Clinical trials
Lymph Node Disease clinical trials
Below are recruiting lymph node disease clinical trials, each written for real people, not researchers. We’re tracking 173 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07585929Recruiting
Radiation Boost Techniques for Advanced Cervical Cancer
This trial compares two ways of delivering targeted radiation therapy to help treat advanced cervical cancer (stage IIIC). The study tests whether adding a focused radiation boost using newer technology improves outcomes alongside chemotherapy and standard radiation.
Delhi, National Capital Territory of DelhiAges 18–65 - NCT04073706RecruitingPhase 3
Sentinel node biopsy for early womb cancer
This trial tests whether a less invasive way to check if cancer has spread to lymph nodes (sentinel node biopsy) works as well as the standard method. It is for people with early-stage endometrial cancer having surgery.
Houston, TexasAges 18 years+ - NCT06161428Recruiting
Dye-guided lymph node biopsy for vulvar cancer
This trial tests a new way to find and remove the first lymph node that might contain cancer cells in women with large or recurrent vulvar cancer. It uses a special dye to guide the surgeon, which may help improve staging and reduce side effects.
CopenhagenAges 18 years+ - NCT07793006Recruiting
New ways to diagnose lymphoma and castleman disease
This study tests new methods to diagnose lymphoma and multicentric castleman disease, which are conditions that can affect people with HIV. It may help find these diseases earlier and more accurately.
LilongweAges 1 year+ - NCT07447869RecruitingEarly Phase 1
Lymph Node Exam in Cat Allergy Treatment Study
This study looks at lymph nodes in the neck to understand how the body responds to cat allergy treatments. It may help researchers improve allergy shots or other therapies for people with cat allergies.
Boston, MassachusettsAges 18–45 - NCT07025785Recruiting
Testing for tumor DNA in blood after early-stage breast cancer surgery
This study looks for tiny bits of tumor DNA in your blood after surgery to see if it can help guide future treatment. It's for people who had surgery first (not chemotherapy before surgery) and have not seen the cancer spread.
Chapel Hill, North CarolinaAges 18 years+ - NCT02147405Recruiting
PET scans and lymph node checks for HIV immune rebound
This study looks at people with HIV who either have not started HIV medicines yet or who recently started/changed them and may develop immune rebound (IRIS). It uses blood tests and optional PET/CT scans and lymph node biopsies to understand what’s happening in the body and to guide care.
Bethesda, MarylandAges 18–100 - NCT07131566Recruiting
Immune response in neck lymph nodes in head and neck cancer
This study looks at how the immune system in the lymph nodes of the neck responds to head and neck cancer. It will help researchers understand how the body fights these cancers, which could lead to better treatments.
Stockholm, Stockholm CountyAges 18 years+ - NCT06353906RecruitingPhase 2
Chemo plus immunotherapy for advanced penile cancer
This trial tests a combination of two chemotherapy drugs (carboplatin and paclitaxel) plus the immunotherapy drug pembrolizumab (Keytruda) for penile cancer that has spread to nearby lymph nodes. The goal is to see if this combination can shrink or control the cancer before or after surgery.
LeuvenAges 18 years+ - NCT07068763RecruitingPhase 2
Short radiation plus drugs for early rectal cancer
This trial tests a combination of short-course radiation, chemotherapy (capecitabine), and two immunotherapy drugs (PD-1 and CTLA-4 inhibitors) for people with early-stage rectal cancer who want to avoid surgery and keep their anus. The goal is to see if this treatment can shrink the tumor enough to avoid major surgery.
Hangzhou, ZhejiangAges 18–80 - NCT00260585Recruiting
Esophageal risk and tissue registry study
This study collects information and, if you already need blood tests or procedures, may take extra small tissue samples (biopsies) to better understand esophageal-related conditions. It may help researchers learn about risk and future management for people with certain esophagus or reflux-related diagnoses.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07777887Recruiting
Finding lymph nodes during testicular cancer surgery
This trial tests a way for surgeons to find the first lymph nodes that testicular cancer might spread to, using a special camera and a dye. It could help doctors decide if you need extra treatment after surgery to remove the testicle.
