Clinical trials
High blood pressure clinical trials
Persistently raised blood pressure, a major risk factor for heart disease and stroke. We’re tracking 980 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05464095Recruiting
Mobile health support for pulmonary arterial hypertension
This study tests whether using a mobile health tool can help people with pulmonary arterial hypertension (PAH) manage their condition in daily life. It’s aimed at adults who are stable on their PAH medicines and can track activity using a wearable device.
Nashville, TennesseeAges 18 years+ - NCT05434195Recruiting
Study folate in pregnancies with high blood pressure
This study looks at how a vitamin called tetrahydrofolate may affect pregnancies with preeclampsia or increased risk of high blood pressure. Participants may receive the supplement to help researchers understand key biology and potential benefits or harms.
Oxford, OxfordhsireAges 18–45 - NCT05442671Recruiting
Exercise coaching program for children with pulmonary hypertension
This trial tests whether a structured exercise program, done with remote support, is safe and helpful for children with pulmonary hypertension. It aims to improve how well kids function day-to-day while they stay on their usual PH medications.
Philadelphia, PennsylvaniaAges 8–18 - NCT02770066Recruiting
Registry study of PTRA in difficult-to-control blood pressure
This study keeps track of people with renovascular hypertension (high blood pressure likely linked to blocked kidney arteries) who may receive a procedure called PTRA. It aims to understand who benefits and how kidney and heart outcomes change over time.
AalborgAges Any age - NCT05179876RecruitingPhase 3
Treatment access study for pulmonary hypertension when no other option
This Phase 3 study continues treatment for people with pulmonary hypertension who finished an earlier parent study and have no other approved treatment option. It tests whether continuing their current medicine can help them keep getting benefit and stay safe.
MinskAges 2 years+ - NCT05156385Recruiting
Study of sexual problems in women with treated high blood pressure
This study looks at sexual dysfunction (sexual problems) in women who are being treated for high blood pressure. It may help researchers understand what causes these issues and what could improve them.
Toulouse, CHU de ToulouseAges 18 years+ - NCT05184933Recruiting
Study sleep timing and blood pressure patterns in adults
This study looks at how your sleep schedule and body clock relate to blood pressure control. You may be asked to follow a study plan that helps researchers understand what sleep and daily timing changes do to hypertension.
Portland, OregonAges 25–64 - NCT04838678RecruitingEarly Phase 1
Testing a new blood-pressure approach in obesity-related hypertension
This early-stage study tests a new way to help control high blood pressure that is linked to obesity. It may help people whose blood pressure is high based on a 24-hour blood pressure monitor.
Dallas, TexasAges 18–55 - NCT04778046RecruitingPhase 2
Study lung pressure treatment for people waiting for transplant
This Phase 2 trial is for adults with pulmonary hypertension who are on the lung transplant waiting list at Duke. It aims to test whether the study treatment can improve lung pressure and related health outcomes, while using things like MRI to monitor changes.
Durham, North CarolinaAges 18 years+ - NCT04753840Recruiting
Remote arm conditioning and mindfulness for mild high blood pressure
This trial studies whether doing “remote ischemic preconditioning” (repeated brief conditioning of a limb) and mindfulness helps people with mild high blood pressure over the long term. It may help lower blood pressure and improve heart-related health, if you can safely do the required activities.
Zhengzhou, HenanAges 18–80 - NCT04388124RecruitingPhase 2
Test drug to block endothelin for hard-to-control blood pressure
This Phase 2 trial tests whether blocking endothelin (using bosentan and related treatments) can improve blood pressure in people with resistant hypertension—high blood pressure that stays high despite multiple medicines. It may help if your blood pressure is still above target even with the right combination of therapy.
RouenAges 18–80 - NCT04401982RecruitingPhase 4
Testing eye drops for blood flow in high eye pressure and glaucoma
This study tests whether three different eye drop treatments (netarsudil, latanoprost, or both together) can improve blood flow to the white part of the eye and the retina. It may help people with high eye pressure or who are glaucoma suspects better understand how these treatments work.
