Clinical trials
Major Depression Severe clinical trials
Below are recruiting major depression severe clinical trials, each written for real people, not researchers. We’re tracking 279 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07478796RecruitingPhase 4
Blood-based dosing of SSRIs for hospitalized depression
This study tests whether adjusting the dose of common antidepressants (SSRIs) based on regular blood tests can help people in the hospital feel better faster. It is for adults and teens age 12 and older with moderate to severe depression who are starting fluoxetine, escitalopram, or sertraline.
Poznan, Greater Poland VoivodeshipAges 12 years+ - NCT06511908RecruitingPhase 2
Testing a new ketamine-like drug for hard-to-treat depression
This study tests a new experimental drug (2R,6R)-HNK, a chemical related to ketamine, given by IV infusion to see if it can help people with depression that hasn't improved with other treatments. The goal is to find a new option for people who have not found relief from standard antidepressants.
Bethesda, MarylandAges 18–70 - NCT06072898RecruitingPhase 2
Psilocybin brain imaging trial for depression
This study tests whether a single dose of psilocybin (a psychedelic compound) can help treat depression by looking at brain changes on MRI. It is designed for people with moderate-to-severe depression who have not responded well to other treatments.
Toronto, OntarioAges 18–64 - NCT07424781Recruiting
Fluoxetine and emotional experience in young adults
This study looks at whether fluoxetine, a common medication for mood, affects how young adults (18-24) experience emotions. It aims to understand emotional processing in healthy individuals without psychiatric history.
Oxford, OxfordshireAges 18–24 - NCT04041479RecruitingPhase 3
Brain-scan guided rTMS for treatment-resistant depression
This trial tests whether using brain-related “biomarkers” from your scans to guide rTMS can improve depression that hasn’t responded to at least one antidepressant. It may help by targeting brain circuits linked to depression more precisely.
Stanford, CaliforniaAges 22–65 - NCT02752542RecruitingPhase 4
Personalized therapy and antidepressants for depression
This trial studies whether a personalized combination of talk therapy (CBT) and antidepressant medication works better for people with moderate to severe depression. It’s meant to match treatment choices to your situation and to see what helps most.
Halifax, Nova ScotiaAges 18 years+ - NCT07576686Recruiting
AI-assisted therapy for depression and anxiety
This trial tests a computer-guided cognitive behavioral therapy (CBT)—a proven talk therapy approach—to help treat mild depression and anxiety. The program runs for 10 weeks with weekly sessions, and AI helps guide your therapist or the process itself.
NišAges 18 years+ - NCT07398040Enrolling by invitation
Anti-inflammatory diet for anxiety and depression
This study tests whether following a personalized anti-inflammatory diet can help reduce symptoms of anxiety, depression, or stress. You would need to live in Zaragoza, speak Spanish, and already have a low-to-moderate Mediterranean diet score.
Zaragoza, ZaragozaAges 18 years+ - NCT06559306RecruitingPhase 3
Seltorexant for depression with insomnia symptoms
This trial tests if adding seltorexant to your current antidepressant can improve depression and sleep problems. It is for people with major depressive disorder who still have symptoms, especially insomnia, despite trying at least one antidepressant.
Birmingham, AlabamaAges 18–74 - NCT06982820Recruiting
Brain training therapy for depression with loss of interest
This trial tests a new type of brain training (self-neuromodulation) to help people with major depression who also have a significant loss of interest or pleasure (anhedonia). If you qualify, you may get a non-invasive treatment that uses real-time brain feedback to improve symptoms.
Providence, Rhode IslandAges 22–75 - NCT06633263Enrolling by invitation
Combined therapy for depression and insomnia
This trial tests a combination of two behavioral therapies to improve both depression symptoms and sleep problems. It may help you if you have moderate depression and insomnia and can participate in French-language sessions.
LiègeAges 18–67 - NCT05925322Recruiting
Social reward therapy for depression-related suicidal thoughts
This study looks at whether “social reward” psychotherapy can change brain activity and reduce suicidal thoughts in adults ages 50–80 who also have major depression. You may be offered psychotherapy along with brain scans to see how your brain responds over time.
