Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 814 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06562634Enrolling by invitation
Ultrasound-guided nerve block for knee surgery pain relief
This study tests a nerve block (erector spinae plane block) to see if it reduces pain after open knee surgery. It aims to find a better way to manage pain with fewer side effects.
CairoAges 18–65 - NCT06565377Recruiting
Pre-surgery program for knee replacement patients
This trial tests a program of exercise, education, and support to help you prepare for knee replacement surgery. It aims to improve your recovery and quality of life.
Geel, AntwerpenAges 18 years+ - NCT06485843RecruitingPhase 2
Testing a new injection for moderate to severe knee osteoarthritis
This study tests the safety of an experimental injection called OA-SYS for people with moderate to severe knee osteoarthritis. It may help if you have not had recent injections or certain other health problems.
Las Vegas, NevadaAges 35–75 - NCT06488144RecruitingPhase 3
Knee arthritis rehab: helping veterans keep improving
This study tests a program that helps veterans with knee osteoarthritis keep up the gains they make in physical therapy. It uses a Fitbit and a smartphone app to support you and track your activity after your PT sessions end.
Birmingham, AlabamaAges 40–90 - NCT06490770Recruiting
Understanding knee pain and function
This study looks at how your knee joint works when you have pain or limited function. It uses MRI and electrical stimulation to learn more about cartilage and meniscus damage, which might help improve future treatments.
BolognaAges 18–60 - NCT06478186RecruitingPhase 4
Knee Osteoarthritis Steroid Injection Study for People with Type 2 Diabetes
This study compares two different steroid knee injections—Zilretta and Kenalog—to see which works better for people with both knee osteoarthritis and type 2 diabetes. It uses a continuous glucose monitor to track blood sugar changes.
Kansas City, KansasAges 40 years+ - NCT06462625Recruiting
Knee realignment surgery for arthritis with bowed legs
This study tests how well a realignment surgery (osteotomy) works for people with mild knee arthritis and a bent knee that's at least 3 degrees off center. The surgery may also fix other knee problems like a torn meniscus or ligament at the same time.
BolognaAges 18–70 - NCT06423716RecruitingPhase 4
Duloxetine to reduce opioid use after knee replacement
This study tests whether taking the pain medication duloxetine before and after knee replacement surgery can reduce the need for opioid painkillers. It may help patients manage pain with fewer side effects from strong narcotics.
Toronto, OntarioAges 50 years+ - NCT06430918Enrolling by invitation
Nerve pain and sleep quality in knee osteoarthritis
This study looks at how nerve pain and sleep quality are related in people with knee osteoarthritis. It aims to help doctors better understand and treat pain.
IzmirAges 18–80 - NCT06414473RecruitingPhase 1/Phase 2
CBD for knee osteoarthritis pain
This study tests whether a CBD (cannabidiol) product can help reduce pain and improve daily life for people with knee osteoarthritis. If you have moderate to severe knee pain and haven't used cannabis recently, you may be able to join.
Gainesville, FloridaAges 40–75 - NCT06384898Recruiting
Remote tai chi for knee osteoarthritis
This study tests whether doing tai chi remotely, twice a week for 12 weeks, helps reduce knee pain and improve function compared to routine care. Tai chi is a gentle exercise that may ease arthritis symptoms and can be done from home.
Boston, MassachusettsAges 50–100 - NCT05332288Recruiting
Observing treatment outcomes for a knee cartilage defect
This observational study follows people with a specific knee cartilage injury from osteochondritis dissecans (OCD) to see how they do after standard care and rehab. It may help doctors understand which patients benefit most and what changes happen over follow-up.
BolognaAges 15–40 - NCT06321042Recruiting
Knee replacement study using sensor-guided implant placement
This study tests whether using small motion sensors during knee replacement surgery leads to better outcomes. It is for people aged 50–84 with severe knee pain from arthritis or bone damage who are scheduled for a first-time cemented total knee replacement.
Bologna, ItaliaAges 50–85 - NCT06290336Recruiting
Exercise and education before knee replacement surgery
This study tests if exercise therapy and patient education before total knee replacement can improve recovery. It may help people waiting for their first knee replacement due to osteoarthritis.
Linköping, Östergötland CountyAges 40–85 - NCT06245109RecruitingPhase 4
Pain medicine study for knee osteoarthritis
This study tests how well different pain medicines work for knee osteoarthritis and looks at brain patterns to understand why some people get more relief. It may help you find a treatment that works best for you.
Chicago, IllinoisAges 41 years+ - NCT06251167Recruiting
Shoe insoles for knee osteoarthritis
This study tests whether shoe insoles can help people with knee osteoarthritis. You might be eligible if you have had knee pain for at least 6 months, your pain is at least moderate, and you also have pain in the same foot.
Vancouver, British ColumbiaAges 50 years+ - NCT06228573Recruiting
Brain stimulation and yoga for knee pain
This study combines a gentle brain stimulation technique (tDCS) with yoga to see if it helps reduce knee pain and improve movement in people with knee osteoarthritis.
Hamilton, OntarioAges 45 years+ - NCT06211387Enrolling by invitation
Stretching plus resistance exercise for knee osteoarthritis
This study tests whether adding a gentle stretching technique to resistance exercises helps reduce knee pain and improve movement in people with knee osteoarthritis. It may be a good option if you have mild-to-moderate knee arthritis and want to strengthen your knees without surgery.
Islamabad, FederalAges 40–65 - NCT06182397Recruiting
Drug-coated balloon for leg artery blockages below the knee
This trial tests a special balloon coated with sirolimus (a drug that helps prevent arteries from re-closing) versus a standard balloon for opening blocked arteries below the knee in people with severe leg pain or foot wounds. The goal is to see if the drug-coated balloon works better to keep the artery open longer.
Scottsdale, ArizonaAges 21 years+ - NCT06182059Recruiting
Pain after knee replacement study
This study looks at long-term pain after total knee replacement surgery. It may help understand why some people have persistent pain and find ways to prevent it.
Monza, Monza BrianzaAges 18–85 - NCT06187038Recruiting
Pain education study for knee osteoarthritis
This trial tests if learning about chronic pain can help people with knee osteoarthritis feel better. You'll join a program that teaches you about pain and how to manage it.
São PauloAges 40–80 - NCT06120023Recruiting
Long-term follow-up of the Madison knee replacement system
This study follows patients in France who receive a Madison total knee replacement. It watches how well the knee works and how the patient feels over time, to make sure the implant is safe and effective.
Lyon, RhôneAges 18 years+ - NCT06118892Recruiting
Knee implant study for inner knee pain from arthritis
This trial is testing a new knee implant designed to relieve pain on the inner side of the knee caused by osteoarthritis. It is for people who have not gotten enough relief from other treatments like physical therapy or injections.
Sonoma, CaliforniaAges 25–65 - NCT06123715RecruitingPhase 2
Vitamin C to reduce pain after knee replacement
This study tests whether taking vitamin C before and after knee replacement surgery can reduce long-term pain. You may be eligible if you are having knee replacement for osteoarthritis and are generally healthy.
Toronto, OntarioAges 18 years+
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 814 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.