Clinical trials
Lymph Node Disease clinical trials
Below are recruiting lymph node disease clinical trials, each written for real people, not researchers. We’re tracking 176 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06840418Recruiting
New imaging to find cancer spread in cervical cancer surgery
This study tests a new imaging technique (NIRFI with ICG dye) to help surgeons see if cervical cancer has spread to lymph nodes during your hysterectomy surgery. It may help guide more precise removal of affected nodes.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05421650Recruiting
Surgery to remove pelvic lymph node spread in cervical cancer
This trial studies whether surgically removing cancerous pelvic or nearby lymph nodes before or as part of standard treatment improves outcomes for women with certain cervical cancers. It focuses on people whose scans suggest lymph node metastasis can be safely removed.
BengaluruAges 20–70 - NCT05976412Recruiting
Radiation to lymph nodes after surgery for higher-risk breast cancer
This trial looks at whether adding targeted radiation to lymph nodes after breast surgery can lower the chance of breast cancer coming back in people with higher-risk, node-negative disease. If you qualify, you may get a planned radiation approach designed for prevention, not treatment of spread.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT04722692RecruitingPhase 3
Delayed sentinel lymph node biopsy for ductal cancer in situ
This trial tests whether doing a sentinel lymph node biopsy later (after breast surgery) is a safe, accurate way to check if cancer has spread. It uses a special tracking shot that helps find the lymph nodes.
Houston, TexasAges 18 years+ - NCT02305654RecruitingPhase 3
Trial for penile squamous cancer with swollen groin or pelvis nodes
This Phase 3 study tests treatment options for penile squamous cell cancer that has spread to nearby groin and/or pelvic lymph nodes (but not to distant organs). If you have the right stage and haven’t had certain prior treatments, this trial may offer a structured treatment plan and close monitoring.
Los Angeles, CaliforniaAges 18 years+ - NCT07060443RecruitingPhase 2
Fluorescent dye study for right-sided colon cancer surgery
This trial tests whether using a fluorescent dye during surgery can help doctors better see and remove lymph nodes in people with right-sided colon cancer. It aims to make surgery more precise and potentially improve outcomes.
DaeguAges 19–85 - NCT06776172Recruiting
Lymph node removal during prostate surgery: a comparison study
This trial tests whether removing pelvic lymph nodes during prostate cancer surgery improves outcomes for men with high-risk prostate cancer. If you have high-risk prostate cancer and no signs of spread, you may be able to join.
AarauAges 18 years+ - NCT07328243Recruiting
New treatment for thyroid cancer that spread to neck lymph nodes
This study tests a minimally invasive treatment called irreversible electroporation for thyroid cancer that has come back or spread to lymph nodes in the neck. It may be an option for people who can't have another surgery or for whom radioactive iodine therapy hasn't worked.
Guangzhou, GuangdongAges 18 years+ - NCT06279299Recruiting
Lymph node removal for rectal neuroendocrine tumors during laparoscopic surgery
This trial tests whether removing lymph nodes in the pelvis during laparoscopic surgery for rectal neuroendocrine tumors (a type of slow-growing or aggressive tumor) improves outcomes. It is for people with larger or recurrent tumors, or those at higher risk due to tumor grade or depth.
Beijing, Beijing MunicipalityAges 18–75 - NCT07003490Recruiting
Lung cancer surgery with removal of lymph nodes on the other side
This study looks at whether removing lymph nodes from the opposite side of the chest during surgery can help people with advanced lung cancer that has spread to the lymph nodes in the middle of the chest. It may offer a more thorough treatment for patients who are healthy enough for surgery.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06085274Recruiting
SHINE: Using a special dye to find lymph nodes after breast cancer chemo
This study tests whether a special dye called indocyanine green (ICG) can help find sentinel lymph nodes during breast cancer surgery after chemotherapy. It may offer a safer and more effective way to check if cancer has spread.
Toronto, OntarioAges 18–80 - NCT06169072RecruitingPhase 2
Finding lymph nodes with a tiny dose of magnetic tracer in breast cancer
This trial is testing whether a very small amount of a magnetic tracer called Magtrace can help find lymph nodes that need to be checked for cancer spread during breast cancer surgery.
