Clinical trials
Locally Advanced or Metastatic Non-small Cell Lung Cancer clinical trials
Below are recruiting locally advanced or metastatic non-small cell lung cancer clinical trials, each written for real people, not researchers. We’re tracking 3,558 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT02074839RecruitingPhase 1
Oral AG-120 for advanced blood cancers with an IDH1 mutation
This Phase 1 study tests an oral medicine called AG-120 in adults with advanced blood cancers that have a specific IDH1 mutation. It also looks at safety and how the treatment works, with frequent blood, urine, and bone marrow samples.
Birmingham, AlabamaAges 18 years+ - NCT02559778RecruitingPhase 2
Precision treatment trial for children with advanced neuroblastoma
This Phase 2 trial studies a targeted treatment approach for children and young adults with advanced neuroblastoma (a childhood cancer). It may help by using lab-tested cancer features to guide therapy after initial treatment and transplant.
Birmingham, AlabamaAges Up to 22 years - NCT02469662Recruiting
Study of outcomes after Nexel total elbow replacement
This study looks at how well the Nexel total elbow replacement works over time for people who need an elbow replacement due to pain, damage, or instability. It may help the doctors understand which patients benefit most and what results to expect.
Golden, ColoradoAges 18 years+ - NCT03357120Recruiting
Using blood DNA to assess response after breast cancer chemotherapy
This study checks whether a blood test that looks for “tumor DNA” (circulating tumor DNA) can help evaluate how well neoadjuvant chemotherapy worked for breast cancer. It may help doctors better understand treatment response after surgery.
BordeauxAges 18 years+ - NCT07659821Recruiting
Nutrition and wellness study for moms and babies
This study offers food kits and nutrition guidance to pregnant women to help support their health and their baby's wellness. You may be eligible if you are in early pregnancy (7–12 weeks) and live in the Dallas-Fort Worth or College Station area.
College Station, TexasAges 18–45 - NCT07398339RecruitingPhase 2
Photodynamic therapy for bile duct cancer
This trial tests a light-activated drug called cosiporfin sodium for people with advanced bile duct cancer that cannot be surgically removed. The treatment targets tumors in the bile ducts and may help shrink them.
Shanghai, Pudong New AreaAges 18 years+ - NCT07419490Recruiting
Moving ovaries and uterus to preserve fertility during pelvic radiation
This trial moves the ovaries and uterus higher in the belly before pelvic radiation to protect them, so patients may still be able to have children later. It is for women aged 18-40 with pelvic cancers that require radiation.
Tampa, FloridaAges 1.5 years–3.3 years - NCT07422753RecruitingPhase 2
TACE with immunotherapy drugs for advanced liver cancer
This trial tests a combination of TACE (a procedure that blocks blood supply to the tumor) plus three immunotherapy drugs (sintilimab, bevacizumab, ipilimumab) for people with advanced liver cancer that cannot be removed by surgery. The goal is to see if this combination works better than TACE alone.
Hangzhou, ZhejiangAges 18–75 - NCT07434843RecruitingPhase 2
Pemigatinib for a rare type of GIST
This trial tests a drug called pemigatinib for people with a specific type of GIST (SDH-deficient GIST) that has spread or cannot be removed with surgery. The goal is to see if the drug can help stop the cancer from growing.
Boston, MassachusettsAges 18 years+ - NCT07461090Recruiting
Laparoscopic vs. open kidney removal surgery study
This study compares laparoscopic (keyhole) and open surgery for removing all or part of a kidney. It looks at how well each method works and how much it costs, to help decide which is better for patients with certain kidney conditions or tumors.
Shibīn al Kawm, Shebin ElkomAges 1 year+ - NCT07474103Recruiting
Chemo, radiation, and immunotherapy for high-risk rectal cancer
This trial tests a treatment plan that combines chemotherapy, radiation, and an immunotherapy drug before surgery for people with high-risk locally advanced rectal cancer. The goal is to see if this approach can improve outcomes.
WuhanAges 18–75 - NCT07478523RecruitingPhase 2
FAPI-PET scan for initial screening of pancreatic and bile duct cancers
This trial tests a new imaging method called FAPI-PET to see if it can better detect pancreatic and bile duct cancers at an early stage. It may help doctors decide on the best treatment plan for you.
PessacAges 18 years+ - NCT07493668RecruitingPhase 2
Fostrox plus Lenvatinib for advanced liver cancer after immunotherapy
This trial tests whether adding the drug Fostrox to the standard drug Lenvatinib works better than Lenvatinib alone for people with advanced liver cancer that has worsened after initial immunotherapy treatment. It is for those who cannot have surgery and have not had more than one prior cancer treatment.
