Clinical trials
Lower Limb clinical trials
Below are recruiting lower limb clinical trials, each written for real people, not researchers. We’re tracking 205 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07607340Recruiting
How Low Gravity Affects Physical Performance and Brain Function
This research study simulates lunar gravity (about 1/6 of Earth's gravity) to understand how your body and brain adapt when gravity is reduced. You'll participate in activities designed to mimic lunar conditions, which could help scientists prepare for future space exploration and better understand how gravity affects human health.
Huddinge, Stockholm CountyAges 18–60 - NCT07254351Recruiting
Limb length inequality study in children
This study looks at how a difference in leg length affects balance and movement in children aged 10 to 15. It uses a special low-dose X-ray (EOS) to take pictures of the child's spine and legs while they stand still.
BronAges 10–15 - NCT07872150Recruiting
Minimally invasive vs. open surgery for varicose vein treatment
This study compares two surgical approaches for treating advanced varicose veins, one using a small camera and the other using traditional open surgery. The goal is to see which method provides better results with fewer complications.
Lahore, Punjab ProvinceAges 18–70 - NCT05830630Recruiting
Methylene blue given during leg amputation surgery
This trial studies whether infusing methylene blue during above- or below-knee leg amputation can improve outcomes for people with poor blood flow to the legs. It targets patients having surgery under general anesthesia, while excluding those with certain allergies or blood clotting problems.
Tanta, Gharbia GovernorateAges 18 years+ - NCT06765486Recruiting
Exercise and pain relief: arm vs leg training
This trial compares how resistance training of the arms versus legs affects your body's natural ability to reduce pain. It may help understand which type of exercise is best for managing pain.
MadridAges 18–64 - NCT06923293Recruiting
Motorized Leg Brace to Improve Walking After Injury
This study tests a custom motorized leg brace (called an AFO) to help people walk better after a past leg injury. If you have had a leg injury for over a year and can stand for 30 minutes, this device might help improve your walking.
West Orange, New JerseyAges 18–80 - NCT02914808Recruiting
Study for leg swelling caused by lymph or vein problems
This trial studies how to measure and possibly treat swelling in the legs caused by long-term lymph or vein blockage (primary or secondary lymphoedema, or PTS). It’s looking at people with one type of leg swelling in one leg, and it checks whether MRI scans can be used safely.
Grenoble, IsèreAges 18–99 - NCT06908538Recruiting
Cryo nerve block for pain after amputation
This study is testing a treatment called a cryo nerve block to reduce pain after amputation, including phantom limb pain. It will look at whether freezing the nerve during surgery helps people feel less pain and use less pain medicine.
Pittsfield, MassachusettsAges 18 years+ - NCT07830472Recruiting
Robot leg training for age-related muscle loss
This study tests whether a leg-training robot can help older adults with sarcopenia—a condition of losing muscle mass and strength as they age—improve their leg strength and function. The robot supports your legs during exercises, which might be safer and more effective than doing them alone.
Taipei, Taipei CityAges 60 years+ - NCT07648784Recruiting
Pain Relief Comparison for Lower Leg Surgery
This trial tests different combinations of two numbing medicines (lidocaine and bupivacaine) given through the spine to manage pain during lower limb surgery. The goal is to find which mixture works best and lasts longest.
Karachi, SindhAges 20–60 - NCT07028723Recruiting
Proprioception and ligament injury risk in pivoting sports
This study tests whether your sense of body position and movement affects your risk of knee or ankle ligament injuries while playing sports like rugby, soccer, or handball. Participating could help identify ways to prevent these injuries.
MontpellierAges 14–25 - NCT06726434Recruiting
Comparing freezing vs. surgery for foot spasticity after stroke
This trial compares a freezing procedure (cryoneurotomy) with standard surgery to treat foot stiffness after a stroke. It aims to see which method better corrects the foot turning inward and downward, helping you walk more easily.
