether a breathing-support treatment (for abnormal breathing during sleep) can improve breathing recovery in people living with a spinal cord injury. It aims to see if treating higher carbon dioxide levels and sleep-breathing problems leads to better breathing and recovery.
Detroit, MichiganAges 18–89 - NCT06988111Recruiting
Breathing support after major surgery
This trial tests two types of non-invasive breathing help (NIV and HVNI) for patients who develop serious breathing problems within two days after major surgery. It aims to see which method works better to avoid needing a breathing tube.
Asyut, AssuitAges 18 years+ - NCT07065799Recruiting
Breathing strategies for COPD with high carbon dioxide
This trial compares different breathing strategies for people with COPD who still have high carbon dioxide levels in their blood a few weeks after a severe flare-up. The goal is to find the best way to help you breathe easier and improve your oxygen levels.
ArezzoAges 18–90 - NCT07674264Recruiting
Breathing therapy for thinking and movement in Parkinson's
This study tests whether a breathing-based therapy (short bursts of controlled air with higher carbon dioxide) can help with thinking and movement in people with Parkinson's disease. It may be an option for those who are not too advanced in their condition and are healthy enough to participate.
Gainesville, FloridaAges 40–75 - NCT07112365RecruitingPhase 4
Study of fenfluramine to prevent SUDEP in Dravet syndrome
This study tests whether the drug fenfluramine can reduce the risk of sudden unexpected death (SUDEP) in people with Dravet syndrome who have generalized convulsive seizures. It aims to see if a lower dose can still prevent seizures and protect the heart and breathing during a seizure.
Houston, TexasAges 16 years+ - NCT04271878Recruiting
Test breathing and blood-pressure response in POTS patients
This study measures how breathing patterns and heart rate/blood pressure change when you move from lying to standing in people with POTS. It may help researchers understand symptoms better and improve ways to manage them.
Calgary, AlbertaAges 18–60 - NCT05051397RecruitingPhase 2
Breathing gas study during clot removal for stroke
This Phase 2 trial tests whether changing breathing gas (CO₂ level) during a mechanical procedure to remove a brain blood clot can improve outcomes for acute ischemic stroke. It may help by protecting the brain during the clot-removal procedure under general anesthesia.
Clermont-FerrandAges 18 years+ - NCT05295810Recruiting
Breathing test for people with low blood pressure on standing
This study checks how your body controls breathing and heart rate when you stand up, especially if you get dizzy from low blood pressure. It may help researchers understand what causes symptoms and how to improve testing for people with this condition.
Calgary, AlbertaAges 18–100 - NCT05761756Recruiting
Study of oxygen side effects in otherwise healthy adults
This study looks at what happens in the body when oxygen levels are too high, to better understand the mechanism of oxygen toxicity. You may be eligible if you are a healthy, non-smoking adult without certain medical conditions.
Durham, North CarolinaAges 18–45 - NCT05829083Recruiting
Test of a new breathing interface for COPD flare-ups
This study compares a new breathing interface (“DUET”) with the usual interface for people with COPD who are having an acute flare-up and higher-than-normal carbon dioxide levels. It aims to see whether the new interface helps you breathe better and recover more safely.
AthensAges 18 years+ - NCT06114667Recruiting
Nasal high flow vs. mask for COPD flare-up
This study compares two types of breathing support for people having a severe COPD flare-up with high carbon dioxide and acidic blood. It tests if a gentle air flow through the nose (nasal high flow) works as well as a mask (non-invasive ventilation) to help you breathe better.
Montpellier, MontepllierAges 18–85 - NCT06303518Recruiting
Carbon dioxide and brain activity in children under anesthesia
This study looks at how levels of carbon dioxide in the breath affect brain activity during anesthesia in children. It helps doctors understand the best way to monitor and keep a child safely asleep during surgery.
Vancouver, British ColumbiaAges 3–11 - NCT06638515Recruiting
Walking and breathing exercise for pain relief
This study tests whether a specific breathing exercise (walking while breathing at a low lung volume) can reduce pain sensitivity. It's looking for healthy people who have no ongoing medical conditions or pain.
MadridAges 18–65 - NCT06638528Recruiting
Can Walking and Breath-Holding Reduce Pain Sensitivity?
This study tests a special breathing technique called 'walking apnea' (holding your breath while walking) to see if it can reduce pain sensitivity. Healthy volunteers will do this exercise, and researchers will measure how it affects your pain perception.
MadridAges 18–65 - NCT07099963Recruiting
Study comparing breathing settings during lung surgery
This trial reviews breathing settings used during surgery on one lung to see if a specific tool can help prevent breathing problems.
Québec, QuebecAges 18 years+ - NCT07211529Recruiting
Nerve block during chest surgery to reduce complications
This trial tests whether a numbing injection near the spine (paravertebral block) given during keyhole chest surgery can lower the risk of problems after surgery. It might help patients recover more comfortably.
Wuhan, HubeiAges 18–80 - NCT07357090Recruiting
Carbon dioxide and brain waste clearance trial
This trial tests if breathing in carbon dioxide helps the brain clear waste. It may show how the brain heals after a traumatic brain injury (TBI).
Albuquerque, New MexicoAges 18–82 - NCT07414108Recruiting
Predicting response to breathing support in COPD
This study looks at whether nighttime breathing problems can predict long-term success with a non-invasive breathing machine in people with COPD who have high carbon dioxide levels in their blood. The goal is to help doctors decide who will benefit most from this therapy.
BolognaAges 18 years+ - NCT07432191Recruiting
Testing a new ventilator for safe breathing support
This study tests a new breathing machine (INBENTUS VERSATILE ventilator) for people who need help breathing. It checks if the machine is safe and works well for patients who need a ventilator and then slowly come off it.
MurciaAges 18 years+ - NCT04258774Enrolling by invitation
Breathing challenge during MRI to test brain blood-flow signals
This study uses a breathing challenge while you’re in an MRI to see how blood flow signals in the brain change. It may help researchers better understand how brain imaging signals respond to breathing and oxygen/carbon dioxide levels.
St Louis, MissouriAges 18 years+
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Common questions
- Are there clinical trials for hypercapnia?
- Yes. Clin2 currently lists 20 recruiting hypercapnia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hypercapnia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hypercapnia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.