Clinical trials
Lymph Node Metastases clinical trials
Below are recruiting lymph node metastases clinical trials, each written for real people, not researchers. We’re tracking 66 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03796559Recruiting
Magnetic marker helps find breast cancer lymph nodes
This study uses a tiny magnetic marker (called Magseed) placed in a breast cancer–affected underarm lymph node, then tracks whether surgeons can find and remove the correct nodes after chemotherapy. It may help reduce the chance of missing cancer in the underarm while aiming for more accurate surgery.
Houston, TexasAges 18 years+ - NCT05981014RecruitingPhase 1/Phase 2
Immune cells from lymph nodes for HER2-negative breast cancer
This trial tests whether taking immune cells from your lymph nodes and giving them back to you can help shrink breast cancer that has not responded fully to initial chemotherapy. It is for women with HER2-negative breast cancer who have had stable disease after two cycles of a standard chemotherapy combination.
Guangzhou, GuangdongAges 18–70 - NCT06121570RecruitingPhase 1
Study of immune cells from lymph nodes for HER2-negative breast cancer
This trial tests whether using a patient's own immune cells from lymph nodes near the tumor, given as a treatment before surgery, can help shrink HER2-negative breast cancer. It is for people whose cancer has not responded fully to two cycles of initial chemotherapy.
Guangzhou, GuangdongAges 18–70 - NCT06978296Recruiting
HIMARS: Stereotactic radiation for prostate cancer spread
This trial tests adding targeted radiation (SRT) to bone or lymph node metastases in men with prostate cancer that has continued to grow despite hormone therapy, chemo, or other treatments. The goal is to see if radiation can help control the disease and improve outcomes.
Saint-HerblainAges 18 years+ - NCT05116475RecruitingPhase 3
New prostate cancer trial adding darolutamide to standard treatment
This Phase 3 trial tests whether adding darolutamide to standard hormone therapy and radiation works better than standard treatment alone for newly diagnosed prostate cancer that has spread to pelvic lymph nodes. If you qualify, you may receive darolutamide or a placebo alongside long-term hormone therapy and radiation.
Chambray-lès-ToursAges 18–120 - NCT06713161Recruiting
New dye to spot breast cancer during surgery
This study tests a special dye that helps surgeons see breast cancer tissue and nearby lymph nodes more clearly during surgery. The goal is to make sure all cancer is removed while sparing healthy tissue.
Kunming, YunnanAges 18–75 - NCT06730529Recruiting
Using 68Ga-FAPI PET/CT scan for thyroid cancer lymph nodes
This study uses a special type of PET/CT scan (68Ga-FAPI) to see how well it finds cancer spread in lymph nodes before thyroid cancer surgery. It may help doctors plan your treatment more accurately.
Shanghai, Shanghai MunicipalityAges 16–80 - NCT07200466Recruiting
Personalized risk assessment for endometrial cancer
This trial uses a prediction model to better estimate the risk of endometrial cancer coming back. It aims to help doctors and patients make more personalized treatment decisions after surgery.
Arnhem, GelderlandAges 45 years+ - NCT05462457Recruiting
Tests adding a targeted approach for breast cancer with many involved nodes
This trial studies a treatment plan for early breast cancer that involves at least three suspicious lymph nodes on the ultrasound/imaging. It looks at whether a targeted technique—done before surgery with chemotherapy—can improve or guide care when surgery will remove the lymph nodes.
EssenAges 18 years+ - NCT06528743Recruiting
Testing primer shot radiotherapy for lung cancer
This study is testing a new way of giving a very short, high-dose radiation treatment (called 'primer shot' radiotherapy) for people with non-small cell lung cancer. The goal is to see if it’s safe and practical for shrinking the main lung tumor and relieving symptoms.
AmsterdamAges 18 years+ - NCT06754904Recruiting
Skipping lymph node removal for melanoma with good treatment response
This trial tests whether patients with stage 3 melanoma that shrinks significantly after initial immunotherapy can safely avoid having all their lymph nodes surgically removed. Instead, only the main affected node is removed for testing.
Rotterdam, South HollandAges 16 years+ - NCT07338721Recruiting
Ultrasound vs. incision for finding sentinel lymph nodes in breast cancer
This trial compares two techniques for finding the first lymph node that breast cancer might spread to (the sentinel node). It tests if using ultrasound guidance through a small axillary incision is better than the standard method.