GarchesAges 18 years+ - NCT06400849Recruiting
Cooling and compression to prevent nerve damage from chemo
This trial tests whether adding a cooling and compression treatment to your hands and feet during chemotherapy can help prevent nerve damage (neuropathy) caused by the drug paclitaxel. It may be a good option for people with breast cancer who are about to start this type of chemotherapy and want to reduce side effects.
NiceAges 18–99 - NCT07420192Recruiting
A study on nerve surgery for pain after leg amputation
This trial tests a surgery called RPNI to treat painful nerve growths (neuromas) in people who have lost a leg. The goal is to reduce severe pain and improve the ability to use a prosthetic limb.
Ankara, AnkaraAges 18–70 - NCT04663893Recruiting
Study of fractures around implants after injury or surgery
This study looks at how often certain shoulder, elbow, hip, and knee fractures happen around orthopedic hardware (implants), and how they affect recovery and outcomes. Results may help doctors choose better treatment and predict risks for patients with these fracture types.
BarcelonaAges 18 years+ - NCT06106984Recruiting
Home rehab for phantom limb pain in veterans
This study tests a home-based rehabilitation program delivered by telehealth (video calls) to help veterans with phantom limb pain after a below-knee amputation. It aims to see if the program can reduce pain and improve function while taking part from home.
Minneapolis, MinnesotaAges 18–89 - NCT07136441Recruiting
Sciatic nerve stiffness test for leg pain patients
This study measures how stiff the sciatic nerve is using ultrasound while you do gentle leg movements. It compares people with sciatica to healthy volunteers to understand nerve changes.
GizaAges 25–40 - NCT02114450Recruiting
Training with a leg exoskeleton after stroke
This trial tests a “human–machine” leg exoskeleton system to help people with stroke improve standing and walking during rehab. You may be able to participate if you have certain levels of disability and spasticity, can safely stand and walk with help, and don’t have skin, joint, or medical issues that would make training unsafe.
Houston, TexasAges 18–75 - NCT06124664Recruiting
Study of leg vein drainage in pelvic varicose veins
This study looks at how blood flows from the legs in people with varicose veins in the pelvis. It may help doctors understand the link between pelvic and leg vein problems.
MoskvaAges 18–40 - NCT06075940Recruiting
A dissolving stent for blocked leg arteries below the knee
This study tests a new bioresorbable scaffold (like a temporary mesh) that slowly dissolves, releasing medication to keep your below-the-knee artery open. It is for people with severely blocked leg arteries causing pain or wounds at rest (Rutherford 4 or 5).
Randwick, New South WalesAges 18 years+ - NCT07094074Recruiting
Walking and balance study for leg amputees
This study looks at how people who have lost a leg walk, balance, and move with an artificial limb (prosthesis). Participating helps researchers understand how to improve prosthetic devices and rehabilitation.
DijonAges 18 years+ - NCT06195540RecruitingPhase 3
Rivaroxaban versus LMWH for leg injuries needing a cast
This trial compares two blood thinners (rivaroxaban pills versus LMWH shots) to see which is better at preventing blood clots in people with leg injuries that require a cast or brace. If you qualify, you can receive one of these treatments while your leg heals.
AgenAges 18 years+ - NCT07705906Recruiting
Robot-assisted leg training for mobility recovery
This trial tests a robot device to help people with leg weakness from stroke, spinal cord injury, or joint surgery improve their walking. It may be a good option if you are medically stable and can work with the robot safely.
Dhaka, Dhaka DivisionAges 18–70 - NCT07797712Recruiting
Mirror therapy with standard rehab for post-stroke walking
This study tests whether adding mirror therapy to regular walking and leg exercises helps people who have had a stroke walk better and improve leg function. Mirror therapy uses a mirror to create the illusion that the affected leg is moving, which may help rewire the brain.
Quetta, BalochistanAges 40–70
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Common questions
- Are there clinical trials for lower limb?
- Yes. Clin2 currently lists 205 recruiting lower limb studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower limb trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower limb trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.