Clinical trials
Low Risk clinical trials
Below are recruiting low risk clinical trials, each written for real people, not researchers. We’re tracking 169 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06181929Recruiting
Early lung cancer detection in Korean women with family history
This study looks at a new way to find lung cancer early in Korean women who have never smoked but have a family history of lung cancer. You would get a special CT scan (low-dose CT) to check for early signs of cancer, which could help catch it sooner.
Seoul, SeoulAges 45–74 - NCT05333328RecruitingPhase 4
Test of ovarian function suppression for low-risk premenopausal node+ breast cancer
This trial studies whether ovarian function suppression (a treatment that lowers hormone production from the ovaries) helps women with hormone-receptor positive, HER2-negative breast cancer that has spread to lymph nodes, but who have a low-risk result on a genomic test. It may help reduce breast cancer recurrence while avoiding more intensive treatment for those who are lower risk.
Seoul, KoreaAges 20–50 - NCT06364644Recruiting
Reducing heart failure risk in low-income adults with diabetes
This study looks at how low income and diabetes together raise the risk of heart failure. It offers a program to help you manage your health and reduce that risk.
Baltimore, MarylandAges 30–70 - NCT06235892RecruitingPhase 3
Lowering Tacrolimus for Low-Risk Kidney Transplant Patients
This trial tests whether safely lowering the dose of tacrolimus—an anti-rejection drug—can still protect a kidney transplant one year after surgery. It's for first-time transplant recipients with low immune risk.
NantesAges 18 years+ - NCT01898039RecruitingPhase 1/Phase 2
Vaccine study for certain melanoma patients with specific blood markers
This trial tests a modified vaccine to help the immune system recognize melanoma. It is mainly for people with melanoma at higher risk or certain stages, and who have specific inherited tissue markers on blood testing.
JerusalemAges Any age - NCT05832736Recruiting
Robot surgery for one-sided prostate cancer with urethra preserved
This study looks at a robotic prostate operation that aims to remove only the affected side while keeping the urethra (the tube for urination) to help preserve urinary function. It’s for people with low- to intermediate-risk, one-sided prostate cancer and no spread to lymph nodes, bones, or other organs.
Candiolo, TOAges 40 years+ - NCT06310564Recruiting
SBRT for limited metastatic colorectal cancer
This trial tests whether focused radiation (SBRT) can treat 1 to 3 metastases in people with colorectal cancer that has spread but is still low or intermediate risk. It may be an option if you are starting first or second line systemic therapy and your primary tumor is under control.
Negrar, VeronaAges 18 years+ - NCT07112781Recruiting
Single dose radiation for early prostate cancer
This trial tests whether a single, high dose of radiation can treat low- to intermediate-risk prostate cancer. It may be a shorter and more convenient option for eligible patients.
MoscowAges 18 years+ - NCT06488222RecruitingPhase 2
Chemotherapy for low-grade bladder cancer that comes back
This trial tests whether putting two chemotherapy drugs (gemcitabine and docetaxel) directly into the bladder can treat low-grade bladder cancer that is at intermediate risk. The goal is to see if this approach can help people avoid more invasive treatments.
Gainesville, FloridaAges 18 years+ - NCT06263491RecruitingPhase 2
Pirtobrutinib and Rituximab for Low/Medium Risk MCL
This trial tests a combination of two medications, pirtobrutinib and rituximab, for people newly diagnosed with low- or medium-risk mantle cell lymphoma. It aims to see if this approach is effective and safe without needing chemotherapy.
Houston, TexasAges 18 years+ - NCT03650595Recruiting
MRI-guided laser treatment for prostate cancer
This trial tests a minimally invasive prostate treatment using MRI guidance and a focal laser to destroy only the cancer spot (not the whole prostate). If you have low-to-intermediate risk, MRI-visible prostate cancer in a limited area, it may help control the cancer while potentially reducing treatment side effects.
Toronto, OntarioAges 40–80 - NCT03770312RecruitingPhase 4
Testing low/moderate statin use to prevent heart problems in older adults
This study looks at whether taking a low- to moderate-dose statin can prevent first-time heart and stroke problems in people age 70 and older. It may help you lower “bad cholesterol” (LDL) and see if that leads to fewer heart events over time.