New York, New YorkAges 50–80 - NCT05973851RecruitingPhase 3
Six-week medicine boost for depression after first treatment failure
This study tests a more intensive antidepressant medicine approach for people whose first tried treatment didn’t work well enough. It compares the intensified treatment with usual care, aiming to improve depression symptoms and daily functioning.
InnsbruckAges 18–65 - NCT07500714Recruiting
Digital therapy for depression using AI
This study uses a smartphone app and artificial intelligence to deliver a special type of talk therapy for people with moderate to severe depression. It aims to provide personalized care without needing to change your current treatment.
Taichung, TaichungAges 18–75 - NCT04159662Recruiting
Brain scans to study thinking in schizophrenia and depression
This study uses brain imaging to better understand how thinking works in people with schizophrenia or major depression. Your results may help researchers learn what brain patterns match different thinking and symptoms.
Ottawa, OntarioAges 18–60 - NCT06163625Recruiting
Brain activity and memory in treatment-resistant depression
This study looks at how the brain's frontal lobe (DLPFC) works during memory tasks in people with treatment-resistant depression. It compares brain activity between depressed patients and healthy controls using MRI and possibly a brain stimulation technique (rTMS). It aims to understand why some people don't respond to standard treatments.
Toronto, OntarioAges 18–65 - NCT06878859Recruiting
Online program for depression and cannabis use
This study tests a digital (online) program designed to help people who struggle with both depression and cannabis use. If you're feeling down and also using cannabis more than you'd like, this program might help you manage both.
Boston, MassachusettsAges 18 years+ - NCT07088380RecruitingPhase 3
Ketamine combined with ECT for hard-to-treat depression
This trial tests whether adding ketamine to electroconvulsive therapy (ECT) works better than ECT alone for people with depression that hasn't improved with at least two different antidepressants. It may offer a new option for those who have not found relief from standard treatments.
MilanAges 18–70 - NCT05051618Recruiting
Exercise program for depression in people with multiple sclerosis
This trial studies whether a structured exercise program can help reduce symptoms of major depressive disorder in people who also have multiple sclerosis. You’ll complete questionnaires, wear an activity sensor, and do exercise testing while being assigned to the study program.
Chicago, IllinoisAges 18–64 - NCT05097586Recruiting
At-home brain stimulation trial for depression during pregnancy
This trial tests whether doing at-home, noninvasive brain stimulation (tDCS) can reduce depression symptoms during pregnancy. It may help people who are in a depressive episode but prefer not to take antidepressant medication right now.
Toronto, OntarioAges 18 years+ - NCT06820723RecruitingPhase 2
Testing a single dose of CYB003 for depression and anxiety
This trial tests a single dose of an investigational drug (CYB003) in people with depression and anxiety who haven't gotten enough help from their current antidepressant. You would take a psilocybin-like medication and be monitored for how it affects your mood and anxiety.
Columbus, OhioAges 21–65 - NCT06480201RecruitingPhase 1
Ketamine for treatment-resistant depression: a brain wave study
This study tests whether a single dose of ketamine can change brain wave patterns (called gamma oscillations) in people with treatment-resistant depression. Researchers want to see if these brain waves can predict who will feel better after treatment.
Houston, TexasAges 21–45 - NCT07380451Recruiting
Personalized therapy for depression with childhood trauma
This trial tests a flexible, personalized therapy program for adults with depression who also have a history of childhood trauma and personality challenges. It aims to see if this approach helps more than standard care, and you'll receive weekly therapy from a community clinic in Chile.
SantiagoAges 18–65 - NCT07180342Recruiting
Nature outings for depression recovery
This study tests whether nature-based group trips can help people with major depression feel better. You would visit parks and do outdoor activities while researchers measure changes in mood and daily function.
Jinan, ShandongAges 18–59
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Common questions
- Are there clinical trials for major depression severe?
- Yes. Clin2 currently lists 279 recruiting major depression severe studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depression severe trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depression severe trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.