Saint Petersburg, Sankt-PeterburgAges 18–60 - NCT04293796Recruiting
Skipping breast surgery after complete response
This trial looks at whether some people with breast cancer can safely avoid breast surgery after they respond completely to treatment before surgery. If you have no remaining cancer in the tissue and lymph node tests, this study checks whether the “watch-and-wait” approach is feasible and safe.
Saint PetersburgAges 18–70 - NCT05618821RecruitingPhase 2
Indocyanine green dye during stomach surgery for leftover cancer
This Phase 2 study tests whether using a special light-activated dye (indocyanine green) during laparoscopic stomach surgery can improve surgical outcomes for people with remnant (leftover) stomach cancer that has not spread to distant organs. It may help surgeons better find lymph nodes while operating.
Fuzhou, FujianAges 18–75 - NCT03587480Recruiting
Surgery methods after chemo-radiation for stage 3 rectal cancer
This trial compares two different surgery approaches after chemo-radiation for stage 3 rectal cancer. It aims to see which operation helps control the cancer more effectively while keeping surgery as safe as possible.
Guangzhou, GuangdongAges 18–75 - NCT05883852RecruitingPhase 3
HER2-positive breast cancer trial for women with lymph node spread
This Phase 3 trial compares two post-surgery drug plans for HER2-positive early breast cancer that has spread to nearby lymph nodes. It may help reduce cancer recurrence by testing which regimen works better after surgery.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT05378087Recruiting
Compare two ways to plan treatment for cervical cancer
This study compares two staging methods—using surgery results versus imaging tests—to help doctors plan treatment for locally advanced cervical cancer. It may improve how accurately the cancer is mapped, which could affect treatment choices and outcomes.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT04741737Recruiting
Repeat lymph node biopsy for recurrent breast cancer
This study tests whether repeating a specific lymph node biopsy (sentinel lymph node biopsy) is safe and useful in people whose breast cancer has come back in the same breast. It may help doctors better understand whether lymph nodes are involved and guide next steps after surgery.
SeoulAges 19 years+ - NCT06091423RecruitingPhase 2
XELOX plus fruquintinib and sintilimab for stomach cancer with liver or lymph node spread
This trial tests a combination of chemotherapy (XELOX), a targeted therapy (fruquintinib), and an immunotherapy (sintilimab) to shrink stomach cancer that has spread only to the liver or retroperitoneal lymph nodes. The goal is to make the cancer removable by surgery.
NanjinAges 18–75 - NCT06259513Recruiting
Skipping armpit surgery for breast cancer patients
This trial tests whether it's safe to skip armpit surgery in older women with small, low-risk breast cancers. If you qualify, you would have a mastectomy without removing lymph nodes from your armpit.
SingaporeAges 21–80 - NCT07858630Recruiting
Radiation targeting for advanced esophageal cancer with immunotherapy
This trial studies how to best target radiation for people with advanced esophageal cancer who are also getting immunotherapy. It aims to improve treatment planning to help patients live longer with fewer side effects.
Beijing, Beijing MunicipalityAges 18–80 - NCT05116475RecruitingPhase 3
New prostate cancer trial adding darolutamide to standard treatment
This Phase 3 trial tests whether adding darolutamide to standard hormone therapy and radiation works better than standard treatment alone for newly diagnosed prostate cancer that has spread to pelvic lymph nodes. If you qualify, you may receive darolutamide or a placebo alongside long-term hormone therapy and radiation.
Chambray-lès-ToursAges 18–120 - NCT06321653Recruiting
Lymphedema after radiation for early breast cancer with 1-2 positive nodes
This trial aims to see if a shorter course of radiation after breast-conserving surgery affects arm swelling (lymphedema) in people with early breast cancer that has spread to 1 or 2 nearby lymph nodes. The goal is to learn if this approach is safe and effective.
MilanAges 18 years+ - NCT06341595RecruitingPhase 2
Chemo, radiation and immunotherapy before surgery for stomach cancer with PALM
This trial tests combining chemotherapy, radiation, and an immunotherapy drug (sintilimab) before surgery for advanced stomach cancer that has spread to lymph nodes near the aorta (called PALM). The goal is to see if this approach can shrink the tumor enough to allow complete removal.
Nanjing, JiangsuAges 18–75
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Common questions
- Are there clinical trials for lymph node disease?
- Yes. Clin2 currently lists 173 recruiting lymph node disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lymph node disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lymph node disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.