SeoulAges 70 years+ - NCT03886662RecruitingPhase 1/Phase 2
LB-100 for low-risk MDS after prior treatment failure
This Phase 1/2 trial studies LB-100 in adults with low or intermediate-1 risk myelodysplastic syndromes (MDS). It may help by improving blood counts or disease control in people whose prior treatments have not worked or stopped working.
Tampa, FloridaAges 18 years+ - NCT06162780Recruiting
Clip repair for severe mitral valve leak
This trial tests a clip-based procedure (TEER) to fix a severe leak in the mitral valve for people who have symptoms or heart changes but are at low to medium risk for surgery. The goal is to see if this less invasive option works well and is safe.
Guangzhou, GuangdongAges 18 years+ - NCT07804056RecruitingPhase 3
Alpha1H before surgery for low-risk bladder cancer
This study tests a new medicine called Alpha1H that is given before the usual surgery to remove bladder cancer. It may help lower the risk of the cancer coming back.
PragueAges 18 years+ - NCT07762885RecruitingPhase 3
Comparing skipping radiation after surgery for early-stage DCIS
This trial compares skipping radiation therapy after breast-conserving surgery for low- or intermediate-risk ductal carcinoma in situ (DCIS) – a very early, non-invasive breast cancer. It aims to see if omitting radiation is as effective as standard treatment while reducing side effects.
ShanghaiAges 40 years+ - NCT07749924Recruiting
Watchful waiting vs. bladder chemotherapy for intermediate-risk bladder cancer
This study compares two approaches for people with intermediate-risk bladder cancer whose urine shows no signs of cancer after surgery. One group will be watched closely (active surveillance), while the other will receive chemotherapy directly into the bladder (intravesical chemotherapy). The goal is to see if surveillance alone can prevent unnecessary treatment while keeping the cancer controlled.
DaqingAges 18 years+ - NCT07348367Recruiting
Comparing two prostate cancer surgeries for low-risk patients
This trial compares two types of prostate surgery (standard removal vs. precision removal) in men with low- or intermediate-risk prostate cancer. It aims to see which surgery preserves urinary and sexual function while still effectively treating the cancer.
Detroit, MichiganAges Any age - NCT06846489RecruitingPhase 2
Acalabrutinib plus rituximab for untreated mantle cell lymphoma
This trial tests a combination of two targeted drugs (acalabrutinib and rituximab) for people with mantle cell lymphoma who have not had treatment before. It is designed for older patients or younger patients with a less aggressive form of the disease.
Guangzhou, GuangdongAges 18 years+ - NCT05783466Recruiting
Testing how dairy affects heart risk in people with high weight
This study looks at whether eating more dairy (from cow’s milk) changes markers linked to heart and metabolic risk in adults with higher body weight. It mainly aims to understand how diet affects the body’s metabolism and related risk factors.
Pierre-BéniteAges 18–70 - NCT06348719Recruiting
Robot vs. standard laparoscopy for early endometrial cancer
This trial compares two types of minimally invasive surgery (robot-assisted vs. conventional laparoscopy) for removing the uterus in people with early-stage, low- to intermediate-risk endometrial cancer. The goal is to see which approach offers the best value and outcomes.
LilleAges 18 years+ - NCT04239157RecruitingPhase 2
Canakinumab shot for lower-risk MDS and related blood disorders
This trial tests canakinumab, a medication that blocks inflammation, given as a skin (subcutaneous) injection. It is for adults with lower-risk myelodysplastic syndromes (MDS) or a related condition (chronic myelomonocytic leukemia or CCUS) to see if it can improve blood counts and reduce problems like anemia or transfusion needs.
Houston, TexasAges 18 years+ - NCT01624805RecruitingPhase 2
Immunosuppressant treatment to help low blood counts in some bone marrow disorders
This trial tests a group of immune-suppressing medicines (with steroids and growth-factor injections) for people with aplastic anemia or certain low-risk myelodysplastic syndromes. The goal is to improve bone marrow function and reduce problems caused by low blood counts, such as fatigue, infections, or bleeding.
Houston, TexasAges 18 years+ - NCT07226895RecruitingPhase 1/Phase 2
Study of MT1988 for people at high risk for psychosis
This trial tests a new drug called MT1988 in people who show early warning signs of psychosis. Researchers want to see if it changes certain markers in the body related to mental health.
Irvine, CaliforniaAges 17–30
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Common questions
- Are there clinical trials for low risk?
- Yes. Clin2 currently lists 169 recruiting low risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a low risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a low risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.