Clinical trials
High blood pressure clinical trials
Persistently raised blood pressure, a major risk factor for heart disease and stroke. We’re tracking 982 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07064473RecruitingPhase 3
Testing vicadrostat plus empagliflozin for diabetes, high blood pressure, and heart disease
This study tests a new pill called vicadrostat taken with another medicine (empagliflozin) to see if it helps people with type 2 diabetes, high blood pressure, and heart disease. It may reduce the risk of heart problems, but you must not have had heart failure or use certain other heart medications.
Anniston, AlabamaAges 18 years+ - NCT07773272Recruiting
Combined heart, kidney, and metabolic care after a heart attack
This study tests a new approach to managing heart, kidney, and metabolic health together after a heart attack or unstable angina. It aims to improve your recovery and reduce future risks.
Heerlen, LimburgAges 18 years+ - NCT05545501Recruiting
Testing a ketone drink and salt in healthy young adults
This study tests how a ketone ester plus salt affects the body in young adults. It likely looks at safety and what changes you can measure after taking it.
Bloomington, IndianaAges 19–39 - NCT06868719Recruiting
Ketone Drink Study in Older Adults
This study tests a special drink made from ketones (a type of energy source) to see how it affects blood pressure and overall health in older adults. It is for people aged 60–85 who are in generally good health.
Bloomington, IndianaAges 50–85 - NCT07288398RecruitingPhase 3
Levosimendan for exercise limitation in PH-HFpEF
This trial tests if the drug levosimendan can help people with a specific type of pulmonary hypertension (PH-HFpEF) feel less tired and breathless during daily activities, and improve their exercise ability.
Alexander City, AlabamaAges 18–85 - NCT07448597RecruitingPhase 4
Progesterone for preventing preeclampsia
This trial tests if taking progesterone early in pregnancy can help prevent preeclampsia, a condition of high blood pressure. You may qualify if you are over 18, speak English, and are less than 12 weeks pregnant.
Charleston, South CarolinaAges 18 years+ - NCT07206628Recruiting
Glaucoma eye drop adherence with easygrip bottle
This study looks at how well people stick to their glaucoma eye drop routine when using a special bottle called EASYGRIP®. If you use this type of bottle for your glaucoma drops, this study may help doctors understand how to make treatment easier.
BolognaAges 18 years+ - NCT03630211RecruitingPhase 2
Study of stem cell transplant for systemic sclerosis in youth
This Phase 2 study tests whether an “autologous” stem cell transplant—using your own stem cells—can reduce systemic sclerosis disease activity. It is mainly for children, teens, and young adults whose disease did not improve despite standard medicines.
Pittsburgh, PennsylvaniaAges 8–60 - NCT06826755Recruiting
Melatonin for heart health in midlife women
This study tests whether melatonin can help improve heart health in midlife women with high blood pressure. It involves taking a melatonin pill or placebo for several weeks and checking blood pressure and other health markers.
Rochester, MinnesotaAges 40–55 - NCT07693699Recruiting
Helping with home blood pressure monitoring in primary care
This study provides support for getting and using a home blood pressure monitor if you have high blood pressure. It tests a training pathway to help you track your blood pressure at home.
Chicago, IllinoisAges 18 years+ - NCT07238556Recruiting
Digital tool for doctors to prescribe exercise
This trial tests a digital tool that helps doctors create personalized exercise plans for patients with heart disease risk factors. It aims to help you become more active in a safe, supported way.
Farmington, ConnecticutAges 18–64 - NCT06297291Recruiting
Long-term safety study for a kidney nerve treatment
This study tests a device that uses ultrasound to calm overactive kidney nerves, which may help lower blood pressure. It is for people with high blood pressure that is hard to control with medication.
Long Beach, CaliforniaAges 18 years+ - NCT06475781RecruitingPhase 2
Study of mirivadelgat for pulmonary hypertension with interstitial lung disease
This study tests a new medication called mirivadelgat for people with pulmonary hypertension associated with interstitial lung disease (PH-ILD). The goal is to see if it can help improve symptoms and slow the progression of the disease.
Hualien City, TaiwanAges 18–85 - NCT07228065Enrolling by invitation
Combination pill study for better blood pressure control
This trial tests whether switching to a single pill that combines two blood pressure medicines helps control high blood pressure better than taking two separate pills. It might make treatment simpler and more effective.
Milwaukee, WisconsinAges 18–80 - NCT07751432Enrolling by invitation
Improving pregnancy care in a changing climate
This study works with clinics in Dar es Salaam, Tanzania to improve pregnancy care for women living in a city, especially as the climate changes. The goal is to help keep mothers and babies healthier.
Dar es Salaam, Temeke DistrictAges 18 years+ - NCT07753681Recruiting
Chronic disease care in Zambia
This study helps improve care for people with long-term illnesses like diabetes or high blood pressure in Zambia. It aims to make sure you get regular check-ups and support.
Lusaka, Lusaka ProvinceAges Any age - NCT06402968Recruiting
Clevidipine for treating high blood pressure after a brain bleed
This trial tests a blood pressure medicine called clevidipine given through an IV to people with a brain bleed (intracerebral hemorrhage). The goal is to see if quickly lowering blood pressure helps prevent more bleeding and improve recovery.
Irvine, CaliforniaAges 18–100 - NCT06280313Recruiting
Splenectomy with targeted therapy and immunotherapy for liver cancer
This trial tests whether removing the spleen (splenectomy) can improve the effectiveness of targeted therapy and immunotherapy for people with advanced liver cancer (HCC) who also have enlarged spleens due to portal hypertension. It aims to see if this combination can help control the cancer better.
Wuhan, HubeiAges 18–75 - NCT04715022RecruitingTeam says not enrollingPhase 1/Phase 2
Vitamin C study for insulin resistance in obesity
This early-stage study tests whether vitamin C (and possibly how your body uses it) affects blood vessel function in people with obesity and insulin resistance. You may be asked to stop certain supplements before starting so researchers can measure the effect more clearly.
Kansas City, KansasAges 35–65 - NCT06975111RecruitingPhase 2/Phase 3
Improving health during menopause
This trial studies ways to help women during the late menopausal transition. It uses a smartphone app and telehealth visits to track your health and help you feel better.
Aurora, ColoradoAges 45–55 - NCT06715280RecruitingPhase 4
Switching from sildenafil to riociguat for CTEPH
This trial tests switching from sildenafil to a newer medicine called riociguat for people with CTEPH (a type of lung blood pressure problem) who still have symptoms after a balloon procedure. The goal is to see if the switch helps them feel better.
Hong KongAges 18 years+ - NCT06577688Recruiting
Checking blood pressure with a smartphone app
This trial tests whether a smartphone app can accurately measure your blood pressure without a cuff. It may help find people with high blood pressure early using only a phone.
Lausanne, Canton of VaudAges 18–80 - NCT06261398Recruiting
Better pregnancy outcomes with text support
This trial uses text messages and education to help improve pregnancy outcomes for women who are less than 21 weeks pregnant. It's designed for patients receiving care at certain Ohio State University clinics.
Columbus, OhioAges 18 years+ - NCT06286891Recruiting
Frailty and lung function after pulmonary endarterectomy
This study looks at how frailty, physical ability, and lung function change in people who have had surgery to remove blood clots from the lungs (pulmonary endarterectomy). It aims to help doctors better understand recovery after this procedure.
São Paulo, São PauloAges 18 years+
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Common questions
- Are there clinical trials for high blood pressure?
- Yes. Clin2 currently lists 982 recruiting high blood pressure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high blood pressure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high blood pressure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.