Clinical trials
Ligament Injury clinical trials
Below are recruiting ligament injury clinical trials, each written for real people, not researchers. We’re tracking 89 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05754632Recruiting
Blood flow restriction exercises after ACL surgery in teens
This trial tests whether a special type of exercise that uses a cuff (blood flow restriction training, or BFRT) can help teens recover after ACL reconstruction. It’s designed to see if adding BFRT to standard rehab improves strength and return to sport.
Farmington, ConnecticutAges 12–18 - NCT03968913RecruitingEarly Phase 1
Biologic shot to prevent knee arthritis after ACL injury
This early-phase trial tests a biologic medicine (anakinra) given after an ACL injury to try to prevent or reduce later osteoarthritis (wear-and-tear arthritis). It enrolls young adults who recently tore their ACL and are planning a specific type of ACL reconstruction.
Los Angeles, CaliforniaAges 18–35 - NCT06505525Recruiting
ACL reconstruction: adding extra support vs standard surgery
This trial compares two surgical techniques for ACL reconstruction. The standard method repairs the ACL inside the knee joint, while the new method also adds extra support outside the joint. The study aims to see which approach gives better stability and recovery for people with specific risk factors, like being a young athlete or having a chronic ACL tear.
São Paulo, São PauloAges 14–40 - NCT07401095Recruiting
BioBrace for Arthroscopic Ankle Ligament Repair
This trial is for people who need a first-time arthroscopic Brostrom repair to fix a loose ankle ligament. It uses a special material called BioBrace to help the repair heal better.
Greenfield, IndianaAges 18 years+ - NCT06357091Recruiting
ACL repair with Shark Screw or standard screw
This trial compares two types of screws used to hold a new ACL in place: a Shark Screw and a standard biocomposite screw. It may help if you have a torn ACL that needs surgery.
Schwaz, TyrolAges 18 years+ - NCT06194682Recruiting
ACL reconstruction follow-up study
This study follows people who have had or will have ACL reconstruction surgery at this hospital. It helps doctors learn more about how patients recover after ACL surgery over the long term.
MilanAges 18–65 - NCT07792863Recruiting
Leg strength and movement after ACL reconstruction
This study looks at how your leg muscles and movement patterns recover after ACL reconstruction surgery. It aims to understand progress and help improve rehabilitation.
Saint-Maurice, DemandeAges 18 years+ - NCT07580157Enrolling by invitation
Shockwave therapy for knee pain after ACL surgery
This study tests whether focused shockwave treatment can reduce knee pain in people who have had ACL (anterior cruciate ligament) reconstruction surgery. Shockwave therapy uses sound waves to reduce pain and inflammation.
Rochester, MinnesotaAges 18 years+ - NCT04875052Recruiting
Study vibration after ACL injury and future arthritis risk
This study looks at whether using vibration after an ACL injury helps predict or reduce the risk of developing post-traumatic osteoarthritis (wear-and-tear arthritis) later. It may help researchers learn which patients are more likely to develop arthritis after ACL reconstruction.
Chapel Hill, North CarolinaAges 16–35 - NCT06368544Recruiting
Early walking training after ACL knee surgery
This trial studies whether starting walking exercises earlier after ACL reconstruction can help protect the knee cartilage from wearing down. It may be a good fit if you are having your first ACL surgery at Peking University Third Hospital and your knee has already healed from the initial injury.
BeijingAges 18–40 - NCT05174611RecruitingPhase 2
Vitamin D to strengthen the thigh after ACL surgery
This Phase 2 study tests whether taking vitamin D can improve thigh (quadriceps) muscle strength after ACL reconstruction. It targets people with low vitamin D levels that persist after surgery and weaker thigh strength on the injured side.
Hong KongAges 18–40 - NCT07876635Recruiting
Knee tunnel placement study for ACL repair outcomes
This study looks at where the bone tunnel is placed during ACL reconstruction surgery and whether that placement affects how well the knee heals and functions after surgery. It could help doctors improve surgery techniques for better recovery.
