Clinical trials
Metformin clinical trials
Below are recruiting metformin clinical trials, each written for real people, not researchers. We’re tracking 148 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05205317Recruiting
VR alone or VR plus metformin for C-section scar healing
This study compares two treatments to help improve a C-section scar defect (an issue seen on the uterus scar). Some participants may receive virtual reality (VR) therapy plus metformin, while others receive VR alone, and the researchers will look at symptoms and scar healing.
Shanghai, Shanghai MunicipalityAges 18–40 - NCT05132439RecruitingPhase 3
Metformin to improve walking in leg artery blockage
This Phase 3 study tests whether metformin can help people with intermittent claudication (leg pain when walking) walk farther. It compares how well metformin works on walking ability alongside standard (already recommended) heart and blood-vessel medicines.
Pittsburgh, PennsylvaniaAges 35–89 - NCT04939935RecruitingPhase 3
Metformin to slow kidney decline in adults with polycystic kidneys
This Phase 3 study tests whether taking metformin can slow the decline of kidney function in adults with autosomal dominant polycystic kidney disease (ADPKD). You may be eligible if you have ADPKD and signs that your kidneys are starting to decline faster than expected.
Gosford, New South WalesAges 18–70 - NCT04530383RecruitingPhase 2
Metformin add-on for adult cystic-fibrosis related diabetes on CF meds
This trial tests whether adding metformin can improve blood-sugar control and related lung cell function in adults who have cystic-fibrosis–related diabetes (CFRD) and are already taking CFTR modulator therapy. It may help if your diabetes is still not well controlled despite those CF medicines.
Kansas City, KansasAges 18 years+ - NCT03675893RecruitingPhase 2
Test abemaciclib plus letrozole with or without extra drugs
This Phase 2 study tests whether adding medicines to standard hormone therapy (letrozole) can control endometrial cancer that has come back, spread, or stopped responding to usual treatments. It also explores whether extra drugs (metformin or gedatolisib) improve results for certain patient groups.
Boston, MassachusettsAges 18 years+ - NCT07589387Recruiting
Combined care for diabetes and blood pressure in Nigeria
This study looks at how to improve care for people who have both diabetes and high blood pressure in Nigeria. It aims to help patients manage their conditions better by offering integrated treatment and support.
AbajiAges 18 years+ - NCT06096259RecruitingPhase 2
Preventing knee arthritis after ACL injury
This trial tests whether metformin, a common diabetes medicine, can prevent arthritis after an ACL injury. If you are planning to have ACL surgery soon, you may be able to join.
Atlanta, GeorgiaAges 18–45 - NCT03925714RecruitingPhase 3
Testing a gene-related approach in people with prediabetes
This trial studies how changes involving p53 and SIRT1 may affect health in people with prediabetes. It may help researchers find better ways to stop or slow progression to type 2 diabetes.
CairoAges 18 years+ - NCT03925701RecruitingPhase 3
Vildagliptin, with or without metformin, for fatty liver and diabetes
This trial studies how vildagliptin compares to vildagliptin plus metformin in people who have fatty liver disease along with type 2 diabetes. It may help find the safest and most effective way to improve liver health and diabetes control.
TantaAges 18 years+ - NCT07785934RecruitingPhase 1
Testing a new weight management injection for drug interactions
This study tests a new injectable medication for weight management in people with overweight or obesity. It investigates how the drug interacts with other medications and checks its safety. Participation requires a 6-month commitment with regular study visits.
Hefei, AnhuiAges 18–45 - NCT07760883Recruiting
Metformin response based on genetic variation in type 2 diabetes
This study looks at how your genes might affect the way your body responds to metformin, a common diabetes medication. It aims to see if a specific genetic variation influences treatment outcomes.
Mexico City, Mexico CityAges 18–65 - NCT06318442Recruiting
Preventing steroid-induced diabetes with a GLP-1 drug
This study tests whether a GLP-1 medication (a type of drug that helps control blood sugar) can prevent diabetes caused by steroid treatments. It is for people who have prediabetes or mild diabetes and are about to receive a short course of steroids.
