Clinical trials
Low Risk clinical trials
Below are recruiting low risk clinical trials, each written for real people, not researchers. We’re tracking 169 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06554158Recruiting
Lowering radiation for low-risk HPV throat cancer patients
This trial tests whether giving less radiation after surgery is safe and effective for people with early-stage HPV-related throat cancer. It aims to reduce side effects while still controlling the cancer.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06537609Recruiting
Testing treatments for Gram-negative bloodstream infections
This trial tests different ways to treat infections in the blood caused by Gram-negative bacteria. It looks at whether reducing antibiotics, switching to pills, or managing central lines improves outcomes while keeping you safe.
Kogarah, New South WalesAges birth–130 years - NCT06465160RecruitingPhase 1
Study of MNV-201 for low-risk MDS with anemia
This study tests a new therapy called MNV-201 for people with low-risk myelodysplastic syndromes (MDS) who have anemia and need regular blood transfusions. The goal is to see if this treatment can help reduce or stop the need for transfusions.
Jerusalem, IsraelAges 18–100 - NCT05684770Recruiting
Remote follow-up for low-risk blood clot patients
This study tests whether remote care (check-ins by phone/video or other remote support) can safely help people with a low-risk deep vein thrombosis or pulmonary embolism after an ER diagnosis. It may improve follow-up and support while reducing the need for frequent in-person visits.
ÉvreuxAges 18 years+ - NCT06329245Recruiting
Tracking social skills and brain growth in infants at risk for autism
This study looks at how social behaviors and brain connections develop in infants who have a higher or lower chance of developing autism. It helps doctors understand early signs and may lead to better support for children and families.
ShanghaiAges birth–1.5 years - NCT05693909RecruitingPhase 2
SP-420 for iron overload in certain blood disorders
This Phase 2 study tests SP-420 to help people with transfusion-related iron overload from either beta-thalassemia or low-risk myelodysplastic syndromes. It aims to see if the treatment can improve how the body handles excess iron, which builds up after repeated transfusions.
CopenhagenAges 18 years+ - NCT06316895Recruiting
Thermal ablation for small, low-risk thyroid cancer
This trial is studying a treatment called thermal ablation (using heat to destroy cancer cells) for people with small, low-risk papillary thyroid cancer. It aims to see how well it works and to predict outcomes.
BeijingAges 18–80 - NCT06300125Recruiting
Freezing small low-risk breast tumors without surgery
This trial tests cryoablation (freezing the tumor with a needle) as a way to treat small, low-risk breast cancers without surgery. It is for women 50 or older whose cancers are hormone-receptor-positive and haven't spread to lymph nodes.
MilanAges 50 years+ - NCT06291311Recruiting
Plasma treatment for cervical HPV infections
This study tests a new non-invasive plasma treatment for cervical infections caused by high- and low-risk HPV types. It may help clear the virus and prevent related health issues.
TübingenAges 18 years+ - NCT06261190Enrolling by invitation
Active monitoring for low-risk thyroid cancer
This trial tests whether it is safe to avoid immediate surgery and instead monitor small thyroid cancers that are considered low-risk. If you join, doctors will check regularly to make sure the cancer does not grow or spread.
Goyang-siAges 18 years+ - NCT06081244RecruitingPhase 3
Testing sacituzumab govitecan with or without pembrolizumab for early triple-negative breast cancer
This trial tests a two-drug combination (sacituzumab govitecan and pembrolizumab) versus sacituzumab govitecan alone before surgery for low-risk, triple-negative breast cancer that hasn't spread. The goal is to see which approach works better at shrinking tumors.
Baden-Baden, Baden-WurttembergAges 18 years+ - NCT06063486RecruitingPhase 2
Curcumin for inflammation and symptoms in blood disorders
This trial tests whether curcumin, a natural compound found in turmeric, can reduce inflammation and improve symptoms like fatigue in people with certain blood disorders that cause low blood counts or overproduction of blood cells. It is for patients with clonal cytopenia of uncertain significance, low-risk myelodysplastic syndrome, or myeloproliferative neoplasms (polycythemia vera, essential thrombocytosis, or myelofibrosis) who have bothersome symptoms.
