Clinical trials
Lower Extremity clinical trials
Below are recruiting lower extremity clinical trials, each written for real people, not researchers. We’re tracking 122 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06878482RecruitingPhase 4
Botulinum toxin injection for severe leg artery disease
This trial tests whether a single injection of botulinum toxin (a muscle-relaxing substance) into the leg can improve blood flow and help heal wounds in people with severe blocked leg arteries who cannot have standard procedures like angioplasty.
Yongin-si, Gyeonggi-doAges 20 years+ - NCT07012642RecruitingEarly Phase 1
GLP-1 drugs for arm or leg swelling (lymphedema)
This trial tests if a class of diabetes drugs (GLP-1 receptor agonists) can reduce swelling in one arm or leg caused by lymphedema. It may help people who have not found relief from other treatments.
Red Bank, New JerseyAges 18 years+ - NCT07073235Recruiting
Brain stimulation to help leg movement after chronic stroke
This trial is testing if a non-invasive brain stimulation technique, called iTBS, can improve leg movement in people who have had a stroke more than six months ago and still have some weakness on one side.
StockholmAges 18 years+ - NCT07076797Recruiting
Exercise and electrical stimulation for older women's legs
This trial tests whether a leg exercise program with or without mild electrical stimulation can improve leg strength and mobility in healthy older women. It may help you stay active and independent.
Istanbul, ZeytinburnuAges 65–84 - NCT07116876Recruiting
Placental membrane vs standard care for diabetic foot ulcers
This study tests a special wound covering made from donated placental tissue to see if it helps diabetic foot ulcers heal better than usual care. It may be an option for people with diabetes who have a foot sore that hasn't healed after 30 days.
Tucson, ArizonaAges 21–80 - NCT07142408RecruitingPhase 3
Bacteria reduction before skin cancer surgery on legs
This trial tests if reducing bacteria on your skin before skin cancer surgery on the leg can lower the risk of infection, especially for wounds left open to heal naturally.
Marlton, New JerseyAges 18 years+ - NCT07219095Recruiting
Dance Mental Health App for Injured Teens
This trial tests a mental health app (SuperBetter) for teens who dance and have a leg injury. It aims to help them cope and stay positive while recovering.
San Diego, CaliforniaAges 13–18 - NCT07241572Recruiting
Heart injury risk during below-knee surgery
This trial checks for heart muscle injury during surgery on the lower leg (below the knee). It helps doctors understand how to better protect patients having this type of operation.
AnkaraAges 18 years+ - NCT07266753RecruitingPhase 4
Comparing oral antibiotics for leg and foot bone infections
This trial compares two common types of oral antibiotics to see which works better for bone infections below the knee. If you have a bone infection that needs at least 28 more days of treatment and you can take pills, this study may help find the best option for you.
Ottawa, OntarioAges 18 years+ - NCT07303582RecruitingPhase 4
Freezing nerves to ease pain from muscle tightness
This study tests if freezing specific nerves (cryoneurolysis) can reduce pain caused by muscle tightness (spasticity) after a brain or spinal cord injury, or from multiple sclerosis. It is for people who already get Botox injections for this pain.
OxfordAges 18 years+ - NCT07353905Recruiting
Ultrasound guidance for leg artery treatment
This trial tests whether using a special ultrasound probe inside the artery (intravascular ultrasound) helps doctors better treat blocked leg arteries. It may lead to more effective procedures for patients with leg pain or wounds due to poor blood flow.
Dallas, TexasAges 18 years+ - NCT07387653Recruiting
Leg circulation monitoring during pelvic surgery
This trial tests a new way to check blood flow and oxygen levels in your legs during pelvic surgery when you're in the lithotomy (legs-up) position. It aims to catch any circulation problems early, which could help prevent leg injuries.
Houston, TexasAges Any age - NCT00623389Recruiting
Testing a leg neuroprosthesis for walking and leg control
This trial tests an advanced device that helps control and use your legs and trunk muscles for movement. It may help people with certain types of paralysis or weakness to improve function, while closely monitoring safety and comfort.
Cleveland, OhioAges 21–75 - NCT07488338Recruiting
Movement and hand training for children with SMA
This study tests whether a combined program of home-based activities and hand training can help children with spinal muscular atrophy improve their movement and daily function. It is for children who can sit or walk with support and have been on stable medication for at least 6 months.
New York, New YorkAges 5–17 - NCT07488429Recruiting
Brain stimulation plus therapy for leg function in cerebral palsy
This study tests whether combining a gentle brain stimulation treatment (rTMS) with physical therapy can help improve leg movement and reduce muscle stiffness in children with cerebral palsy. The goal is to see if this combination works better than therapy alone.
AnkaraAges 5–18 - NCT07550348Recruiting
Pain Relief Comparison for Lower Leg Surgery Nerve Block
This study compares two common numbing medications used together versus one alone for nerve-blocking surgery on the lower leg. Researchers want to see which approach works better and lasts longer for pain relief after your procedure.
ErzurumAges 18–65 - NCT07558174Recruiting
Monitoring blood flow during leg artery surgery with imaging
This study tests a special imaging camera that measures blood flow in your leg before, during, and after surgery to improve the artery. The goal is to help doctors see in real time whether the surgery is working properly.
Leiden, South HollandAges 18 years+ - NCT07570277Recruiting
Nursing Support for Leg Vein Surgery Recovery
This study tests whether specialized nursing guidance helps patients recover better after surgery for varicose veins (enlarged veins in the legs). The nursing support focuses on helping you manage your own care at home after surgery.
Nanchang, Jang XIAges 18 years+ - NCT07202780Enrolling by invitation
MS and Muscle Strength in Breathing and Legs
This study looks at how MS affects the strength of your breathing muscles and leg muscles. If you join, you will have tests to measure your muscle strength, walking ability, and fatigue. This may help doctors understand how to better treat MS-related weakness.
Gaziantep, şehitkamilAges 18–50 - NCT05521958Enrolling by invitation
Gene activity study in severe leg muscle swelling after fracture
This study looks at gene activity (what genes are “turned on or off”) in the lower leg in people with acute compartment syndrome after a tibia (shin bone) injury. The goal is to better understand what is happening in the body and potentially guide future treatment decisions.
Salt Lake City, UtahAges 18–90 - NCT06492733Recruiting
FastWire device for unblocking leg arteries (FREEFLOW trial)
This trial tests a new wire system to reopen completely blocked leg arteries without surgery. It is for people with severe leg pain or tissue damage caused by blocked arteries, and aims to restore blood flow and improve walking ability.
Wilmington, DelawareAges 18–85 - NCT07750639Enrolling by invitationPhase 4
Reducing painkiller use after hand surgery
This study tests a new approach to prescribing fewer opioid pain pills after hand, wrist, or elbow surgery. It aims to help reduce the risk of opioid misuse while still controlling pain after surgery.
Orlando, FloridaAges 18 years+ - NCT07312383Recruiting
Skin blood flow study in leg artery disease
This trial uses a special device to measure tiny blood vessels in the skin of patients with severe leg artery disease. It aims to understand how blood flow changes before and after a common treatment to open blocked leg arteries (angioplasty).
OsloAges 18 years+ - NCT06908538Recruiting
Cryo nerve block for pain after amputation
This study is testing a treatment called a cryo nerve block to reduce pain after amputation, including phantom limb pain. It will look at whether freezing the nerve during surgery helps people feel less pain and use less pain medicine.
Pittsfield, MassachusettsAges 18 years+
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Common questions
- Are there clinical trials for lower extremity?
- Yes. Clin2 currently lists 122 recruiting lower extremity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower extremity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower extremity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.