SakaryaAges 18–50 - NCT07475351Recruiting
Comparing two grafts for ACL reconstruction
This trial compares two types of grafts to rebuild the ACL in the knee, to see if one leads to better results. It is for active athletes with a recent ACL tear and healthy knees.
Granada, GranadaAges 12–40 - NCT06826898Recruiting
Hydrogel to prevent scar tissue after ankle ligament repair
This trial tests a special gel placed during ankle ligament repair surgery to see if it prevents painful scar tissue from forming. It might help people with chronic ankle sprains who need surgery.
ChanghuaAges 18–60 - NCT06762392Recruiting
Blood flow restriction for ACL rehab: a pilot study
This study tests whether using a special band that slightly restricts blood flow (blood flow restriction) during rehabilitation can help people recover better after ACL knee surgery. It's a small early study to see if this method is safe and effective.
Valencia, ValenciaAges 18 years+ - NCT06942754Recruiting
Bracing vs. surgery for ACL tears
This study compares two ways to treat a torn ACL: bracing alone or surgery using your own quadriceps tendon. It aims to find which option helps you return to sports best.
Winston-Salem, North CarolinaAges 14–39 - NCT07322497Recruiting
Phone app vs. supervised exercise before ACL surgery
This study compares two ways to exercise before ACL surgery: using a video app on your phone versus doing exercises with a physical therapist. The goal is to see which approach helps you recover better.
Istanbul, KartalAges 18–45 - NCT05701579Recruiting
Testing treatment choices for early ACL cartilage changes before surgery
This trial looks at a treatment strategy for people with specific early changes in the ACL seen on MRI who are planning knee surgery. It may help by testing the best way to address those ACL-related cartilage/mucosa-like changes before or during surgical care.
Bełchatów, Łódź VoivodeshipAges Any age - NCT06341868Recruiting
Electrical stimulation for ACL recovery in military cadets
This trial tests whether a special electrical stimulation device (KneeStim) can help military academy cadets recover faster after ACL reconstruction surgery. It aims to improve muscle strength and knee function using gentle electrical pulses during rehabilitation.
West Point, New YorkAges 17–27 - NCT06311513RecruitingPhase 4
Concentrated bone marrow injection during repeat ACL surgery
This study tests whether adding a concentrated bone marrow injection during repeat ACL surgery helps healing and recovery better than surgery alone. If you have had a previous ACL reconstruction that failed, you may be eligible.
Atlanta, GeorgiaAges 18–55 - NCT05965310Recruiting
Virtual psychology support for ACL repair recovery
This study tests a virtual (online) psychological program to help people recover after ACL ligament surgery. It focuses on first-time ACL repairs and aims to improve how patients cope during recovery.
Detroit, MichiganAges 13 years+ - NCT06442319Recruiting
PRP after ACL reconstruction
This trial tests if injecting platelet-rich plasma (a concentration of your own blood platelets) after ACL reconstruction helps with healing and reduces pain. It's for people who recently had ACL surgery and want to try an extra treatment to improve recovery.
TorunAges 18–45 - NCT05848622Recruiting
Gait retraining after ACL surgery for fast knee recovery
This trial tests a walking (gait) rehabilitation program to improve how you move after ACL reconstruction. It may help if you are still having walking mechanics issues in the months to years after surgery.
Chapel Hill, North CarolinaAges 16–35 - NCT06147427Recruiting
ACL reconstruction with or without Lemaire procedure
This study compares two surgical techniques for repairing a torn ACL: standard ACL reconstruction alone versus ACL reconstruction plus a Lemaire procedure (an extra side-stabilizing repair). It aims to see which approach provides better knee stability for active patients over at least 2 years.
LyonAges 18–50
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Common questions
- Are there clinical trials for ligament injury?
- Yes. Clin2 currently lists 89 recruiting ligament injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a ligament injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a ligament injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.