Los Angeles, CaliforniaAges 18 years+ - NCT05604963Recruiting
Half or full thyroid surgery for low-risk thyroid cancer
This study looks at people with low-risk thyroid cancer who have already had (or are about to have) surgery, comparing half-thyroid removal versus full-thyroid removal. It may help doctors choose the safest and most effective surgery for your cancer type and risk level.
Crewe, CheshireAges 16 years+ - NCT05350722Recruiting
Single pre-surgery radiation for low-risk breast cancer
This trial tests a single, shorter course of radiation given before breast surgery for people with low-risk, hormone-receptor–positive breast cancer. It may help treat the breast tumor while reducing the number and length of radiation treatments.
SydneyAges 40 years+ - NCT05297617RecruitingPhase 2
Shorter hormone therapy for low-risk postmenopausal breast cancer
This Phase 2 trial studies whether women with very low-risk, hormone-receptor positive breast cancer can safely take hormone therapy for a shorter time. It may help reduce side effects if shorter treatment works as well as the longer standard plan.
LimogesAges 51 years+ - NCT05273762Recruiting
Removing blood clots from the lungs with a catheter
This trial tests a device called the FlowTriever to remove blood clots from the lungs in people with a pulmonary embolism that is not too severe. The goal is to see if this treatment can help improve heart function and symptoms without major surgery.
Mount Kisco, New YorkAges 18 years+ - NCT05018520RecruitingPhase 3
Two chemotherapy schedules for newly diagnosed low-risk DLBCL
This trial compares two different shortened treatment schedules of R-CHOP to see which one is safer and works better for people with low-risk diffuse large B-cell lymphoma (DLBCL). It aims to reduce risk from treatment while maintaining strong cancer control after an initial response.
Shanghai, Shanghai MunicipalityAges 14–75 - NCT04263038RecruitingPhase 4
Watchful waiting versus blood thinners for small lung clots
This trial compares close monitoring (“watch and wait”) versus taking the blood thinner rivaroxaban in people with a small type of lung blood clot. It aims to find out whether low-risk patients can safely avoid or reduce anticoagulation while still staying healthy.
Woluwe-Saint-Lambert, Brussels CapitalAges 18 years+ - NCT03769766RecruitingPhase 3
Curcumin to help keep low-risk prostate cancer from worsening
This study tests whether curcumin (a supplement made from turmeric) can prevent low-risk prostate cancer from progressing while you stay on active surveillance. If you qualify, you would take curcumin and be monitored closely with regular checkups.
Dallas, TexasAges 40–89 - NCT03703271RecruitingPhase 3
Uterine scraping as first treatment for low-risk GTN
This trial tests whether using a hysteroscope (a tiny camera) to gently scrape the uterus again, instead of starting chemotherapy right away, can effectively treat a low-risk, pregnancy-related tumor that returns after a molar pregnancy. It's for Chinese women whose disease is still in an early, low-risk stage.
Hangzhou, ZhejiangAges 12–60 - NCT02958462Recruiting
Clinic study for early blood or bone marrow warning signs
This study follows people who may have early, unclear blood count problems or certain genetic/immune patterns that can later lead to bone marrow failure or blood cancers. It may help doctors better understand risks over time and guide earlier care.
Scottsdale, ArizonaAges 18 years+ - NCT00539162Recruiting
CA-125 and other tests to check for early ovarian cancer risk
This study looks at how well a blood test called CA-125, along with other markers and checkups, can detect ovarian cancer early. It’s for women considered low risk who will do regular blood tests and possibly a vaginal ultrasound if results suggest it.
Miami, FloridaAges 50–74 - NCT07339943Recruiting
Focal laser ablation for intermediate-risk prostate cancer
This trial tests a new way to treat intermediate-risk prostate cancer using a targeted laser guided by micro-ultrasound and MRI. It aims to see if this less invasive approach is safe and effective for men who have not had prior prostate cancer treatments.
Toronto, OntarioAges 40–85 - NCT06995677RecruitingPhase 2
Study of TYRA-300 for bladder cancer that has not spread into muscle
This trial tests a new pill, TYRA-300, for people with a certain type of early-stage bladder cancer that has a specific genetic change (FGFR3). The goal is to see if it can help by targeting the cancer cells and possibly avoiding more invasive treatments.
Homewood, AlabamaAges 18 years+
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Common questions
- Are there clinical trials for low risk?
- Yes. Clin2 currently lists 169 recruiting low risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a low risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a low risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.