AntalyaAges 18 years+ - NCT06972511RecruitingPhase 2/Phase 3
Maximal tumor removal for prostate cancer that has spread a little
This trial tests a combination of surgery and radiation to remove as much cancer as possible in men with prostate cancer that has spread to a few spots outside the prostate. It aims to see if this aggressive approach can improve long-term outcomes.
ShanghaiAges 18–75 - NCT06262516Recruiting
Lymph node removal during kidney/ureter cancer surgery
This study looks at whether removing nearby lymph nodes during standard kidney/ureter removal surgery helps people with upper tract urothelial carcinoma. You will be placed into one of two groups – one gets the usual surgery alone, the other gets surgery plus lymph node removal.
Gainesville, FloridaAges 19 years+ - NCT07060443RecruitingPhase 2
Fluorescent dye study for right-sided colon cancer surgery
This trial tests whether using a fluorescent dye during surgery can help doctors better see and remove lymph nodes in people with right-sided colon cancer. It aims to make surgery more precise and potentially improve outcomes.
DaeguAges 19–85 - NCT05109910Recruiting
Checking lymph node surgery impact in men having prostate removal
This study looks at whether removing lymph nodes during prostate removal helps predict outcomes in men whose scans do not show spread. It may help improve how doctors decide who benefits from lymph node surgery based on your risk level and scan results.
AmsterdamAges 18 years+ - NCT05108090Recruiting
Sentinel node biopsy for head and neck skin cancer
This study checks whether a “sentinel lymph node biopsy” can help find if skin cancer in the head or neck has spread to nearby lymph nodes. It uses special dye/medicine and imaging, then removes the cancer and the sentinel node soon after scanning.
Indianapolis, IndianaAges 18 years+ - NCT05333523RecruitingPhase 3
Personalized neck radiation using a lymph node sentinel biopsy
This Phase 3 trial tests whether guiding neck radiation by checking the “sentinel” lymph node can target treatment more precisely in certain larynx, hypopharynx, or oropharynx cancers. It aims to improve control while potentially reducing unnecessary radiation to areas that don’t need it.
AmsterdamAges 18 years+ - NCT07508306Recruiting
Blue dye sentinel node mapping for early ovarian cancer
This study is testing a blue dye called Patent Blue to see if it can help surgeons find sentinel lymph nodes (the first nodes cancer might spread to) during surgery for early-stage ovarian cancer. The goal is to reduce the need for more extensive lymph node removal, possibly leading to fewer side effects.
La RabtaAges 18 years+ - NCT07007182RecruitingPhase 2
Treating stomach cancer spread to lymph nodes with chemo, surgery, and radiation
This trial tests a combination of chemotherapy (conversion therapy), surgery, and radiation for people with stomach cancer that has spread only to lymph nodes behind the stomach. The goal is to see if this approach can help shrink the cancer and improve outcomes.
Jinan, ShandongAges 18–75 - NCT06133543Recruiting
Robotic sentinel node biopsy for testicular cancer
This trial uses a robot and a special dye (ICG) to find and remove the first lymph node that might contain cancer cells in men with testicular cancer. It aims to reduce unnecessary lymph node removal while still detecting spread.
DüsseldorfAges 18–99 - NCT06559696RecruitingPhase 3
Radiation to internal mammary lymph nodes for high-risk breast cancer after chemo
This trial tests whether giving radiation to the internal mammary lymph nodes (the lymph nodes behind your breastbone) can help women with high-risk breast cancer after they have had chemotherapy before surgery. It is for people whose cancer has spread to nearby lymph nodes despite chemotherapy.
Fuzhou, FujianAges 18–75 - NCT07068763RecruitingPhase 2
Short radiation plus drugs for early rectal cancer
This trial tests a combination of short-course radiation, chemotherapy (capecitabine), and two immunotherapy drugs (PD-1 and CTLA-4 inhibitors) for people with early-stage rectal cancer who want to avoid surgery and keep their anus. The goal is to see if this treatment can shrink the tumor enough to avoid major surgery.
Hangzhou, ZhejiangAges 18–80 - NCT07746258Recruiting
Checking if skin cancer has spread to nearby lymph nodes
This study uses a test to see if a type of skin cancer called high-risk cutaneous squamous cell carcinoma has spread to lymph nodes. The goal is to learn more about how to detect spread early, which could help guide treatment decisions.
Badalona, BarcelonaAges 18 years+
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Common questions
- Are there clinical trials for lymph node metastases?
- Yes. Clin2 currently lists 66 recruiting lymph node metastases studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lymph node metastases trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lymph node metastases trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.