Baltimore, MarylandAges 18 years+ - NCT01607502Recruiting
Database study for people with pulmonary hypertension symptoms
This study builds a medical and symptom database for people who have pulmonary hypertension or may be at risk, to better understand the condition. If you choose to participate, your basic health information and symptom history may be recorded and used for research.
GrazAges 18 years+ - NCT04356326RecruitingPhase 3
Aspirin to prevent complications in pregnancy with chronic high blood pressure
This trial studies whether taking acetyl salicylic acid (aspirin) during pregnancy can reduce problems caused by chronic high blood pressure. It focuses on pregnant people already known to have high blood pressure before or early in pregnancy.
BordeauxAges 18 years+ - NCT04278404Recruiting
Drug safety study for children already on certain medicines
This study measures how certain medicines move through the body and checks their safety in children. It may help doctors better understand dosing and side effects in kids who are already receiving these treatments, or in some kids who recently tested positive for COVID-19.
Phoenix, ArizonaAges birth–20 years - NCT03042988Recruiting
Heat stress test in people with low nerve control and high blood pressure
This study checks how your body’s blood pressure and stress responses change after being exposed to heat overnight. It’s meant for people with autonomic failure (like certain Parkinson-related or nerve-function conditions) who also have high blood pressure while lying down, which may help researchers understand safer ways to manage it.
Nashville, TennesseeAges 18–80 - NCT04160533Recruiting
Registry for people diagnosed with high blood pressure
This registry collects information from people who have been diagnosed with high blood pressure. It may help researchers better understand who has it and how it’s managed in real life.
Moscow, Moscow OblastAges 18–99 - NCT04194632Recruiting
Right heart pacing study for pulmonary hypertension
This study tests whether a temporary pacemaker placed in the right heart chamber can improve heart function in people with pulmonary arterial hypertension. It aims to see if pacing can help the right heart pump more efficiently, potentially reducing symptoms.
San Francisco, CaliforniaAges 18–75 - NCT04078243Recruiting
Trial setup and testing in adults with pulmonary hypertension
This study tests new “trial tools” and designs for running early research in people with pulmonary hypertension. If you qualify, you may be asked to do extra trial-related procedures to help researchers test the process safely and smoothly.
Sheffield, South YorkshireAges 18 years+ - NCT03945305Recruiting
Remote ischemic conditioning for high blood pressure
This trial tests if a simple, non-invasive treatment called remote ischemic conditioning (briefly restricting blood flow to an arm) can safely lower blood pressure in people with essential hypertension. It is for adults aged 30-75 whose blood pressure is consistently high despite standard care.
Changchun, JilinAges 30–75 - NCT03755726Recruiting
Study of care for dangerously high blood pressure
This trial looks at a health-care plan for people with malignant hypertension (very high blood pressure causing emergency eye and organ damage). It may help doctors better organize treatment and follow-up after this high-risk diagnosis.
AnnecyAges 18 years+ - NCT03762499Recruiting
Personalized blood pressure care for young adults using heart ultrasound
This study looks at a personalized approach to managing high blood pressure in adults aged 18–40, using heart ultrasound information along with regular clinical checkups. It may help clinicians tailor treatment to each person’s heart-related findings.
OxfordAges 18–40 - NCT00710177Recruiting
Study genes and risk of persistent lung blood pressure in newborns
This study looks at a newborn’s genes (PTGS1 variation) and whether that relates to persistent pulmonary hypertension of the newborn (PPHN), a serious breathing/lung blood-pressure problem. It may help doctors understand who is at higher risk and how to better identify affected babies early.
Milwaukee, WisconsinAges Up to 1 year - NCT02880631Recruiting
Barostim therapy for resistant hypertension
This trial is evaluating a device called BAROSTIM NEO, which sends electrical signals to help lower high blood pressure. It is for people who have recently had the device implanted and still have high blood pressure despite taking multiple medications.
BerlinAges Any age
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Common questions
- Are there clinical trials for high blood pressure?
- Yes. Clin2 currently lists 980 recruiting high blood pressure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high blood pressure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high blood pressure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.