Seongnam-si, Gyeonggi-doAges 19 years+ - NCT07519564RecruitingPhase 1
Study of GB18 Injection for Cancer-Related Weight Loss
This Phase 1 trial tests a new drug called GB18 to help cancer patients who have experienced significant weight loss and muscle wasting—a condition called cancer cachexia. The drug works by targeting a specific protein involved in weight loss, and researchers want to learn if it can help patients regain weight and strength while also being safe.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07532018RecruitingPhase 1
DXP-106 Treatment for Advanced Solid Tumors
This early-stage trial tests a new drug called DXP-106 in patients with advanced cancers (like lung, pancreatic, or breast cancer) that have stopped responding to standard treatments. The study aims to find the right dose and see if this drug can help slow or shrink these tumors.
Harbin, HeilongjiangAges 18–75 - NCT07548177RecruitingPhase 2
Combination drug study for advanced soft tissue sarcoma
This study tests two cancer drugs (benmelstobart and anlotinib) together to treat alveolar soft part sarcoma, a rare soft tissue cancer that has spread or cannot be surgically removed. The drugs work by boosting the immune system and blocking tumor blood vessel growth.
Beijing, Beijing MunicipalityAges 14 years+ - NCT07560566RecruitingPhase 2
Preventing Hand-Foot Skin Reaction in Liver Cancer Treatment
This study tests whether a topical anti-inflammatory cream (indomethacin) applied preventively to hands and feet can reduce a painful skin side effect called hand-foot syndrome that occurs in advanced liver cancer patients taking sorafenib. If effective, it could help patients tolerate their cancer medication better.
TaipeiAges 18 years+ - NCT07567222RecruitingPhase 1
Vaccine therapy for advanced solid tumors
This study tests a new therapeutic vaccine designed to help your immune system fight advanced solid cancers. You would receive vaccine injections alongside standard cancer care if your cancer has progressed despite previous treatments.
Chengdu, SichuanAges 18–75 - NCT07570849RecruitingPhase 2
Chidamide with chemotherapy and immunotherapy for advanced bile duct cancer
This trial tests a combination of three treatments—chidamide (a new type of cancer drug), chemotherapy, and immunotherapy—for advanced intrahepatic cholangiocarcinoma (a cancer of the bile ducts inside the liver). The goal is to see if this combination can shrink tumors and help patients live longer when used as a first treatment.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07579117Recruiting
Video-Assisted Breast Surgery With Nipple Preservation
This trial tests a minimally invasive surgical technique that removes breast tissue while preserving the nipple and immediately reconstructing the breast. It may be suitable if you have early-stage breast cancer or are at high genetic risk and need preventive breast removal.
MilanAges 18 years+ - NCT07588295Recruiting
How immune cells respond in heart and leg blood vessel disease
This study examines how immune cells (macrophages) behave differently in patients with blocked arteries in the heart or legs. Understanding this may help doctors develop better treatments for these conditions.
Cotignola, RavennaAges 18 years+ - NCT07609329Recruiting
Nutritional Support Before Sarcoma Surgery
This study tests whether special nutritional supplements given before surgery for bone or soft tissue sarcoma (a type of cancer) can help your body heal better and recover faster. You'll take oral supplements for at least a week before your planned surgery.
BrnoAges Any age - NCT07627334Recruiting
Personalized drug testing for newly diagnosed brain tumors
This trial tests whether customized drug screening on your tumor cells can help doctors choose the best treatment for you. Your tumor cells will be grown in the lab and tested against different drugs to find what works best, combined with short-course radiation therapy.
Vienna, State of ViennaAges Any age - NCT07629245RecruitingPhase 1/Phase 2
Cell therapy for Crohn's disease fistulas after prior treatment
This trial tests whether injecting your own fat-derived cells combined with a skin graft can heal anal fistulas (abnormal passages near the anus) that didn't respond to or came back after a previous cell therapy study. You must have already participated in the ADICROHN-2 study.
MarseilleAges 18 years+
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Common questions
- Are there clinical trials for locally advanced or metastatic non-small cell lung cancer?
- Yes. Clin2 currently lists 3,558 recruiting locally advanced or metastatic non-small cell lung cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a locally advanced or metastatic non-small cell lung cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a locally advanced or metastatic non-small cell lung cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced Non-Small Cell Lung Cancer
- Advanced or Metastatic Non-small Cell Lung Cancer
- Metastatic Non-squamous Non Small Cell Lung Cancer
- Advanced Non-squamous Non-small-cell Lung Cancer
- NSCLC (Advanced Non-small Cell Lung Cancer)
- Non Small Cell Lung Cancer Metastatic
- Non Small Cell Lung Cancer
- Non-squamous Non-small Cell Lung Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.