GothenburgAges 18 years+ - NCT07112599Recruiting
AI predicts lymph node spread in high-risk prostate cancer
This study uses artificial intelligence to examine MRI and other health data to better predict if high-risk prostate cancer has spread to nearby lymph nodes. Researchers hope this will help guide treatment decisions.
Hefei, AnhuiAges 50 years+ - NCT01397669Recruiting
Study immune differences in HIV and HIV-negative adults
This research compares the immune system in the gut lining, spinal fluid, lymph nodes, and blood between people living with HIV and people not living with HIV. Results may help scientists understand how immunity works and how it differs with HIV.
Bangkok, BangkokAges 18–50 - NCT07023601Enrolling by invitation
Study of sentinel node detection in recurrent vulvar cancer
This study tests whether a special dye injection can reliably find the first lymph node that might contain cancer in women whose vulvar cancer has come back for the first time. It aims to help doctors know if the cancer has spread without removing many lymph nodes.
Madrid, MadridAges 18 years+ - NCT07579286Recruiting
Skipping lymph node surgery in early breast cancer
This trial tests whether older women with early-stage, slow-growing breast cancer can safely skip removal of underarm lymph nodes during surgery. The goal is to reduce surgery-related side effects while maintaining safety.
Saint Petersburg, Russian FederationAges 60 years+ - NCT06788548Recruiting
Fluorescence-Guided Surgery for Early Stomach Cancer
This trial tests a new technique that uses a special dye to highlight the first lymph nodes where stomach cancer might spread, allowing surgeons to remove only the necessary nodes during surgery. The goal is to reduce side effects while still effectively treating the cancer.
Beijing, Beijing MunicipalityAges 18–80 - NCT06290687RecruitingPhase 2
Partial cystectomy with chemo for bladder cancer
This trial tests whether removing part of the bladder (partial cystectomy) along with standard chemotherapy or immunotherapy before surgery is effective for people with a specific type of bladder cancer that hasn't spread beyond the bladder.
Cleveland, OhioAges 19 years+ - NCT05333523RecruitingPhase 3
Personalized neck radiation using a lymph node sentinel biopsy
This Phase 3 trial tests whether guiding neck radiation by checking the “sentinel” lymph node can target treatment more precisely in certain larynx, hypopharynx, or oropharynx cancers. It aims to improve control while potentially reducing unnecessary radiation to areas that don’t need it.
AmsterdamAges 18 years+ - NCT05797415Recruiting
Check sentinel lymph node biopsy for several eye skin cancers
This trial studies whether a “sentinel lymph node biopsy” can better detect cancer spread in people with specific cancers of the eye surface and nearby tissues. It may help doctors find the right next treatment by learning whether lymph nodes are involved.
Roma, RomeAges 18–95 - NCT07301983Enrolling by invitation
Testing a faster way to check lymph nodes in lung cancer surgery
This trial compares a new, quick test called OSNA to the standard method for checking lymph nodes in people with early-stage lung cancer who are having robotic surgery. The goal is to see if the new test works as well or better.
Pisa, PisaAges 18 years+ - NCT05646316RecruitingPhase 3
Sentinel lymph node mapping to reduce leg swelling after surgery
This study tests whether a special way of finding lymph nodes during hysterectomy can lower the risk of long-term leg swelling or related dysfunction in people with stage I endometrial cancer. It compares standard lymph node assessment with sentinel lymph node mapping and looks at how this affects day-to-day leg functioning.
Washington D.C., District of ColumbiaAges 18 years+ - NCT04333537RecruitingPhase 2/Phase 3
Sentinel node biopsy versus standard neck surgery for early mouth cancer
This trial compares two ways of checking whether early oral cavity squamous cell cancer has spread to neck lymph nodes. It tests whether sentinel lymph node biopsy can find spread as well as standard neck dissection, while potentially reducing more extensive surgery for some people.
Birmingham, AlabamaAges 18 years+ - NCT06358222Recruiting
Lung cancer trial testing blood test and PET scan for spread
This trial studies if a blood test that looks for tumor DNA combined with a PET-CT scan can better predict if lung cancer has spread to lymph nodes. It may help guide treatment decisions for people with non-small cell lung cancer that hasn't been treated yet.
ShanghaiAges 18–75
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Common questions
- Are there clinical trials for lymph node disease?
- Yes. Clin2 currently lists 176 recruiting lymph node disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lymph node disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lymph node disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.