LondonAges 18 years+ - NCT07724132RecruitingPhase 3
Treatments for sustained response in Alzheimer's disease
This study tests whether a treatment (atomoxetine or metformin) can help people with Alzheimer's disease maintain an improved state for at least 18 months. It may help you or a loved one stabilize symptoms and slow disease progression.
CambridgeAges 55 years+ - NCT07653477RecruitingPhase 3
New diabetes drug for type 2 diabetes not well controlled with metformin
This trial tests an investigational drug called UBT251 for people with type 2 diabetes whose blood sugar is not well controlled despite taking metformin, either alone or with another diabetes medicine. The goal is to see if it can lower blood sugar levels more than a placebo.
ShanghaiAges 18–75 - NCT07588932RecruitingEarly Phase 1
Medication and Robot Training for Stroke Arm Recovery
This study tests whether three medications (Telmisartan, Cilostazol, and Metformin) combined with robotic arm training can help people improve arm movement and strength after a chronic stroke. You would participate in supervised training sessions using a robotic rehabilitation system.
Charlestown, MassachusettsAges 21–80 - NCT07568574Enrolling by invitation
Medical Study of Performance-Enhancing Substances in Elite Athletes
This study looks at how medically supervised performance-enhancing substances affect elite athletes' health and quality of life. Participants must be retired from professional sports and willing to undergo careful medical monitoring throughout the trial.
Abu DhabiAges 18 years+ - NCT05345327RecruitingPhase 3
First diabetes pill to protect kidneys
This Phase 3 trial tests whether starting a diabetes medicine called dapagliflozin can better slow kidney damage than starting metformin in adults with type 2 diabetes. It may help preserve kidney function over time and reduce future kidney decline.
Sydney, New South WalesAges 18 years+ - NCT07550816RecruitingPhase 1
Safety study of ZT002 injection in overweight adults
This study tests how a new diabetes medicine called ZT002 works in the body and whether it interacts safely with other common medications. Researchers will monitor healthy volunteers who are overweight to understand the medicine's safety and effectiveness.
Chengdu, SichuanAges 18–45 - NCT07442006RecruitingPhase 4
Comparing diabetes combos for stable blood sugar
This trial is testing different combinations of diabetes medicines to see which one helps keep your blood sugar more steady throughout the day. It's for people with type 2 diabetes who are already taking metformin and an SGLT-2 inhibitor but still have high blood sugar.
SeoulAges 19 years+ - NCT07395960RecruitingPhase 1/Phase 2
Metformin for older adults with mild memory loss and higher weight
This trial tests if metformin can help older adults (60-75) who are overweight and have mild memory problems. It aims to see if the drug can slow down or improve memory issues.
ShanghaiAges 60–75 - NCT07379333RecruitingPhase 3
Testing a new drug for type 2 diabetes when metformin and dapagliflozin aren't enough
This study tests a new medicine (HM11260C) to see if it helps people with type 2 diabetes who are already taking metformin and dapagliflozin but still have high blood sugar. If you qualify, it could give you a new option to better control your diabetes.
Gyeonggi-doAges 19 years+ - NCT06846411RecruitingPhase 4
Empagliflozin in newly untreated type 2 diabetes
This trial tests a medication called empagliflozin (a type 2 diabetes pill) to see how well it works in people with type 2 diabetes who have not taken any diabetes drugs for at least 8 weeks. If you qualify, you may receive the study drug and help researchers learn more about managing blood sugar.
SeongnamAges 20 years+ - NCT07339722RecruitingPhase 1
Study of LY4515100 in healthy volunteers
This trial tests a new oral medication in healthy volunteers to see how it moves through the body and how safe it is. Taking part helps researchers understand how the drug works before it's studied in people with a certain condition.
Dallas, TexasAges 18–65 - NCT07300293Recruiting
Metformin and lactic acidosis in intensive care
This study looks at patients in intensive care who had lactic acidosis, to see if taking metformin before admission played a role. It may help understand how metformin affects recovery.
StrasbourgAges 18 years+
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Common questions
- Are there clinical trials for metformin?
- Yes. Clin2 currently lists 148 recruiting metformin studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a metformin trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a metformin trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.