Clinical trials
Knee Arthroplasty clinical trials
Below are recruiting knee arthroplasty clinical trials, each written for real people, not researchers. We’re tracking 235 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07337772Recruiting
Comparing corticosteroid doses in knee replacement pain relief injection
This study compares different doses of a corticosteroid (an anti-inflammatory medicine) injected into the knee during total knee replacement surgery. The goal is to see which dose provides the best pain relief after surgery. It is for people having their first knee replacement due to osteoarthritis.
Fuzhou, FujianAges 18–100 - NCT06239649Recruiting
Nerve block before knee replacement for faster recovery
This trial tests whether a numbing injection (nerve block) around the knee before surgery can help you recover faster and feel less pain after a total knee replacement. It is for people with knee osteoarthritis who are ready for their first knee replacement surgery.
Denizli, PamukkaleAges 40–85 - NCT06617871Recruiting
Comparing two ways to align a new knee replacement
This study compares two different techniques (mechanical alignment vs. kinematic alignment) used during knee replacement surgery with a special knee system. It aims to see which technique leads to better results for patients.
Chicago, IllinoisAges 21–79 - NCT07532785Recruiting
Water and Land Exercise Before Knee Replacement Surgery
This trial tests whether a 6-week program combining weekly water-based exercise and three times weekly land-based training can help reduce knee pain and improve strength before total knee replacement surgery. The program aims to help you recover better after your operation.
London, EnglandAges 18 years+ - NCT04960098Recruiting
Survey after hip or knee replacement surgery
This study asks people who have had a hip or knee replacement to share how they’re doing over time. It’s testing whether patient-reported survey answers can help measure recovery and outcomes.
MilanAges 18 years+ - NCT07869615Recruiting
Blood thinners after knee replacement surgery
This study compares two types of blood thinners to prevent blood clots after knee replacement surgery. It will help find which one works better and is safer for patients.
Tunis, Tunis GovernorateAges 18–80 - NCT07199738Recruiting
Knee replacement study with a new implant option
This study tests a specific knee implant insert (LEGION Medial Stabilized) in people who need a total knee replacement due to arthritis or similar joint disease. It aims to see if the device is safe and works well over time.
Newton, MassachusettsAges 18–80 - NCT06740214RecruitingPhase 3
Different doses of liposomal bupivacaine for knee replacement pain
This trial tests different doses of a long-acting painkiller (liposomal bupivacaine) injected into a nerve block in the thigh to see which dose works best for pain after knee replacement surgery. It may help you have better pain control and recover faster.
Hong Kong, Hong KongAges 18–80 - NCT05288803Recruiting
Personalized rehab after knee replacement for veterans
This study tests a personalized rehabilitation program for veterans who have had a total knee replacement. It aims to improve recovery by tailoring therapy to each person's progress.
Aurora, ColoradoAges 40–90 - NCT07050277RecruitingPhase 3
Morphine for bladder issues after knee replacement
This study tests whether adding morphine to spinal anesthesia can reduce trouble urinating after a second knee replacement surgery. It may help you avoid needing a catheter after surgery.
Toronto, OntarioAges 21 years+ - NCT04692714Recruiting
Cemented vs cement-free robotic knee replacement surgery
This trial compares two ways surgeons can attach a knee replacement using robotic-assisted surgery: with cement or without cement. It may help improve how well the new knee lasts and how patients recover after a first-time knee replacement.
LyonAges 50–80 - NCT06234631RecruitingPhase 2
CBD to reduce opioids after knee replacement
This study tests if a daily CBD capsule can help reduce the need for opioid pain pills after a first-time total knee replacement. It is for people with osteoarthritis who are having surgery and are willing to avoid cannabis for a short time before and after.
Ann Arbor, MichiganAges 18–80 - NCT07058623Recruiting
Nurse-led telehealth vs in-person follow-up after knee replacement
This trial compares follow-up care with a nurse via video calls or phone versus in-person visits after your first total knee replacement. It aims to see if telehealth is as good as in-person for your recovery.
Hong KongAges 18 years+ - NCT05653102Recruiting
Collecting data on a knee replacement system after surgery
This study collects real-world health and surgery records to better understand how the Truliant total knee replacement performs. It may help doctors and patients by improving future guidance on this knee system’s safety and effectiveness.
Aurora, ColoradoAges 18 years+ - NCT06038240Recruiting
Pain self-management program for knee replacement
This study is testing a program to help people manage pain on their own before and after total knee replacement surgery. It aims to improve recovery and reduce reliance on pain medications.
Charlottesville, VirginiaAges 18–85 - NCT07511985Recruiting
Managing Pain After Knee Replacement Surgery
This study looks at how "rebound pain" (increased pain when pain medication wears off) affects long-term pain after total knee replacement. Researchers want to understand this connection and potentially improve pain management strategies for knee surgery patients.
Konya, MeramAges 18 years+ - NCT07069179Recruiting
Choose to Move replacement study for older adults
This study tests a program called Choose to Move Replacement Ready (CTM-RR) designed for older adults. It looks at how well activity coaches and healthcare referral partners can help people get active.
Vancouver, British ColumbiaAges 50 years+ - NCT07511842Recruiting
Keeping Your Knee Still After Surgery to Reduce Pain
This study tests whether keeping your knee immobilized (held still) for 72 hours after knee replacement surgery helps reduce pain. Researchers will compare this approach to standard care to see if it makes recovery easier.
Sherbrooke, QuebecAges 18 years+ - NCT06837844Recruiting
Pain relief study for knee replacement surgery
This trial tests a combination of two pain-relief methods after total knee replacement: a spinal injection and a nerve block in the thigh. It aims to provide better pain control during and after surgery.
Kafr ash Shaykh, KafrelsheikhAges 18–75 - NCT07465159Recruiting
Prehabilitation for frail patients before hip or knee replacement
This study tests whether a 'prehabilitation' program (tailored exercise and nutrition support before surgery) helps older patients who are frail recover better after hip or knee replacement. Participants will be randomly assigned to either the prehabilitation group or the usual care group.
ReykjavikAges 70 years+ - NCT06929871Recruiting
Cementless vs. cementless knee replacement for osteoarthritis
This trial compares two types of knee replacements: one where the implant is glued in (cemented) and one where it locks into the bone without glue (cementless). It is for people with knee osteoarthritis who need a first-time total knee replacement.
LondonAges 18 years+ - NCT04821154Recruiting
Testing outcomes after revision knee replacement with a Persona system
This study looks at how well a specific revision knee replacement system (the Persona system) works after earlier knee problems or surgeries. You may be eligible if you need a revision knee and can follow follow-up care instructions; the trial also checks for certain infection, bone, and health-safety factors.
Fayetteville, ArkansasAges 18 years+ - NCT06580899Enrolling by invitationPhase 4
Knee pain pump study for single knee replacement surgery
This study tests whether a small pain pump placed in your knee joint during surgery can help control pain after a single knee replacement. It is for people who are having outpatient knee replacement surgery and have not been taking strong pain medicines recently.
Charlotte, North CarolinaAges 18 years+ - NCT07555067Enrolling by invitation
Robotic Knee Replacement Surgery Comparison
This trial compares two different robotic systems used during knee replacement surgery for knee arthritis (wear and tear). The study helps doctors understand which robotic system may provide better results.
Bydgoszcz, Kuyavian-Pomeranian VoivodeshipAges 18 years+
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Common questions
- Are there clinical trials for knee arthroplasty?
- Yes. Clin2 currently lists 235 recruiting knee arthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee arthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee arthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.