Clinical trials
Major Depression Severe clinical trials
Below are recruiting major depression severe clinical trials, each written for real people, not researchers. We’re tracking 279 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06966401RecruitingPhase 3
Long-term safety study of a new depression treatment
This study tests a new oral medication (NBI-1065845) added to your current antidepressant to see if it's safe and tolerable over a long period for people with depression that hasn't fully responded to treatment.
Huntsville, AlabamaAges 18 years+ - NCT07196501RecruitingPhase 3
Study of a new add-on treatment for depression maintenance
This trial tests a new medication (NBI-1065845) added to your current antidepressant to see if it helps maintain improvement in depression. It is for people whose depression hasn't fully responded to their current oral antidepressant.
Oceanside, CaliforniaAges 18 years+ - NCT04984512RecruitingPhase 2/Phase 3
Testing mitizodone tablets for major depression symptoms
This trial studies whether mitizodone phosphate tablets can improve symptoms of major depressive disorder (MDD). It also checks the treatment’s safety, including mood and physical health effects.
Dongguan, GuangdongAges 18–65 - NCT05757791RecruitingPhase 2
Testing an SGLT2 diabetes drug for depression
This Phase 2 trial tests whether an SGLT2 medicine (like empagliflozin) can reduce symptoms of major depression. It may help people with moderate-to-severe depression who are otherwise eligible for the study.
New York, New YorkAges 18–65 - NCT05909267Recruiting
Testing dopamine-targeted treatment for depression and body inflammation
This study looks at how changing dopamine signaling may affect motivation and movement in people with major depression, and it also involves healthy volunteers. It may help researchers understand whether dopamine changes can improve symptoms and how inflammation may relate to brain function.
SteglitzAges 18–65 - NCT06152705Recruiting
fMRI-Guided vs. Standard Brain Stimulation for Depression
This study compares two types of repetitive transcranial magnetic stimulation (rTMS) to treat depression. One type uses a brain scan (fMRI) to guide the treatment, while the other uses a standard approach. It may help people whose depression hasn't improved with medication.
Ottawa, OntarioAges 18 years+ - NCT06633016RecruitingPhase 2
ABX-002 for major depression (add-on treatment)
This trial tests a new medication called ABX-002 as an add-on to your current antidepressant. It's for people with moderate to severe depression who haven't gotten enough help from their current antidepressant alone.
Birmingham, AlabamaAges 18–65 - NCT07684911Recruiting
Long-term effects of TMS for depression
This study looks at how well the benefits of transcranial magnetic stimulation (TMS) last over time for people with depression that didn't get better with other treatments. It also uses brain scans to find markers that might predict who will keep doing well.
RennesAges 18 years+ - NCT06786624RecruitingPhase 3
Testing a new drug for depression that hasn't fully responded to treatment
This trial tests a new medication called NBI-1065845 added to your current antidepressant for people with depression that hasn't fully responded to treatment. It aims to see if this combination can better improve your symptoms.
Little Rock, ArkansasAges 18 years+ - NCT06913309Recruiting
Home bright light therapy for teen depression
This study tests whether a bright light therapy device you can use at home can help improve depression symptoms in teenagers aged 13-17. It compares the results of using the light with a non-active placebo device.
Beijing, Beijing MunicipalityAges 13–17 - NCT07228468Recruiting
Home brain stimulation for depression
This trial tests if a gentle electrical current applied to the head at home can help reduce symptoms of major depression. You would use a device for short sessions over several weeks, while continuing your usual care.
CardiffAges 18 years+ - NCT05603104RecruitingPhase 3
Medication intensification after first treatment failure in mood and psychosis
This Phase 3 study tests a stronger medication approach after your first current treatment hasn’t worked well enough. It targets people with schizophrenia, major depressive disorder, or bipolar depression who still have significant symptoms and life impact.
Ramat GanAges 18–70 - NCT06801925Enrolling by invitation
Voice Chatbot for Depression Screening
This trial tests a voice chatbot that uses artificial intelligence to screen for depression. It aims to see if the chatbot is effective and easy to use.
LondonAges 18–65 - NCT07136714RecruitingPhase 4
Semaglutide for depression in people with overweight
This study tests whether a weekly injection of semaglutide (a medication used for weight loss and diabetes) can help reduce symptoms of depression in people who have major depressive disorder and are overweight or obese.
Hillerød, DenmarkAges 18–65 - NCT07479758Recruiting
Brain scans and vision tests for severe mental illness
This study uses advanced MRI scans and visual perception tests to learn more about severe mental disorders like depression, schizophrenia, and bipolar disorder. It aims to improve diagnosis and treatment outcomes.
Hangzhou, ZhejiangAges 18–45 - NCT07120880RecruitingPhase 3
Light therapy timing for depression with insomnia
This trial tests whether giving light therapy at a specific time of day can improve both depression and sleep problems. It is for adults with major depression and insomnia who are not currently on antidepressants.
ParisAges 18–65 - NCT06968390Recruiting
Faster TMS for depression during pregnancy or after childbirth
This trial tests a faster form of TMS (brain stimulation) for people with depression who are pregnant (14-34 weeks) or within one year of giving birth. It aims to see if the treatment is safe and well-tolerated.
Boston, MassachusettsAges 18–55 - NCT07211750Recruiting
Integrated care for older adults with depression and multiple health conditions
This trial tests a new integrated care program for older adults who have depression or bipolar disorder along with at least two other long-term physical health problems. The program aims to bring together your doctors and psychiatrist to improve your overall health.
LeuvenAges 65 years+ - NCT06594588Recruiting
Aerobic exercise for depression in adults
This trial tests whether adding a personalized aerobic exercise program to your usual depression treatment can help you feel better. It is for adults aged 18-45 with depression who are not currently in regular psychotherapy.
Beijing, Beijing MunicipalityAges 18–45 - NCT07143838Recruiting
Enhancing deep sleep to help depression
This study tests a gentle brain stimulation method (called transcranial electrical stimulation) during sleep to see if it can improve deep sleep and help with depression symptoms. It is for adults with moderate depression who also have some memory or thinking complaints.
Winston-Salem, North CarolinaAges 40–80 - NCT07250893Recruiting
Resolving early life stress in depression: a psychotherapy study
This trial tests if a specific type of psychotherapy can help people with moderate-to-severe depression who experienced stress or adversity in childhood (before age 18). Researchers want to see how the treatment works in the brain and whether it improves depression symptoms.
Hamilton, OntarioAges 18–65 - NCT06620276Recruiting
Ketamine and therapy for alcohol use disorder and depression
This trial tests if combining ketamine infusions with weekly therapy can help people who have both alcohol use disorder and hard-to-treat depression. You may qualify if you drink at least moderately, have treatment-resistant depression, and are willing to attend 8 therapy sessions.
Montreal, QuebecAges 18–70 - NCT07031817Recruiting
Using a blood test to better diagnose bipolar disorder
This trial tests a new medical device that uses a blood test to help doctors accurately diagnose bipolar disorder in people who were thought to have major depression. It aims to see if the device can tell the difference and improve treatment choices.
MontpellierAges 18–65 - NCT07679204Recruiting
Personality and life satisfaction in bipolar and depression
This study looks at how personality traits and life satisfaction affect people with bipolar II disorder or major depression. You will fill out questionnaires about your feelings and daily life.
ElâzığAges 18 years+
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Common questions
- Are there clinical trials for major depression severe?
- Yes. Clin2 currently lists 279 recruiting major depression severe studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depression severe trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depression severe trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.